FlyBase Gene Report: Dmel\Tie

General Information

Symbol

Dmel\Tie

Species

D. melanogaster

Name

Tie-like receptor tyrosine kinase

Annotation Symbol

CG7525

Feature Type

protein_coding_gene

FlyBase ID

FBgn0014073

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

receptor protein-tyrosine kinase (2.7.10.1)

Gene Summary

Tie-like receptor tyrosine kinase (Tie) encodes a predicted transmembrane tyrosine kinase receptor. Its potential ligands for include Pvf protein family members. It may be involved in cell survival and cell migration. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

RTK, DPR1

Key Links

Genomic Location

Cytogenetic map

64B9-64B9

Sequence location

3L:4,510,698..4,532,145 [-]

Recombination map

3-12

RefSeq locus

NT_037436 REGION:4510698..4532145

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(InterPro Project Members, 2004-)

enables protein tyrosine kinase activity

inferred from electronic annotation with InterPro:IPR020635

(InterPro Project Members, 2004-)

enables transmembrane receptor protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in negative regulation of apoptotic signaling pathway

inferred from mutant phenotype

(Bilak et al., 2014)

involved_in positive regulation of border follicle cell migration

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Wang et al., 2006)

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Wang et al., 2006)

involved_in regulation of cellular response to X-ray

inferred from mutant phenotype

(Bilak et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:Q02763

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with UniProtKB:Q02763

(Gene Ontology Curators, 2002-)

part_of receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein tyrosine kinase activity

RHEA 10596: transmembrane receptor protein tyrosine kinase activity

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) (2.7.10.1)

Summaries

Gene Snapshot

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Summary (Interactive Fly)

anti-apoptotic receptor for Pvf1 - bystander effect - resistance to ionizing radiation - guidance receptor for border cells

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tie for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VZA8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tie-RA

FBtr0073323

NM_079204

5236

1233

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tie-PA

FBpp0073179

135.1

1233

8.48

Q9VZA8

NP_523928

AAF47916

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1235 (aa)

(Ito et al., 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tie using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tie_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

border follicle cell

(Wang et al., 2006)

centripetal follicle cell

(Wang et al., 2006)

Additional Descriptive Data

Tie expression is enriched in border cells and in centripetal cells relative to other cells in the egg chamber.

(Wang et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tie in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tie

View exonic expression by tissue for Dmel\Tie

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38559/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014073

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014073

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014073

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7525

Flygut - An atlas of the Drosophila adult midgut

FBgn0014073

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tie

Transgenic constructs containing regulatory region of Tie

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3L)Exel6101

(Ryder, 2004.4.26)

Df(3L)Exel7208

(Ryder, 2004.4.26)

Df(3L)Exel9028

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Tub.PU

Tie^GD14425

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

Tie^e03394

Other Phenotypes

Allele

majority die during P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

Tie^GD14425

radiation sensitive

radiation sensitive | dominant

Tie^Exel9028

Phenotype manifest in

Allele

female germline stem cell | conditional

Tie^e03394

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (60)

Hsap\FLT3

3 of 14

Yes

Hsap\PDGFRA

3 of 14

Yes

Hsap\PDGFRB

3 of 14

Yes

Hsap\TEK

3 of 14

Yes

Hsap\TIE1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LMTK3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (31)

Rnor\Flt3

2 of 14

Yes

Rnor\Pdgfra

2 of 14

Yes

Rnor\Tek

2 of 14

Yes

Rnor\Tie1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Flt3

2 of 14

Yes

Mmus\Pdgfra

2 of 14

Yes

Mmus\Pdgfrb

2 of 14

Yes

Mmus\Tek

2 of 14

Yes

Mmus\Tie1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\tie1

2 of 13

Yes

Xtro\blk

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101733045

1 of 13

Xtro\lyn

1 of 13

Xtro\ntrk1

1 of 13

Yes

Xtro\ntrk3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tek

1 of 13

Yes

Xtro\trim44

1 of 13

Yes

Xtro\tyro3

1 of 13

Yes

Xtro\ubxn7

1 of 13

Xtro\yes1

1 of 13

Danio rerio (Zebrafish) (38)

Drer\flt3

2 of 14

Yes

Drer\tek

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch73-206d17.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\F09A5.2

3 of 14

Yes

Cele\kin-30

3 of 14

Yes

Cele\old-1

3 of 14

Yes

Cele\old-2

3 of 14

Yes

Cele\R09D1.12

3 of 14

Yes

Cele\R09D1.13

3 of 14

Yes

Cele\T01G5.1

3 of 14

Yes

Cele\ver-1

3 of 14

Yes

Cele\W04G5.10

3 of 14

Yes

Cele\Y50D4B.6

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\trk-1

1 of 14

Cele\ver-2

1 of 14

Yes

Cele\Y47G6A.5

1 of 14

Cele\zig-13

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP006490

8 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (11)

