Subject: Info
Dear Flybase,
Here is some clarifying information on two genes listed in Flybase:
CIP-61 \- 'Corkscrew Interacting Protein-61' was the name we initially gave
to the predicted protein encoded by a cDNA that we isolated by its ability
to bind to the PTP csw. We subsequently named the protein DIM-7 based on
the phenotype of embryos deleted for the genomic region encoding CIP-61.
These embryos display 'diminished' nuclear staining of the activated form
of D-ERK. Mutant alleles of the gene were isolated (in Danny Brower's lab)
by their ability to suppress wing blisters and the gene ID'd by these
alleles was named moleskin. So in collaboration with Danny we decided to
call the gene moleskin and the protein product Dim-7. Interestingly, Dim-7
is also the Drosophila homologue of the vertebrate protein Importin-7, a
member of the Importin superfamily of nuclear import proteins.
CIP-D2 \- 'Corkscrew Interacting Protein-D2' was the name we initially gave
to the predicted protein encoded by a cDNA that we isolated by its ability
to bind to the phosphatase insert of the PTP csw. We have subsequently
determined that the cDNA that encodes CIP-D2 is an alternative splice
product of the gene nuclear fallout, Nuf. Therefore, we now call this
predicted protein NufD2 (with D2 in superscript).
Gene listed in Flybase as anon-D2 is also NufD2.
If you have any questions please do not hesitate to contact me.
Thanks,
Liz Perkins
Lizabeth A. Perkins, Ph.D.
Assistant Professor of Surgery (Genetics)
Pediatric Surgical Research Laboratories
Warren 10
Massachusetts General Hospital
Boston, MA 02114