U2A', l(2)43Ee, dU2A'
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with the SMN complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\U2A using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\U2A in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
The gene products of U2A and snf are co-immunoprecipitated by antibodies to either protein, demonstrating that, like their yeast and human counterparts, they heterodimerize in vivo. A mutation in the U2A binding motif of snf reduces the amount of heterodimer formation but does not abolish it completely. The U2A binding motif from snf is only essential for heterodimer formation in the absence of the C-terminal end of the protein. The RNA binding specificity domain of snf is essential for interaction with U2A. The U2A gene product incorporation into U2 snRNP does not depend on dimerization of the U2A and snf gene products.
Mutants are embryonic lethal.