Toll-8, Toll8, Tl-8
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
May interact (via the extracellular domain) with 18w (via the extracellular domain).
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tollo using the Feature Mapper tool.
Tollo transcript is expressed in the proximal region of the wing disc, and the anterior compartment in leg discs; expression is absent from the wing pouch.
Tollo is expressed in a pair rule pattern in cellular blastoderm embryos. The pair rule stripes overlap the eve stripes, while the 18w stripes are posterior and adjacent to the eve stripes. At germ band extension, Tollo expression is strong in 14 bands (a segment polarity pattern). The Tollo stripes are situated posterior to the wg stripes while the 18w stripes overlap the wg stripes. Tollo is also expressed in the head region in both of these stages
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tollo in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant embryos show a dramatic loss of difucosylated glycans accompanied by decreases in monofucosylated and nonfucosylated hybrid glycans and increases in some nonfucosylated paucimannose and biantennary glycans.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.