FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\tn
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General Information
Symbol
Dmel\tn
Species
D. melanogaster
Name
thin
Annotation Symbol
CG15105
Feature Type
protein_coding_gene
FlyBase ID
FBgn0265356
Gene Model Status
Current
Stock Availability
108 publicly available
Enzyme Name (EC)
Gene Summary
thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

abba, l(2)tn, TRIM32

Key Links
Genomic Location
Cytogenetic map
56A2-56A3
Sequence location
Recombination map
2-87
RefSeq locus
NT_033778 REGION:18987344..19008944
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables metal ion binding
inferred from electronic annotation with InterPro:IPR018957
(InterPro Project Members, 2004-)
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN001188366
(GO Reference Genome Project, 2011-)
enables ubiquitin-protein transferase activity
inferred from sequence or structural similarity with UniProtKB:Q13049
(Labeau-Dimenna et al., 2012)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in larval locomotory behavior
inferred from mutant phenotype
(Brooks et al., 2016)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Labeau-Dimenna et al., 2012)
involved_in muscle cell development
inferred from mutant phenotype
(Labeau-Dimenna et al., 2012)
involved_in myofibril assembly
inferred from mutant phenotype
(Domsch et al., 2013)
acts_upstream_of positive regulation of amino acid biosynthetic process
inferred from mutant phenotype
(Bawa et al., 2020)
involved_in positive regulation of glycolytic process
inferred from mutant phenotype
(Bawa et al., 2020)
involved_in striated muscle contraction
inferred from mutant phenotype
(Domsch et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001188366
(GO Reference Genome Project, 2011-)
involved_in protein polyubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN001188366
(GO Reference Genome Project, 2011-)
involved_in protein ubiquitination
inferred from sequence or structural similarity with UniProtKB:Q13049
(Labeau-Dimenna et al., 2012)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in Z disc
inferred from direct assay
(Labeau-Dimenna et al., 2012)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ubiquitin protein ligase activity
Summaries
Gene Snapshot
thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
TRIM UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The TRIM family are E3 ligases characterized a TRIpartite Motif, which consists of a RING domain, one or two B-box motifs and a coiled-coil region. As well as ubiquitination, TRIM proteins are also involved in ubiquitin-like modifications such as SUMOylation and ISGylation. (Adapted from PMID:18673550).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
tn: thin
Fully penetrant recessive lethal (no homozygous adults recovered). Hatching occurs late and second/third instar moult is delayed. Third instar larvae are long, thin, and rather slow-moving; histological examination shows abnormal muscle structure. Puparium also long and thin. Pupal development of homozygotes incomplete. Since mutants are unable to perform movements necessary for pupation, they die prior to eclosion.
Summary (Interactive Fly)

E3 ligase activity - myofibril assembly and stability, maintenance of glycolytic flux mediated by biochemical interactions with the glycolytic enzymes - a Drosophila model for Limb Girdle Muscular Dystrophy type 2H required for cell death in the Drosophila abdominal muscles by targeting DIAP1

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\tn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry B7YZK8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tn-RA
FBtr0086573
NM_137546
4536
1353
tn-RB
FBtr0086572
NM_166318
4678
1353
tn-RC
FBtr0114622
NM_001144235
5170
1517
tn-RD
FBtr0340447
NM_001299667
4668
1248
tn-RE
FBtr0340448
NM_001299668
4308
1277
tn-RF
FBtr0340449
NM_001299669
3182
827
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
tn-PA
FBpp0085757
145.6
1353
7.34
Q7JUV6
NP_611390
AAF57612
tn-PB
FBpp0085756
145.6
1353
7.34
Q7JUV6
NP_725843
AAF57611
tn-PC
FBpp0113114
164.3
1517
4.69
B7YZK8
NP_001137707
ACL83161
tn-PD
FBpp0309389
134.2
1248
7.33
A0A0B4LFP7
NP_001286596
AHN56391
tn-PE
FBpp0309390
137.2
1277
7.23
A0A0B4LFW8
NP_001286597
AHN56392
tn-PF
FBpp0309391
90.1
827
7.75
A0A0B4LG15
NP_001286598
AHN56393
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1353 aa isoforms: tn-PA, tn-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- third instar larval stage
larval somatic muscle cell
• Z disc
(Labeau-Dimenna et al., 2012)
third instar larval stage
embryonic/larval hypodermal muscle cell
• Z disc
(Domsch et al., 2013)
adult stage
adult somatic muscle cell
• Z disc
(Domsch et al., 2013)
adult somatic muscle cell
• M band
(Domsch et al., 2013)
Additional Descriptive Data

tn protein expression at larval body wall muscle Z discs coincides with, but is broader than, that of Mlp84B and sls. tn expression partially colocalizes with F-actin, but does not overlaps with myosin tn is not localized to muscle attachment sites. tn protein is localized to Z discs and M bands in the myofibrils of adult somatic muscles.

