Tβh, TβM, tyramine-beta-hydroxylase, tyramine β-monooxygenase, tyramine beta-hydroxylase
an enzyme that converts tyramine to octopamine, a neurotransmitter that is the insect equivalent of norepinephrine - octopamine modulates several physiological functions and behaviors including sleep, aggression and ovulation
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tbh using the Feature Mapper tool.
Tbh protein is detected in around 112 neurons in the adult brain, corresponding to 16 distinct clusters, and around 39 neurons in the thoracico-abdominal ganglion, corresponding to 5 clusters. Co-localisation with Scer\GAL4Tdc2.PC in the brain is observed in the octopaminergic AL2 (G3a) cluster, in the G3b and 3 ventral clusters (VMI to VMIII). In the thoracico-abdominal ganglion, 37 of the 39 Tbh-positive neurons also express Scer\GAL4Tdc2.PC.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tbh in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Tbh CG1543
Mutants show partially impaired sugar-reward learning, but relief learning is unaffected.
Tbh controls ovulation (the passage of eggs from the ovaries to the oviducts) in females.