FB2025_04 , released October 2, 2025
Gene: Dmel\Trim9
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General Information
Symbol
Dmel\Trim9
Species
D. melanogaster
Name
Tripartite motif containing 9
Annotation Symbol
CG31721
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051721
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Summary
Tripartite motif containing 9 (Trim9) encodes a ring finger domain-containing E3 ubiquitin ligase that contributes to neurogenesis, axon guidance, eye development and regulation of locomotive behaviour. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dTrim9, asap

Key Links
Genomic Location
Cytogenetic map
31F5-32A2
Sequence location
Recombination map
2-43
RefSeq locus
NT_033779 REGION:10544883..10628054
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:A1Z920
(Morikawa et al., 2011)
inferred from physical interaction with UniProtKB:Q9VWB7
(Morikawa et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from sequence or structural similarity with UniProtKB:Q9C026
(Gene Ontology Curators, 2002-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
inferred from electronic annotation with InterPro:IPR000315
(InterPro Project Members, 2004-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Song et al., 2011)
involved_in axon midline choice point recognition
inferred from mutant phenotype
(Song et al., 2011)
inferred from mutant phenotype
(Yang et al., 2014, Morikawa et al., 2011)
involved_in axonogenesis
inferred from mutant phenotype
(Morikawa et al., 2011)
involved_in compound eye development
inferred from mutant phenotype
(Akin and Zipursky, 2016)
inferred from genetic interaction with UniProtKB:A1Z920
(Akin and Zipursky, 2016)
involved_in negative regulation of glycolytic process
inferred from genetic interaction with FLYBASE:Uch; FB:FBgn0010288,FLYBASE:Pink1; FB:FBgn0029891
(Ham et al., 2021)
involved_in netrin-activated signaling pathway
inferred from mutant phenotype
(Song et al., 2011)
inferred from genetic interaction with FLYBASE:fra; FB:FBgn0011592
(Morikawa et al., 2011)
inferred from physical interaction with FLYBASE:fra; FB:FBgn0011592
(Morikawa et al., 2011)
inferred from physical interaction with FLYBASE:pico; FB:FBgn0261811
(Morikawa et al., 2011)
involved_in peripheral nervous system neuron axonogenesis
inferred from mutant phenotype
(Yang et al., 2014, Morikawa et al., 2011)
inferred from genetic interaction with UniProtKB:A1Z920
(Morikawa et al., 2011)
involved_in regulation of axonogenesis
inferred from mutant phenotype
(Yang et al., 2014, Morikawa et al., 2011)
inferred from genetic interaction with UniProtKB:A1Z920
(Morikawa et al., 2011)
involved_in regulation of locomotion involved in locomotory behavior
inferred from mutant phenotype
(Morikawa et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN002788108
(GO Reference Genome Project, 2011-)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from sequence or structural similarity with UniProtKB:Q9C026
(Song et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in axonal growth cone
inferred from mutant phenotype
(Akin and Zipursky, 2016)
inferred from genetic interaction with UniProtKB:A1Z920
(Akin and Zipursky, 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN002788108
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TRIM/RBCC family. (M9MRI4)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Tripartite motif containing 9 (Trim9) encodes a ring finger domain-containing E3 ubiquitin ligase that contributes to neurogenesis, axon guidance, eye development and regulation of locomotive behaviour. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
TRIM UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The TRIM family are E3 ligases characterized a TRIpartite Motif, which consists of a RING domain, one or two B-box motifs and a coiled-coil region. As well as ubiquitination, TRIM proteins are also involved in ubiquitin-like modifications such as SUMOylation and ISGylation. (Adapted from PMID:18673550).
Protein Function (UniProtKB)
E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra (PubMed:21338947, PubMed:22084112). Regulates fine-scale topography of C4da axon terminals upon neuronal activity (PubMed:24746793). During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra (PubMed:27743477).
(UniProt, M9MRI4)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Trim9 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9MRI4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Trim9-RA
FBtr0080096
NM_164935
3103
729
Trim9-RB
FBtr0304114
NM_001201857
3816
740
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Trim9-PA
FBpp0079685
79.0
729
5.76
Q86P21
NP_723600
AAF52977
Trim9-PB
FBpp0293057
80.2
740
5.67
M9MRI4
NP_001188786
ADV37036
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via fibronectin type-III domain) with pico. Interacts (via SPRY domain) with netrin receptor fra.