(Domsch et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in Z disc
inferred from direct assay
(Labeau-Dimenna et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tn in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tn
Transgenic constructs containing regulatory region of tn
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2R)Exel6068
(Labeau-Dimenna et al., 2012, Ryder, 2004.4.26)
Gene not disrupted in
Df(2R)BSC349
(Labeau-Dimenna et al., 2012)
Df(2R)Exel6067
(Labeau-Dimenna et al., 2012)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4how-24B
lethal (with Df(2R)Exel6068)
lethal (with tn1)
lethal (with tnΔA)
lethal (with tnΔB)
lethal | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage (with Df(2R)Exel6068)
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate
abnormal locomotor behavior | third instar larval stage
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4how-24B
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Mef2.PR
decreased body size
decreased body size (with Df(2R)Exel6068)
decreased cell size | third instar larval stage
decreased size | larval stage, with Scer\GAL4Mef2.PR
decreased size | larval stage, with Scer\GAL4tey-5053A
decreased size | second instar larval stage
decreased size | third instar larval stage
decreased size | third instar larval stage, with Scer\GAL4Mef2.PR
flightless
increased body size | pupal stage
visible | pupal stage, with Scer\GAL4how-24B
visible | pupal stage (with Df(2R)Exel6068)
visible | pupal stage (with tn1)
visible | pupal stage (with tnΔA)
visible | pupal stage (with tnΔB)
Phenotype manifest in
Allele
filamentous actin
filamentous actin (with Df(2R)Exel6068)
hypodermal muscle cell of A1-7
larval brain | third instar larval stage
larval somatic muscle cell | third instar larval stage, with Scer\GAL4how-24B
larval somatic muscle cell | third instar larval stage (with Df(2R)Exel6068)
muscle cell of ventral longitudinal muscle 3 | second instar larval stage
muscle cell of ventral longitudinal muscle 3 | third instar larval stage
muscle cell of ventral longitudinal muscle 4 | second instar larval stage
muscle cell of ventral longitudinal muscle 4 | third instar larval stage
myofibril, with Scer\GAL4Mef2.PR, Scer\GAL80ts.αTub84B
myofibril | third instar larval stage, with Scer\GAL4how-24B
myofibril | third instar larval stage (with Df(2R)Exel6068)
sarcomere, with Scer\GAL4Mef2.PR, Scer\GAL80ts.αTub84B
sarcomere | second instar larval stage
sarcomere | third instar larval stage
ventral longitudinal muscle cell | larval stage, with Scer\GAL4Mef2.PR
ventral longitudinal muscle cell | larval stage, with Scer\GAL4tey-5053A
visceral muscle fiber
visceral muscle fiber (with Df(2R)Exel6068)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (61)
Hsap\TRIM2
6 of 14
Yes
Yes
