FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mxc, mute
FlyBase ID
FBig0000095210
Interaction Network
Interactions Browser links
mxc network
mute network
Reported Interactions
FBrf0213662-3.coIP.WB
Reference
White et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mxc 

MPM-2

bait
mute 

Mute

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

The MPM-2 antibody, raised against human mitotic phosphoproteins, marks the histone locus body during the S phase of Drosophila cells and reacts with phosphorylated mxc among other proteins.

(White et al., 2011)

mute may coimmunoprecipitate with the MPM-2 antibody because it reacts with mxc and/or some other MPM-2-reactive HLB protein.

(White et al., 2011)

mute and mxc colocalize at the HLB during S phase.

(White et al., 2011)

Bait endogenous to nuclear extract.

(White et al., 2011)

Prey endogenous to nuclear extract.

(White et al., 2011)
FBrf0226935-1.PD.A
Reference
Yang et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mxc 

mxc

bait

GST tag

mxc 
mxc 
mute 

mute

prey

[35]S label

mute 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
mxc 
interaction domain
sufficient binding region
aa 1669-1837
mxc 
interaction domain
necessary binding region
aa 1824-1837
mute 
interaction domain
sufficient binding region
aa 1684-1739

coordinates relative to mute-PC

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro translation.

(Yang et al., 2014)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)