FB2026_02 , released June 18, 2026
Allele: Dmel\Tbhhs.PS
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General Information
Symbol
Dmel\Tbhhs.PS
Species
D. melanogaster
Name
heat shock construct of Schwaerzel
FlyBase ID
FBal0152162
Feature type
allele
Associated gene
Dmel\Tbh
Associated Insertion(s)
Carried in Construct
P{hs-Tbh.S}
Also Known As
hsp-Tβh
Key Links
Transgenic product class
cDNA
(Monastirioti, 2003)
wild_type
(Monastirioti, 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Monastirioti, 2003)
wild_type
(Monastirioti, 2003)
Mutagen
in vitro construct
(Monastirioti, 2003)
Progenitor genotype
Carried in construct
P{hs-Tbh.S}
Cytology
Description

An Hsp70 promoter drives expression of a Tbh cDNA.

(Monastirioti, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Tbh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      3 hours after a 30 minute heat shock to induce expression of Tbhhs.PS, flies have a shortened fighting latency, increased lunging frequency and increased high-intensity fighting (holding, boxing and tussling) compare to control flies when two flies are placed in a small closed chamber containing a food pad at the centre.

      (Zhou et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Tbhhs.PS rescues TbhnM18

      (Brembs et al., 2007)

      Tbhhs.PS rescues TbhnM18

      (Monastirioti, 2003)
      Partially rescues

      Tbhhs.PS partially rescues TbhnM18

      (Schwaerzel et al., 2003)
      Comments

      Expression of Tbhhs.PS through heat-shock rescues flight initiation and maintenance in TbhnM18 mutants. No rescue is seen without heat-shock.

      (Brembs et al., 2007)

      TbhnM18 females which are carrying Tbhhs.PS are completely sterile at 18oC and lay a few eggs at 25oC. These females start laying eggs within a few hours of a single heat shock (37oC for 1 hour) and continue to lay eggs for almost 3 days. The rhythmicity of egg laying in the heat shocked females is the same as that of wild-type females. The fertility of these females is 50-60% that of wild type.

      (Monastirioti, 2003)

      Following heat shock, the Tbhhs.PS transgene rescues the sugar memory phenotype of TbhnM18 flies.

      (Schwaerzel et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tbhhs.PS
      Name Synonyms
      heat shock construct of Schwaerzel
      (Monastirioti, 2003)
      Secondary FlyBase IDs
        References (6)