FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-P26fs1
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General Information
Symbol
Dmel\mei-P26fs1
Species
D. melanogaster
Name
FlyBase ID
FBal0118093
Feature type
allele
Associated gene
Dmel\mei-P26
Associated Insertion(s)
P{lacW}mei-P26-1
P{lacW}mei-P26-fs1
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Glasscock et al., 2005)
Mutagen
Delta2-3 transposase
(Page et al., 2000)
Progenitor genotype
mei-P261
(Page et al., 2000)
Associated Insertion(s)
P{lacW}mei-P26-1
P{lacW}mei-P26-fs1
Cytology
Description

Tandem duplication of the P{lacW} element, such that two copies of the P{lacW} element are present in the first intron.

(Page et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
P{lacW}
Encoded product / tool
lacZ
lacZ
Tagged with
Tag:NLS(P)
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-P261/mei-P26fs1 ovaries are mostly wild-type in appearance, with less than 5% of egg chambers having fewer or more than 15 nurse cells or being incorrectly patterned.

      (Liu et al., 2009)

      Nucleoli in mutant ovaries are larger than those in wild-type ovaries.

      Cell diameters are increased compared to wild type and no longer decrease as cells are displaced from the stem cell niche in mei-P26fs1/mei-P26mfs1 ovaries.

      (Neumuller et al., 2008)

      mei-P2616/mei-P26fs1 flies have a high seizure threshold (the minimum voltage required to induce seizure activity in the dorsal longitudinal muscles after a high-frequency stimulus) compared to controls. mei-P2616/mei-P26fs1 flies show defects in X chromosome nondisjunction.

      (Glasscock et al., 2005)

      The ovary phenotypes of homozygous females are not suppressed by Wolbachia infection; 100% of ovaries of homozygous infected females have no eggs.

      (Starr and Cline, 2002)

      mei-P261/mei-P26fs1 females show 22.4% X chromosome nondisjunction and 18.1% 4th chromosome nondisjunction. Recombination frequency on chromosome 2 is decreased in mei-P261/mei-P26fs1 females and the recombination distribution is polar. Homozygous ovaries often contain chamber cysts filled with large numbers of small, apparently undifferentiated cells. 84.4% of egg chambers show this "tumourous" phenotype. The remaining chambers more closely resemble wild type, in that nurse cells are present, although many contain abnormal numbers of nurse cells. Homozygous females lay a reduced number of eggs compared to wild type.

      (Page et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      mei-P26fs1/mei-P2616 is a suppressor of bang sensitive phenotype of eas2

      (Glasscock et al., 2005)

      mei-P26fs1/mei-P2616 is a suppressor of bang sensitive phenotype of jusiso7.8

      (Glasscock et al., 2005)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      mei-P26fs1/mei-P261 has oocyte phenotype, enhanceable by vasPH165/vas1

      (Liu et al., 2009)

      mei-P26fs1/mei-P261 has egg chamber phenotype, enhanceable by vasPH165/vas1

      (Liu et al., 2009)

      mei-P26fs1/mei-P261 has nurse cell phenotype, enhanceable by vasPH165/vas1

      (Liu et al., 2009)
      Suppressed by
      Statement
      Reference

      mei-P26fs1 has ovary phenotype, suppressible by loqs[+]/loqsKO

      (Neumuller et al., 2008)
      Suppressor of
      Statement
      Reference

      mei-P26fs1/mei-P26[+] is a suppressor | partially of female germline stem cell phenotype of twinDG24102

      (Joly et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The loss of germline stem cells seen in the ovaries of homozygous twinDG24102 females is strongly rescued if the females are also heterozygous for mei-P26fs1 .

      (Joly et al., 2013)

      More than 50% of vas1/vasPH165 ; mei-P261/mei-P26fs1 egg chambers are tumorous and fail to differentiate nurse cells and oocytes. The double mutant egg chambers contain mostly early-stage cystocytes as they contain either punctate spectrosomes or branched fusomes.

      (Liu et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mei-P26fs1
      (Hernández et al., 2013, Joly et al., 2013, Liu et al., 2009, Neumuller et al., 2008)
      mei-p26fs1
      (Rastegari et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)