FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term catalytic activity ID (Ontology) GO:0003824 (Gene Ontology)
Definition Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.[ ISBN:0198506732 ]
Also Known As "enzyme activity"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     171
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
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 Gene Groups Genes
 catalytic activity (all annotations which use CV term, excluding "NOT" statements)       1    171
     enables | catalytic activity       --     158
 NOT | enables | catalytic activity       --       1
Spanning Tree (Parents/Children)
Only view relationship:
  molecular_function
   |__catalytic activity  4653 rec.
       |__catalytic activity, acting on a nucleic acid 523 rec.
       |   |__annealing activity(+) 4 rec.
       |   |__catalytic activity, acting on DNA(+) 196 rec.
       |   |__catalytic activity, acting on RNA(+) 340 rec.
       |   |__G-quadruplex unwinding activity 1 rec.
       |   |__helicase activity(+) 100 rec.
       |   |__nuclease activity(+) 152 rec.
       |__catalytic activity, acting on a protein 1595 rec.
       |   |__[acyl-carrier-protein] phosphodiesterase activity
       |   |__[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity
       |   |__[protein-PII] uridylyltransferase activity
       |   |__[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity 1 rec.
       |   |__[protein]-asparagine 3-dioxygenase activity
       |   |__ADP-ribosylarginine hydrolase activity 2 rec.
       |   |__ADP-ribosylglutamate hydrolase activity 3 rec.
       |   |__ADP-ribosylserine hydrolase activity 1 rec.
       |   |__ADP-riboxanase activity
       |   |__alpha-1,4-glucan-protein synthase (ADP-forming) activity
       |   |__arginyl-tRNA--protein transferase activity 1 rec.
       |   |__ATP-dependent histone chaperone activity(+) 1 rec.
       |   |__biotin--[biotin carboxyl-carrier protein] ligase activity 1 rec.
       |   |__catalytic activity, acting on a glycoprotein(+) 21 rec.
       |   |__cholesterol-protein transferase activity 1 rec.
       |   |__deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity
       |   |__deoxyhypusine monooxygenase activity 1 rec.
       |   |__dihydrolipoyllysine-residue acetyltransferase activity 4 rec.
       |   |__dihydrolipoyllysine-residue succinyltransferase activity 5 rec.
       |   |__dolichyl-phosphate-mannose-protein mannosyltransferase activity 8 rec.
       |   |__glutaminyl-peptide cyclotransferase activity 5 rec.
       |   |__histone modifying activity(+) 101 rec.
       |   |__holocytochrome-c synthase activity 1 rec.
       |   |__leucyl-tRNA--protein transferase activity
       |   |__lipoate-protein ligase activity
       |   |__lipoyl(octanoyl) transferase activity 1 rec.
       |   |__microtubule plus end polymerase activity 2 rec.
       |   |__microtubule severing ATPase activity 6 rec.
       |   |__NAD+-protein mono-ADP-ribosyltransferase activity(+) 2 rec.
       |   |__NAD-dependent protein lysine deacylase activity(+) 6 rec.
       |   |__palmitoyl-(protein) hydrolase activity 6 rec.
       |   |__peptidase activity(+) 571 rec.
       |   |__peptide alpha-N-propionyltransferase activity
       |   |__peptide lactyltransferase (ATP-dependent) activity
       |   |__peptide-methionine (R)-S-oxide reductase activity 1 rec.
       |   |__peptide-methionine (S)-S-oxide reductase activity 1 rec.
       |   |__peptide-O-fucosyltransferase activity 2 rec.
       |   |__peptidyl-arginine 3-dioxygenase activity 1 rec.
       |   |__peptidyl-aspartic acid 3-dioxygenase activity 1 rec.
       |   |__peptidyl-cysteine S-nitrosylase activity 4 rec.
       |   |__peptidyl-histidine dioxygenase activity
       |   |__peptidyl-lysine 3-dioxygenase activity 1 rec.
       |   |__peptidyl-lysine 4-dioxygenase activity
       |   |__peptidyl-lysine 5-dioxygenase activity 1 rec.
       |   |__peptidyl-lysine N6-myristoyltransferase activity(+)
       |   |__peptidyl-lysine N6-palmitoyltransferase activity(+)
       |   |__peptidyl-proline dioxygenase activity(+) 29 rec.
