Cavicchi, S., Guerra, D., Natali, V., Giorgi, G., Pezzoli, C., Villani, L. (1989). Developmental effects of modifiers of the vg mutant in Drosophila melanogaster.  Dev. Genet. 10(): 386--392.

FBrf0049528

Research paper

An analysis of the modifiers affecting the expression of the vg gene was performed. We selected for weak and strong expression of the vg mutant in F2 segregating populations obtained by crossing a vestigial stock with an Oregon laboratory stock (O) and with a wild strain (B) captured near Bologna, Italy. The selection for enlarged wings was more effective in the vg B population where wild wings appeared from the 10th generation. The assay of the three major chromosomes showed that the modifiers are located on chromosomes 2 and 3. The mutant imaginal disc cell death phenotype is evident in vg/vg strains that have a wild-type wing phenotype. It is suggested that the selected modifiers do not prevent cell death but induce regenerative growth.