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FB2026_01
,
released March 12, 2026
DIM-7, CIP-61, Corkscrew Interacting Protein-61, Imp7/8, Dim7
Importin 7 - functions in nuclear transport of MAPK - surface receptor signaling regulates MAPK localization through the adaptor protein Corkscrew
Please see the JBrowse view of Dmel\msk for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\msk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
JBrowse - Visual display of RNA-Seq signals
View Dmel\msk in JBrowse
3-22
3-19.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In an EMS screen for dominant modifiers of the eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4. 15 alleles of msk have been isolated in the screen.
msk is required for cell proliferation and survival in phase 0 of eye development, as well as for correct ommatidial rotation (and not chirality) in phase 2.
msk is required for cell proliferation in the larval stage, and later for the survival of postmitotic cells.
Identification: in a yeast two hybrid screen for interactors with csw protein.
Identification: Screen for proteins that bind csw protein.
Identification: Yeast two hybrid screen for proteins that interact specifically with the carboxyl terminal region of the csw protein.
Source for merge of: dim-7 CG7935
Source for merge of: msk CIP-61
Source for merge of dim-7 CG7935 was sequence comparison ( date:000414 ).
Source for identity of: msk dim-7
Since this locus was identified as a suppressor of blistering, the gene has been named "moleskin".
Name "dim-7" denotes the strikingly DIMinished activated MAP kinase immunostaining observed in embryos mutant for Importin 7/RanBP7.
