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Chen, J., Wang, Y., Zhang, Y., Shen, P. (2013). Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila.  Neuropharmacology 67(): 25--31.
FlyBase ID
FBrf0220671
Publication Type
Research paper
Abstract

Fruit flies and humans display remarkably similar behavioral responses to ethanol intoxication. Here we report that loss-of-function mutations in the CG9894 gene (now named Bacchus or Bacc) attenuate ethanol sensitivity in flies. Bacc encodes a broadly expressed nuclear protein with a motif similar to ribosomal RNA-binding domains. The ethanol-related activity of Bacc was mapped to Tdc2-GAL4 neurons. Genetic and pharmacological analyses suggest that ethanol resistance of Bacc mutants is caused by increased tyramine β-hydroxylase (tβh) activity that results in excessive conversion of tyramine (TA) to octopmaine (OA). Thus, tβh and its negative regulator Bacc define a novel biogenic amine-mediated signaling pathway that regulates fly ethanol sensitivity. Importantly, elevated tbh activity has been shown to promote fighting behavior, raising the possibility that the Bacc/tbh pathway may regulate complex traits in addition to acute ethanol response.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuropharmacology
    Title
    Neuropharmacology
    Publication Year
    1970-
    ISBN/ISSN
    0028-3908
    Data From Reference
    Alleles (12)
    Genes (6)
    Natural transposons (2)
    Insertions (4)
    Transgenic Constructs (7)
    Transcripts (1)