E(sev)1A, EG:BACN25G24.2 , l(1)2Db, l(1)csw, l(1)G0170
7.2, 6.0, 4.7 (northern blot)
None of the polypeptides share 100% sequence identity.
841 (aa); 92.4 (kD)
One of a couple of products generated by alternative splicing.
Interacts with drpr isoform A.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\csw using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\csw in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
csw SH2 domain function is essential for csw function, but either SH2 domain can fulfill this requirement. csw protein-tyrosine phosphatase activity is required for full csw function, but a catalytically inactive csw protein is capable of providing partial function. Deletion of either the csw protein-tyrosine phosphatase insert of the entire carboxyl terminus does not abolish csw function. csw and activated sev proteins are associated in vivo in a manner that does not require either csw SH2 domain function or tyrosine phosphorylation of sev protein. In contrast, the interaction between csw and dos proteins is dependent on csw SH2 domain function.
The csw SH2-containing tyrosine phosphatase is required during signalling by sev, Ras85D and phl. Expression of a membrane targeted form of csw can drive R7 photoreceptor development in the absence of sev function.
The protein encoded by dos is a csw substrate and may also be a direct or indirect target for the tyrosine kinase activity of sev. Mutations that inactivate dos dominantly enhance the effects of reduced csw activity and suppress the effects of either excessive sev or csw activity. Results indicate that dos is a crucial component of the sev signalling pathway and strongly suggest that dephosphorylation of dos by csw promotes R7 photoreceptor differentiation.
csw is required for terminal embryonic development, for the development of adult structures and during oogenesis for follicle cell development. csw has a role in embryonic ventral cell fate development, in embryonic CNS development and in embryonic tracheal development.
Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.
During late embryogenesis csw is required for tracheal morphogenesis as well as determination of ventral ectodermal fates. Embryos that lack csw develop tracheal precursor cells which fail to migrate into their final positions and markers specific for ventral ectodermal cells are missing. csw is also required during imaginal and adult stages.
Sequence similarity between human src homology protein-tyrosine-phosphatase 2 (SH-PTP2) and csw and their similar patterns of expression suggest that SH-PTP2 is the human homolog of csw.
Synonym given as "l(1)2Db" on p129 and "l(1)2Dd" on p311.
csw and phl act in concert to regulate tll expression. csw functions downstream of tor.
csw is required for photoreceptor development, acts in the developing R7 cell to attenuate the signalling by the sev gene product and is a suppressor of the Egfr phenotype to restore the eye to a nearly normal appearance.
Hemizygotes die at the larval-pupal transition; dissected third instar larvae display small imaginal discs. Larval neuroblast cells show low mitotic index, but chromosome morphology appears normal. Homozygous germ-line clones produce inviable embryos with U-shaped or twisted phenotypes, which are unaffected by paternal genotype or developmental temperature.