FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\mei-P26
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General Information
Symbol
Dmel\mei-P26
Species
D. melanogaster
Name
meiotic P26
Annotation Symbol
CG12218
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026206
Gene Model Status
Current
Stock Availability
19 publicly available
Enzyme Name (EC)
Gene Summary
meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BcDNA:GH10646

Key Links
Genomic Location
Cytogenetic map
8C15-8C17
Sequence location
Recombination map
1-26
RefSeq locus
NC_004354 REGION:9163255..9189309
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables mRNA 3'-UTR binding
inferred from direct assay
(Salerno-Kochan et al., 2022)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN008619076
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q80VI1
(Gene Ontology Curators, 2002-)
enables ubiquitin-protein transferase activity
inferred from sequence or structural similarity with MGI:MGI:1860040
(Gene Ontology Curators, 2002-)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR000315
(InterPro Project Members, 2004-)
inferred from sequence model
(Ying et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in post-transcriptional regulation of gene expression
inferred from direct assay
(Salerno-Kochan et al., 2022)
involved_in spermatogenesis
inferred from mutant phenotype
(Wu et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein ubiquitination
inferred from sequence or structural similarity with MGI:MGI:1860040
(Gene Ontology Curators, 2002-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with MGI:MGI:1860040
(Gene Ontology Curators, 2002-)
is_active_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN008619077
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ubiquitin protein ligase activity
Summaries
Gene Snapshot
meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
TRIM UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The TRIM family are E3 ligases characterized a TRIpartite Motif, which consists of a RING domain, one or two B-box motifs and a coiled-coil region. As well as ubiquitination, TRIM proteins are also involved in ubiquitin-like modifications such as SUMOylation and ISGylation. (Adapted from PMID:18673550).
Protein Function (UniProtKB)
RNA binding protein and post-transcriptional regulator of mRNA translation; can act as a repressor or activator of gene expression (PubMed:35512835). Binds and represses translation of several mRNAs in a miRNA and 3'-UTR-dependent manner, possibly in association with components of the RNA-induced silencing complex (RISC) (PubMed:22438571). Represses expression of brat in a RISC-independent manner, possibly in coordination with nanos, to derepress the BMP signaling pathway (PubMed:22438571). Binds nanos mRNA and involved in bam-bgcn mediated repression of nanos mRNA translation (PubMed:23526974). Regulator of stem cell proliferation (PubMed:18528333, PubMed:23122292). Promotes both germline stem cell (GSC) self-renewal and downstream GSC-lineage cell differentiation (PubMed:22438571). Represses the microRNA pathway in cystocytes inhibiting expression of a subset of microRNAs involved in differentiation (PubMed:18528333). Involved in a regulatory cascade with bam to control the progression of cystocytes through transit amplification and the switch to spermatocyte differentiation; mei-P26 facilitates bam accumulation, which in turn represses translation of mei-P26 (PubMed:10924472, PubMed:18528333, PubMed:23122292). Negatively regulates the levels of Myc protein in a proteasome-dependent manner; involved in maintaining tissue homeostasis by regulating cell and tissue growth and Myc-induced apoptosis (PubMed:20400939, PubMed:24990993).
(UniProt, M9PH32)
Summary (Interactive Fly)

a conserved translational regulator that facilitate the switch from proliferation to differentiation - associates with miRNA pathway components to represses the translation of target mRNAs - cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary - a target of Vasa in promoting stem cell differentiation

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\mei-P26 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PH32)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated.

Gene model reviewed during 5.52

Stop-codon suppression (UGA) postulated; FBrf0234051.