Hsap\TRIM3
6 of 14
Yes
Yes
Hsap\TRIM71
5 of 14
No
No
Hsap\NHLRC1
2 of 14
No
Yes
Hsap\NHLRC3
2 of 14
No
Yes
Hsap\RNF152
2 of 14
No
Yes
Hsap\RNF207
2 of 14
No
Yes
Hsap\RNF208
2 of 14
No
Yes
Hsap\TRIM32
2 of 14
No
Yes
Hsap\TRIM45
2 of 14
No
No
Hsap\TRIM56
2 of 14
No
No
Hsap\LNX2
1 of 14
No
No
Hsap\NHLRC2
1 of 14
No
No
Hsap\PAM
1 of 14
No
No
Hsap\PHRF1
1 of 14
No
No
Hsap\RC3H2
1 of 14
No
No
Hsap\RFPL4B
1 of 14
No
Yes
Hsap\RNF4
1 of 14
No
No
Hsap\RNF126
1 of 14
No
No
1  
Hsap\RNF151
1 of 14
No
No
Hsap\RNF182
1 of 14
No
Yes
Hsap\RNF183
1 of 14
No
Yes
Hsap\RNF186
1 of 14
No
Yes
Hsap\RNF222
1 of 14
No
Yes
Hsap\RNF223
1 of 14
No
Yes
Hsap\RNF224
1 of 14
No
Yes
Hsap\RNF225
1 of 14
No
Yes
Hsap\SH3RF1
1 of 14
No
No
Hsap\SH3RF2
1 of 14
No
No
Hsap\SH3RF3
1 of 14
No
No
Hsap\TOPORS
1 of 14
No
No
Hsap\TRIM4
1 of 14
No
Yes
Hsap\TRIM5
1 of 14
No
Yes
Hsap\TRIM6
1 of 14
No
Yes
Hsap\TRIM7
1 of 14
No
Yes
Hsap\TRIM10
1 of 14
No
Yes
Hsap\TRIM11
1 of 14
No
Yes
Hsap\TRIM13
1 of 14
No
Yes
Hsap\TRIM21
1 of 14
No
Yes
Hsap\TRIM22
1 of 14
No
Yes
Hsap\TRIM23
1 of 14
No
No
Hsap\TRIM26
1 of 14
No
Yes
Hsap\TRIM27
1 of 14
No
Yes
Hsap\TRIM31
1 of 14
No
Yes
Hsap\TRIM35
1 of 14
No
Yes
Hsap\TRIM38
1 of 14
No
Yes
Hsap\TRIM41
1 of 14
No
Yes
Hsap\TRIM43B
1 of 14
No
Yes
Hsap\TRIM43
1 of 14
No
Yes
Hsap\TRIM50
1 of 14
No
Yes
Hsap\TRIM55
1 of 14
No
Yes
Hsap\TRIM59
1 of 14
No
No
1  
Hsap\TRIM62
1 of 14
No
Yes
Hsap\TRIM63
1 of 14
No
Yes
Hsap\TRIM64B
1 of 14
No
Yes
Hsap\TRIM64C
1 of 14
No
Yes
Hsap\TRIM65
1 of 14
No
Yes
Hsap\TRIM68
1 of 14
No
No
Hsap\TRIM73
1 of 14
No
Yes
Hsap\TRIM74
1 of 14
No
Yes
Hsap\TRIM75P
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (26)
Rnor\Trim2
6 of 14
Yes
Yes
Rnor\Trim3
6 of 14
Yes
Yes
Rnor\Trim71
5 of 14
No
No
Rnor\Nhlrc1
2 of 14
No
Yes
Rnor\Nhlrc3
2 of 14
No
Yes
Rnor\Rnf152
2 of 14
No
Yes
Rnor\Rnf207
2 of 14
No
Yes
Rnor\Rnf208
2 of 14
No
Yes
Rnor\Trim32
2 of 14
No
Yes
Rnor\Trim45
2 of 14
No
No
Rnor\Lnx2
1 of 14
No
No
Rnor\Nhlrc2
1 of 14
No
No
Rnor\Pam
1 of 14
No
No
Rnor\Rnf4
1 of 14
No
No
Rnor\Rnf126
1 of 14
No
No
Rnor\Rnf182
1 of 14
No
Yes
Rnor\Rnf183
1 of 14
No
Yes
Rnor\Rnf186
1 of 14
No
Yes
Rnor\Rnf224
1 of 14
No
Yes
Rnor\Rnf225
1 of 14
No
Yes
Rnor\Rnf227
1 of 14
No
Yes
Rnor\Sh3rf2
1 of 14
No
No
Rnor\Trim13
1 of 14
No
Yes
Rnor\Trim23
1 of 14
No
No
Rnor\Trim50
1 of 14
No
Yes
Rnor\Trim59
1 of 14
No
No
Mus musculus (laboratory mouse) (35)
Mmus\Trim2
6 of 14
Yes
Yes
Mmus\Trim3
6 of 14
Yes
Yes
Mmus\Trim71
5 of 14
No
No
Mmus\Nhlrc1
2 of 14
No
Yes
Mmus\Nhlrc3
2 of 14
No
Yes
Mmus\Rnf207
2 of 14
No
Yes
Mmus\Rnf208
2 of 14
No
Yes
Mmus\Trim32
2 of 14
No
Yes
Mmus\Trim45
2 of 14
No
No
Mmus\Trim56
2 of 14
No
No
Mmus\Nhlrc2
1 of 14
No
No
Mmus\Obi1
1 of 14
No
Yes
Mmus\Pam
1 of 14
No
No
Mmus\Rnf4
1 of 14
No
No
Mmus\Rnf126
1 of 14
No
No
Mmus\Rnf151
1 of 14
No
No
Mmus\Rnf152
1 of 14