(UniProt, M9MRI4)
Domain

The fibronectin type-III, SPRY and coil-coil domains are necessary for C4da axon patterning.

(UniProt, M9MRI4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Trim9 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
larval dorsal multidendritic neuron ddaC
(Morikawa et al., 2011)
larval ventral multidendritic neuron vdaB
(Morikawa et al., 2011)
embryonic stage 15 -- 17
larval multidendritic class IV neuron
(Morikawa et al., 2011)
Additional Descriptive Data

Trim9 is expressed predominantly in the nervous system. It is first detected in PNS neurons in stage 13-14 embryos and persists in later embryonic stages. It is detected in a a subset of neurons including class IV dendritic arborizing (C4da) neurons. Expression is stronger in ddaC and vdaB neurons than in v'ada neurons.

(Morikawa et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axonal growth cone
inferred from mutant phenotype
(Akin and Zipursky, 2016)
inferred from genetic interaction with UniProtKB:A1Z920
(Akin and Zipursky, 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Trim9 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 24 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Trim9
Transgenic constructs containing regulatory region of Trim9
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel8026
(Ryder, 2004.4.26)
Inferred from location ( 10 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal locomotor behavior | third instar larval stage
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage (with Df(2L)Exel8026)
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | larval stage (with Df(2L)Exel8026)
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | somatic clone, with Scer\GAL4ppk.PU
abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage (with Df(2L)Exel8026)
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
abdominal anterior ventral multidendritic neuron vdaa | somatic clone | third instar larval stage, with Scer\GAL4ppk.PG
commissure
dendritic branch | larval stage, with Scer\GAL4221
dopaminergic neuron
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval dorsal multidendritic neuron ddaC | third instar larval stage (with Df(2L)Exel8026)
larval dorsal multidendritic neuron ddaE, with Scer\GAL4221
larval multidendritic class IV neuron | embryonic stage
larval multidendritic class IV neuron | embryonic stage (with Df(2L)Exel8026)
larval multidendritic class IV neuron | third instar larval stage
larval multidendritic class IV neuron | third instar larval stage (with Df(2L)Exel8026)
larval ventral multidendritic neuron vdaB | somatic clone
