FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: obesity and metabolic disorder, susceptibility to (postulated), MIR33-related
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General Information
Name
obesity and metabolic disorder, susceptibility to (postulated), MIR33-related
FlyBase ID
FBhh0001190
Disease Ontology Term
Parent Disease
OMIM
Overview

Expanding upon work done in human systems, animals in which the Drosophila microRNA mir-33 was overexpressed were studied; results support the role of this microRNA family (MIR33A and MIR33B in human) in maintaining lipid homeostasis. Flies in which Dmel\mir-33 is overexpressed in fat body exhibit several lipid storage phenotypes: cells of the fat body contain more large droplets compared to controls; the animals accumulate more triglycerides upon starvation.

In a subsequent study, Dmel\mir-33 was identified in a screen for miRNAs which alter the amount of body fat in Drosophila. In this case, mir-33 overexpression was driven by a ubiquitously-expressed driver; increased levels of triglycerides were again observed, with females exhibiting a higher percentage increase than males.

[updated Feb. 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: obesity, susceptibility to (fly models overview)
Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)
Specific Disease Summary: obesity and metabolic disorder, susceptibility to (postulated), MIR33-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    Symbol / Name
    MIR33B; microRNA 33b
    D. melanogaster ortholog (based on DIOPT)
    Dmel\mir-33
    (FlyBase Curators, 2018-)
    Comments on ortholog(s)

    Many to one: 2 human to 1 Drosophila.

    Human gene (HGNC)
    Symbol / Name
    MIR33A; microRNA 33a
    D. melanogaster ortholog (based on DIOPT)
    Dmel\mir-33
    (FlyBase Curators, 2018-)
    Comments on ortholog(s)

    Many to one: 2 human to 1 Drosophila.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Dmel\mir-33
      Gene Snapshot
      Contributions welcome
      Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
          Comments on ortholog(s)

          Orthologous to human MIR33A and MIR33B; 5' seed sequences similar to additional human miRNAs (FBrf0215696).

          Orthologs and Alignments from DRSC
          DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
          H. sapiens (Human)
          Other Genes Used: Viral, Bacterial, Synthetic (0)
            Summary of Physical Interactions (3 groups)
            mir-33
            RNA-protein
            Interacting group
            Assay
            References
            mir-33 - SmB
            anti tag coimmunoprecipitation, primer specific pcr
            (Xiong et al., 2015)
            mir-33 - SmD1
            anti bait coimmunoprecipitation, primer specific pcr
            (Xiong et al., 2015)
            mir-33 - SmD2
            anti tag coimmunoprecipitation, primer specific pcr
            (Xiong et al., 2015)
            Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
            Alleles Representing Disease-Implicated Variants
            Genetic Tools, Stocks and Reagents
            Sources of Stocks
            Contact lab of origin for a reagent not available from a public stock center.
            Bloomington Stock Center Disease Page
            Related mammalian, viral, bacterial, or synthetic transgenes
            Allele
            Transgene
            Publicly Available Stocks
            Selected Drosophila transgenes
            Allele
            Transgene
            Publicly Available Stocks
            RNAi constructs available
            Allele
            Transgene
            Publicly Available Stocks
            Selected Drosophila classical alleles
            Allele
            Allele class
            Mutagen
            Publicly Available Stocks
            mir-33KO
            amorphic allele - molecular evidence
            ends-out gene targeting
            References (5)