Gene model reviewed during 6.25

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mei-P26-RA
FBtr0071303
NM_143765
5232
1189
mei-P26-RB
FBtr0333473
NM_001272447
22580
1189
mei-P26-RC
FBtr0333474
NM_001272448
23041
1206
mei-P26-RD
FBtr0333475
NM_001272449
8899
1189
mei-P26-RE
FBtr0340341
NM_001298110
4966
1206
mei-P26-RF
FBtr0474151
NM_001369966
5232
1310
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mei-P26-PA
FBpp0071238
129.5
1189
6.00
Q9W378
NP_652022
AAF46457
mei-P26-PB
FBpp0305660
129.5
1189
6.00
Q9W378
NP_001259376
AGB95219
mei-P26-PC
FBpp0305661
131.3
1206
5.81
M9PH32
NP_001259377
AGB95220
mei-P26-PD
FBpp0305662
129.5
1189
6.00
Q9W378
NP_001259378
AGB95221
mei-P26-PE
FBpp0309300
131.3
1206
5.81
M9PH32
NP_001285039
AHN59510
mei-P26-PF
FBpp0423150
142.8
1310
6.36
QCD25231
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1189 aa isoforms: mei-P26-PA, mei-P26-PB, mei-P26-PD
1206 aa isoforms: mei-P26-PC, mei-P26-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

May dimerize (via N-terminus) (Probable). Part of a complex composed of at least mei-P26, bam, bgcn and Sxl; this complex is involved in translational repression of nanos mRNA (PubMed:23526974). Interacts (via NHL domain) with AGO1; the interaction is not direct but does not require RNA (PubMed:18528333, PubMed:22438571, PubMed:23526974). Interacts with bam (PubMed:23526974). Interacts with bgcn; the interaction is direct and does not require bam (PubMed:23526974). Interacts with Sxl (PubMed:23526974). Interacts with wech; possibly involved in RISC-mediated translational repression (PubMed:22438571). Interacts with nanos; possibly involved in RISC-independent regulation of brat protein levels (PubMed:22438571). Interacts with wh/wuho; this interaction may be required for the function or formation of the mei-P26-bgcn-bam-Sxl complex (PubMed:31941704).

(UniProt, M9PH32)
Domain

The C-terminal region containing the NHL repeats is required for interaction with AGO1 and for regulating ovarian germline stem cell proliferation (PubMed:18528333, PubMed:22438571). The C-terminal NHL repeats are also required for regulation of brat expression (PubMed:22438571). The C-terminal NHL domain binds single stranded RNA in a sequence-specific manner; preferentially binds uridine-rich RNA with at least 4 U residues followed by an ACA anchor sequence (5'-UUUUACA-3') (PubMed:35512835). The NHL domain is essential, but not sufficient, for post-transcriptional regulation of mRNA translation (PubMed:35512835). The NHL domain is required for proteasomal-dependent regulation of Myc protein levels (PubMed:24990993).

The N-terminal RING-type Zinc finger domain is not required for post-transcriptional regulation of mRNA translation.

(UniProt, M9PH32)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mei-P26 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.66

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 2
pole plasm
(Yatsu et al., 2008)
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 5
primordial germ cell
(Yatsu et al., 2008)
embryonic stage 4 -- 6
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
primordial germ cell
(Fisher et al., 2012)
embryonic stage 8 -- 10
primordial germ cell
(Yatsu et al., 2008)
embryonic stage 9 -- 17
organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
embryonic stage 12 -- 15
larval nervous system

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
embryonic stage 14 -- 16
primordial germ cell
(Yatsu et al., 2008)
Additional Descriptive Data

Isoforms of mei-P26 with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis). The 3' UTR extension isoforms are highly enriched in nervous system tissues.

(Hilgers et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
spermatogonium
(Chen et al., 2014)
adult stage | female & oogenesis
female germline stem cell

Comment: in regions 1 through 2b of germarium

(Liu et al., 2009)
oogenesis & adult stage | female
female germline cyst of germarium

Comment: in regions 1 through 2b of germarium

(Liu et al., 2009)
oogenesis
female germline stem cell
(Neumuller et al., 2008)
cyst cell of ovary
(Neumuller et al., 2008)
spermatogenesis
male germline cyst
(Insco et al., 2012)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Liu et al., 2009)
Additional Descriptive Data

mei-P26 levels are low in stem cells and are upregulated in cysts as they decrease growth and exit mitotic proliferation. Expression peaks in 16-cell cysts.