larval ventral multidendritic neuron vdaB | somatic clone, with Scer\GAL4ppk.PU
larval ventral multidendritic neuron vdaB | third instar larval stage (with Df(2L)Exel8026)
larval ventral nerve cord commissure (with Df(2L)Exel8026)
larval ventral nerve cord commissure | ectopic | somatic clone | third instar larval stage, with Scer\GAL4ppk.PG
larval ventral nerve cord commissure | embryonic stage
larval ventral nerve cord commissure | embryonic stage (with Df(2L)Exel8026)
larval ventral nerve cord commissure | third instar larval stage
larval ventral nerve cord commissure | third instar larval stage (with Df(2L)Exel8026)
microtubule plus-end | larval stage, with Scer\GAL4221
trichogen cell, with Scer\GAL4pnr-MD237
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (47)
Hsap\TRIM9
13 of 14
Yes
Yes
Hsap\TRIM67
12 of 14
No
Yes
Hsap\TRIM36
3 of 14
No
Yes
Hsap\CMYA5
2 of 14
No
Yes
Hsap\FSD1
2 of 14
No
Yes
Hsap\FSD1L
2 of 14
No
Yes
Hsap\FSD2
2 of 14
No
Yes
Hsap\MID1
2 of 14
No
Yes
Hsap\MID2
2 of 14
No
Yes
Hsap\RNF207
2 of 14
No
Yes
Hsap\TRIM46
2 of 14
No
Yes
Hsap\BTN2A2
1 of 14
No
Yes
Hsap\BTN2A3P
1 of 14
No
Yes
Hsap\FBXO45
1 of 14
No
No
Hsap\HERC1
1 of 14
No
No
Hsap\MEFV
1 of 14
No
Yes
Hsap\PML
1 of 14
No
No
Hsap\RANBP9
1 of 14
No
No
Hsap\RANBP10
1 of 14
No
No
Hsap\RYR2
1 of 14
No
No
Hsap\SPRYD4
1 of 14
No
Yes
Hsap\SPSB1
1 of 14
No
No
Hsap\SPSB2
1 of 14
No
No
Hsap\SPSB3
1 of 14
No
No
Hsap\SPSB4
1 of 14
No
No
Hsap\TRIM2
1 of 14
No
No
Hsap\TRIM3
1 of 14
No
No
Hsap\TRIM5
1 of 14
No
Yes
Hsap\TRIM6
1 of 14
No
Yes
Hsap\TRIM7
1 of 14
No
Yes
Hsap\TRIM8
1 of 14
No
Yes
Hsap\TRIM22
1 of 14
No
Yes
Hsap\TRIM23
1 of 14
No
No
Hsap\TRIM24
1 of 14
No
No
Hsap\TRIM25
1 of 14
No
Yes
Hsap\TRIM28
1 of 14
No
No
Hsap\TRIM33
1 of 14
No
No
Hsap\TRIM37
1 of 14
No
Yes
1  
Hsap\TRIM42
1 of 14
No
Yes
Hsap\TRIM45
1 of 14
No
No
Hsap\TRIM54
1 of 14
No
Yes
Hsap\TRIM55
1 of 14
No
Yes
Hsap\TRIM56
1 of 14
No
No
Hsap\TRIM63
1 of 14
No
Yes
Hsap\TRIM71
1 of 14
No
No
Hsap\TRIM75P
1 of 14
No
Yes
Hsap\TTN
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (37)
Rnor\Trim9
13 of 14
Yes
Yes
Rnor\Trim67
12 of 14
No
Yes
Rnor\Trim36
3 of 14
No
Yes
Rnor\Cmya5
2 of 14
No
Yes
Rnor\Fsd1l
2 of 14
No
Yes
Rnor\Fsd2
2 of 14
No
Yes
Rnor\Mid1
2 of 14
No
Yes
Rnor\Mid2
2 of 14
No
Yes
Rnor\Rnf207
2 of 14
No
Yes
Rnor\Spryd4
2 of 14
No
Yes
Rnor\Trim46
2 of 14
No
Yes
Rnor\Btnl9
1 of 14
No
Yes
Rnor\Fbxo45
1 of 14
No
No
Rnor\Herc1
1 of 14
No
No
Rnor\Hnrnpul2
1 of 14
No
No
Rnor\Pml
1 of 14
No
No
Rnor\Ranbp9
1 of 14
No
No
Rnor\Ranbp10
1 of 14
No
No
Rnor\Rnf123
1 of 14
No
No
Rnor\Ryr2
1 of 14
No
No
Rnor\Spsb1
1 of 14
No
No
Rnor\Spsb2
1 of 14
No
No
Rnor\Spsb3
1 of 14
No
No
Rnor\Spsb4
