FlyBase Allele Report: Scer\GAL4[Tdc2.PC]

ScerGAL4^Tdc2.PC drives expression in 44 neurons of the ventral nerve cord. In brain hemispheres labeling is observed in three distinct locations with one neuron located basomedial to the calyx, a cluster of four anterior to the vertical mushroom body lobes and around two cells dorsomedial to the antennal lobe. ScerGAL4^Tdc2.PC is detected in clusters of VM neurons in all three larval gnathal neuromeres and in one cell at the margin of the subesophageal ganglion to the ventral nerve cord. All ScerGAL4^Tdc2.PC-expressing neurons are tyraminergic, whereas labeled cells positioned in the subesophageal ganglion are octopaminergic as well.

(Selcho et al., 2014)

FLP/FRT intersectional strategy shows expression of ScerGAL4^Tdc2.PC in a subset of cell bodies in the posterior part of the thoracico-abdominal ganglion when combined with dsx^KI.FLPG5. On average nine neurons are labeled in females and three in males. In females these project to the spermathecum, the seminal receptacle, the female accessory gland, the uterus and to both the common and lateral oviduct. In males projections lead to the testis, the ejaculatory duct and the male accessory gland. In both male and female expression can also be detected in a motor neuron that innervates abdominal 6 dorsal muscle 133.

(Rezával et al., 2014)

ScerGAL4^Tdc2.PC drives expression in motor neurons that form type II terminal buttons at the neuromuscular junction.

(Koon and Budnik, 2012)

ScerGAL4^Tdc2.PC drives expression in the adult octopaminergic neurons. Positive GRASP (GFP reconstitution across synaptic partners) signals between the mushroom body alpha and beta lobes labelled with EcollexA^L5076 or EcollexA^L5251 and ScerGAL4^Tdc2.PC are observed sporadically in the alpha and beta lobes and in the calyx.

(Zhou et al., 2012)

ScerGAL4^Tdc2.PC drives expression in clusters of neurons in the adult brain and thoracico-abdominal ganglion. Co-localisation with Tbh protein in the brain is observed in the octopaminergic AL2 cluster, in the G3b and 3 ventral clusters (VMI to VMIII). In the thoracico-abdominal ganglion, 37 of the 39 Tbh-positive neurons also express ScerGAL4^Tdc2.PC.

(Schneider et al., 2012)

The octopaminergic neurons VPM1 and VUM labelled with ScerGAL4^Tdc2.PC co-localise with male-specific fru protein (FruM).

(Certel et al., 2010)

Expression of ScerGAL4^Tdc2.PC is in both octopaminergic and tyraminergic neurons.

(Boerner and Duch, 2010)

Expression observed in neurons that innervate the antennal lobes, mushroom body gamma lobes and their spurs, the subesophageal ganglion, the areas surrounding the esophagus, and the mushroom body calyces.

(Yarali and Gerber, 2010)

ScerGAL4^Tdc2.PC drives expression in several clusters of cells in the adult, in a total of 137 cells per hemisphere. These clusters include the octopaminergic neurons VM (27 cells), AL2 (7 cells), VL (2 cells) and ASM (8 cells). In addition, ScerGAL4^Tdc2.PC labels cells around the protocerebral bridge (PB1 cluster, 65 cells), ventral to the protocerebral bridge (PB2 cluster, 2 cells), posterior superior medial protocerebrum (PSM cluster, 5 cells) and at the anterior margin of the antennal lobe (AL1 cluster, 1 cell).

(Busch et al., 2009)

In larva, ScerGAL4^Tdc.PJ drives expression in a few processes that invade the calyx of the mushroom body and in neurites that surround the peduncle.

(Johard et al., 2008)

Expression is seen in discrete unilateral subsets of cells located along the ventral medial line of the brain, as well as in discrete

(Crocker and Sehgal, 2008)

bilateral clusters of cells in the lateral protocerebrum region and surrounding the esophagus cavity.

