FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term dopamine beta-monooxygenase activity ID (Ontology) GO:0004500 (Gene Ontology)
Definition Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O.[ EC:1 ]
Also Known As "dopamine b-hydroxylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 dopamine beta-monooxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | dopamine beta-monooxygenase activity
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
                                                                                          |__dopamine beta-monooxygenase activity  3 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" RELATED[ EC:1 ]
    "3,4-dihydroxyphenethylamine beta-oxidase activity" RELATED[ EC:1 ]
    "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" RELATED[ EC:1 ]
    "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" RELATED[ EC:1 ]
    "dopa beta-hydroxylase activity" RELATED[ EC:1 ]
    "dopamine b-hydroxylase activity" EXACT
    "dopamine beta-hydroxylase activity" RELATED[ EC:1 ]
    "dopamine beta-oxidase activity" RELATED[ EC:1 ]
    "dopamine hydroxylase activity" RELATED[ EC:1 ]
    "dopamine-B-hydroxylase activity" RELATED[ EC:1 ]
    "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED[ EC:1 ]
    "oxygenase, dopamine beta-mono-" RELATED[ EC:1 ]
    "phenylamine beta-hydroxylase activity" RELATED[ EC:1 ]
    "SDBH (soluble dopamine beta-monooxygenase)" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.17.1
KEGG_REACTION:R02535
MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN
Reactome:R-HSA-209891 "Dopamine is oxidised to noradrenaline"
RHEA:19117