FlyBase Gene Report: Dmel\Ror

General Information

Symbol

Dmel\Ror

Species

D. melanogaster

Name

RTK-like orphan receptor

Annotation Symbol

CG4926

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010407

Gene Model Status

Current

Stock Availability

12 publicly available

Enzyme Name (EC)

receptor protein-tyrosine kinase (2.7.10.1)

Gene Summary

Ror (Ror) encodes a transmembrane receptor tyrosine kinase structurally related to vertebrate neural-specific Wnt-binding Ror receptors. It is primarily expressed in the nervous system and it is likely to signal through the ERK MAP kinase pathway. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dror, DmHD-2

Key Links

Genomic Location

Cytogenetic map

31B1-31B1

Sequence location

2L:10,251,843..10,254,686 [+]

Recombination map

2-40

RefSeq locus

NT_033779 REGION:10251843..10254686

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002011, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(InterPro Project Members, 2004-)

enables protein tyrosine kinase activity

non-traceable author statement

(Wilson et al., 1993)

inferred from electronic annotation with InterPro:IPR020635

(InterPro Project Members, 2004-)

enables transmembrane receptor protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002011

(InterPro Project Members, 2004-)

enables Wnt-protein binding

inferred from biological aspect of ancestor with PANTHER:PTN004704195

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in central nervous system development

inferred from expression pattern

(Wilson et al., 1993)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002011

(InterPro Project Members, 2004-)

involved_in protein phosphorylation

non-traceable author statement

(Wilson et al., 1993)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN000699763

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR002011

(InterPro Project Members, 2004-)

non-traceable author statement

(Wilson et al., 1993)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

part_of receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (Q24488)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

transmembrane receptor protein tyrosine kinase activity

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) (2.7.10.1)

protein tyrosine kinase activity

RHEA 10596:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Protein Function (UniProtKB)

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

(UniProt, Q24488)

Summary (Interactive Fly)

Ror proteins are ROR proteins are a class of Wnt-binding receptor tyrosine kinases - expressed during neural differentiation - promotes dendrite regeneration as part of a Wnt signaling pathway that regulates dendritic microtubule nucleation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ror for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24488)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ror-RA

FBtr0079978

NM_057614

2271

685

Additional Transcript Data and Comments

Reported size (kB)

2.272 (longest cDNA)

(Wilson et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ror-PA

FBpp0079568

78.1

685

7.89

Q24488

NP_476962

AAF52885

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

685 (aa)

(Wilson et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q24488

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ror using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ror_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.31

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval peripheral nervous system | restricted

(Wilson et al., 1993)

embryonic stage 11 -- 17

central nervous system

(Wilson et al., 1993)

Additional Descriptive Data

Ror transcripts are first detected at embryonic stage 11. They are expressed in most of the cells of the brain and ventral nerve cord and may be restricted to neurons. They are also present in some cells of the head and trunk that are thought to be sense organs of the PNS.

(Wilson et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ror in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ror

View exonic expression by tissue for Dmel\Ror

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34367/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010407

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010407

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010407

Flygut - An atlas of the Drosophila adult midgut

FBgn0010407

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ror

Transgenic constructs containing regulatory region of Ror

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)41C

(Goberdhan et al., 1999)

Df(2L)Exel6026

(Ryder, 2004.4.26)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ror⁴

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ror^GD40

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Ror^GD40

Sterility

Allele

fertile

Ror⁴

Other Phenotypes

Allele

some die during embryonic stage

Ror⁴

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (116)

Hsap\ROR1

13 of 14

Yes

Hsap\ROR2

12 of 14

Yes

Hsap\MUSK

3 of 14

Hsap\NTRK1

2 of 14

Yes

Hsap\NTRK2

2 of 14

Yes

Hsap\NTRK3

2 of 14

Yes

Hsap\PTK7

2 of 14

Hsap\AATK

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LCK

1 of 14

Hsap\LMTK2

1 of 14

Yes

Hsap\LMTK3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\YES1

1 of 14

Hsap\ZAP70

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (70)

Rnor\Ror1

13 of 14

Yes

Rnor\Ror2

11 of 14

Yes

Rnor\Musk

3 of 14

Rnor\Ntrk1

2 of 14

Yes

Rnor\Ntrk2

2 of 14

Yes

Rnor\Ntrk3

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (75)

Mmus\Ror1

13 of 14

Yes

Mmus\Ror2

12 of 14

Yes

Mmus\Musk

3 of 14

Mmus\Ntrk1

2 of 14

Yes

Mmus\Ntrk2

2 of 14

Yes

Mmus\Ntrk3

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (62)