(Crocker and Sehgal, 2008)

ScerGAL4^Tdc2.PC drives expression in adult thoracic and abdominal neuromeres. Their cell bodies are located at the midline extending bilateral symmetric axons as well as a net of finer processes.

(Brembs et al., 2007)

Marker for

octopaminergic neuron

(Selcho et al., 2014, Busch et al., 2009)

tyraminergic neuron

(Selcho et al., 2014)

Reflects expression of

Tdc2

(Matsuo et al., 2016, Rezával et al., 2014, Selcho et al., 2014, Burke et al., 2012, Koon and Budnik, 2012, Schneider et al., 2012, Zhou et al., 2012, Kahsai and Winther, 2011, Koon et al., 2011, Boerner and Duch, 2010, Certel et al., 2010, Crocker et al., 2010, Busch et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Crocker and Sehgal, 2008, Zhou et al., 2008, Brembs et al., 2007)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior, with Hsap\KCNJ2^UAS.EGFP

(Dankert et al., 2009)

abnormal behavior, with tra^UAS.cFa

(Dankert et al., 2009)

abnormal behavior | adult stage | heat sensitive, with Bhal\NaChBac^UAS.cNa, Scer\GAL80^ts.αTub84B

(Zhou et al., 2008)

abnormal behavior | heat sensitive, with shi^1.UAS

(Zhou et al., 2008)

abnormal behavior | male limited, with TfAP-2^B.UAS

(Williams et al., 2014)

abnormal behavior | male limited, with twz^KK107922

(Williams et al., 2014)

abnormal chemosensory behavior, with Hsap\KCNJ2^UAS.EGFP

(Schneider et al., 2012)

abnormal chemosensory behavior | adult stage, with Hsap\KCNJ2^UAS.EGFP

(Hardie et al., 2007)

abnormal courtship behavior, with tra^UAS.cFa

(Dankert et al., 2009)

abnormal courtship behavior | female limited, with Ctet\tetX^{TNT-LC.UAS.cSa}

(Rezával et al., 2014)

abnormal courtship behavior | female limited, with Ctet\tetX^TNT-LC.UAS

(Rezával et al., 2014)

abnormal courtship behavior | male | heat sensitive, with shi^1.UAS

(Zhou et al., 2012)

abnormal courtship behavior | male | heat sensitive, with TrpA1^UAS.(B).cKa

(Zhou et al., 2012)

abnormal courtship behavior | male limited, with TfAP-2^B.UAS

(Williams et al., 2014)

abnormal courtship behavior | male limited, with TfAP-2^KK109052

(Williams et al., 2014)

abnormal courtship behavior | male limited, with twz^KK107922

(Williams et al., 2014)

abnormal feeding behavior | male limited, with Bhal\NaChBac^UAS.EGFP

(Williams et al., 2014)

abnormal feeding behavior | male limited, with TfAP-2^B.UAS

(Williams et al., 2014)

abnormal feeding behavior | male limited, with TfAP-2^JF03500

(Williams et al., 2014)

abnormal feeding behavior | male limited, with TfAP-2^KK109052

(Williams et al., 2014)

abnormal feeding behavior | male limited, with twz^JF01867

(Williams et al., 2014)

abnormal feeding behavior | male limited, with twz^KK107922

(Williams et al., 2014)

abnormal flight, with rpr^UAS.C

(Brembs et al., 2007)

abnormal flight | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(O'Sullivan et al., 2018)

abnormal flight | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\FLP1^{FLPo.oc.Tag:NLS(SV40-largeT)}, Scer\GAL80^FRT.αTub84B

