FB2025_04 , released October 2, 2025
Gene: Dmel\wech
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General Information
Symbol
Dmel\wech
Species
D. melanogaster
Name
wech
Annotation Symbol
CG42396
Feature Type
protein_coding_gene
FlyBase ID
FBgn0259745
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dpld, dappled, lin-41

Key Links
Genomic Location
Cytogenetic map
43C5-43C5
Sequence location
Recombination map
2-56
RefSeq locus
NT_033778 REGION:7478853..7489823
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein-macromolecule adaptor activity
inferred from direct assay
(Loer et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR000315
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in instar larval development
inferred from mutant phenotype
(Rodriguez et al., 1996)
involved_in somatic muscle attachment to chitin-based cuticle
inferred from mutant phenotype
(Loer et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cell-substrate junction
inferred from direct assay
(Loer et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites.
(UniProt, Q9V4M2)
Summary (Interactive Fly)

LIN-41 subclade multiple domain protein of unknown function - let-7 micro RNA regulated

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\wech for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V4M2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wech-RA
FBtr0300080
NM_080033
4495
832
wech-RB
FBtr0300081
NM_165533
3290
832
wech-RC
FBtr0300082
NM_165534
7593
832
wech-RD
FBtr0300083
NM_001144142
6021
832
wech-RE
FBtr0300084
NM_001144143
4316
832
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
wech-PA
FBpp0289357
90.6
832
6.46
Q9V4M2
NP_524772
AAM68901
wech-PB
FBpp0289358
90.6
832
6.46
Q9V4M2
NP_724567
AAF59246
wech-PC
FBpp0289359
90.6
832
6.46
Q9V4M2
NP_724568
AAF59245
wech-PD
FBpp0289360
90.6
832
6.46
Q9V4M2
NP_001137614
ACL83068
wech-PE
FBpp0289361
90.6
832
6.46
Q9V4M2
NP_001137615
ACL83069
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

832 aa isoforms: wech-PA, wech-PB, wech-PC, wech-PD, wech-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with the head domain of rhea and the kinase domain of Ilk. Interacts with AGO1 (PubMed:18528333). Interacts with mei-P26 (PubMed:22438571).

(UniProt, Q9V4M2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wech using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.57

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
organism | ubiquitous
(O'Farrell et al., 2008)
organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12 -- 15
larval nervous system

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
medial-most cell body glial cell
(Kearney et al., 2004)
embryonic stage 16
multidendritic neuron
(O'Farrell et al., 2008)
chordotonal neuron
(O'Farrell et al., 2008)
larval peripheral nervous system | restricted
(O'Farrell et al., 2008)
larval central nervous system | restricted
(O'Farrell et al., 2008)
larval neuron
(O'Farrell et al., 2008)
third instar larval stage
wing disc
(O'Farrell et al., 2008)
presumptive wing margin
(O'Farrell et al., 2008)
eye disc anterior to the morphogenetic furrow
(O'Farrell et al., 2008)
eye disc posterior to the morphogenetic furrow
(O'Farrell et al., 2008)
photoreceptor neuron
(O'Farrell et al., 2008)
embryonic/larval optic lobe
(O'Farrell et al., 2008)
Additional Descriptive Data

Isoforms of wech with long 3' UTR extensions were observed. There is an extended 3' UTR isoform or wech that is expressed maternally. The 3' UTR extension isoforms are highly enriched in nervous system tissues.

(Hilgers et al., 2011)

wech expression is ubiquitous in early embryos. wech is expressed later in a dynamic pattern in neurons of the embryonic CNS and PNS. Both chordotonal and multidendritic neurons express wech at the end of PNS development. In wing disc, wech is expressed in specific cells along the future anterior wing margin. In eye discs, it is expressed both immediately anterior and posterior to the morphogenetic furrow. It is also expressed further posterior to the furrow in photoreceptor cells both before and after their specification. Expression is also observed in the optic lobes and regions that appear to be the proliferation zones.