(Neumuller et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mei-P26 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mei-P26
Transgenic constructs containing regulatory region of mei-P26
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal | pupal stage, with Scer\GAL4pnr-MD237
viable
Sterility
Allele
female semi-fertile
female sterile | recessive
male fertile
male sterile | recessive
sterile
Other Phenotypes
Allele
abnormal meiotic cell cycle
abnormal meiotic cell cycle | semidominant
abnormal neurophysiology
abnormal neurophysiology (with mei-P2616)
abnormal neurophysiology (with mei-P26fs1)
decreased cell number, with Scer\GAL4VP16.nanos.UTR
decreased cell number | larval stage, with Scer\GAL4Act.PU
decreased fecundity | female
decreased occurrence of cell division | larval stage, with Scer\GAL4Act.PU
decreased size | larval stage, with Scer\GAL4Act.PU
increased cell number | larval stage, with Scer\GAL4Act.PU
increased occurrence of cell division | adult stage | male
increased occurrence of cell division | larval stage, with Scer\GAL4Act.PU
increased size | larval stage, with Scer\GAL4Act.PU
wild-type
Phenotype manifest in
Allele
egg
egg chamber
egg chamber (with mei-P261)
egg chamber (with mei-P26fs1)
egg chamber (with mei-P26mfs1)
ganglion mother cell, with Scer\GAL4Act.PU
larval brain, with Scer\GAL4Act.PU
male germline cell, with Scer\GAL4VP16.nanos.UTR
male germline cyst
nucleolus
nucleolus & ovary
nurse cell
nurse cell (with mei-P261)
nurse cell (with mei-P26fs1)
oocyte
ovary
spermatid
spermatocyte cyst, with Scer\GAL4VP16.bam
spermatozoon
testis
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (31)
Hsap\TRIM56
4 of 14
Yes
Yes
Hsap\TRIM45
3 of 14
No
No
Hsap\TRIM71
3 of 14
No
No
Hsap\PML
2 of 14
No
Yes
Hsap\RNF207
2 of 14
No
Yes
Hsap\TRIM2
2 of 14
No
No
Hsap\TRIM3
2 of 14
No
No
Hsap\CMYA5
1 of 14
No
No
Hsap\FSD1
1 of 14
No
No
Hsap\FSD1L
1 of 14
No
No
Hsap\FSD2
1 of 14
No
No
Hsap\MID1
1 of 14
No
No
Hsap\MID2
1 of 14
No
No
Hsap\NHLRC3
1 of 14
No
No
Hsap\RNF152
1 of 14
No
No
Hsap\RNF208
1 of 14
No
No
Hsap\TRIM8
1 of 14
No
Yes
Hsap\TRIM9
1 of 14
No
No
Hsap\TRIM23
1 of 14
No
No
Hsap\TRIM24
1 of 14
No
No
Hsap\TRIM28
1 of 14
No
No
Hsap\TRIM32
1 of 14
No
No
Hsap\TRIM33
1 of 14
No
No
Hsap\TRIM36
1 of 14
No
No
Hsap\TRIM42
1 of 14
No
Yes
Hsap\TRIM46
1 of 14
No
No
Hsap\TRIM54
1 of 14
No
Yes
Hsap\TRIM55
1 of 14
No
Yes
Hsap\TRIM63
1 of 14
No
Yes
Hsap\TRIM66
1 of 14
No
No
Hsap\TRIM67
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (24)
Rnor\Trim45
3 of 14
Yes
No
Rnor\Trim71
3 of 14
Yes
No
Rnor\Pml
2 of 14
No
Yes
Rnor\Rnf207
2 of 14
No
Yes
Rnor\Trim2
2 of 14
No
No
Rnor\Trim3
2 of 14
No
No
Rnor\Trim42
2 of 14
No
Yes
Rnor\Cmya5
1 of 14
No
No
Rnor\Fsd1l
1 of 14
No
No
Rnor\Fsd2
1 of 14
No
No
Rnor\Mid1
1 of 14
No
No
Rnor\Mid2
1 of 14
No
No
Rnor\Nhlrc3
1 of 14
No
No
Rnor\Rnf152
1 of 14
No
No
Rnor\Rnf208
1 of 14
No
No
Rnor\Trim9
1 of 14
No
No
Rnor\Trim24
1 of 14
No
No
Rnor\Trim28
1 of 14
No
No
Rnor\Trim32
1 of 14
No
No
Rnor\Trim33
1 of 14
No
No
Rnor\Trim36
1 of 14
No
No
Rnor\Trim46
1 of 14
No
No
Rnor\Trim66
