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FB2026_01
,
released March 12, 2026
DAlk
transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk to specify a select group of visceral muscle precursors as muscle-patterning pioneers
Please see the JBrowse view of Dmel\Alk for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: type Ib boutons
Comment: synapse
Alk protein is expressed throughout the third instar larval and adult brain. In the adult, labelling is stronger in the mushroom body calyx (dendrites of Kenyon cells), protocerebral bridge, antennal lobe, subesophageal ganglion and optic lobe. Alk protein is not detected in the mushroom body lobes (axons of Kenyon cells). The expression of Alk protein is similar but more widespread than labelling with ScerGAL4Alk.38.
Alk is concentrated postsynaptically at larval glutamergic neuromusclular junction synapses. It is strongly expressed in type Ib boutons and is more weakly localized at type Is boutons. Alk superimposed extensively with the anti-HRP labeled presynaptic membrane, but had a much broader domain and was localized to the surrounding postsynaptic muscle. In mature embryos, Alk is present in developing CNS synapses.
In third instar larvae, Alk protein is expressed at low levels in the lamina plexus, and at high levels in the medulla neuropil; expression is absent from photoreceptor axons and repo-positive glial cells. At pupal timepoints 24, 40, and 50 hours APF, and at adult stages, Alk protein expresson increases in optic cartridges (lamina cartridges) and remains strong in the medulla and lobula neuropils. The expression pattern in the developing visual system is complementay to that of jeb.
Expression of Alk protein is observed in both muscle founder cells and in fusion-competent myoblasts in the visceral mesoderm, and is localized to the cell membrane.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Alk in JBrowse2-80
2-83.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Alk is required in target neurons in the lamina for the correct formation of adult R cell projections.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Source for merge of: Alk CG8250
Named 'Alk' / 'Anaplastic lymphoma kinase' because of shared homology with mammalian ALK.