(O'Farrell et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 4
organism
(Loer et al., 2008)
embryonic stage 5 -- 11
epithelial cell
(Loer et al., 2008)
embryonic stage 16
muscle attachment site
(Loer et al., 2008)
embryonic stage 16 -- 17
muscle attachment site
(Loer et al., 2008)
embryonic/larval hypodermal muscle cell | restricted
(Loer et al., 2008)
tendon cell | restricted
(Loer et al., 2008)
oogenesis
oocyte
(Loer et al., 2008)
Additional Descriptive Data

wech protein is distributed in a punctate pattern in the cell membranes of oocytes and pre-blastoderm embryos. Later in embryogenesis, wech protein colocalizes with shg protein in epithelial cells. After germ band retraction, wech is accumulates at epidermal muscle attachment sites, where it colocalizes with mys protein.

(Loer et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell-substrate junction
inferred from direct assay
(Loer et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\wech in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wech
Transgenic constructs containing regulatory region of wech
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene not disrupted in
Df(2R)k08815
(Kleinhesselink et al., 2011)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (30)
Hsap\TRIM71
10 of 14
Yes
Yes
Hsap\TRIM2
4 of 14
No
No
Hsap\TRIM3
4 of 14
No
No
Hsap\NHLRC1
2 of 14
No
Yes
Hsap\NHLRC3
2 of 14
No
Yes
Hsap\RNF207
2 of 14
No
Yes
Hsap\TRIM32
2 of 14
No
Yes
Hsap\TRIM45
2 of 14
No
No
Hsap\CMYA5
1 of 14
No
No
Hsap\DBH
1 of 14
No
No
Hsap\FSD1
1 of 14
No
No
Hsap\FSD1L
1 of 14
No
No
Hsap\FSD2
1 of 14
No
No
Hsap\MID1
1 of 14
No
No
Hsap\MID2
1 of 14
No
No
Hsap\MOXD1
1 of 14
No
No
Hsap\MOXD2P
1 of 14
No
No
Hsap\NHLRC2
1 of 14
No
No
Hsap\PAM
1 of 14
No
No
Hsap\RNF152
1 of 14
No
No
Hsap\RNF208
1 of 14
No
No
Hsap\TRIM9
1 of 14
No
No
Hsap\TRIM36
1 of 14
No
No
Hsap\TRIM42
1 of 14
No
Yes
Hsap\TRIM46
1 of 14
No
No
Hsap\TRIM54
1 of 14
No
Yes
Hsap\TRIM55
1 of 14
No
Yes
Hsap\TRIM56
1 of 14
No
No
Hsap\TRIM63
1 of 14
No
Yes
Hsap\TRIM67
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Trim71
11 of 14
Yes
Yes
Rnor\Trim2
4 of 14
No
No
Rnor\Trim3
4 of 14
No
No
Rnor\Nhlrc1
2 of 14
No
Yes
Rnor\Nhlrc3
2 of 14
No
Yes
Rnor\Trim32
2 of 14
No
Yes
Rnor\Trim45
2 of 14
No
No
Rnor\Dbh
1 of 14
No
No
Rnor\Moxd1
1 of 14
No
No
Rnor\Moxd2
1 of 14
No
No
Rnor\Nhlrc2
1 of 14
No
No
Rnor\Pam
1 of 14
No
No
Rnor\Rnf152
1 of 14
No
No
Rnor\Rnf207
1 of 14
No
No
Rnor\Rnf208
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Trim71
11 of 14
Yes
Yes
Mmus\Trim2
4 of 14
No
No
Mmus\Trim3
4 of 14
No
No
Mmus\Nhlrc1
2 of 14
No
Yes
Mmus\Nhlrc3
2 of 14
No
Yes
Mmus\Trim32
2 of 14
No
Yes
Mmus\Trim45
2 of 14
No
No
Mmus\Dbh
1 of 14
No
No
Mmus\Moxd1
1 of 14
No
No
Mmus\Moxd2
1 of 14
No
No
Mmus\Nhlrc2
1 of 14
No
No
Mmus\Pam
1 of 14
No
No
Mmus\Rnf207
1 of 14
No
No
Mmus\Rnf208
1 of 14
No
No
Mmus\Trim34b
1 of 14
No
Yes
Mmus\Trim56
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\nudcd1
6 of 13
Yes
No
Xtro\trim71
6 of 13
Yes
Yes
Xtro\trim2
4 of 13
No
No
Xtro\trim3
4 of 13
No
No
Xtro\nhlrc1
2 of 13
No
Yes
Xtro\rnf207
2 of 13
No
Yes
Xtro\trim32
2 of 13
No
Yes
Xtro\cmya5
1 of 13
No
No
Xtro\cox15
1 of 13
No
No
Xtro\fsd2
1 of 13
No
No
Xtro\LOC100489697
1 of 13
No
No
Xtro\LOC100495443
1 of 13
No
No
Xtro\lto1
1 of 13
No
No
Xtro\MGC79670
1 of 13
No
No
Xtro\nhlrc2
1 of 13
No
No
Xtro\nhlrc3
1 of 13
No
Yes
Xtro\nhlrc4
1 of 13
No
Yes
Xtro\ppp2r3b
1 of 13
No
No
Xtro\pspc1
1 of 13
No
No
Xtro\rnf152
1 of 13
No
No
Xtro\trim24
1 of 13
No
No