1 of 14
No
No
Rnor\Trim67
1 of 14
No
No
Mus musculus (laboratory mouse) (25)
Mmus\Trim56
4 of 14
Yes
Yes
Mmus\Trim45
3 of 14
No
No
Mmus\Pml
2 of 14
No
Yes
Mmus\Rnf207
2 of 14
No
Yes
Mmus\Trim2
2 of 14
No
No
Mmus\Trim3
2 of 14
No
No
Mmus\Trim24
2 of 14
No
No
Mmus\Trim33
2 of 14
No
No
Mmus\Trim42
2 of 14
No
Yes
Mmus\Trim71
2 of 14
No
No
Mmus\Cmya5
1 of 14
No
No
Mmus\Fsd1l
1 of 14
No
No
Mmus\Fsd1
1 of 14
No
No
Mmus\Fsd2
1 of 14
No
No
Mmus\Mid1
1 of 14
No
No
Mmus\Mid2
1 of 14
No
No
Mmus\Nhlrc3
1 of 14
No
No
Mmus\Rnf208
1 of 14
No
No
Mmus\Trim9
1 of 14
No
No
Mmus\Trim28
1 of 14
No
No
Mmus\Trim32
1 of 14
No
No
Mmus\Trim36
1 of 14
No
No
Mmus\Trim46
1 of 14
No
No
Mmus\Trim66
1 of 14
No
No
Mmus\Trim67
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (32)
Xtro\rnf207
2 of 13
Yes
Yes
Xtro\trim2
2 of 13
Yes
No
Xtro\trim45
2 of 13
Yes
No
Xtro\cmya5
1 of 13
No
No
Xtro\cox15
1 of 13
No
No
Xtro\dennd2b
1 of 13
No
No
Xtro\fsd2
1 of 13
No
No
Xtro\LOC100485004
1 of 13
No
No
Xtro\LOC100489697
1 of 13
No
No
Xtro\LOC100494464
1 of 13
No
Yes
Xtro\LOC100495443
1 of 13
No
No
Xtro\LOC100495885
1 of 13
No
Yes
Xtro\MGC79670
1 of 13
No
No
Xtro\nhlrc3
1 of 13
No
Yes
Xtro\ppp2r3b
1 of 13
No
No
Xtro\rnf152
1 of 13
No
No
Xtro\trim3
1 of 13
No
No
Xtro\trim8
1 of 13
No
No
Xtro\trim24
1 of 13
No
No
Xtro\trim25l
1 of 13
No
Yes
Xtro\trim27
1 of 13
No
Yes
Xtro\trim28
1 of 13
No
No
Xtro\trim32
1 of 13
No
No
Xtro\trim33
1 of 13
No
No
Xtro\trim55
1 of 13
No
No
Xtro\trim63
1 of 13
No
Yes
Xtro\trim69.1
1 of 13
No
No
Xtro\trim71
1 of 13
No
No
Xtro\XB5729271
1 of 13
No
Yes
Xtro\XB5729975
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (69)
Drer\trim45
3 of 14
Yes
No
Drer\ftr06
2 of 14
No
Yes
Drer\ftr79
2 of 14
No
Yes
Drer\ftr97
2 of 14
No
Yes
Drer\rnf207b
2 of 14
No
Yes
Drer\trim2a
2 of 14
No
No
Drer\trim2b
2 of 14
No
No
Drer\trim3a
2 of 14
No
No
Drer\trim3b
2 of 14
No
No
Drer\trim33l
2 of 14
No
Yes
Drer\trim71
2 of 14
No
No
Drer\btr04
1 of 14
No
Yes
Drer\btr05
1 of 14
No
Yes
Drer\btr06
1 of 14
No
Yes
Drer\btr07
1 of 14
No
Yes
Drer\btr20
1 of 14
No
Yes
Drer\btr21
1 of 14
No
Yes
Drer\btr22
1 of 14
No
Yes
Drer\btr24
1 of 14
No
No
Drer\btr25
1 of 14
No
Yes
Drer\btr26
1 of 14
No
Yes
Drer\btr32
1 of 14
No
Yes
Drer\cmya5
1 of 14
No
No
Drer\fsd1
1 of 14
No
No
Drer\fsd1l
1 of 14
No
No
Drer\ftr02
1 of 14
No
Yes
Drer\ftr11
1 of 14
No
No
Drer\ftr26
1 of 14
No
No
Drer\ftr30
1 of 14
No
No
Drer\ftr33
1 of 14
No
Yes
Drer\ftr38
1 of 14
No
Yes
Drer\ftr41
1 of 14
No
No
Drer\ftr43
1 of 14
No
No
Drer\ftr51
1 of 14
No
Yes
Drer\ftr54
1 of 14
No
Yes
Drer\ftr55
1 of 14
No
Yes
Drer\ftr57
1 of 14
No
No
Drer\ftr59
1 of 14
No
No
Drer\ftr66
1 of 14
No
Yes
Drer\ftr67
1 of 14
No
Yes
Drer\ftr69
1 of 14
No
Yes
Drer\ftr70
1 of 14
No
No
Drer\ftr72
1 of 14
No
No
Drer\ftr80
1 of 14
No
Yes
Drer\ftr85
1 of 14
No
Yes
Drer\ftr95
1 of 14
No
Yes
Drer\LOC570185
1 of 14
No
Yes
Drer\LOC100000832
1 of 14
No
Yes
Drer\mid1
1 of 14
No
No
Drer\mid2
1 of 14
No
No
Drer\rnf152
1 of 14
No
No
Drer\rnf207a
1 of 14
No
Yes
Drer\si:ch211-12p12.2
1 of 14
No
Yes
Drer\si:ch211-216p19.6
1 of 14
No
Yes
Drer\si:dkey-106l3.6
1 of 14
No
No
Drer\trim9
1 of 14
No
No
Drer\trim23
1 of 14
No
No
Drer\trim24
1 of 14
No
No
Drer\trim32
1 of 14
No
No
Drer\trim33
1 of 14
No
No
Drer\trim36
1 of 14
No
No
Drer\trim46a
1 of 14
No
No
Drer\trim46b
1 of 14
No
No
Drer\trim47
1 of 14
No
Yes
Drer\trim63a
1 of 14
No
Yes
Drer\trim66
1 of 14
No
No
Drer\trim67
1 of 14
No
No
Drer\trim101
1 of 14
No
Yes
Drer\zgc:173581
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (24)
Cele\nhl-2
7 of 14
Yes
Yes
Cele\ncl-1
3 of 14
No
No
Cele\F43G6.8
2 of 14
No
Yes
Cele\lin-41
2 of 14
No
No
Cele\nhl-1
2 of 14
No
No
Cele\B0281.3
1 of 14
No
Yes
Cele\B0416.4
1 of 14
No
Yes
Cele\B0416.10
1 of 14
No
Yes
Cele\C32E8.1
1 of 14
No
Yes
Cele\F40G9.12
1 of 14
No
No
Cele\F40G9.19
1 of 14
No
No
Cele\F43C11.8
1 of 14
No
No
Cele\F44D12.10
1 of 14
No
Yes
Cele\F47G9.4
1 of 14
No
Yes
Cele\F53F8.3
1 of 14
No
Yes
Cele\madd-2
1 of 14
No
No
Cele\nhl-3
1 of 14
No
No
Cele\rcs-1
1 of 14
No
Yes
Cele\T01G5.7
1 of 14
No
Yes
Cele\T20F5.6
1 of 14
No
Yes
Cele\Y6D1A.2
1 of 14
No
Yes
Cele\Y45F10B.8
1 of 14
No
No
Cele\Y45F10B.9
1 of 14
No
No
Cele\ZK945.4
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP002344
11 of 12
Yes
Yes
Agam\AgaP_AGAP005125
2 of 12
No
No
Agam\AgaP_AGAP010054
2 of 12
No
No
Agam\AgaP_AGAP001328
1 of 12
No
No
Agam\AgaP_AGAP007095
1 of 12
No
No
Agam\AgaP_AGAP007135
1 of 12
No
No
Agam\AgaP_AGAP008750
1 of 12
No
No
Agam\AgaP_AGAP008751
1 of 12
No
No
Agam\AgaP_AGAP009708
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT4G01350
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mei-P26. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG8419
3 of 13
wech
3 of 13
bon
2 of 13
brat
2 of 13
tn
2 of 13
Trim9
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIM56; tripartite motif containing 56
    4 of 14
    616996
        TRIM45; tripartite motif containing 45
        3 of 14
        609318
            TRIM71; tripartite motif containing 71
            3 of 14
            618570
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              mei-P26 - AGO1
              anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy
              (Malik et al., 2017, Li et al., 2012, Neumuller et al., 2008)
              mei-P26 - CG6304
              experimental knowledge based
              (Guruharsha et al., 2011)
              mei-P26 - Sxl
              two hybrid, anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, molecular sieving
              (Malik et al., 2017, Li et al., 2013)
              mei-P26 - bam
              molecular sieving, western blot, two hybrid, anti bait coimmunoprecipitation, pull down, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation
              (Malik et al., 2017, Li et al., 2013, Insco et al., 2012)
              mei-P26 - bgcn
              anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, molecular sieving, western blot, anti bait coimmunoprecipitation
              (Malik et al., 2017, Li et al., 2013, Insco et al., 2012)
              mei-P26 - gw
              anti bait coimmunoprecipitation, western blot
              (Li et al., 2012)
              mei-P26 - nanos
              anti bait coimmunoprecipitation, primer specific pcr, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, western blot
              (Malik et al., 2020, Li et al., 2013, Li et al., 2012)
              mei-P26 - wuho
              anti tag coimmunoprecipitation, western blot
              (Rastegari et al., 2020)
              RNA-protein
              Physical Interaction
              Assay
              References
              mei-P26 - Col4a1
              nucleic acid uv cross-linking assay, autoradiography
              (Salerno-Kochan et al., 2022)
              mei-P26 - Hrb27C
              electrophoretic mobility shift assay, autoradiography, nucleic acid uv cross-linking assay
              (Salerno-Kochan et al., 2022)
              mei-P26 - LanA
              nucleic acid uv cross-linking assay, autoradiography
              (Salerno-Kochan et al., 2022)
              mei-P26 - Mlc-c
              nucleic acid uv cross-linking assay, autoradiography
              (Salerno-Kochan et al., 2022)
              mei-P26 - U2A
              anti tag coimmunoprecipitation, primer specific pcr
              (Wu et al., 2016)
              mei-P26 - aub
              iclip, partial RNA sequence identification
              (Ma et al., 2017)
              mei-P26 - bam
              molecular sieving, western blot, two hybrid, anti bait coimmunoprecipitation, pull down, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation
              (Malik et al., 2017, Li et al., 2013, Insco et al., 2012)
              mei-P26 - bgcn
              anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, molecular sieving, western blot, anti bait coimmunoprecipitation
              (Malik et al., 2017, Li et al., 2013, Insco et al., 2012)
              mei-P26 - lost
              nucleic acid uv cross-linking assay, autoradiography
              (Salerno-Kochan et al., 2022)
              mei-P26 - nanos
              anti bait coimmunoprecipitation, primer specific pcr, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, western blot
              (Malik et al., 2020, Li et al., 2013, Li et al., 2012)
              mei-P26 - orb
              anti bait coimmunoprecipitation, quantitative reverse transcription pcr
              (Li et al., 2012)
              mei-P26 - pum
              pull down, autoradiography, anti bait coimmunoprecipitation, primer specific pcr, quantitative reverse transcription pcr
              (Flora et al., 2018, Joly et al., 2013)
              mei-P26 - tut
              anti tag coimmunoprecipitation, primer specific pcr, rna three hybrid
              (Chen et al., 2014)
              mei-P26 - twin
              anti tag coimmunoprecipitation, primer specific pcr
              (Joly et al., 2013)
              mei-P26 - vas
              electrophoretic mobility shift assay, autoradiography
              (Liu et al., 2009)
              RNA-RNA
              Physical Interaction
              Assay
              References
