FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-P2616
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General Information
Symbol
Dmel\mei-P2616
Species
D. melanogaster
Name
FlyBase ID
FBal0192079
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: S627L. Amino acid replacement: P1071L. Nucleotide substitution: C?T.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C9168543T

Amino acid change:

S627L | mei-P26-PA; S627L | mei-P26-PB; S627L | mei-P26-PC; S627L | mei-P26-PD; S627L | mei-P26-PE; S627L | mei-P26-PF

Reported amino acid change:

S627L

Comment:

One of two amino acid substitutions in mutant

Nucleotide change:

C9170202T

Reported nucleotide change:

C?T

Amino acid change:

P1071L | mei-P26-PA; P1071L | mei-P26-PB; P1088L | mei-P26-PC; P1071L | mei-P26-PD; P1088L | mei-P26-PE; P1071L | mei-P26-PF

Reported amino acid change:

P1071L

Comment:

One of two amino acid substitutions in mutant; likely cause of mutant phenotype.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mei-P2616 and mei-P2616/mei-P26fs1 flies have a high seizure threshold (the minimum voltage required to induce seizure activity in the dorsal longitudinal muscles after a high-frequency stimulus) compared to controls. mei-P2616 and mei-P2616/mei-P26fs1 flies show defects in X chromosome nondisjunction.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The suppression of bang sensitivity of eas2/Y mutants caused by mei-P2616/mei-P2616 is age dependent, with the strength of the suppression increasing with age; approximately 32% of 1-2 day old double mutant flies show bang sensitivity, but only 1% of 4-5 day old double mutant flies show bang sensitivity. The recovery time of eas2 flies after being subjected to a 10 second vortex is reduced if they are also mutant for mei-P2616; the time needed for recovery is reduced by about 12% in double mutant 1-2 day old bang sensitive flies and is reduced by about 19% in double mutant 2-3 day old bang sensitive flies. The reduced seizure threshold (the minimum voltage required to induce seizure activity in the dorsal longitudinal muscles after a high-frequency stimulus) of eas2 flies is partly suppressed if they are also mutant for mei-P2616, although the seizure threshold in the double mutant flies is still lower than that of wild-type controls. The increase in seizure threshold in the double mutants is not accompanied by an increase in giant fiber firing threshold. The reduced seizure threshold (the minimum voltage required to induce seizure activity in the dorsal longitudinal muscles after a high-frequency stimulus) of sdaiso7.8 flies is restored to wild-type if the flies are also mutant for mei-P2616.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that suppresses the eas2 bang sensitive phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mei-P2616
Name Synonyms
Secondary FlyBase IDs
    References (1)