FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\U2A
Open Close
General Information
Symbol
Dmel\U2A
Species
D. melanogaster
Name
U2A
Annotation Symbol
CG1406
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033210
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
U2A (U2A) encodes a protein component of the U2 snRNP, which combines with other snRNPs on the pre-mRNA to assemble a spliceosome. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

U2A', l(2)43Ee, dU2A'

Key Links
Genomic Location
Cytogenetic map
43E9-43E9
Sequence location
Recombination map
2-57
RefSeq locus
NT_033778 REGION:7675362..7676362
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables U2 snRNA binding
inferred from electronic annotation with InterPro:IPR044640
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000058203
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from mutant phenotype
(Klusza et al., 2013)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
inferred from sequence or structural similarity with SGD:S000006134
(Mount and Salz, 2000)
inferred from electronic annotation with InterPro:IPR044640
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000058166
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of small nuclear ribonucleoprotein complex
inferred from sequence or structural similarity with SGD:S000006134
(Mount and Salz, 2000)
part_of spliceosomal complex
inferred from biological aspect of ancestor with PANTHER:PTN000058166
(GO Reference Genome Project, 2011-)
part_of U2 snRNP
inferred from biological aspect of ancestor with PANTHER:PTN000058166
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the U2 small nuclear ribonucleoprotein A family. (Q9V4Q8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
U2A (U2A) encodes a protein component of the U2 snRNP, which combines with other snRNPs on the pre-mRNA to assemble a spliceosome. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -
The U2 small nuclear ribonucleoprotein particle (U2 snRNP) contains U2 snRNA. It is recruited to the spliceosome after U1 snRNP and forms a stable interaction with the branch site and 3' splice site in pre-mRNA. (Adapted from PMID:23829528 and PMID:21441581).
SPLICEOSOME COMPLEX A -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX B -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
Protein Function (UniProtKB)
Involved in pre-mRNA splicing as component of the spliceosome (By similarity). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity). In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26 (PubMed:24244416, PubMed:27035939).
(UniProt, Q9V4Q8)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\U2A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V4Q8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
U2A-RA
FBtr0088941
NM_136471
1001
265
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
U2A-PA
FBpp0088015
29.7
265
8.78
Q9V4Q8
NP_610315
AAF59207
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with the SMN complex.

(UniProt, Q9V4Q8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\U2A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.72

