FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

protein polyubiquitination

ID (Ontology)

GO:0000209 (Gene Ontology)

Definition

Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.[ PubMed:26906419 ]

Also Known As

"protein polyubiquitinylation" ; "protein polyubiquitylation"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
protein polyubiquitination (all annotations which use CV term, excluding "NOT" statements)
involved_in \| protein polyubiquitination

Spanning Tree (Parents/Children)

  protein modification by small protein conjugation
   |__protein ubiquitination
       |__protein polyubiquitination  89 rec.
           |__protein branched polyubiquitination
           |__protein K6-linked ubiquitination
           |__protein K11-linked ubiquitination 7 rec.
           |__protein K27-linked ubiquitination
           |__protein K29-linked ubiquitination
           |__protein K33-linked ubiquitination
           |__protein K48-linked ubiquitination 10 rec.
           |   |__regulation of protein K48-linked ubiquitination(+)
           |__protein K63-linked ubiquitination 7 rec.
           |   |__regulation of protein K63-linked ubiquitination(+)
           |__protein linear polyubiquitination 3 rec.
           |   |__regulation of protein linear polyubiquitination(+)
           |__regulation of protein polyubiquitination
               |__negative regulation of protein polyubiquitination(+)
               |__positive regulation of protein polyubiquitination(+)
               |__regulation of protein K48-linked ubiquitination(+)
               |__regulation of protein K63-linked ubiquitination(+)
               |__regulation of protein linear polyubiquitination(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein ubiquitination
Part of
Synonyms & Secondary IDs
Synonyms
	"polyubiquitin" RELATED "protein polyubiquitinylation" EXACT "protein polyubiquitylation" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation"