FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term ubiquitin-protein transferase activity ID (Ontology) GO:0004842 (Gene Ontology)
Definition Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.[ PubMed:9635407 ]
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Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     100
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ubiquitin-protein transferase activity (all annotations which use CV term, excluding "NOT" statements)       2    100
     contributes_to | ubiquitin-protein transferase activity       --       2
     enables | ubiquitin-protein transferase activity       --     100
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aminoacyltransferase activity____________
catalytic activity, acting on a protein__|
                                         ubiquitin-like protein transferase activity
                                          |__ubiquitin-protein transferase activity  202 rec.
                                              |__ubiquitin conjugating enzyme activity 28 rec.
                                              |__ubiquitin protein ligase activity 172 rec.
                                                  |__histone ubiquitin ligase activity(+) 3 rec.
                                                  |__ubiquitin-ubiquitin ligase activity 5 rec.
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Is a ubiquitin-like protein transferase activity
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Synonyms
  • "E2" BROAD
    "E3" BROAD
    "ubiquitin conjugating enzyme activity" NARROW
    "ubiquitin ligase activity" NARROW
    "ubiquitin protein ligase activity" NARROW
    "ubiquitin protein-ligase activity" NARROW
    "ubiquitin-conjugating enzyme activity" NARROW
Secondary IDs
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KEGG_REACTION:R03876
Reactome:R-HSA-1169394 "ISGylation of IRF3"
Reactome:R-HSA-1169395 "ISGylation of viral protein NS1"
Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase"
Reactome:R-HSA-1169398 "ISGylation of host protein filamin B"
Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes"
Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)"
Reactome:R-HSA-1169406 "ISGylation of host proteins"
Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha"
Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha"
Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH"
Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41"
Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3"
Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3"
Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)"
Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex"
Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2"
Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling"
Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1"
Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP"
Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
Reactome:R-HSA-179417 "Multiubiquitination of Nek2A"
Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G"
Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex"
Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85"
Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)"
Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty"
Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix"
Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty"
Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7"
Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21"
Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX"
Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand"
Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2"
Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2"
Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer"
Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1"
Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination"
Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling"
Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6"
Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6"
Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF"
Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex"
Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34"
Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7"
Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2"
Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3"
Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2"
Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7"
Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3"
Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3"
Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )"
Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels"
Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6"
Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants"
Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants"
Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants"
Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA"
Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56"
Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21"
Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1"
Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2"
Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1"
Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2"
Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)"
Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins"
Reactome:R-HSA-4332236 "CBL neddylates TGFBR2"
Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated"
Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation"
Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1"
Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1"
Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments"
Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated"
Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP"
Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex"
Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates"
Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1"
Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1"
Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2"
Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3"
Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA"
Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH"
Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA"
Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP"
Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP"
Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3"
Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK"
Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated"
Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2"
Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2"
Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains"
Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1"
Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A"
Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO"
Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1"
Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4"
Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3"
Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha"
Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3"
Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex"
Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex"
Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated"
Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS"
Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2"
Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains"
Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation"
Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation"
Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer"
Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363"
Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates"
Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5"
Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex"
Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane"
Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6"
Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50"
Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3"
Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627"
Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634"
Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627"
Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR"
Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530"
Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex"
Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2"
Reactome:R-HSA-983153 "E1 mediated ubiquitin activation"
Reactome:R-HSA-983156 "Polyubiquitination of substrate"
Reactome:R-HSA-9833155 "Ubiquitination of STAT2"
Reactome:R-HSA-9833973 "ISGylation of PKR"
Reactome:R-HSA-9834070 "PRKN ubiquitinates MOM substrates"
Reactome:R-HSA-9861563 "CTLH E3 ligase ubiquitinates LDHA"
Reactome:R-HSA-9861640 "CTLH E3 ligase ubiquitinates PKM-1"