Xtro\trim25l
1 of 13
No
Yes
Xtro\trim28
1 of 13
No
No
Xtro\trim33
1 of 13
No
No
Xtro\trim45
1 of 13
No
No
Xtro\trim55
1 of 13
No
No
Xtro\trim63
1 of 13
No
Yes
Xtro\XB5729975
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (16)
Drer\trim71
11 of 14
Yes
Yes
Drer\trim2a
4 of 14
No
No
Drer\trim2b
4 of 14
No
No
Drer\trim3a
4 of 14
No
No
Drer\trim3b
4 of 14
No
No
Drer\trim32
2 of 14
No
Yes
Drer\trim45
2 of 14
No
No
Drer\dbh
1 of 14
No
No
Drer\moxd1
1 of 14
No
No
Drer\moxd1l
1 of 14
No
No
Drer\nhlrc2
1 of 14
No
No
Drer\pam
1 of 14
No
No
Drer\rnf152
1 of 14
No
No
Drer\rnf207a
1 of 14
No
Yes
Drer\rnf207b
1 of 14
No
No
Drer\si:dkey-106l3.6
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (26)
Cele\lin-41
9 of 14
Yes
Yes
Cele\nhl-1
4 of 14
No
No
Cele\F43C11.8
3 of 14
No
Yes
Cele\ncl-1
2 of 14
No
No
Cele\B0281.3
1 of 14
No
Yes
Cele\B0281.8
1 of 14
No
Yes
Cele\C28G1.6
1 of 14
No
Yes
Cele\F40G9.12
1 of 14
No
No
Cele\F40G9.19
1 of 14
No
No
Cele\F43C11.7
1 of 14
No
Yes
Cele\F43G6.8
1 of 14
No
No
Cele\K09F6.7
1 of 14
No
Yes
Cele\madd-2
1 of 14
No
No
Cele\nhl-2
1 of 14
No
No
Cele\nhl-3
1 of 14
No
No
Cele\pamn-1
1 of 14
No
No
Cele\pgal-1
1 of 14
No
No
Cele\pghm-1
1 of 14
No
No
Cele\rcs-1
1 of 14
No
Yes
Cele\tbh-1
1 of 14
No
No
Cele\ZK1240.1
1 of 14
No
Yes
Cele\ZK1240.2
1 of 14
No
Yes
Cele\ZK1240.3
1 of 14
No
Yes
Cele\ZK1240.5
1 of 14
No
Yes
Cele\ZK1240.8
1 of 14
No
Yes
Cele\ZK1240.9
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP005125
12 of 12
Yes
Yes
Agam\AgaP_AGAP007135
3 of 12
No
No
Agam\AgaP_AGAP007095
2 of 12
No
No
Agam\AgaP_AGAP010054
2 of 12
No
No
Agam\AgaP_AGAP001328
1 of 12
No
No
Agam\AgaP_AGAP002344
1 of 12
No
No
Agam\AgaP_AGAP005784
1 of 12
No
No
Agam\AgaP_AGAP007420
1 of 12
No
No
Agam\AgaP_AGAP007606
1 of 12
No
No
Agam\AgaP_AGAP008750
1 of 12
No
No
Agam\AgaP_AGAP009708
1 of 12
No
No
Agam\AgaP_AGAP010485
1 of 12
No
No
Agam\AgaP_AGAP010610
1 of 12
No
No
Agam\AgaP_AGAP011450
1 of 12
No
No
Agam\AgaP_AGAP011609
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT1G56500
1 of 13
Yes
No
Atha\AT2G16760
1 of 13
Yes
Yes
Atha\AT4G01350
1 of 13
Yes
Yes
Atha\AT5G14890
1 of 13
Yes
Yes
Atha\emb1974
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:wech. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
tn
6 of 13
brat
4 of 13
CG8419
3 of 13
mei-P26
3 of 13
Trim9
2 of 13
bon
1 of 13
CG5235
1 of 13
CG12547
1 of 13
Pal1
1 of 13
Pal2
1 of 13
Phm
1 of 13
Tbh
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIM71; tripartite motif containing 71
    10 of 14
    618570
      TRIM2; tripartite motif containing 2
      4 of 14
      614141
      TRIM3; tripartite motif containing 3
      4 of 14
      605493
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          hid
          suppressible
          wech
          (Bilen and Bonini, 2007)
          Nsf2
          suppressible
          wech
          (Laviolette et al., 2005)
          parvin
          suppressible
          wech
          (Chountala et al., 2012)
          pnr
          enhanceable
          wech
          (Pena-Rangel et al., 2002)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with the head domain of rhea and the kinase domain of Ilk. Interacts with AGO1 (PubMed:18528333). Interacts with mei-P26 (PubMed:22438571).
          (UniProt, Q9V4M2 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-56
          Cytogenetic map
          43C5-43C5
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          43C5-43C5
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-56