1 of 14
No
No
Rnor\Trim2
1 of 14
No
No
Rnor\Trim3
1 of 14
No
No
Rnor\Trim17
1 of 14
No
Yes
Rnor\Trim23
1 of 14
No
No
Rnor\Trim28
1 of 14
No
No
Rnor\Trim30c
1 of 14
No
Yes
Rnor\Trim42
1 of 14
No
No
Rnor\Trim43a
1 of 14
No
Yes
Rnor\Trim45
1 of 14
No
No
Rnor\Trim54
1 of 14
No
Yes
Rnor\Trim55
1 of 14
No
Yes
Rnor\Trim63
1 of 14
No
Yes
Rnor\Trim71
1 of 14
No
No
Mus musculus (laboratory mouse) (43)
Mmus\Trim9
13 of 14
Yes
Yes
Mmus\Trim67
10 of 14
No
Yes
Mmus\Trim36
3 of 14
No
Yes
Mmus\Cmya5
2 of 14
No
Yes
Mmus\Fsd1l
2 of 14
No
Yes
Mmus\Fsd1
2 of 14
No
Yes
Mmus\Fsd2
2 of 14
No
Yes
Mmus\Mid1
2 of 14
No
Yes
Mmus\Mid2
2 of 14
No
Yes
Mmus\Rnf207
2 of 14
No
Yes
Mmus\Trim46
2 of 14
No
Yes
Mmus\Btn2a2
1 of 14
No
Yes
Mmus\Btnl9
1 of 14
No
Yes
Mmus\Ddx1
1 of 14
No
No
Mmus\Fbxo45
1 of 14
No
No
Mmus\Herc1
1 of 14
No
No
Mmus\Pml
1 of 14
No
No
Mmus\Ranbp9
1 of 14
No
No
Mmus\Ranbp10
1 of 14
No
No
Mmus\Rnf123
1 of 14
No
No
Mmus\Ryr2
1 of 14
No
No
Mmus\Spryd4
1 of 14
No
Yes
Mmus\Spsb1
1 of 14
No
No
Mmus\Spsb2
1 of 14
No
No
Mmus\Spsb3
1 of 14
No
No
Mmus\Spsb4
1 of 14
No
No
Mmus\Trim2
1 of 14
No
No
Mmus\Trim3
1 of 14
No
No
Mmus\Trim12a
1 of 14
No
Yes
Mmus\Trim13
1 of 14
No
Yes
Mmus\Trim21
1 of 14
No
Yes
Mmus\Trim23
1 of 14
No
No
Mmus\Trim24
1 of 14
No
No
Mmus\Trim28
1 of 14
No
No
Mmus\Trim37
1 of 14
No
Yes
Mmus\Trim42
1 of 14
No
No
Mmus\Trim45
1 of 14
No
No
Mmus\Trim54
1 of 14
No
Yes
Mmus\Trim55
1 of 14
No
Yes
Mmus\Trim56
1 of 14
No
No
Mmus\Trim63
1 of 14
No
Yes
Mmus\Trim71
1 of 14
No
No
Mmus\Ttn
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (43)
Xtro\trim9
7 of 13
Yes
Yes
Xtro\trim67
7 of 13
Yes
Yes
Xtro\cmya5
2 of 13
No
Yes
Xtro\fsd2
2 of 13
No
Yes
Xtro\cox15
1 of 13
No
No
Xtro\eif5
1 of 13
No
No
Xtro\fbxo45
1 of 13
No
No
Xtro\fndc3b
1 of 13
No
No
Xtro\fsd1l
1 of 13
No
Yes
Xtro\herc1
1 of 13
No
No
Xtro\LOC100485004
1 of 13
No
No
Xtro\LOC100489639
1 of 13
No
No
Xtro\LOC100489697
1 of 13
No
No
Xtro\LOC100492977
1 of 13
No
Yes
Xtro\LOC100494464
1 of 13
No
Yes
Xtro\LOC100495443
1 of 13
No
No
Xtro\LOC100495885
1 of 13
No
Yes
Xtro\LOC100495931
1 of 13
No
No
Xtro\LOC105947078
1 of 13
No
No
Xtro\MGC79670
1 of 13
No
No
Xtro\mid1
1 of 13
No
Yes
Xtro\ppp2r3b
1 of 13
No
No
Xtro\rnf207
1 of 13
No
No
Xtro\spsb1
1 of 13
No
No
Xtro\spsb3
1 of 13
No
No
Xtro\spsb4
1 of 13
No
No
Xtro\trim2
1 of 13
No
No
Xtro\trim3
1 of 13
No
No
Xtro\trim8
1 of 13
No
No
Xtro\trim14
1 of 13
No
Yes
Xtro\trim24
1 of 13
No
No
Xtro\trim25l
1 of 13
No
Yes
Xtro\trim27
1 of 13
No
Yes
Xtro\trim28
1 of 13
No
No
Xtro\trim33
1 of 13
No
No
Xtro\trim55
1 of 13
No
No
Xtro\trim63
1 of 13
No
Yes
Xtro\trim69.1
1 of 13
No
No
Xtro\trim72
1 of 13
No
No
Xtro\XB5729271
1 of 13