       |   |__peptidyl-prolyl cis-trans isomerase activity(+) 38 rec.
       |   |__peptidylamidoglycolate lyase activity 2 rec.
       |   |__peptidyltransferase activity
       |   |__phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
       |   |__phosphoprotein phosphatase activity(+) 109 rec.
       |   |__polypeptide N-acetylgalactosaminyltransferase activity 13 rec.
       |   |__procollagen galactosyltransferase activity 3 rec.
       |   |__procollagen glucosyltransferase activity 1 rec.
       |   |__procollagen-lysine 5-dioxygenase activity 1 rec.
       |   |__protein adenylylhydrolase activity 1 rec.
       |   |__protein asparagine deamidase activity(+) 2 rec.
       |   |__protein deglycase activity 2 rec.
       |   |__protein demethylase activity(+) 15 rec.
       |   |__protein disulfide isomerase activity 13 rec.
       |   |__protein kinase activity(+) 265 rec.
       |   |__protein lysine deacetylase activity(+) 13 rec.
       |   |__protein lysine delactylase activity
       |   |__protein methylesterase activity(+) 1 rec.
       |   |__protein methylthiotransferase activity
       |   |__protein methyltransferase activity(+) 80 rec.
       |   |__protein N-acetylglucosaminyltransferase activity(+)
       |   |__protein N-acyltransferase activity(+) 45 rec.
       |   |__protein O-acetylglucosaminyltransferase activity(+) 3 rec.
       |   |__protein prenyltransferase activity(+) 7 rec.
       |   |__protein xylosyltransferase activity 1 rec.
       |   |__protein-cysteine S-acyltransferase activity(+) 23 rec.
       |   |__protein-disulfide reductase activity(+) 27 rec.
       |   |__protein-fructosamine 3-kinase activity
       |   |__protein-glucosylgalactosylhydroxylysine glucosidase activity 1 rec.
       |   |__protein-glutamic acid ligase activity(+) 8 rec.
       |   |__protein-glutamine gamma-glutamyltransferase activity 1 rec.
       |   |__protein-glutamine glutaminase activity
       |   |__protein-glutathione oxidoreductase (glutathione) activity 5 rec.
       |   |__protein-glycine ligase activity(+) 3 rec.
       |   |__protein-lysine 6-oxidase activity 2 rec.
       |   |__protein-lysine lysyltransferase activity
       |   |__protein-malonyllysine demalonylase activity
       |   |__protein-N-terminal glutamine amidohydrolase activity 1 rec.
       |   |__protein-phosphatidylethanolamide deconjugating activity 3 rec.
       |   |__protein-ribulosamine 3-kinase activity
       |   |__protein-tyrosine sulfotransferase activity 1 rec.
       |   |__RNA polymerase II CTD heptapeptide repeat modifying activity(+) 10 rec.
       |   |__Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity
       |   |__tubulin-tyrosine ligase activity
       |   |__ubiquitin-like modifier activating enzyme activity(+) 16 rec.
       |   |__ubiquitin-like protein transferase activity(+) 228 rec.
       |__cyclase activity 33 rec.
       |   |__(-)-E-beta-caryophyllene synthase activity
       |   |__adenylate cyclase activity(+) 14 rec.
       |   |__allene-oxide cyclase activity
       |   |__alpha-humulene synthase activity
       |   |__carboxy-cis,cis-muconate cyclase activity
       |   |__cyclic 2,3-diphosphoglycerate synthetase activity
       |   |__cytidylate cyclase activity
       |   |__D-glutamate cyclase activity
       |   |__FAD-AMP lyase (cyclizing) activity
       |   |__geranyl-diphosphate cyclase activity
       |   |__guanylate cyclase activity 17 rec.
       |   |__halimadienyl-diphosphate synthase activity
       |   |__lycopene beta cyclase activity
       |   |__lycopene epsilon cyclase activity
       |   |__purine imidazole-ring cyclase activity
       |   |__RNA-3'-phosphate cyclase activity 2 rec.
       |   |__sabinene synthase activity
       |   |__solanapyrone synthase activity
       |   |__squalene cyclase activity(+)
       |   |__tocopherol cyclase activity
       |__deacylase activity 45 rec.