No
Yes
Mmus\Rnf182
1 of 14
No
Yes
Mmus\Rnf183
1 of 14
No
Yes
Mmus\Rnf186
1 of 14
No
Yes
Mmus\Rnf223
1 of 14
No
Yes
Mmus\Rnf224
1 of 14
No
Yes
Mmus\Rnf225
1 of 14
No
Yes
Mmus\Rnf227
1 of 14
No
Yes
Mmus\Sh3rf2
1 of 14
No
No
Mmus\Sh3rf3
1 of 14
No
No
Mmus\Trim5
1 of 14
No
Yes
Mmus\Trim12a
1 of 14
No
Yes
Mmus\Trim12c
1 of 14
No
Yes
Mmus\Trim13
1 of 14
No
Yes
Mmus\Trim23
1 of 14
No
No
Mmus\Trim50
1 of 14
No
Yes
Mmus\Trim59
1 of 14
No
No
Mmus\Trim65
1 of 14
No
Yes
Mmus\Trim75
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (42)
Xtro\trim2
6 of 13
Yes
Yes
Xtro\trim3
6 of 13
Yes
Yes
Xtro\nhlrc1
2 of 13
No
Yes
Xtro\rnf152
2 of 13
No
Yes
Xtro\trim32
2 of 13
No
Yes
Xtro\trim71
2 of 13
No
No
Xtro\LOC100485004
1 of 13
No
No
Xtro\LOC100485254
1 of 13
No
Yes
Xtro\LOC100487072
1 of 13
No
Yes
Xtro\LOC100489639
1 of 13
No
No
Xtro\LOC100489697
1 of 13
No
No
Xtro\LOC100491979
1 of 13
No
No
Xtro\LOC100492977
1 of 13
No
Yes
Xtro\LOC100495443
1 of 13
No
No
Xtro\LOC100495931
1 of 13
No
No
Xtro\LOC101730305
1 of 13
No
Yes
Xtro\LOC105947078
1 of 13
No
No
Xtro\LOC116410408
1 of 13
No
Yes
Xtro\lto1
1 of 13
No
No
Xtro\nhlrc2
1 of 13
No
No
Xtro\nhlrc3
1 of 13
No
Yes
Xtro\nhlrc4
1 of 13
No
Yes
Xtro\nudcd1
1 of 13
No
No
Xtro\phrf1
1 of 13
No
No
Xtro\rnf181
1 of 13
No
No
Xtro\rnf182
1 of 13
No
Yes
Xtro\rnf186
1 of 13
No
Yes
Xtro\rnf207
1 of 13
No
No
Xtro\rnf222
1 of 13
No
Yes
Xtro\rnf223
1 of 13
No
Yes
Xtro\rnf225
1 of 13
No
Yes
Xtro\sh3rf1
1 of 13
No
No
Xtro\sh3rf3
1 of 13
No
No
Xtro\trim13
1 of 13
No
No
Xtro\trim33
1 of 13
No
No
Xtro\trim45
1 of 13
No
No
Xtro\trim47
1 of 13
No
Yes
Xtro\trim63
1 of 13
No
Yes
Xtro\trim69.1
1 of 13
No
No
Xtro\trim72
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (41)
Drer\trim2a
6 of 14
Yes
Yes
Drer\trim2b
6 of 14
Yes
Yes
Drer\trim3a
6 of 14
Yes
Yes
Drer\trim3b
6 of 14
Yes
Yes
Drer\trim71
5 of 14
No
No
Drer\rnf152
2 of 14
No
Yes
Drer\si:dkey-106l3.6
2 of 14
No
Yes
Drer\trim32
2 of 14
No
Yes
Drer\trim45
2 of 14
No
No
Drer\amfrb
1 of 14
No
No
Drer\btr04
1 of 14
No
Yes
Drer\btr16
1 of 14
No
Yes
Drer\btr20
1 of 14
No
Yes
Drer\btr21
1 of 14
No
Yes
Drer\btr22
1 of 14
No
Yes
Drer\btr24
1 of 14
No
No
Drer\ftr33
1 of 14
No
Yes
Drer\ftr34
1 of 14
No
Yes
Drer\ftr35
1 of 14
No
Yes
Drer\ftr70
1 of 14
No
No
Drer\im:7152348
1 of 14
No
Yes
Drer\LOC797048
1 of 14
No
Yes
Drer\nhlrc2
1 of 14
No
No
Drer\pam
1 of 14
No
No
Drer\rnf181
1 of 14
No
No
Drer\rnf182
1 of 14
No
No
Drer\rnf183
1 of 14
No
Yes
Drer\rnf207a
1 of 14
No
Yes
Drer\rnf207b
1 of 14
No
No
Drer\rnf224
1 of 14
No
Yes
Drer\si:ch73-335l21.2
1 of 14
No
Yes
Drer\si:ch73-335l21.4
1 of 14
No
Yes
Drer\trim23
1 of 14
No
No
Drer\trim35-1
1 of 14
No
Yes
Drer\trim35-13
1 of 14
No
Yes
Drer\trim35-31
1 of 14
No
Yes
Drer\trim35-40
1 of 14
No
Yes
Drer\trim59
1 of 14
No
Yes
Drer\zgc:153151
1 of 14
No
No