          (FlyBase, 2016)

          2-56.6

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (20)
          Genomic Clones (17)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (102)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Loer et al., 2008)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Annotation CG1624 renamed CG42396 in release 5.10 of the genome annotation.

              (FlyBase Genome Annotators, 2008)
              Relationship to Other Genes
              Source for database merge of
              Additional comments

              FlyBase curator comment: The gene referred to as "dpld/dappled/wech" corresponds exclusively to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (Hilgers et al., 2011)

              Previous genome annotation had assigned the 'dappled' ('dpld') complementation group to CG1624 (now CG42396, 'wech') based on the position of the k08815 insertion, which does not complement one of the original 'dpld' insertional alleles, k14202. However, analysis of flanking sequence of both the original 'dpld' insertional alleles, k14202 and k09716, indicates they map to the 5' UTR of CG2140/'Cyt-b5'. Re-analysis of the flanking sequences of k08815 indicates that this insertion is accompanied by a large deletion, thereby explaining the discrepancy and the original error. Thus, the 'dappled' complementation group is correctly identified as CG2140/'Cyt-b5'.

              (Kleinhesselink et al., 2011)

              FlyBase curator comment: The gene referred to as "dpld" corresponds to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (Shieh and Bonini, 2011)

              The "dpld, dappled" complementation group does not correspond to CG1624. CG1624 has been renamed "wech".

              (Loer et al., 2008)

              FlyBase curator comment: The gene referred to as "dappled/dpld" corresponds to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (O'Farrell et al., 2008)

              FlyBase curator comment: The gene referred to as "CG1624/dappled/dpld" corresponds to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (Bilen and Bonini, 2007, Pilot et al., 2006)

              FlyBase curator comment: The gene referred to as "Dappled/Dpld" in Table 4 corresponds to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (Greene et al., 2005)

              FlyBase curator comment: The gene referred to as "CG1624/dpld" in Fig 1B corresponds to the 'wech' gene (now re-annotated as CG42396) and NOT the "dpld/dappled" complementation group, which has since been identified as 'Cyt-b5/CG2140'. (The 'dpld/dappled' nomenclature has been used to refer to two different genes in the literature and in FlyBase because of confusion about the gene model to which the "dappled" complementation group corresponds - see Kleinhesselink et al., 2011, FBrf0214429.)

              (Stark et al., 2005)
              Nomenclature History
              Source for database identify of

              Source for identity of: wech CG42396

              (Loer et al., 2008)
              Nomenclature comments
              Etymology

              The gene is named "wech" (a German Rhineland term for "detached" or "gone") due to its essential role in muscle attachment suring embryogenesis.

              (Loer et al., 2008)
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 145 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (75)