       |   |__acyl-CoA hydrolase activity(+) 10 rec.
       |   |__aminoacyl-tRNA deacylase activity(+) 13 rec.
       |   |__deacetylase activity(+) 21 rec.
       |   |__NAD-dependent protein lysine deacylase activity(+) 6 rec.
       |   |__protein lysine delactylase activity
       |__demethylase activity 18 rec.
       |   |__DNA demethylase activity(+) 3 rec.
       |   |__methylselenol demethylase activity
       |   |__oxidative RNA demethylase activity(+) 1 rec.
       |   |__protein demethylase activity(+) 15 rec.
       |   |__sterol 14-demethylase activity
       |   |__vanillate monooxygenase activity
       |__hydrolase activity 1827 rec.
       |   |__cytosine C-5 DNA demethylase activity
       |   |__hydrolase activity, acting on acid anhydrides(+) 450 rec.
       |   |__hydrolase activity, acting on carbon-carbon bonds(+) 5 rec.
       |   |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(+) 107 rec.
       |   |__hydrolase activity, acting on carbon-phosphorus bonds(+)
       |   |__hydrolase activity, acting on carbon-sulfur bonds(+) 2 rec.
       |   |__hydrolase activity, acting on ester bonds(+) 531 rec.
       |   |__hydrolase activity, acting on ether bonds(+) 9 rec.
       |   |__hydrolase activity, acting on glycosyl bonds(+) 129 rec.
       |   |__hydrolase activity, acting on halide bonds(+)
       |   |__hydrolase activity, acting on phosphorus-nitrogen bonds(+) 7 rec.
       |   |__hydrolase activity, acting on sulfur-nitrogen bonds(+) 2 rec.
       |   |__hydrolase activity, acting on sulfur-sulfur bonds(+)
       |   |__palmitoyl hydrolase activity(+) 7 rec.
       |   |__peptidase activity(+) 571 rec.
       |   |__protein-phosphatidylethanolamide deconjugating activity 3 rec.
       |   |__serine hydrolase activity(+) 314 rec.
       |   |__steryl deacetylase activity
       |__isomerase activity 304 rec.
       |   |__cis-trans isomerase activity(+) 42 rec.
       |   |__intramolecular lyase activity(+) 2 rec.
       |   |__intramolecular oxidoreductase activity(+) 40 rec.
       |   |__intramolecular transferase activity(+) 20 rec.
       |   |__macromolecular conformation isomerase activity(+) 186 rec.
       |   |__peroxynitrite isomerase activity
       |   |__racemase and epimerase activity(+) 13 rec.
       |   |__S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
       |__ligase activity 191 rec.
       |   |__ligase activity, forming carbon-carbon bonds(+) 8 rec.
       |   |__ligase activity, forming carbon-nitrogen bonds(+) 47 rec.
       |   |__ligase activity, forming carbon-oxygen bonds(+) 44 rec.
       |   |__ligase activity, forming carbon-sulfur bonds(+) 54 rec.
       |   |__ligase activity, forming nitrogen-metal bonds(+)
       |   |__ligase activity, forming phosphoric ester bonds(+) 9 rec.
       |   |__proton-transporting ATP synthase activity, rotational mechanism 29 rec.
       |   |__sodium-transporting ATP synthase activity, rotational mechanism
       |__lyase activity 165 rec.
       |   |__3'-deoxyribose phosphate lyase activity
       |   |__alkylmercury lyase activity
       |   |__carbon phosphorus lyase activity(+)
       |   |__carbon-carbon lyase activity(+) 40 rec.
       |   |__carbon-halide lyase activity(+) 2 rec.
       |   |__carbon-nitrogen lyase activity(+) 14 rec.
       |   |__carbon-oxygen lyase activity(+) 63 rec.
       |   |__carbon-sulfur lyase activity(+) 5 rec.
       |   |__ferrochelatase activity(+) 1 rec.
       |   |__nitrogen-oxygen lyase activity(+)
       |   |__phosphorus-oxygen lyase activity(+) 38 rec.
       |   |__protein-DNA covalent cross-linking activity 1 rec.
