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FB2026_01
,
released March 12, 2026
PDGF/VEGF receptor, VEGFR, VEGF receptor, stai
Ig C-2 type domain receptor tyrosine kinase - required for border cell migration
Please see the JBrowse view of Dmel\Pvr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: Expression is strongest in female adults and in early embryos.
In addition to hemocytes, Pvr is expressed in the developing salivary gland. Salivary gland expression is strongest at embryonic stage 11 when salivary gland cells are circular placodes situated on the surface of the embryo. Transcript levels steadily decline during stage 12, when the placode cells invaginate and are nearly unetectable by stage 13.
Transcript is detected first at early stage 8 in two groups of bilaterally clustered cells of the mesoderm. These cells demonstrated to be developing blood cells undergo characteristic migragtion and end up distributed throughout the developing organism. Transcripts are also detected in larval hemocytes. Expression is also detected in some tracheal cells and a few cells in the ventral midline which may correspond to midline glia. The tracheal and midline cells are still present in srpneo45 mutants which lack all blood cells.
No Pvr transcript expression observed before embryonic stage 10.
Pvr protein is detected in the developing salivary gland starting in embryonic stage 12 and is localized to the cell membrane.
Pvr protein is uniformly distributed along the apicobasal axis of the plasma membrane.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pvr in JBrowse
2-30
2-27.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
New stable cell line derived from S2-unspecified : S2 cell lines expressing circCG32369, circMCPH1, circeIF5B, circrl, circPde11, circCG17715, circzfh2, circTao, circcrol, circdrn, circMeltrin, circpxb, circfru, circdati, circstw, circSarm, circStim, circCG2991, circPvr, circHil, circmub, circsxc, circbnl, and circCG9743 were created. The author reports new stable cell lines S2-circMCPH1, S2-circCG32369, S2-Flag-Ddx56 , and S2-Flag-gw.
Hyperactive Pvr signals disrupt midgut homeostasis and promote intestinal dysplasia.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the proportion of S phase cells, an increase in the proportion of G2/M phase cells, a decrease in mitotic index and a decrease in cytokinetic index are seen.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.
Pvr has a role in controlling the embryonic migration of blood cells.
Pvr appears to have a role in haematopoeitic cells.
Source for identity of Vgr1 CG8222 was sequence comparison ( date:010525 ).
Source for identity of: Pvr Vgr1
Source for identity of: Vgr1 CG8222
