FlyBase Gene Report: Dmel\csw

CEA

(Pagani et al., 2009)

csw^A72S.UASp

model of Noonan syndrome 1

CEA

(Pagani et al., 2009)

csw^I282V.UASp

model of Noonan syndrome 1

CEA

(Pagani et al., 2009)

csw^D61Y.UASp

CEA

(Pagani et al., 2009)

csw^T73I.UASp

model of Noonan syndrome 1

CEA

(Ruzzi et al., 2020, Pagani et al., 2009)

PTPN11; protein tyrosine phosphatase non-receptor type 11

CEA

(Pagani et al., 2009)

CEC

(Ruzzi et al., 2020)

model of leukemia

CEA

(Ruzzi et al., 2020)

csw^RNAi.UAS.cUa

model of Noonan syndrome

CEA

(Leahy et al., 2024)

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

PTPN11; protein tyrosine phosphatase non-receptor type 11

IEA

(FlyBase, 2019-)

model of Noonan syndrome with multiple lentigines 1

IEA

(FlyBase, 2019-)

model of Noonan syndrome 1

IEA

(FlyBase, 2019-)

model of metachondromatosis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

csw⁵

model of Noonan syndrome

is ameliorated by rl¹

(Leahy et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 14

PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 11; PTPN11

PTPN6; protein tyrosine phosphatase non-receptor type 6

10 of 14

176883

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

anti tag coimmunoprecipitation, peptide massfingerprinting

Hsap\PTPN11

(Perkins et al., 1996)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

csw - ATPsynβ

(Friedman et al., 2011)

csw - Alk

proximity ligation assay, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot

(Uçkun et al., 2021)

csw - CCT1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Hsp60A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Hsp83

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Larp4B

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Mbs

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Nup50

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - P32

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - Pi3K21B

anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry

(Breitkopf et al., 2016, Vinayagam et al., 2016)

csw - Pvr

two hybrid

(Bianco et al., 2007)

csw - Pyk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - RpL37-1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - RpL37A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - RpS27

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - UQCR-C2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - blanks

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - caz

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - dos

anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, western blot

(Friedman et al., 2011, Allard et al., 1998)

csw - drk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - drpr

anti bait coimmunoprecipitation, anti tag western blot

(Logan et al., 2012)

csw - eIF4A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - msk

anti bait coimmunoprecipitation, western blot, two hybrid, pull down

(Lorenzen et al., 2001)

csw - rin

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - sev

anti bait coimmunoprecipitation, western blot

(Allard et al., 1998)

csw - stumps

anti tag coimmunoprecipitation, anti tag western blot

(Petit et al., 2004)

csw - wal

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

csw - βTub97EF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RNA-protein

Physical Interaction

Assay

References

csw - Fmr1

anti tag coimmunoprecipitation, reverse transcription pcr

(Leahy et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

aos

(Oishi et al., 2009, Oishi et al., 2006)

suppressible

(Firth et al., 2000)

enhanceable

(Oishi et al., 2006)

enhanceable

Delta

(Oishi et al., 2006)

enhanceable

dos

(Firth et al., 2000, Herbst et al., 1999, Herbst et al., 1996)

suppressible

dos

(Herbst et al., 1999, Herbst et al., 1996)

suppressible

dpp

(Oishi et al., 2006)

suppressible

drk

(Oishi et al., 2006)

enhanceable

drk

(Firth et al., 2000)

suppressible

Dsor1

(Oishi et al., 2006, Tsuda et al., 1993)

enhanceable

E(spl)m8-HLH

(Oishi et al., 2006)

suppressible

E(spl)m8-HLH

(Oishi et al., 2006)

enhanceable

(Firth et al., 2000)

suppressible

(Oishi et al., 2009, Oishi et al., 2006)

suppressible

hop

(Oishi et al., 2006)

enhanceable

hop

(Oishi et al., 2006)

suppressible

Hsp83

(Oishi et al., 2006)

enhanceable

ksr

(Firth et al., 2000)

enhanceable

lace

(Oishi et al., 2006)

suppressible

Mad

(Oishi et al., 2006)

enhanceable

mago

(Ashton-Beaucage et al., 2010)

enhanceable

mask

(Smith et al., 2002)

suppressible

mask

(Smith et al., 2002)

suppressible

msk

(Johnson Hamlet and Perkins, 2001)

suppressible

pnt

(Oishi et al., 2006)

enhanceable

pnt

(Firth et al., 2000)

suppressible

(Oishi et al., 2009, Oishi et al., 2006)

enhanceable

(Firth et al., 2000)

suppressible

RasGAP1

(Firth et al., 2000)

enhanceable

RasGAP1

(Oishi et al., 2009, Oishi et al., 2006)

suppressible

rho

(Oishi et al., 2006)

suppressible

(Oishi et al., 2009, Oishi et al., 2006, Firth et al., 2000)

suppressible

(Oishi et al., 2009, Oishi et al., 2006)

enhanceable

(Firth et al., 2000)

enhanceable

Smurf

(Oishi et al., 2006)

suppressible

Sos

(Oishi et al., 2009, Oishi et al., 2006)

enhanceable

Sos

(Firth et al., 2000)

suppressible

spi

(Oishi et al., 2009)

enhanceable

Src64B

(Firth et al., 2000)

enhanceable

Stat92E

(Oishi et al., 2006)

enhanceable

sty

(Oishi et al., 2009, Jarvis et al., 2006, Oishi et al., 2006)

suppressible

sty

(Jarvis et al., 2006)

suppressible

Su(H)

(Oishi et al., 2006)

suppressible

tkv

(Oishi et al., 2006)

enhanceable

Usp47

(Ashton-Beaucage et al., 2016)

suppressible

(Oishi et al., 2009, Oishi et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bnl

enhanceable

(Jarvis et al., 2006)

suppressible

(Firth et al., 2000)

dos

suppressible

(Johnson Hamlet and Perkins, 2001)

suppressible

(Johnson Hamlet and Perkins, 2001)

enhanceable

(Perkins et al., 1996)

suppressible

(Baker et al., 2002)

ksr

suppressible

(Johnson Hamlet and Perkins, 2001)

Raf::tor

suppressible

(Firth et al., 2000, Allard et al., 1996)

Raf

suppressible

(Johnson Hamlet and Perkins, 2001)

enhanceable

(Firth et al., 2000)

suppressible

(Johnson Hamlet and Perkins, 2001, Firth et al., 2000, Allard et al., 1996)

rho

suppressible

(Johnson Hamlet and Perkins, 2001)

spi

suppressible

(Johnson Hamlet and Perkins, 2001)

Src42A

suppressible

(Takahashi et al., 1996)

Src64B

suppressible

(Cooper et al., 1996)

svp

enhanceable

(Kramer et al., 1995)

svp

suppressible

(Begemann et al., 1995, Kramer et al., 1995)

tor

suppressible