Xtro\ror2

9 of 13

Yes

Xtro\ror1

7 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pick1

1 of 13

Xtro\pik3ip1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (90)

Drer\ror1

13 of 14

Yes

Drer\ror2

12 of 14

Yes

Drer\musk

2 of 14

Drer\ntrk2a

2 of 14

Yes

Drer\ntrk3a

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ltk

1 of 14

Drer\matk

1 of 14

Drer\mertka

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ntrk2b

1 of 14

Yes

Drer\ntrk3b

1 of 14

Yes

Drer\pik3ip1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\yrk

1 of 14

Drer\zap70

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (78)

Cele\cam-1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (39)

Agam\AgaP_AGAP006219

12 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (100)

Atha\AT3G45410

2 of 13

Yes

Atha\AT5G60320

2 of 13

Yes

Atha\FEI1

2 of 13

Yes

Atha\STY46

2 of 13

Yes

Atha\VIK

2 of 13

Yes

Atha\AT1G11050

1 of 13

Yes

Atha\AT1G15530

1 of 13

Yes

Atha\AT1G18160

1 of 13

Atha\AT1G25390

1 of 13

Yes

Atha\AT1G54820

1 of 13

Atha\AT1G66910

1 of 13

Yes

Atha\AT1G66920

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G31010

1 of 13

Atha\AT2G42640

1 of 13

Atha\AT2G43700

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G45330

1 of 13

Yes

Atha\AT3G45420

1 of 13

Yes

Atha\AT3G45430

1 of 13

Yes

Atha\AT3G45440

1 of 13

Yes

Atha\AT3G50730

1 of 13

Atha\AT3G53380

1 of 13

Yes

Atha\AT3G53810

1 of 13

Atha\AT3G53840

1 of 13

Yes

Atha\AT3G56050

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G11900

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G29050

1 of 13

Yes

Atha\AT4G31170

1 of 13

Atha\AT5G02070

1 of 13

Atha\AT5G03140

1 of 13

Yes

Atha\AT5G10530

1 of 13

Atha\AT5G24080

1 of 13

Yes

Atha\AT5G38240

1 of 13

Yes

Atha\AT5G40540

1 of 13

Atha\AT5G56790

1 of 13

Yes

Atha\AT5G57035

1 of 13

Yes

Atha\AT5G59260

1 of 13

Atha\AT5G59270

1 of 13

Yes

Atha\AT5G60270

1 of 13

Yes

Atha\AT5G60280

1 of 13

Atha\AT5G60310

1 of 13

Yes

Atha\AT5G65600

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK11

1 of 13

Atha\CRK12

1 of 13

Atha\CRK13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK22

1 of 13

Yes

Atha\CRK23

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK36

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\LECRKA4.2

1 of 13

Yes

Atha\LECRKA4.3

1 of 13

Yes

Atha\LecRK-I.9

1 of 13

Yes

Atha\MEKK3

1 of 13

Atha\PSY1R

1 of 13

Atha\RKF3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TPK2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ror. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (41)

Nrk

8 of 13

Alk

4 of 13

btl

4 of 13

Cad96Ca

4 of 13

CG3277

4 of 13

Egfr

4 of 13

Eph

4 of 13

htl

4 of 13

Ret

4 of 13

sev

4 of 13

Ddr

3 of 13

dnt

3 of 13

drl

3 of 13

InR

3 of 13

Pvr

3 of 13

Tie

3 of 13

Abl

2 of 13

Ack

2 of 13

Btk

2 of 13

Csk

2 of 13

Drl-2

2 of 13

Fak

2 of 13

FER

2 of 13

otk

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Ank

1 of 13

CG10702

1 of 13

hop

1 of 13

Ilk

1 of 13

JIL-1

1 of 13

otk2

1 of 13

Raf

1 of 13

Sdr

1 of 13

Shark

1 of 13

tor

1 of 13

tutl

1 of 13

Wsck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ROR1; receptor tyrosine kinase like orphan receptor 1

model of autosomal recessive nonsyndromic deafness 108

IEA

(FlyBase, 2019-)

ROR2; receptor tyrosine kinase like orphan receptor 2

model of autosomal recessive Robinow syndrome

IEA

(FlyBase, 2019-)

model of brachydactyly type B1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ROR1; receptor tyrosine kinase like orphan receptor 1