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Wu et al., 2016)
adult stage | female
ovary
(Wu et al., 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\U2A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of U2A
Transgenic constructs containing regulatory region of U2A
Aberrations (Deficiencies and Duplications) ( 41 )
Inferred from experimentation ( 41 )
Gene disrupted in
Df(2R)cn-S5
(Heitzler et al., 1993)
Df(2R)cn-S6
(Heitzler et al., 1993)
Df(2R)cn-S8
(Heitzler et al., 1993)
Df(2R)Drlrv5
(Heitzler et al., 1993)
Df(2R)Drlrv7
(Heitzler et al., 1993)
Df(2R)Drlrv18
(Heitzler et al., 1993)
Df(2R)Drlrv24
(Heitzler et al., 1993)
Df(2R)Drlrv26
(Heitzler et al., 1993)
Df(2R)Drlrv30
(Heitzler et al., 1993)
Df(2R)Exel6054
(Kahsai and Cook, 2018, Ryder, 2004.4.26)
Df(2R)Exel7092
(Kahsai and Cook, 2018, Ryder, 2004.4.26)
Df(2R)NCX8
(Eeken et al., 2001, Nagengast and Salz, 2001, Heitzler et al., 1993)
Df(2R)NCX9
(Heitzler et al., 1993)
Df(2R)NCX11
(Heitzler et al., 1993)
Df(2R)NCX13
(Eeken et al., 2001)
Df(2R)sple-N3
(Heitzler et al., 1993)
Df(2R)ST1
(Eeken et al., 2001)
Gene not disrupted in
Df(2R)cos-2
(Heitzler et al., 1993)
Df(2R)cos-3
(Heitzler et al., 1993)
Df(2R)Drlrv3
(Heitzler et al., 1993)
Df(2R)Drlrv15
(Heitzler et al., 1993)
Df(2R)Drlrv17
(Heitzler et al., 1993)
Df(2R)Drlrv20
(Heitzler et al., 1993)
Df(2R)Drlrv21
(Heitzler et al., 1993)
Df(2R)Drlrv22
(Heitzler et al., 1993)
Df(2R)Drlrv25
(Heitzler et al., 1993)
Df(2R)Drlrv28
(Heitzler et al., 1993)
Df(2R)DX1
(Heitzler et al., 1993)
Df(2R)DX14
(Heitzler et al., 1993)
Df(2R)EW60
(Heitzler et al., 1993)
Df(2R)H23
(Heitzler et al., 1993)
Df(2R)nap2
(Heitzler et al., 1993)
Df(2R)NCX5
(Heitzler et al., 1993)
Df(2R)NCX10
(Heitzler et al., 1993)
Df(2R)pk-N5
(Heitzler et al., 1993)
Df(2R)pwn5
(Heitzler et al., 1993)
Df(2R)sple-D1
(Heitzler et al., 1993)
Df(2R)sple-D2
(Heitzler et al., 1993)
Df(2R)sple-D3
(Heitzler et al., 1993)
Df(2R)sple-J1
(Heitzler et al., 1993)
Df(2R)sple-J2
(Heitzler et al., 1993)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Mef2.PR
lethal (with Df(2R)Exel6054)
lethal (with Df(2R)Exel7092)
lethal | female limited, with Scer\GAL4dome-PG14
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4VP16.otu
male semi-fertile, with Scer\GAL4VP16.nanos.UTR
male sterile, with Scer\GAL4VP16.bam
male sterile, with Scer\GAL4αTub84B.PL
male sterile | temperature conditional, with U2A1.W
male sterile | temperature conditional, with U2Ahs.PW
Other Phenotypes
Allele
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
increased cell number | temperature conditional, with U2A1.W
increased cell number | temperature conditional, with U2Ahs.PW
some die during embryonic stage | recessive
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
chaeta | increased number, with Scer\GAL4pnr-MD237
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
mesonotum, with Scer\GAL4pnr-MD237
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
nucleus, with Scer\GAL4VP16.mat.αTub67C
nurse cell, with Scer\GAL4VP16.mat.αTub67C
spermatocyte cyst | temperature conditional, with U2A1.W
spermatocyte cyst | temperature conditional, with U2Ahs.PW
spermatogonium, with Scer\GAL4VP16.bam
spermatogonium | temperature conditional, with U2A1.W
spermatogonium | temperature conditional, with U2Ahs.PW
spermatozoon, with Scer\GAL4VP16.bam
spermatozoon | temperature conditional, with U2A1.W
spermatozoon | temperature conditional, with U2Ahs.PW
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (37)
Hsap\SNRPA1
13 of 14
Yes
Yes
 