Atha\AT1G80640

1 of 13

Yes

Atha\AT3G06630

1 of 13

Yes

Atha\AT3G50720

1 of 13

Yes

Atha\AT5G50180

1 of 13

Yes

Atha\AT5G66710

1 of 13

Yes

Atha\ATN1

1 of 13

Yes

Atha\CCR3

1 of 13

Yes

Atha\CRLK1

1 of 13

Yes

Atha\LYK3

1 of 13

Yes

Atha\PERK14

1 of 13

Yes

Atha\STY8

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tie. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (29)

btl

4 of 13

CG3277

4 of 13

htl

4 of 13

Pvr

4 of 13

Alk

3 of 13

Cad96Ca

3 of 13

Eph

3 of 13

InR

3 of 13

Nrk

3 of 13

Ret

3 of 13

Ror

3 of 13

sev

3 of 13

Ddr

2 of 13

dnt

2 of 13

drl

2 of 13

Egfr

2 of 13

tor

2 of 13

Ack-like

1 of 13

Btk

1 of 13

CG10702

1 of 13

Csk

1 of 13

Drl-2

1 of 13

drpr

1 of 13

otk

1 of 13

Sdr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

TEK; TEK receptor tyrosine kinase

model of multiple cutaneous and mucosal venous malformations

IEA

(FlyBase, 2019-)

model of acute myeloid leukemia

IEA

(FlyBase, 2019-)

model of acute lymphoblastic leukemia

IEA

(FlyBase, 2019-)

PDGFRB; platelet derived growth factor receptor beta

model of infantile myofibromatosis 1

IEA

(FlyBase, 2019-)

model of basal ganglia calcification

IEA

(FlyBase, 2019-)

KIT; KIT proto-oncogene, receptor tyrosine kinase

model of acute myeloid leukemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

3 of 14

136351

PDGFRA; platelet derived growth factor receptor alpha

3 of 14

173490

PDGFRB; platelet derived growth factor receptor beta

3 of 14

173410

TEK; TEK receptor tyrosine kinase

3 of 14

600221

multiple cutaneous and mucosal venous malformations

TIE1; tyrosine kinase with immunoglobulin like and EGF like domains 1

3 of 14

600222

LYMPHATIC MALFORMATION 11; LMPHM11

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Tie

suppressible

mir-ban

(Bilak et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

E2f1

suppressible

Tie

(Bilak et al., 2014)

mir-ban

enhanceable

Tie

(Bilak et al., 2014)

Pvr

enhanceable

Tie

(Wang et al., 2006)

Pvr|Egfr

enhanceable

Tie

(Wang et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64033

DroID - A comprehensive database of gene and protein interactions.

FBgn0014073

MIST (genetic) - An integrated Molecular Interaction Database

38559

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-12

Cytogenetic map

64B9-64B9

Sequence location

3L:4,510,698..4,532,145 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64B9-64B9

Limits computationally determined from genome sequence between P{PZ}l(3)rG166^rG166 and P{PZ}sinu⁰⁶⁵²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-12

(FlyBase, 2016)

3-10.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

86031

w¹¹¹⁸; PBac{RB}Tie^e03394

54005

y¹ v¹; P{TRiP.HMJ21428}attP40

37331

y¹ w^*; Mi{MIC}Tie^MI02904

85038

w¹¹¹⁸; PBac{PB}Tie^c03340/TM6B, Tb¹

77540

w¹¹¹⁸; PBac{IT.GAL4}Tie^0265-G4/TM6B, Tb¹

FlyORF

F003556

M{UAS-Tie.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

7525R-2

P{NIG.7525R}2

7525R-3

P{NIG.7525R}3

HMJ22743

y¹ v¹; P{TRiP.HMJ22743}attP40/CyO

VDRC

v26879

w¹¹¹⁸; P{GD13190}v26879

v27087

w¹¹¹⁸; P{GD14425}v27087

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0014073

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0014073

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Isolated from a genomic library using a cDNA fragment encoding the human α-platelet derived growth factor receptor tyrosine kinase domain as a probe, under low stringency conditions.

(Ito et al., 1994)

Tie has been cloned and sequenced.

(Ito et al., 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG7525

(National Institute of Genetics Fly Stocks, 2023-, Ni et al., 2010.12.1, Morrison et al., 2000)

DPR1

(Ito et al., 1994)

RTK

(Texada et al., 2020, Baker and Firth, 2011, Morrison et al., 2000)

tie

(Su, 2015, Xing et al., 2015, Bilak et al., 2014, Aerts et al., 2010, Manning et al., 2002, Matsui, 1993)

Name Synonyms

Tie-like receptor

(Mele and Johnson, 2019)

Tie-like receptor tyrosine kinase

(Wang et al., 2006, Nybakken et al., 2005)

Tyrosine kinase with Ig and epidermal growth factor homology domain

(Bilak et al., 2014)

tyrosine kinase

(Matsui, 1993)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38559

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VZA8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VZA8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38559/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014073

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014073

FlyMine - An integrated database for Drosophila genomics

FBgn0014073

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7525

MARRVEL_MODEL - MARRVEL (model organism gene)

38559

Linkouts

BioGRID - A database of protein and genetic interactions.

64033

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0014073

DroID - A comprehensive database of gene and protein interactions.

FBgn0014073

DRSC - Results frm RNAi screens

FBgn0014073

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tie_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014073

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0014073

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7525

Flygut - An atlas of the Drosophila adult midgut

FBgn0014073

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0014073

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

38559

References (71)

The following external sites may use different assemblies or annotations than FlyBase.

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