Drer\zgc:165481
1 of 14
No
Yes
Drer\zgc:173581
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (43)
Cele\nhl-1
13 of 14
Yes
Yes
Cele\lin-41
3 of 14
No
No
Cele\F40G9.12
2 of 14
No
Yes
Cele\F40G9.19
2 of 14
No
Yes
Cele\F43C11.8
2 of 14
No
No
Cele\F43G6.8
2 of 14
No
Yes
Cele\ncl-1
2 of 14
No
No
Cele\nhl-3
2 of 14
No
No
Cele\arc-1
1 of 14
No
No
Cele\B0281.3
1 of 14
No
Yes
Cele\B0281.8
1 of 14
No
Yes
Cele\B0416.10
1 of 14
No
Yes
Cele\C06A5.8
1 of 14
No
Yes
Cele\C28G1.6
1 of 14
No
Yes
Cele\C36B1.9
1 of 14
No
Yes
Cele\C45G7.4
1 of 14
No
Yes
Cele\F19G12.1
1 of 14
No
Yes
Cele\F40G9.14
1 of 14
No
Yes
Cele\F42G2.5
1 of 14
No
No
Cele\F43C11.7
1 of 14
No
Yes
Cele\F53F8.3
1 of 14
No
Yes
Cele\K09F6.7
1 of 14
No
Yes
Cele\nhl-2
1 of 14
No
No
Cele\pamn-1
1 of 14
No
No
Cele\pgal-1
1 of 14
No
No
Cele\rcs-1
1 of 14
No
Yes
Cele\sli-1
1 of 14
No
No
Cele\T13A10.2
1 of 14
No
Yes
Cele\T20F5.6
1 of 14
No
Yes
Cele\Y4C6A.3
1 of 14
No
No
Cele\Y6D1A.2
1 of 14
No
Yes
Cele\Y47G6A.14
1 of 14
No
Yes
Cele\Y47G6A.31
1 of 14
No
No
Cele\Y51F10.2
1 of 14
No
Yes
Cele\Y54F10BM.6
1 of 14
No
Yes
Cele\ZK945.4
1 of 14
No
Yes
Cele\ZK1240.1
1 of 14
No
Yes
Cele\ZK1240.2
1 of 14
No
Yes
Cele\ZK1240.3
1 of 14
No
Yes
Cele\ZK1240.5
1 of 14
No
Yes
Cele\ZK1240.6
1 of 14
No
Yes
Cele\ZK1240.8
1 of 14
No
Yes
Cele\ZK1240.9
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP007135
12 of 12
Yes
Yes
Agam\AgaP_AGAP005125
3 of 12
No
No
Agam\AgaP_AGAP002344
2 of 12
No
No
Agam\AgaP_AGAP007095
2 of 12
No
No
Agam\AgaP_AGAP010054
2 of 12
No
No
Agam\AgaP_AGAP001987
1 of 12
No
No
Agam\AgaP_AGAP003004
1 of 12
No
No
Agam\AgaP_AGAP005784
1 of 12
No
No
Agam\AgaP_AGAP007606
1 of 12
No
No
Agam\AgaP_AGAP009708
1 of 12
No
No
Agam\AgaP_AGAP010610
1 of 12
No
No
Agam\AgaP_AGAP011487
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\AT1G18660
1 of 13
Yes
No
Atha\AT1G33480
1 of 13
Yes
No
Atha\AT1G35330
1 of 13
Yes
No
Atha\AT1G53820
1 of 13
Yes
Yes
Atha\AT1G56500
1 of 13
Yes
No
Atha\AT3G10910
1 of 13
Yes
No
Atha\AT3G14320
1 of 13
Yes
No
Atha\AT3G18930
1 of 13
Yes
No
Atha\AT3G29270
1 of 13
Yes
Yes
Atha\AT4G01350
1 of 13
Yes
Yes
Atha\AT4G09100
1 of 13
Yes
No
Atha\AT5G14890
1 of 13
Yes
Yes
Atha\AT5G37230
1 of 13
Yes
No
Atha\AT5G37250
1 of 13
Yes
No
Atha\AT5G37270
1 of 13
Yes
No
Atha\AT5G46650
1 of 13
Yes
No
Atha\ATL6
1 of 13
Yes
No
Atha\emb1974
1 of 13
Yes
Yes
Atha\KEG
1 of 13
Yes
Yes
Atha\RHF2A
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:tn. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
wech
6 of 13
brat
4 of 13
CG8419
3 of 13
mei-P26
2 of 13
bon
1 of 13
CG7694
1 of 13
CG12547
1 of 13
CG32847
1 of 13
Pal1
1 of 13
Pal2
1 of 13
POSH
1 of 13
Trim9
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
TRIM2; tripartite motif containing 2
model of  Charcot-Marie-Tooth disease type 2R