2  
Hsap\LRMDA
2 of 14
No
No
Hsap\LRRC72
2 of 14
No
Yes
Hsap\ADGRA3
1 of 14
No
No
Hsap\ANP32A
1 of 14
No
No
Hsap\ANP32B
1 of 14
No
No
Hsap\ANP32C
1 of 14
No
No
Hsap\ANP32D
1 of 14
No
No
Hsap\ANP32E
1 of 14
No
No
Hsap\CD180
1 of 14
No
No
Hsap\CEP72
1 of 14
No
Yes
Hsap\CEP97
1 of 14
No
No
Hsap\CFAP410
1 of 14
No
No
Hsap\CNTRL
1 of 14
No
No
Hsap\DNAAF1
1 of 14
No
No
Hsap\DNAAF11
1 of 14
No
No
Hsap\DNAL1
1 of 14
No
No
1  
Hsap\DRC3
1 of 14
No
No
Hsap\LRGUK
1 of 14
No
No
Hsap\LRIG2
1 of 14
No
No
Hsap\LRRC9
1 of 14
No
No
Hsap\LRRC23
1 of 14
No
No
Hsap\LRRC36
1 of 14
No
Yes
Hsap\LRRC46
1 of 14
No
No
Hsap\LRRC49
1 of 14
No
No
Hsap\LRRC56
1 of 14
No
No
Hsap\LRRC57
1 of 14
No
No
1  
Hsap\LRRC61
1 of 14
No
No
Hsap\LRRCC1
1 of 14
No
No
Hsap\LRRIQ3
1 of 14
No
No
Hsap\NISCH
1 of 14
No
No
Hsap\PPP1R7
1 of 14
No
No
Hsap\RABGGTA
1 of 14
No
No
Hsap\TBCE
1 of 14
No
No
Hsap\TBCEL
1 of 14
No
No
Hsap\TLR3
1 of 14
No
No
1  
Hsap\TLR9
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (34)
Rnor\Snrpa1
14 of 14
Yes
Yes
Rnor\Lrrc51
3 of 14
No
Yes
Rnor\Lrrc72
2 of 14
No
Yes
Rnor\Adgra3
1 of 14
No
No
Rnor\Anp32a
1 of 14
No
No
Rnor\Anp32b
1 of 14
No
No
Rnor\Anp32e
1 of 14
No
No
Rnor\Cep72
1 of 14
No
Yes
Rnor\Cep97
1 of 14
No
No
Rnor\Cfap410
1 of 14
No
No
Rnor\Cntrl
1 of 14
No
No
Rnor\Dnaaf1
1 of 14
No
No
Rnor\Dnaaf11
1 of 14
No
No
Rnor\Dnal1
1 of 14
No
No
Rnor\Drc3
1 of 14
No
No
Rnor\LOC108350036
1 of 14
No
Yes
Rnor\Lrguk
1 of 14
No
No
Rnor\Lrrc9
1 of 14
No
No
Rnor\Lrrc23
1 of 14
No
No
Rnor\Lrrc46
1 of 14
No
No
Rnor\Lrrc49
1 of 14
No
No
Rnor\Lrrc57
1 of 14
No
No
Rnor\Lrrc61
1 of 14
No
No
Rnor\Lrrcc1
1 of 14
No
No
Rnor\Nisch
1 of 14
No
No
Rnor\Ppp1r7
1 of 14
No
No
Rnor\Rabggta
1 of 14
No
No
Rnor\Slc24a1
1 of 14
No
No
Rnor\Slitrk5
1 of 14
No
Yes
Rnor\Tbcel
1 of 14
No
No
Rnor\Tbce
1 of 14
No
No
Rnor\Tlr2
1 of 14
No
No
Rnor\Tlr3
1 of 14
No
No
Rnor\Tlr13
1 of 14
No
No
Mus musculus (laboratory mouse) (35)
Mmus\Snrpa1
13 of 14
Yes
Yes
Mmus\Lrrc72
3 of 14
No
Yes
Mmus\Lrmda
2 of 14
No
No
Mmus\Lrrc51
2 of 14
No
Yes
Mmus\Adgra3
1 of 14
No
No
Mmus\Anp32a
1 of 14
No
No
Mmus\Anp32b
1 of 14
No
No
Mmus\Anp32e
1 of 14
No
No
Mmus\Anp32-ps
1 of 14
No
No
Mmus\Cep72
1 of 14
No
Yes
Mmus\Cep97
1 of 14
No
No
Mmus\Cfap410
1 of 14
No
No
Mmus\Cntrl
1 of 14
No
No
Mmus\Dnaaf1
1 of 14
No
No
Mmus\Dnal1
1 of 14
No
No
Mmus\Drc3
1 of 14
No
No
Mmus\Lrguk
1 of 14
No
No
Mmus\Lrrc6
1 of 14
No
No
Mmus\Lrrc9
1 of 14
No
No
Mmus\Lrrc23
1 of 14
No
No
Mmus\Lrrc36
1 of 14
No
Yes
Mmus\Lrrc46
1 of 14
No
No
Mmus\Lrrc49
1 of 14
No
No
Mmus\Lrrc56
1 of 14
No
No
Mmus\Lrrc61
1 of 14
No
No
Mmus\Lrrcc1
1 of 14
No
No
Mmus\Lrriq1
1 of 14
No
No
Mmus\Nisch
1 of 14
No
No
Mmus\Nlrc5
1 of 14
No
No
Mmus\Ppp1r7
1 of 14
No
No
Mmus\Rabggta
1 of 14
No
No
Mmus\Slitrk5
1 of 14
No
Yes
Mmus\Tbcel
1 of 14
No
No
Mmus\Tbce
1 of 14
No
No
Mmus\Tlr13
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\snrpa1
6 of 13
Yes
Yes
Xtro\lrrc72
2 of 13
No
Yes
Xtro\lrtomt
2 of 13
No
Yes
Xtro\anp32a
1 of 13
No
No
Xtro\anp32b
1 of 13
No
No
Xtro\cep97
1 of 13
No
No
Xtro\cfap410