       |   |__sirohydrochlorin cobaltochelatase activity
       |__non-ribosomal peptide synthetase activity 2 rec.
       |   |__amino acid ligation activity by nonribosomal peptide synthase
       |   |__glutathione synthase activity 2 rec.
       |__oxidoreductase activity 712 rec.
       |   |__chlorate reductase activity
       |   |__dioxygenase activity(+) 71 rec.
       |   |__geranylgeranyl reductase activity
       |   |__glycyl-radical enzyme activating activity(+)
       |   |__monooxygenase activity(+) 123 rec.
       |   |__ortho-trichlorophenol reductive dehalogenase activity
       |   |__oxidoreductase activity, acting on a heme group of donors(+)
       |   |__oxidoreductase activity, acting on a sulfur group of donors(+) 71 rec.
       |   |__oxidoreductase activity, acting on CH or CH2 groups(+) 7 rec.
       |   |__oxidoreductase activity, acting on CH-OH group of donors(+) 155 rec.
       |   |__oxidoreductase activity, acting on diphenols and related substances as donors(+) 10 rec.
       |   |__oxidoreductase activity, acting on hydrogen as donor(+)
       |   |__oxidoreductase activity, acting on iron-sulfur proteins as donors(+) 3 rec.
       |   |__oxidoreductase activity, acting on metal ions(+) 19 rec.
       |   |__oxidoreductase activity, acting on NAD(P)H(+) 25 rec.
       |   |__oxidoreductase activity, acting on other nitrogenous compounds as donors(+) 4 rec.
       |   |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(+) 190 rec.
       |   |__oxidoreductase activity, acting on peroxide as acceptor(+) 49 rec.
       |   |__oxidoreductase activity, acting on phosphorus or arsenic in donors(+)
       |   |__oxidoreductase activity, acting on reduced flavodoxin as donor(+)
       |   |__oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(+) 9 rec.
       |   |__oxidoreductase activity, acting on superoxide radicals as acceptor(+) 5 rec.
       |   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors(+) 68 rec.
       |   |__oxidoreductase activity, acting on the CH-CH group of donors(+) 47 rec.
       |   |__oxidoreductase activity, acting on the CH-NH group of donors(+) 27 rec.
       |   |__oxidoreductase activity, acting on the CH-NH2 group of donors(+) 17 rec.
       |   |__oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond(+) 1 rec.
       |   |__oxidoreductase activity, reducing C-O-C group as acceptor(+)
       |   |__oxygen evolving activity
       |   |__pyrogallol hydroxytransferase activity
       |   |__selenate reductase activity
       |   |__steroid dehydrogenase activity(+) 13 rec.
       |   |__transmembrane monodehydroascorbate reductase activity 5 rec.
       |__peptidoglycan muralytic activity 26 rec.
       |   |__lysozyme activity 18 rec.
       |   |__N-acetylmuramoyl-L-alanine amidase activity 8 rec.
       |   |__peptidoglycan endopeptidase activity(+)
       |   |__peptidoglycan lytic transglycosylase activity(+)
       |   |__peptidoglycan N-acetylglucosaminidase activity
       |__polyketide synthase activity
       |__transferase activity 1554 rec.
           |__4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
           |__acyltransferase activity(+) 470 rec.
           |__cholesterol-protein transferase activity 1 rec.
           |__glucanosyltransferase activity(+)
           |__glycosyltransferase activity(+) 224 rec.
           |__microtubule plus end polymerase activity 2 rec.
           |__molybdopterin molybdotransferase activity 2 rec.
           |__selenotransferase activity(+) 2 rec.
           |__THPH synthase activity
           |__transferase activity, transferring alkyl or aryl (other than methyl) groups(+) 78 rec.
           |__transferase activity, transferring nitrogenous groups(+) 24 rec.
           |__transferase activity, transferring one-carbon groups(+) 160 rec.
           |__transferase activity, transferring phosphorus-containing groups(+) 552 rec.
           |__transferase activity, transferring sulphur-containing groups(+) 40 rec.
           |__transketolase or transaldolase activity(+) 3 rec.
           |__tRNA 5-taurinomethyluridine synthase activity 2 rec.
           |__UDP-L-rhamnose synthase activity
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