(O'Sullivan et al., 2018)

abnormal learning, with shi^1.UAS

(Lin et al., 2014)

abnormal learning, with shi^{ts1.IVS.p10.20xUAS}

(Lin et al., 2014)

abnormal learning | heat sensitive, with shi^1.UAS

(Honjo and Furukubo-Tokunaga, 2009)

abnormal learning | male | heat sensitive, with shi^1.UAS

(Zhou et al., 2012)

abnormal learning | male | heat sensitive, with TrpA1^UAS.(B).cKa

(Zhou et al., 2012)

abnormal locomotor behavior, with rpr^UAS.C

(Brembs et al., 2007)

abnormal locomotor behavior, with tra^UAS.cFa

(Dankert et al., 2009)

abnormal locomotor behavior | adult stage, with Hsap\KCNJ2^{IVS.10xUAS.EGFP}

(Strother et al., 2018)

abnormal locomotor behavior | adult stage, with Hsap\KCNJ2^UAS.EGFP

(Hardie et al., 2007)

abnormal locomotor behavior | larval stage, with Hsap\KCNJ2^UAS.EGFP

(Selcho et al., 2012)

abnormal locomotor behavior | male limited, with TfAP-2^B.UAS

(Williams et al., 2014)

abnormal locomotor behavior | male limited, with TfAP-2^KK109052

(Williams et al., 2014)

abnormal locomotor behavior | male limited, with twz^KK107922

(Williams et al., 2014)

abnormal mating behavior | female limited, with Ctet\tetX^{TNT-LC.UAS.cSa}

(Rezával et al., 2014)

abnormal mating behavior | female limited, with Ctet\tetX^TNT-LC.UAS

(Rezával et al., 2014)

abnormal mating behavior | female limited, with TrpA1^UAS.cUa

(Rezával et al., 2014)

abnormal mating behavior | female limited, with TrpA1^UAS.Tag:MYC

(Rezával et al., 2014)

abnormal memory | heat sensitive, with shi^1.UAS

(Burke et al., 2012, Honjo and Furukubo-Tokunaga, 2009)

abnormal neuroanatomy | adult stage, with hid^UAS.cUa

(Andrews et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Bper\ptxA^act.UAS

(Koon and Budnik, 2012)

abnormal neuroanatomy | third instar larval stage, with Gαo^GD8640

(Koon and Budnik, 2012)

abnormal neuroanatomy | third instar larval stage, with Gαo^KK109018

(Koon and Budnik, 2012)

abnormal neuroanatomy | third instar larval stage, with Octβ1R^KK102153

(Koon and Budnik, 2012)

abnormal neuroanatomy | third instar larval stage, with Pde4^UAS.cCa

(Koon and Budnik, 2012)

abnormal sleep, with Bhal\NaChBac^UAS.EGFP

(Crocker et al., 2010)

abnormal sleep, with Bhal\NaChBac^UAS.EGFP, Scer\GAL80^αTub84B.PL

(Crocker et al., 2010)

abnormal sleep | heat sensitive, with TrpA1^UAS.(B).cKa

(Liu et al., 2012)

abnormal song, with Ctet\tetX^TNT-LC.UAS

(O'Sullivan et al., 2018)

abnormal song | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(O'Sullivan et al., 2018)

abnormal song | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\FLP1^{FLPo.oc.Tag:NLS(SV40-largeT)}, Scer\GAL80^FRT.αTub84B

(O'Sullivan et al., 2018)

abnormal song | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\GAL80^{tsh-md621-GAL80}

(O'Sullivan et al., 2018)

abnormal starvation stress response, with hid^UAS.cZa

(Koon et al., 2011)

abnormal starvation stress response, with Octβ2R^GD2954

(Koon et al., 2011)

abnormal starvation stress response, with Octβ2R^KK109808

(Koon et al., 2011)

abnormal starvation stress response | adult stage, with AkhR^JF03256

(Yu et al., 2016)

abnormal starvation stress response | drug conditional, with CrebB^b.UAS

(Koon et al., 2011)

abnormal starvation stress response | third instar larval stage, with Bper\ptxA^act.UAS

(Koon and Budnik, 2012)

abnormal starvation stress response | third instar larval stage, with Gαo^KK109018

