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FB2025_05
,
released December 11, 2025
dCsk, l(3)j1D8, l(3)S017909, flik, Src
tyrosine kinase acts as a tumor suppressor through Src pathway regulation - loss of Csk activity leads to increased organ size, organismal lethality, and increased cell proliferation
Please see the JBrowse view of Dmel\Csk for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Csk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Csk in JBrowse3-51
3-48.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Csk is a regulator of sustained homeostatic plasticity at the neuromuscular junction.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutants have increased body size and show over-proliferation of adult tissues.
New annotation (CG32852) in release 3 of the genome annotation.
Homozygous flik animals display disc overproliferation and enlarged animal phenotypes.
Lethal complementation group identified by insertion of a P{lacW} element in the 86E-87F region.
Source for merge of: Csk CG32852
Source for merge of: Csk flik l(3)j1D8
Source for merge of: Csk l(3)S017909
Source for merge of: Csk flik
Annotations CG17309 and CG32852 merged as CG42317 in release 5.9 of the genome annotation.
Source for identity of: Csk CG17309