1 of 13
No
No
Xtro\cntrl
1 of 13
No
No
Xtro\cyb561d1
1 of 13
No
No
Xtro\dnaaf1
1 of 13
No
No
Xtro\dnaaf11
1 of 13
No
No
Xtro\dnal1
1 of 13
No
No
Xtro\drc3
1 of 13
No
No
Xtro\lrrc9
1 of 13
No
Yes
Xtro\lrrc23
1 of 13
No
No
Xtro\lrrc56
1 of 13
No
No
Xtro\lrriq1
1 of 13
No
Yes
Xtro\lrriq3
1 of 13
No
Yes
Xtro\lrrk2
1 of 13
No
No
Xtro\mnat1
1 of 13
No
No
Xtro\nlrc4
1 of 13
No
Yes
Xtro\ppp1r7
1 of 13
No
No
Xtro\stk11ip
1 of 13
No
No
Xtro\sycp2l
1 of 13
No
No
Xtro\tbcel
1 of 13
No
No
Xtro\tbce
1 of 13
No
No
Xtro\tlr2
1 of 13
No
No
Xtro\tlrs5
1 of 13
No
No
Xtro\ube2k
1 of 13
No
No
Xtro\XB5889249
1 of 13
No
No
Danio rerio (Zebrafish) (34)
Drer\snrpa1
13 of 14
Yes
Yes
Drer\lrrc51
3 of 14
No
Yes
Drer\lrmda
2 of 14
No
No
Drer\anp32a
1 of 14
No
No
Drer\anp32b
1 of 14
No
No
Drer\anp32e
1 of 14
No
No
Drer\cep72
1 of 14
No
Yes
Drer\cep97
1 of 14
No
No
Drer\cfap410
1 of 14
No
No
Drer\dnaaf1
1 of 14
No
No
Drer\dnaaf11
1 of 14
No
No
Drer\dnal1
1 of 14
No
No
Drer\drc3
1 of 14
No
No
Drer\LOC100331330
1 of 14
No
No
Drer\LOC100534875
1 of 14
No
No
Drer\LOC101885127
1 of 14
No
Yes
Drer\lrguk
1 of 14
No
No
Drer\lrrc23
1 of 14
No
No
Drer\lrrc40
1 of 14
No
No
Drer\lrrc61
1 of 14
No
No
Drer\lrrc72
1 of 14
No
Yes
Drer\lrrcc1
1 of 14
No
No
Drer\nisch
1 of 14
No
No
Drer\nxf1b
1 of 14
No
No
Drer\phlpp1
1 of 14
No
No
Drer\ppp1r7
1 of 14
No
No
Drer\si:ch211-237i5.4
1 of 14
No
No
Drer\tbce
1 of 14
No
No
Drer\tbcela
1 of 14
No
No
Drer\tbcelb
1 of 14
No
No
Drer\tlr5a
1 of 14
No
No
Drer\tlr5b
1 of 14
No
No
Drer\tlr8b
1 of 14
No
No
Drer\tril
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\mog-2
14 of 14
Yes
Yes
Cele\C06A8.6
1 of 14
No
No
Cele\coel-1
1 of 14
No
No
Cele\F09G8.5
1 of 14
No
No
Cele\F33H2.3
1 of 14
No
No
Cele\K10D2.8
1 of 14
No
No
Cele\lron-15
1 of 14
No
No
Cele\nish-1
1 of 14
No
No
Cele\phlp-2
1 of 14
No
No
Cele\R02F11.4
1 of 14
No
No
Cele\sds-22
1 of 14
No
No
Cele\T05H4.3
1 of 14
No
No
Cele\T19D7.6
1 of 14
No
No
Cele\T19H12.2
1 of 14
No
No
Cele\tbce-1
1 of 14
No
No
Cele\Y54E10A.6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (27)
Agam\AgaP_AGAP007670
11 of 12
Yes
Yes
Agam\AgaP_AGAP001422
2 of 12
No
No
Agam\AgaP_AGAP007552
2 of 12
No
No
Agam\AgaP_AGAP000360
1 of 12
No
No
Agam\AgaP_AGAP002013
1 of 12
No
No
Agam\AgaP_AGAP002792
1 of 12
No
No
Agam\AgaP_AGAP002793
1 of 12
No
No
Agam\AgaP_AGAP004016
1 of 12
No
Yes
Agam\AgaP_AGAP004416
1 of 12
No
No
Agam\AgaP_AGAP005075
1 of 12
No
No
Agam\AgaP_AGAP005693
1 of 12
No
No
Agam\AgaP_AGAP005870
1 of 12
No
No
Agam\AgaP_AGAP006643
1 of 12
No
No
Agam\AgaP_AGAP007059
1 of 12
No
No
Agam\AgaP_AGAP007443
1 of 12
No
Yes
Agam\AgaP_AGAP007632
1 of 12
No
No
Agam\AgaP_AGAP008927
1 of 12
No
No
Agam\AgaP_AGAP009839
1 of 12
No
No
Agam\AgaP_AGAP010129
1 of 12
No
No
Agam\AgaP_AGAP010180
1 of 12
No
No
Agam\AgaP_AGAP010770
1 of 12
No
No
Agam\AgaP_AGAP011141
1 of 12
No
No
Agam\AgaP_AGAP011394
1 of 12
No
No
Agam\AgaP_AGAP011947
1 of 12
No
No
Agam\AgaP_AGAP011969
1 of 12
No
No
Agam\AgaP_AGAP012385
1 of 12
No
No
Agam\LRC50_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\U2A'
