FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

RISC complex

ID (Ontology)

GO:0016442 (Gene Ontology)

Definition

A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.[ PubMed:10749213 PubMed:15145345 ]

Also Known As

"RNA-induced silencing complex"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
RISC complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| RISC complex	--

Spanning Tree (Parents/Children)

  ribonucleoprotein complex
   |__RNAi effector complex
       |__RISC complex  87 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	RNAi effector complex
Part of
Synonyms & Secondary IDs
Synonyms
	"micro-ribonucleoprotein complex" RELATED "miRNP complex" RELATED "RNA-induced silencing complex" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Wikipedia:RNA-induced_silencing_complex