(Koon and Budnik, 2012)

abnormal visual behavior | adult stage, with Hsap\KCNJ2^{IVS.10xUAS.EGFP}

(Strother et al., 2018)

chemical resistant, with Bacc^GD12572

(Chen et al., 2013)

chemical resistant | heat sensitive, with shi^1.UAS

(Chen et al., 2013)

decreased rate of movement | adult stage, with Octα2R^HMC03079

(Nakagawa et al., 2022)

decreased rate of movement | adult stage | nutrition conditional, with AkhR^JF03256

(Yu et al., 2016)

female sterile, with Hsap\KCNJ2^UAS.EGFP

(Hardie et al., 2007)

female sterile, with Tbh^JF02746

(Castellanos et al., 2013)

fertile, with VGlut1^JF02689

(Castellanos et al., 2013)

increased body size | P-stage, with Tbh^JF02746

(Imura et al., 2020)

increased body size | P-stage, with Tbh^KK102670

(Imura et al., 2020)

increased body size | P-stage, with Tdc2^JF01910

(Imura et al., 2020)

increased body size | P-stage, with Tdc2^VSH330541

(Imura et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | drug conditional, with CrebB^b.UAS

(Koon et al., 2011)

embryonic/larval neuromuscular junction | first instar larval stage | heat sensitive, with Hsap\KCNJ2^UAS.EGFP, Scer\GAL80^ts.αTub84B

(Koon et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Bper\ptxA^act.UAS

(Koon and Budnik, 2012)

embryonic/larval neuromuscular junction | third instar larval stage, with Gαo^GD8640

(Koon and Budnik, 2012)

embryonic/larval neuromuscular junction | third instar larval stage, with Gαo^KK109018

(Koon and Budnik, 2012)

embryonic/larval neuromuscular junction | third instar larval stage, with hid^UAS.cZa

(Koon et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Hsap\KCNJ2^UAS.EGFP

(Koon et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Octβ1R^KK102153

(Koon and Budnik, 2012)

embryonic/larval neuromuscular junction | third instar larval stage, with Octβ2R^GD2954

(Koon et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Octβ2R^KK109808

(Koon et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Pde4^UAS.cCa

(Koon and Budnik, 2012)

embryonic/larval neuromuscular junction | third instar larval stage | heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.UAS

(Koon et al., 2011)

gustatory receptor neuron, with hid^UAS.cUa

(Andrews et al., 2014)

multidendritic neuron, with Hsap\KCNJ2^UAS.EGFP

(Koon et al., 2011)

multidendritic neuron | drug conditional, with CrebB^b.UAS

(Koon et al., 2011)

multidendritic neuron | heat sensitive, with Hsap\KCNJ2^UAS.EGFP, Scer\GAL80^ts.αTub84B

(Koon et al., 2011)

multidendritic neuron | heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.UAS

(Koon et al., 2011)

type I bouton, with Hsap\KCNJ2^UAS.EGFP

(Koon et al., 2011)

type I bouton | third instar larval stage, with hid^UAS.cZa

(Koon et al., 2011)

type I bouton | third instar larval stage, with Octβ2R^GD2954

(Koon et al., 2011)

type I bouton | third instar larval stage, with Octβ2R^KK109808

(Koon et al., 2011)

type II bouton, with Hsap\KCNJ2^UAS.EGFP

(Koon et al., 2011)

type II bouton | first instar larval stage | heat sensitive, with Hsap\KCNJ2^UAS.EGFP, Scer\GAL80^ts.αTub84B

(Koon et al., 2011)

type II bouton | increased number | third instar larval stage, with Gαo^GD8640

(Koon and Budnik, 2012)

type II bouton | increased number | third instar larval stage, with Gαo^KK109018

(Koon and Budnik, 2012)

type II bouton | increased number | third instar larval stage, with Octβ1R^KK102153