12 of 13
Yes
Yes
Atha\AIR9
1 of 13
No
No
Atha\AT1G04210
1 of 13
No
Yes
Atha\AT1G48540
1 of 13
No
No
Atha\AT1G51890
1 of 13
No
No
Atha\AT1G54475
1 of 13
No
No
Atha\AT2G27060
1 of 13
No
Yes
Atha\AT3G17920
1 of 13
No
No
Atha\AT3G50690
1 of 13
No
No
Atha\AT4G03260
1 of 13
No
No
Atha\AT4G15475
1 of 13
No
No
Atha\AT4G39270
1 of 13
No
Yes
Atha\AT5G19680
1 of 13
No
No
Atha\AT5G22320
1 of 13
No
No
Atha\PFI
1 of 13
No
No
Atha\RGTA2
1 of 13
No
No
Atha\RLP1
1 of 13
No
No
Atha\RLP7
1 of 13
No
No
Atha\RLP9
1 of 13
No
Yes
Atha\RPP27
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\LEA1
10 of 13
Yes
Yes
Scer\PAC2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\lea1
11 of 12
Yes
Yes
Spom\alp21
1 of 12
No
No
Spom\mex67
1 of 12
No
No
Spom\sds22
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:U2A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (28)
CG31076
2 of 13
CG31274
2 of 13
MESK4
2 of 13
Cep97
1 of 13
CG5819
1 of 13
CG9044
1 of 13
CG10839
1 of 13
CG13708
1 of 13
CG14185
1 of 13
CG14995
1 of 13
CG15208
1 of 13
CG42346
1 of 13
chp
1 of 13
dom
1 of 13
dtr
1 of 13
f-cup
1 of 13
klu
1 of 13
Lgr3
1 of 13
Mapmodulin
1 of 13
mlt
1 of 13
ODA-Dnal1
1 of 13
Ppr-Y
1 of 13
sds22
1 of 13
Tbce
1 of 13
TbCMF46
1 of 13
tilB
1 of 13
Toll-7
1 of 13
Tollo
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
U2ARNAi.UASp
model of  azoospermia
CEA
(Wu et al., 2016)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SNRPA1; small nuclear ribonucleoprotein polypeptide A'
13 of 14
SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE A-PRIME; SNRPA1
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      U2A
      Hsap\SNRPA1
      (Wu et al., 2016)
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      U2A - Bx42
      pull down, western blot
      (Penn et al., 2008)
      U2A - Gem2
      experimental knowledge based
      (Guruharsha et al., 2011)
      U2A - Sf3b5
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Stegeman et al., 2016)
      U2A - SmD2
      experimental knowledge based
      (Guruharsha et al., 2011)
      U2A - SmF
      experimental knowledge based
      (Guruharsha et al., 2011)
      U2A - Smn
      experimental knowledge based
      (Guruharsha et al., 2011)
      U2A - Spf45
      anti bait coimmunoprecipitation, western blot, two hybrid, pull down
      (Chaouki and Salz, 2006)
      U2A - Spt3
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Stegeman et al., 2016)
      U2A - snRNP-U1-70K
      experimental knowledge based
      (Guruharsha et al., 2011)
      U2A - snf
      anti bait coimmunoprecipitation, western blot, nuclear magnetic resonance, isothermal titration calorimetry, predetermined participant, x-ray crystallography, pull down, anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid, experimental knowledge based
      (Weber et al., 2018, Stegeman et al., 2016, Williams and Hall, 2014, Guruharsha et al., 2011, Johnson et al., 2010, Penn et al., 2008, Chaouki and Salz, 2006, Nagengast and Salz, 2001)
      RNA-protein