No
Yes
Xtro\XB5729975
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (111)
Drer\trim9
13 of 14
Yes
Yes
Drer\trim67
11 of 14
No
Yes
Drer\cmya5
2 of 14
No
Yes
Drer\fsd1
2 of 14
No
Yes
Drer\fsd1l
2 of 14
No
Yes
Drer\mid1
2 of 14
No
Yes
Drer\mid2
2 of 14
No
Yes
Drer\spryd4
2 of 14
No
Yes
Drer\trim36
2 of 14
No
Yes
Drer\trim46a
2 of 14
No
Yes
Drer\trim46b
2 of 14
No
Yes
Drer\bspry
1 of 14
No
Yes
Drer\btr05
1 of 14
No
Yes
Drer\btr06
1 of 14
No
Yes
Drer\btr07
1 of 14
No
Yes
Drer\btr12
1 of 14
No
No
Drer\btr20
1 of 14
No
Yes
Drer\btr30
1 of 14
No
No
Drer\btr32
1 of 14
No
Yes
Drer\dscama
1 of 14
No
No
Drer\fbxo45
1 of 14
No
No
Drer\ftr14l
1 of 14
No
Yes
Drer\ftr16
1 of 14
No
No
Drer\ftr19
1 of 14
No
Yes
Drer\ftr23
1 of 14
No
No
Drer\ftr24
1 of 14
No
Yes
Drer\ftr27
1 of 14
No
Yes
Drer\ftr36
1 of 14
No
No
Drer\ftr37
1 of 14
No
No
Drer\ftr55
1 of 14
No
Yes
Drer\ftr58
1 of 14
No
Yes
Drer\ftr59
1 of 14
No
No
Drer\ftr64
1 of 14
No
No
Drer\ftr66
1 of 14
No
Yes
Drer\ftr72
1 of 14
No
No
Drer\ftr73
1 of 14
No
No
Drer\ftr76
1 of 14
No
No
Drer\ftr79
1 of 14
No
No
Drer\ftr82
1 of 14
No
Yes
Drer\ftr84
1 of 14
No
Yes
Drer\ftr88
1 of 14
No
No
Drer\ftr92
1 of 14
No
Yes
Drer\ftr97
1 of 14
No
No
Drer\herc1
1 of 14
No
No
Drer\hnrnpua
1 of 14
No
No
Drer\igfn1.4
1 of 14
No
No
Drer\LOC108183562
1 of 14
No
Yes
Drer\nlrc10
1 of 14
No
Yes
Drer\ranbp9
1 of 14
No
No
Drer\ranbp10
1 of 14
No
No
Drer\rnf123
1 of 14
No
No
Drer\rnf207b
1 of 14
No
No
Drer\rspry1
1 of 14
No
No
Drer\sdk2a
1 of 14
No
No
Drer\si:ch73-236c18.7
1 of 14
No
Yes
Drer\si:ch211-12p12.2
1 of 14
No
Yes
Drer\si:ch211-15j1.1
1 of 14
No
Yes
Drer\si:ch211-15j1.3
1 of 14
No
Yes
Drer\si:ch211-15j1.5
1 of 14
No
Yes
Drer\si:ch211-76m11.5
1 of 14
No
Yes
Drer\si:ch211-107m4.1
1 of 14
No
No
Drer\si:ch211-114c12.5
1 of 14
No
Yes
Drer\si:ch211-114l13.13
1 of 14
No
Yes
Drer\si:ch211-197e7.1
1 of 14
No
Yes
Drer\si:ch211-214b16.3
1 of 14
No
Yes
Drer\si:ch211-216p19.6
1 of 14
No
Yes
Drer\si:ch211-278p9.2
1 of 14
No
Yes
Drer\si:ch1073-228j22.2
1 of 14
No
No
Drer\si:dkey-7i4.1
1 of 14
No
Yes
Drer\si:dkey-13n15.11
1 of 14
No
Yes
Drer\si:dkey-23n7.10
1 of 14
No
No
Drer\si:dkey-219e21.2
1 of 14
No
Yes
Drer\si:dkey-219e21.4
1 of 14
No
Yes
Drer\si:dkey-222h21.3
1 of 14
No
Yes
Drer\si:dkey-222h21.5
1 of 14
No
Yes
Drer\si:dkey-222h21.8
1 of 14
No
Yes
Drer\si:dkey-222h21.11
1 of 14
No
Yes
Drer\si:zfos-364h11.1
1 of 14
No
Yes
Drer\spsb1
1 of 14
No
No
Drer\spsb3a
1 of 14
No
No
Drer\spsb3b
1 of 14
No
No
Drer\spsb4a
1 of 14
No
No
Drer\spsb4b
1 of 14
No
No
Drer\trim2a
1 of 14
No
No
Drer\trim2b
1 of 14
No
No
Drer\trim3a
1 of 14
No
No
Drer\trim3b
1 of 14
No
No
Drer\trim8b
1 of 14
No
Yes
Drer\trim23
