FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: nociceptive pain sensitization, injury-induced
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General Information
Name
nociceptive pain sensitization, injury-induced
FlyBase ID
FBhh0001398
Disease Ontology Term
Parent Disease
OMIM
Overview

Injury-induced nociceptive pain sensitization is a normal response to injury: the nociceptive threshold for pain is reduced (allodynia) and an increased pain signal is produced (hyperalgesia). However, if the response persists after the injury is healed, chronic pain can result.

Injury-induced nociceptive pain sensitization has been characterized in multiple studies in Drosophila. Ultraviolet (UV) irradiation is typically used to induce tissue damage, usually in third instar larvae. Thermal (heat) nociception assays are most common; response to mechanical force has also been used. Several molecular pathways involved in the pain sensitization response have been investigated. Work in flies has allowed investigation of allodynia and hyperalgesia as separable responses.

[updated Oct. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: nociceptive pain sensitization, injury-induced
OMIM report
Human gene(s) implicated
Symptoms and phenotype

When an injury occurs the nociceptive threshold for pain is reduced (allodynia) and an increased pain signal is produced (hyperalgesia); this fosters behavior that protects damaged tissue during healing. Sensitization normally subsides after the injury is healed, however, dysregulation can occur which results in sensitization that persists after the injury has healed and can result in chronic pain (FBrf0250205 and references cited therein).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology

Nociceptors are sensory end organs in the skin, muscle, joints and viscera that selectively respond to noxious or potentially tissue-damaging stimuli. Pain usually starts with the activation of nociceptors, which convey nociceptive (pain) information to the CNS. An important property of nociceptors is that they sensitize (that is, their excitability can be increased). Sensitization, which typically develops as a consequence of tissue insult and inflammation, is defined as a reduction in the threshold and an increase in the magnitude of a response to noxious stimulation. (Gold and Gebhart, 2010; pubmed:20948530).

(FlyBase Curators, 2013-)
Molecular information
External links
    Disease synonyms
    chronic pain
    injury-induced allodynia
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
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          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
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          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
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          Publicly Available Stocks
          References (17)