      Physical Interaction
      Assay
      References
      U2A - mei-P26
      anti tag coimmunoprecipitation, primer specific pcr
      (Wu et al., 2016)
      U2A - snRNA:U2:14B
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      U2A - snRNA:U2:34ABa
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      U2A - snRNA:U2:34ABb
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      U2A - snRNA:U2:34ABc
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      U2A - snRNA:U2:38ABa
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      U2A - snRNA:U2:38ABb
      anti bait coimmunoprecipitation, northern blot
      (Nagengast and Salz, 2001)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      mei-P26
      suppressible
      U2A
      (Wu et al., 2016)
      External Data
      Subunit Structure (UniProtKB)
      Interacts with the SMN complex.
      (UniProt, Q9V4Q8 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-57
      Cytogenetic map
      43E9-43E9
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      43E9-43E9
      Limits computationally determined from genome sequence between P{PZ}scra03427&P{EP}EP2179 and P{PZ}l(2)0849208492
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      43E-43E
      (determined by in situ hybridisation)
      (Nagengast and Salz, 2001)
      Experimentally Determined Recombination Data
      Location

      2-57

      (FlyBase, 2016)

      2-56.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (9)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Wu et al., 2016, Nagengast and Salz, 2001)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

          (Goshima et al., 2007)

          The gene products of U2A and snf are co-immunoprecipitated by antibodies to either protein, demonstrating that, like their yeast and human counterparts, they heterodimerize in vivo. A mutation in the U2A binding motif of snf reduces the amount of heterodimer formation but does not abolish it completely. The U2A binding motif from snf is only essential for heterodimer formation in the absence of the C-terminal end of the protein. The RNA binding specificity domain of snf is essential for interaction with U2A. The U2A gene product incorporation into U2 snRNP does not depend on dimerization of the U2A and snf gene products.

          (Nagengast and Salz, 2001)

          Homozygous U2A mutants complete embryogenesis but do not hatch.

          (Nagengast and Salz, 2001)

          Mutants are embryonic lethal.

          (Nagengast et al., 2001)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: U2A BcDNA:RE56869

          (Salz, 2001.7.18, FlyBase, 1996-)
          Additional comments

          Source for merge of U2A BcDNA:RE56869 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: U2A' CG1406

          (Salz, 2001.3.5)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (10)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 37 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (62)