FB2026_02 , released June 18, 2026
Allele: Dmel\JraJF01184
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General Information
Symbol
Dmel\JraJF01184
Species
D. melanogaster
Name
FlyBase ID
FBal0245476
Feature type
allele
Associated gene
Dmel\Jra
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01184}
Also Known As
UAS-JraRNAi, UAS-Jra-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01184}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01184
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.E693G.UAS.VTR
      (Ray et al., 2017)
      ameliorates  nephrolithiasis
      modeled by Pvrλ.UASp.Tag:MYC
      (Xu et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of JraJF01184 under the control of Scer\GAL4P2.4.Pdf in the presence of Dcr-2Scer\UAS.cDa (which increases RNAi efficiency) does not affect the period of locomotor activity (measured in flies kept under constant darkness conditions).

      (Ling et al., 2012)

      Expression of JraJF01184 under the control of Scer\GAL4Hand.ΔVM.Switch (initiated by feeding flies RU486 during adulthood) results in improved cardiac function compared to controls. Heart period (mean time between successive end-diastolic positions) and frequency of arrhythmicity are reduced at both 10 and 45 days compared to age-matched controls. No difference from controls is seen in three day-old flies. Expression of JraJF01184 also prevents the age-related decrease in End-Diastolic Diameter (EDD) seen in wild type flies.

      (Monnier et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      JraJF01184
      JraRNAiJF01184
      (Ling et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (16)