(Koon and Budnik, 2012)

type II bouton | third instar larval stage, with Bper\ptxA^act.UAS

(Koon and Budnik, 2012)

type II bouton | third instar larval stage, with hid^UAS.cZa

(Koon et al., 2011)

type II bouton | third instar larval stage, with Octβ2R^GD2954

(Koon et al., 2011)

type II bouton | third instar larval stage, with Octβ2R^KK109808

(Koon et al., 2011)

type II bouton | third instar larval stage, with Pde4^UAS.cCa

(Koon and Budnik, 2012)

type II bouton | third instar larval stage | heat sensitive, with Scer\GAL80^ts.αTub84B, shi^1.UAS

(Koon et al., 2011)

Detailed Description

Statement

Reference

Optogenetic activation (using Cnoc\ChR1^{Cs.IVS.20xUAS.Venus} with 590 nm (yellow) light) of Scer\GAL4^Tdc2.PC neurons in adult males results in a significant suppression of pulse song in the presence of a female and a significant increase in wing beat amplitude during flight, compared to controls; both of these effects are also seen when the number of activated neurons is restricted using Scer\FLP1^{FLPo.oc.Tag:NLS(SV40-largeT)} and Scer\GAL80^FRT.αTub84B, but with a smaller suppression of pulse song and no suppression of pulse amplitude; full pulse song suppression, but no wing beat amplitude increase, occurs when the number of activated neurons is restricted using Scer\GAL80^tsh-GAL80.

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 30[o]C) of Scer\GAL4^Tdc2.PC neurons in adult males results in a significant suppression of pulse song in the presence of a female.

(O'Sullivan et al., 2018)

Inhibition (using Hsap\KCNJ2^{IVS.10xUAS.EGFP}) of Scer\GAL4^Tdc2.PC cells in adults significantly reduces turning responses to fast-moving light stimuli and longer-duration, slow-moving light stimuli, compared to controls, with no effect on the speed of forward locomotion.

(Strother et al., 2018)

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^Tdc2.PC cells in adults does not affect 5 min (single-trial conditioned) aversive taste memory, compared to controls.

(Kirkhart and Scott, 2015)

Inhibition of neural activity in Scer\GAL4^Tdc2.PC-expressing neurons does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

(Shankar et al., 2015)

Activation of Tdc-positive neurons by expressing TrpA1^{Scer\UAS.(B).cKa} under the control of Scer\GAL4^Tdc2.PC at the permissive temperature induces post-mating behaviors in virgin females. These include reduced levels of copulation within one hour, increased rejection behaviors (ovipositor extrusion) and increased egg laying.

Activation of Tdc and dsx-positive neurons by expressing TrpA1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Tdc2.PC (in which the Scer\FRT cassette has been excised by Scer\FLP1^dsx) at the permissive temperature reduces receptivity in virgin females. Only a small percentage of females copulate within 1 hour and they show increased rejection behaviors (ovipositor extrusion) and egg laying compared to controls.

Silencing Tdc-positive neurons by expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^Tdc2.PC at the permissive temperature inhibits post-mating behaviors in mated females, including increased levels of remating, reduced rejection behaviors (ovipositor extrusion) and reduced egg laying. These mated females remain highly attractive to males.

Silencing of Tdc and dsx-positive neurons by expressing Ctet\TeTxLC^Scer\UAS.cSa under the control of Scer\GAL4^Tdc2.PC (in which the Scer\FRTcassette has been excised by Scer\FLP1^dsx) at the permissive temperature results in disrupted post-mating practices in mated females. These females are more receptive than wild type females, as they remate at a significantly higher frequency and show decreased levels of rejection behaviors (ovipositor extrusion). In addition, they elicit more male courtship and show decreased levels of egg laying.

(Rezával et al., 2014)

Inhibition (using shi^1.UAS at 33[o]C) of Scer\GAL4^Tdc2.PC cells in adults does not significantly affect appetitive or aversive 1-min visual memory, compared to controls.

