FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term proteasome-mediated ubiquitin-dependent protein catabolic process ID (Ontology) GO:0043161 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Also Known As"proteasomal pathway" ; "proteasomal ubiquitin-dependent protein breakdown" ; "proteasomal ubiquitin-dependent protein catabolic process" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 proteasome-mediated ubiquitin-dependent protein catabolic process (all annotations which use CV term, excluding "NOT" statements)
     involved_in | proteasome-mediated ubiquitin-dependent protein catabolic process       --
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modification-dependent protein catabolic process
 |__ubiquitin-dependent protein catabolic process__
protein catabolic process                          |
 |__proteasomal protein catabolic process__________|
                                                   proteasome-mediated ubiquitin-dependent protein catabolic process  285 rec.
                                                    |__anaphase-promoting complex-dependent catabolic process 19 rec.
                                                    |   |__regulation of anaphase-promoting complex-dependent catabolic process(+) 4 rec.
                                                    |__cytoplasm protein quality control by the ubiquitin-proteasome system
                                                    |__mitochondria-associated ubiquitin-dependent protein catabolic process
                                                    |__negative regulation of transcription by transcription factor catabolism
                                                    |__nuclear protein quality control by the ubiquitin-proteasome system 1 rec.
                                                    |   |__inner nuclear membrane-associated protein degradation pathway
                                                    |__RADAR pathway
                                                    |__regulation of proteasomal ubiquitin-dependent protein catabolic process 60 rec.
                                                    |   |__negative regulation of proteasomal ubiquitin-dependent protein catabolic process(+) 13 rec.
                                                    |   |__positive regulation of proteasomal ubiquitin-dependent protein catabolic process(+) 46 rec.
                                                    |   |__regulation of anaphase-promoting complex-dependent catabolic process(+) 4 rec.
                                                    |   |__regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(+) 1 rec.
                                                    |__ribosome-associated ubiquitin-dependent protein catabolic process 4 rec.
                                                    |   |__CAT tailing 1 rec.
                                                    |__SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 69 rec.
                                                    |   |__regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(+) 1 rec.
                                                    |__stress-induced homeostatically regulated protein degradation pathway
                                                    |__ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 2 rec.
                                                    |__ubiquitin-dependent protein catabolic process via the N-end rule pathway 5 rec.
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Is a ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
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Synonyms
  • "proteasomal pathway" EXACT
    "proteasomal processing" RELATED
    "proteasomal ubiquitin-dependent protein breakdown" EXACT
    "proteasomal ubiquitin-dependent protein catabolic process" EXACT
    "proteasomal ubiquitin-dependent protein catabolism" EXACT
    "proteasomal ubiquitin-dependent protein degradation" EXACT
    "proteasome pathway" RELATED
Secondary IDs
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Reactome:R-HSA-75815 "Ubiquitin-dependent degradation of Cyclin D"