1 of 14
No
No
Drer\trim24
1 of 14
No
No
Drer\trim25
1 of 14
No
Yes
Drer\trim33l
1 of 14
No
No
Drer\trim35-13
1 of 14
No
Yes
Drer\trim35-31
1 of 14
No
Yes
Drer\trim35-33
1 of 14
No
Yes
Drer\trim45
1 of 14
No
No
Drer\trim47
1 of 14
No
Yes
Drer\trim54
1 of 14
No
Yes
Drer\trim55a
1 of 14
No
Yes
Drer\trim55b
1 of 14
No
Yes
Drer\trim63a
1 of 14
No
Yes
Drer\trim63b
1 of 14
No
Yes
Drer\trim69
1 of 14
No
Yes
Drer\trim71
1 of 14
No
No
Drer\trim101
1 of 14
No
Yes
Drer\trim105
1 of 14
No
Yes
Drer\trim109
1 of 14
No
Yes
Drer\ttn.2
1 of 14
No
No
Drer\zgc:92594
1 of 14
No
Yes
Drer\zgc:136767
1 of 14
No
Yes
Drer\zgc:171679
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (24)
Cele\madd-2
13 of 14
Yes
Yes
Cele\arc-1
1 of 14
No
No
Cele\B0281.3
1 of 14
No
Yes
Cele\B0281.8
1 of 14
No
Yes
Cele\C28G1.6
1 of 14
No
Yes
Cele\F43C11.7
1 of 14
No
Yes
Cele\F47G9.4
1 of 14
No
Yes
Cele\fsn-1
1 of 14
No
No
Cele\gpa-4
1 of 14
No
No
Cele\gpa-6
1 of 14
No
No
Cele\gpa-15
1 of 14
No
No
Cele\lin-41
1 of 14
No
No
Cele\ncl-1
1 of 14
No
No
Cele\nhl-2
1 of 14
No
No
Cele\rcs-1
1 of 14
No
Yes
Cele\spsb-1
1 of 14
No
No
Cele\spsb-2
1 of 14
No
No
Cele\unc-68
1 of 14
No
No
Cele\ZK945.4
1 of 14
No
Yes
Cele\ZK1240.1
1 of 14
No
Yes
Cele\ZK1240.3
1 of 14
No
Yes
Cele\ZK1240.5
1 of 14
No
Yes
Cele\ZK1240.8
1 of 14
No
Yes
Cele\ZK1240.9
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP008750
12 of 12
Yes
Yes
Agam\AgaP_AGAP008751
2 of 12
No
Yes
Agam\AgaP_AGAP001328
1 of 12
No
No
Agam\AgaP_AGAP002344
1 of 12
No
No
Agam\AgaP_AGAP004765
1 of 12
No
No
Agam\AgaP_AGAP005063
1 of 12
No
No
Agam\AgaP_AGAP009203
1 of 12
No
No
Agam\AgaP_AGAP009522
1 of 12
No
No
Agam\AgaP_AGAP010197
1 of 12
No
No
Agam\FBSP1_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC1259.12c
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Trim9. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (14)
CG8419
2 of 13
mei-P26
2 of 13
wech
2 of 13
bon
1 of 13
brat
1 of 13
CG10516
1 of 13
Fsn
1 of 13
Gαo
1 of 13
gus
1 of 13
Lar
1 of 13
mtgo
1 of 13
RanBPM
1 of 13
SP555
1 of 13
tn
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TRIM36; tripartite motif containing 36
    model of  anencephaly
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIM9; tripartite motif containing 9
    13 of 14
    606555
        TRIM67; tripartite motif containing 67
        12 of 14
        610584
            TRIM36; tripartite motif containing 36
            3 of 14
            609317
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Trim9 - fra
            two hybrid
            (Morikawa et al., 2011)
            Trim9 - pico
            two hybrid, anti tag coimmunoprecipitation, anti tag western blot