(Vogt et al., 2014)

Blocking synaptic transmission (using Hsap\KCNJ2^UAS.EGFP) of Scer\GAL4^Tdc2.PC neurons in larvae results in a significant reduction in the distance they crawl and a partial circling behavior, relative to controls.

(Selcho et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS has abnormal behavior | male limited phenotype, suppressible by twz^KK107922/Scer\GAL4^Tdc2.PC

(Williams et al., 2014)

Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS has abnormal locomotor behavior | male limited phenotype, suppressible by twz^KK107922/Scer\GAL4^Tdc2.PC

(Williams et al., 2014)

Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS has abnormal feeding behavior | male limited phenotype, suppressible by twz^KK107922/Scer\GAL4^Tdc2.PC

(Williams et al., 2014)

Suppressor of

Statement

Reference

Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}/Scer\GAL4^Tdc2.PC is a suppressor | conditional of abnormal song | conditional phenotype of Crei\ChR1::Vcar\ChR1::Vcar\ChR2^{ReaChR.lexAop.FRT.mCherry.Citrine}, Ecol\lexA^VT040556.PU, Scer\FLP1^fru

(O'Sullivan et al., 2018)

twz^KK107922/Scer\GAL4^Tdc2.PC is a suppressor of abnormal behavior | male limited phenotype of Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS

(Williams et al., 2014)

twz^KK107922/Scer\GAL4^Tdc2.PC is a suppressor of abnormal locomotor behavior | male limited phenotype of Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS

(Williams et al., 2014)

twz^KK107922/Scer\GAL4^Tdc2.PC is a suppressor of abnormal feeding behavior | male limited phenotype of Scer\GAL4^Tdc2.PC, TfAP-2^B.UAS

(Williams et al., 2014)

Scer\GAL4^Tdc2.PC/Tdc1^UAS.cCa is a suppressor of abnormal chemosensory behavior | semidominant | adult stage phenotype of Tdc2^RO54

(Hardie et al., 2007)

Scer\GAL4^Tdc2.PC/Tdc1^UAS.cCa is a suppressor of female sterile | recessive phenotype of Tdc2^RO54

(Cole et al., 2005)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^Tdc2.PC/Tdc1^UAS.cCa is a non-suppressor of adult brain phenotype of Tdc2^RO54

(Cole et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Ablation (using hid^UAS.cUa and rpr^UAS.cUa) of Scer\GAL4^Tdc2.PC neurons in larvae results in a significant reduction in the distance they crawl and a partial circling behavior, relative to controls; when ablation is restricted to a smaller subset of cells, using Scer\GAL80^tsh-GAL80, this effect is not seen.

(Selcho et al., 2012)

Xenogenetic Interactions

Statement

Reference

Optogenetic activation (using Cnoc\ChR1^{Cs.IVS.20xUAS.Venus} with 590 nm (yellow) light) of Scer\GAL4^Tdc2.PC neurons suppresses the induction of pulse song observed due to optogenetic activation (using Crei\ChR1^{ReaChR.lexAop.FRT.mCherry.Citrine} with 590 nm (yellow) light) of Ecol\lexA^VT040556 neurons that express Scer\FLP1^fru in adult males.

(O'Sullivan et al., 2018)

Complementation and Rescue Data

Rescues

fd59A^UAS.cLa/Scer\GAL4^Tdc2.PC rescues fd59A¹/fd59A²

(Lacin et al., 2014)

Tbh^UAS.cSa/Scer\GAL4^Tdc2.PC rescues Tbh^nM18

(Schneider et al., 2012)

Tbh^UAS.cMa/Scer\GAL4^Tdc2.PC rescues Tbh^nM18

(Zhou et al., 2012)

Pde4^UAS.cCa/Scer\GAL4^Tdc2.PC rescues Pde4^ML

(Koon et al., 2011)

Pde4^UAS.cCa/Scer\GAL4^Tdc2.PC rescues Pde4^ML/Pde4^dnc-M14