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TRIM2; tripartite motif containing 2
6 of 14
614141
TRIM3; tripartite motif containing 3
6 of 14
605493
      TRIM71; tripartite motif containing 71
      5 of 14
      618570
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        tn
        enhanceable
        Actn
        (Domsch et al., 2013)
        tn
        suppressible
        ERR
        (Bawa et al., 2020)
        tn
        suppressible
        sls
        (Domsch et al., 2013)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        cindr
        enhanceable
        tn
        (Ketosugbo et al., 2017)
        Mhc
        suppressible
        tn
        (Dahl-Halvarsson et al., 2018)
        Mhc
        enhanceable
        tn
        (Dahl-Halvarsson et al., 2018)
        Mlp84B
        suppressible
        tn
        (Domsch et al., 2013)
        Pvr
        suppressible
        tn
        (Bawa et al., 2020)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-87
        Cytogenetic map
        56A2-56A3
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        56A2-56A3
        Limits computationally determined from genome sequence between P{lacW}prodk08810 and P{PZ}ena02029&P{lacW}corak08713
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-87

        (FlyBase, 2016)

        2-92.6

        (Comeron et al., 2012)

        2-85.6

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (108)
        Genomic Clones (38)
        cDNA Clones (45)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Domsch et al., 2013, Labeau-Dimenna et al., 2012)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              tn function is not needed during embryogenesis for the initial formation of the larval musculature, but it is required for proper muscle growth and function during subsequent larval and pupal stages.

              (Domsch et al., 2013)

              tn, Actn, sls and Mlp84B act in concert to maintain the integrity and stability of Z-discs, thereby ensuring myofibril stability and optimal muscle function.

              (Domsch et al., 2013)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: tn abba

              (Labeau-Dimenna et al., 2012)
              Additional comments

              snoRNA:abba-a is encoded in an intron of abba.

              (Graveley et al., 2011)
              Nomenclature History
              Source for database identify of

              Source for identity of: abba CG15105

              (O'Farrell et al., 2008)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (13)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 59 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              PDB - An information portal to biological macromolecular structures
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (83)