              mei-P26 - mir-137
              luminiscence technology, necessary binding region
              (Herranz et al., 2010)
              mei-P26 - mir-ban
              immunohistochemistry, luminiscence technology, necessary binding region
              (Herranz et al., 2010)
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              mei-P26
              suppressible
              bam
              (Insco et al., 2012)
              mei-P26
              enhanceable
              bam
              (Page et al., 2000)
              mei-P26
              suppressible
              loqs
              (Neumuller et al., 2008)
              mei-P26
              suppressible
              pros
              (Hu et al., 2025)
              mei-P26
              suppressible
              U2A
              (Wu et al., 2016)
              mei-P26
              enhanceable
              vas
              (Liu et al., 2009)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Dcr-1
              suppressible
              mei-P26
              (Herranz et al., 2010)
              eas
              suppressible
              mei-P26
              (Glasscock et al., 2005)
              jus
              suppressible
              mei-P26
              (Glasscock et al., 2005)
              twin
              suppressible
              mei-P26
              (Joly et al., 2013)
              External Data
              Subunit Structure (UniProtKB)
              May dimerize (via N-terminus) (Probable). Part of a complex composed of at least mei-P26, bam, bgcn and Sxl; this complex is involved in translational repression of nanos mRNA (PubMed:23526974). Interacts (via NHL domain) with AGO1; the interaction is not direct but does not require RNA (PubMed:18528333, PubMed:22438571, PubMed:23526974). Interacts with bam (PubMed:23526974). Interacts with bgcn; the interaction is direct and does not require bam (PubMed:23526974). Interacts with Sxl (PubMed:23526974). Interacts with wech; possibly involved in RISC-mediated translational repression (PubMed:22438571). Interacts with nanos; possibly involved in RISC-independent regulation of brat protein levels (PubMed:22438571). Interacts with wh/wuho; this interaction may be required for the function or formation of the mei-P26-bgcn-bam-Sxl complex (PubMed:31941704).
              (UniProt, M9PH32 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              X
              Recombination map
              1-26
              Cytogenetic map
              8C15-8C17
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              8C15-8C17
              Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912;
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              8-8
              (determined by in situ hybridisation)
              (Page et al., 2000)
              8C-8C
              (Sekelsky et al., 1999)
              8C10-8D3
              (Page, 1999.3.11)
              Experimentally Determined Recombination Data
              Location

