FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term protein-macromolecule adaptor activity ID (Ontology) GO:0030674 (Gene Ontology)
Definition An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
Also Known As "protein binding, bridging"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      77
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 protein-macromolecule adaptor activity (all annotations which use CV term, excluding "NOT" statements)       1     77
     enables | protein-macromolecule adaptor activity       --      77
Spanning Tree (Parents/Children)
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  molecular_function
   |__molecular adaptor activity
       |__protein-macromolecule adaptor activity  524 rec.
           |__autophagy cargo adaptor activity 5 rec.
           |   |__autophagosome-membrane adaptor activity(+) 4 rec.
           |__cargo adaptor activity 23 rec.
           |   |__clathrin-cargo adaptor activity 14 rec.
           |__centriole scaffold activity
           |__chromatin-protein adaptor activity 36 rec.
           |   |__dsDNA-RNA triple helix-forming chromatin adaptor activity
           |   |__histone reader activity(+) 28 rec.
           |__cytoskeletal anchor activity 7 rec.
           |   |__cytoskeletal protein-membrane anchor activity 2 rec.
           |   |__spindle pole body anchor activity(+)
           |__enzyme-substrate adaptor activity 42 rec.
           |   |__protein ADP-ribosyltransferase-substrate adaptor activity
           |   |__ubiquitin-like ligase-substrate adaptor activity 36 rec.
           |__guanyl-nucleotide exchange factor adaptor activity 1 rec.
           |__kinetochore adaptor activity 2 rec.
           |__microtubule site clamp
           |__molecular condensate scaffold activity 9 rec.
           |__protein-membrane adaptor activity 32 rec.
           |   |__autophagosome-membrane adaptor activity(+) 4 rec.
           |   |__centromere-nuclear envelope anchor activity
           |   |__chromatin-nuclear membrane anchor activity(+)
           |   |__cytoskeletal protein-membrane anchor activity 2 rec.
           |   |__cytoskeleton-nuclear membrane anchor activity
           |   |__double strand break-nuclear membrane anchor activity
           |   |__endoplasmic reticulum-lipid droplet tether activity
           |   |__endoplasmic reticulum-organelle membrane tether activity(+) 5 rec.
           |   |__endoplasmic reticulum-plasma membrane adaptor activity
           |   |__mitochondrion-mitochondrion outer membrane tether activity 1 rec.
           |   |__mitochondrion-plasma membrane adaptor activity 1 rec.
           |   |__peroxisome-mitochondrion membrane tether activity
           |   |__proteasome-nuclear membrane anchor activity
           |   |__protein-mitochondrial outer membrane tethering activity
           |   |__spindle pole body-nuclear membrane anchor activity
           |   |__telomere-nuclear envelope anchor activity
           |__protein-RNA adaptor activity 17 rec.
           |   |__C5-methylcytidine-containing RNA reader activity 1 rec.
           |   |__internal N(7)-methylguanine-containing RNA reader activity
           |   |__N6-methyladenosine-containing RNA reader activity 3 rec.
           |   |__protein-RNA sequence-specific adaptor activity 1 rec.
           |   |__protein-tRNA adaptor activity
           |__receptor clustering activity
           |__RNA polymerase II complex recruiting activity
           |__RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
           |__signaling adaptor activity 37 rec.
           |   |__JAK pathway signal transduction adaptor activity
           |   |__MAP-kinase scaffold activity 6 rec.
           |   |__signaling receptor complex adaptor activity(+) 13 rec.
           |__SNAP receptor activity 32 rec.
           |__soluble NSF attachment protein activity 4 rec.
           |__transcription coregulator activity 206 rec.
           |   |__transcription coactivator activity 94 rec.
           |   |__transcription corepressor activity(+) 61 rec.
           |__ubiquitin ligase complex scaffold activity 7 rec.
           |__ubiquitin-like protein reader activity 5 rec.
               |__SUMO-modified protein reader activity
               |__ubiquitin-modified protein reader activity(+) 4 rec.
               |__UFM1-modified protein reader activity 1 rec.
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Is a molecular adaptor activity
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Synonyms
  • "protein binding, bridging" EXACT
    "protein complex scaffold activity" BROAD
    "protein recruiting activity" RELATED
    "protein-containing complex scaffold activity" BROAD
    "protein-protein adaptor" NARROW
Secondary IDs
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