FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein-macromolecule adaptor activity ID (Ontology) GO:0030674 (Gene Ontology)
Definition An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
Also Known As"protein binding, bridging"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 protein-macromolecule adaptor activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein-macromolecule adaptor activity       --
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Vocabulary search
  molecular_function
   |__molecular adaptor activity
       |__protein-macromolecule adaptor activity  372 rec.
           |__autophagy cargo adaptor activity 5 rec.
           |   |__autophagosome-membrane adaptor activity(+) 4 rec.
           |__cargo adaptor activity 22 rec.
           |   |__clathrin-cargo adaptor activity 13 rec.
           |__chromatin-protein adaptor activity 42 rec.
           |   |__dsDNA-RNA triple helix-forming chromatin adaptor activity
           |   |__histone reader activity(+) 30 rec.
           |__cytoskeletal adaptor activity 10 rec.
           |   |__actin-filament cross-linking activity
           |   |__cytoskeletal protein-membrane anchor activity 5 rec.
           |   |__spindle pole body anchor activity(+)
           |__enzyme-substrate adaptor activity 53 rec.
           |   |__protein ADP-ribosyltransferase-substrate adaptor activity
           |   |__ubiquitin-like ligase-substrate adaptor activity 44 rec.
           |__guanyl-nucleotide exchange factor adaptor activity
           |__kinetochore adaptor activity 4 rec.
           |__microtubule site clamp
           |__molecular condensate scaffold activity 13 rec.
           |__protein-membrane adaptor activity 34 rec.
           |   |__centromere-nuclear envelope anchor activity
           |   |__chromatin-nuclear membrane anchor activity(+)
           |   |__cytoskeletal protein-membrane anchor activity 5 rec.
           |   |__cytoskeleton-nuclear membrane anchor activity
           |   |__double strand break-nuclear membrane anchor activity
           |   |__endoplasmic reticulum-lipid droplet tether activity
           |   |__proteasome-nuclear membrane anchor activity
           |   |__protein-mitochondrial outer membrane tethering activity
           |   |__spindle pole body-nuclear membrane anchor activity
           |   |__telomere-nuclear envelope anchor activity
           |__protein-RNA adaptor activity 23 rec.
           |   |__C5-methylcytidine-containing RNA reader activity 2 rec.
           |   |__internal N(7)-methylguanine-containing RNA reader activity
           |   |__N6-methyladenosine-containing RNA reader activity 3 rec.
           |   |__protein-RNA sequence-specific adaptor activity 3 rec.
           |   |__protein-tRNA adaptor activity 1 rec.
           |__receptor clustering activity
           |__signaling adaptor activity 37 rec.
           |   |__JAK pathway signal transduction adaptor activity
           |   |__MAP kinase scaffold activity 6 rec.
           |   |__signaling receptor complex adaptor activity(+) 13 rec.
           |__SNAP receptor activity 32 rec.
           |__soluble NSF attachment protein activity 4 rec.
           |__ubiquitin-like protein reader activity 6 rec.
               |__SUMO-modified protein reader activity
               |__ubiquitin-modified protein reader activity(+) 5 rec.
               |__UFM1-modified protein reader activity 1 rec.
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Is a molecular adaptor activity
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Synonyms
  • "protein binding, bridging" EXACT
    "protein recruiting activity" RELATED
    "protein-protein adaptor" NARROW
Secondary IDs
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Reactome:R-HSA-3780997 "PPP1R3C binds to glycogen:GYG2:GYS2"
Reactome:R-HSA-3781001 "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex"
Reactome:R-HSA-3781021 "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex"
Reactome:R-HSA-3781023 "PPP1R3C binds to glycogen:GYG1:GYS1"
Reactome:R-HSA-8871366 "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP"
Reactome:R-HSA-8871376 "p-Y389,400-RUFY1 binds PI3P"