13 of 14

602336

DEAFNESS, AUTOSOMAL RECESSIVE 108; DFNB108

autosomal recessive nonsyndromic deafness 108

ROR2; receptor tyrosine kinase like orphan receptor 2

12 of 14

602337

MUSK; muscle associated receptor tyrosine kinase

3 of 14

601296

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ror - Wnt4

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - Wnt5

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Shi et al., 2021, Ripp et al., 2018)

Ror - fz2

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - otk

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - wg

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010407

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-40

Cytogenetic map

31B1-31B1

Sequence location

2L:10,251,843..10,254,686 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31B1-31B1

Limits computationally determined from genome sequence between P{lacW}me31B^k06607 and P{PZ}nmd⁰⁸⁷⁷⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

31B-31B

(Wilson, 1993.9.21)

31B-31C

(determined by in situ hybridisation)

(Wilson et al., 1993)

Experimentally Determined Recombination Data

Location

2-40

(FlyBase, 2016)

2-34.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

98088

w^*; Ror⁴

94428

w^*; TI{CRIMIC.TG4.2}Ror^{CR60409-TG4.2}/CyO

62868

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05341}attP40

Kyoto

201394

y¹ w^67c23; P{GSV3}Ror^GS8107/SM1

NIG-Fly

4926R-1

P{NIG.4926R}1

4926R-2

P{NIG.4926R}2

M2L-2731

y¹ w¹¹¹⁸; Ror^SK2 P{neoFRT}40A/CyO-Tb

M2L-2732

y¹ w¹¹¹⁸; Ror^SK5 P{neoFRT}40A/CyO-Tb

2LG-2171

y² VhaAC39-1^cho-1 v¹; P{U6-Ror.NIG.sgRNA}attP40/CyO

VDRC

v932

w¹¹¹⁸; P{GD40}v932

v29930

w¹¹¹⁸ P{GD14377}v29930

v341078

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00095}attP40/CyO-GFP

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP23956

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010407

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010407

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Phylogenetic analysis of the PTK family.

(Suga et al., 1997)

Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS-induced alleles of bsk.

(Goberdhan et al., 1995)

cDNA encoding Ror identified by screening a late-third-instar larval brain library with a PCR-based approach designed to identify receptor tyrosine kinase-encoding genes: from its DNA sequence and neural-specific expression pattern authors conclude ror protein related to vertebrate neurotrophin receptors.

(Wilson et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

(Oates, 1997.11.10)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG4926

(National Institute of Genetics Fly Stocks, 2022-, Kim et al., 2021, Neuert et al., 2017, Vogel et al., 2013, Perkins et al., 2009, Morrison et al., 2000)

DRor

(Bai and Montell, 1998)

DmHD-2

(Oates et al., 1998, Oates, 1997.11.10)

Dror

(Goberdhan and Wilson, 2002, Hidalgo, 2002, Jaaro et al., 2001, Goberdhan et al., 1999, Huang et al., 1999, Wilson, 1999.3.4, Oates et al., 1998, Goberdhan et al., 1997, Suga et al., 1997, Wilson et al., 1997, Wilson et al., 1995, Steller and Grether, 1994, Wilson, 1993.9.21, Wilson et al., 1993)

HD-2

ROR

(Rehn et al., 1998)

ROR-α

(Cavieres-Lepe and Ewer, 2021)

ROR1

(Banyai and Patthy, 2004)

Ror

(Bischoff et al., 2025, Liang and Luan, 2024, Deshpande et al., 2022, Pan and O'Connor, 2021, Nye et al., 2020, Port et al., 2020, Hall et al., 2019, Gene Disruption Project members, 2018-, Ripp et al., 2018, Neuert et al., 2017, Aradska et al., 2015, Yasunaga et al., 2015, Sopko and Perrimon, 2013, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Korcsmáros et al., 2011, Reeves and Posakony, 2005)

ror

(Sutton et al., 2024)

Name Synonyms

RTK-like orphan receptor

(Mele and Johnson, 2019)

Ror

Secondary FlyBase IDs

FBgn0022797

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34367

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24488

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24488

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24488

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34367/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010407

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010407

FlyMine - An integrated database for Drosophila genomics

FBgn0010407

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4926

MARRVEL_MODEL - MARRVEL (model organism gene)

34367

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010407

DroID - A comprehensive database of gene and protein interactions.

FBgn0010407

DRSC - Results frm RNAi screens

FBgn0010407

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ror_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010407

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010407

Flygut - An atlas of the Drosophila adult midgut

FBgn0010407

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010407

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015667

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

-0.31

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