              1-26

              (FlyBase, 2016)

              1-28.1

              (Comeron et al., 2012)

              1-

              (Page et al., 1999)
              Left of (cM)
              (Glasscock et al., 2005)
              Right of (cM)
              (Glasscock et al., 2005)
              Notes
              Stocks and Reagents
              Stocks (19)
              Genomic Clones (22)
              cDNA Clones (65)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              monoclonal

              (Na et al., 2016)

              polyclonal

              (Chen et al., 2014, Liu et al., 2009)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Mutations in mei-P26 act as suppressors of seizure susceptible mutants.

                  (Glasscock et al., 2005)

                  RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                  (Boutros et al., 2004)

                  Identification: Defined in a large P-element mutagenesis screen for novel meiotic mutants.

                  (Page et al., 1999)

                  Identification: In a genetic screen for meiotic mutants.

                  (Sekelsky et al., 1999)

                  Mutant females show reduced meiotic recombination.

                  (Sekelsky et al., 1999)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: mei-P26 BcDNA:GH10646

                  (Page et al., 2000)
                  Additional comments
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: mei-P26 CG12218

                  (Page, 2001.4.4)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (11)
                  Reported As
                  Symbol Synonym
                  AF145661
                  (Arama et al., 2000)
                  BcDNA:GH10646
                  (Boutros et al., 2004)
                  CG12218
                  (Na et al., 2016, Sing et al., 2014, Cui et al., 2013, Ni et al., 2011.7.19, Ying et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Sardiello et al., 2008, Mack et al., 2006, Page, 2001.4.4)
                  MEI-P26
                  (O'Farrell et al., 2008)
                  Mei-P26
                  (Salerno-Kochan et al., 2022, Connacher and Goldstrohm, 2021, Malik et al., 2020, Malik et al., 2017, Moschall et al., 2017, Siddall and Hime, 2017, Sanfilippo et al., 2016, Loedige et al., 2015, Gallant, 2013, Hernández et al., 2013, Li et al., 2013, Marin, 2012, Siddiqui et al., 2012, Pek and Kai, 2011, Smibert et al., 2011, Ying et al., 2011, Herranz et al., 2010, Neumuller et al., 2008, Neumüller et al., 2007)
                  Mei-p26
                  (Arnce et al., 2025)
                  mei-P26
                  (Kagemann et al., 2025, Cabrita and Martinho, 2023, Gui et al., 2023, Vidaurre and Chen, 2021, Avilés-Pagán et al., 2020, Wei et al., 2020, Drummond-Barbosa, 2019, Tiwari et al., 2019, Flora et al., 2018, Rojas-Ríos et al., 2017, Salz et al., 2017, Sanfilippo et al., 2017, Wong et al., 2017, Zajitschek et al., 2017, Fear et al., 2016, Jungreis et al., 2016, Na et al., 2016, Flores et al., 2015, Liu and Lasko, 2015, Chen et al., 2014, Ferreira et al., 2014, Hamada-Kawaguchi et al., 2014, Temme et al., 2014, Yan et al., 2014, Joly et al., 2013, Lasko, 2013, Li et al., 2013, Insco et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Li et al., 2012, Smibert et al., 2012, Du et al., 2011, Hilgers et al., 2011, Reis et al., 2011, Herranz et al., 2010, Tastan et al., 2010, Anderson et al., 2009, Liu et al., 2009, Rhiner et al., 2009, McGraw et al., 2008, Page, 2008.10.22, Yatsu et al., 2008, Haerty et al., 2007, Nurminsky, 2007, Tadros et al., 2007, Mukai et al., 2006, Musters et al., 2006)
                  mei-p26
                  (Wang et al., 2021, Blatt et al., 2020, Rastegari et al., 2020, Kang et al., 2018, Ma et al., 2017, Wu et al., 2016, Cui et al., 2013)
                  meiP26
                  (Kina et al., 2019)
                  Name Synonyms
                  mei-P26
                  (Dehghani and Lasko, 2017)
                  meiotic P26
                  meiotic-P26
                  (Kroll et al., 2015)
                  Secondary FlyBase IDs
                  • FBgn0027551
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 70 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  PDB - An information portal to biological macromolecular structures
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (137)