FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fd59A1
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General Information
Symbol
Dmel\fd59A1
Species
D. melanogaster
Name
FlyBase ID
FBal0295499
Feature type
allele
Associated gene
Dmel\fd59A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Lacin et al., 2014)
Mutagen
ethyl methanesulfonate
(Lacin et al., 2014)
Progenitor genotype
Cytology
Description

Contains a point mutation in the fd59A splice donor site at amino acid 118.

(Lacin et al., 2014)

Nucleotide substitution: T?A.

(Lacin et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:22,868,856..22,868,856 [+]
Nucleotide change:

T22868856A

Reported nucleotide change:

T?A

Comment:

T to A mutation in splice donor site.

(Lacin et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous fd59A1 mutant flies are viable, morphologically normal, but sub-fertile.

      fd59A1/fd59A2 mutant flies are viable, morphologically normal, but are sub-fertile; male mutant flies crossed to control females lay normal number of eggs, but mutant females crossed to control males lay fewer eggs. Even fewer eggs are laid when mutant males are crossed to mutant females.

      (Lacin et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      fd59A1/fd59A2 is rescued by fd59AUAS.cLa/Scer\GAL4Tdc2.PC

      (Lacin et al., 2014)
      Comments

      Expression of fd59AScer\UAS.cLa under the control of Scer\GAL4Tdc2.PC rescues the egg laying defect seen in fd59A1/fd59A2 mutant females. The morphology and axonal pathway selection of Tdc2[+] neurons are essentially identical between fd59A1/fd59A2 mutant and wild type controls.

      (Lacin et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fd59A1
      fd59a1
      (Lacin et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)