            (Morikawa et al., 2011)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Trim9
            suppressible
            fra
            (Morikawa et al., 2011, Song et al., 2011)
            Trim9
            enhanceable
            fra
            (Song et al., 2011)
            Trim9
            suppressible
            robo1
            (Song et al., 2011)
            Trim9
            enhanceable
            robo1|fra
            (Song et al., 2011)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            park
            suppressible
            Uch|Trim9
            (Ham et al., 2021)
            park
            suppressible
            Trim9
            (Ham et al., 2021)
            Pink1
            suppressible
            Trim9
            (Ham et al., 2021)
            Pink1
            suppressible
            Uch|Trim9
            (Ham et al., 2021)
            External Data
            Subunit Structure (UniProtKB)
            Interacts (via fibronectin type-III domain) with pico. Interacts (via SPRY domain) with netrin receptor fra.
            (UniProt, M9MRI4 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-43
            Cytogenetic map
            31F5-32A2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            31F5-32A2
            Limits computationally determined from genome sequence between P{lacW}l(2)k09116k09116&P{lacW}Fatpk10307 and P{PZ}dbf1
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-43

            (FlyBase, 2016)

            2-36.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (26)
            Genomic Clones (73)
            cDNA Clones (23)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Morikawa et al., 2011)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Trim9 functions cell autonomously in midline guidance.

                  (Song et al., 2011)

                  One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

                  (Inlow and Restifo, 2004)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG13145 CG6256

                  (FlyBase Genome Annotators, 2002-2003)
                  Additional comments

                  Annotations CG13145 and CG6256 merged as CG31721 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  Source for identity of Trim9 CG31721 was sequence comparison ( date:030807 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Trim9 CG31721

                  (FlyBase, 1996-)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (11)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 53 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (85)