FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term receptor ligand activity ID (Ontology) GO:0048018 (Gene Ontology)
Definition The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
Also Known As "signaling receptor ligand activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 receptor ligand activity (all annotations which use CV term, excluding "NOT" statements)
     enables | receptor ligand activity       --
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signaling receptor regulator activity__
molecular function activator activity__|
                                       signaling receptor activator activity
                                        |__receptor ligand activity  132 rec.
                                            |__chemoattractant activity 2 rec.
                                            |   |__chemoattractant activity involved in axon guidance
                                            |__chemorepellent activity 5 rec.
                                            |__cytokine activity 28 rec.
                                            |   |__chemokine activity 1 rec.
                                            |__death receptor agonist activity
                                            |__growth factor activity 22 rec.
                                            |__hormone activity 49 rec.
                                            |   |__corticotropin-releasing hormone activity
                                            |   |__digestive hormone activity
                                            |   |__diuretic hormone activity 4 rec.
                                            |   |__follicle-stimulating hormone activity
                                            |   |__gonadotropin hormone-releasing hormone activity
                                            |   |__growth hormone activity
                                            |   |__growth hormone-releasing hormone activity
                                            |   |__melanin-concentrating hormone activity
                                            |   |__melanocyte-stimulating hormone activity
                                            |   |__myoinhibitory hormone activity 1 rec.
                                            |   |__myostimulatory hormone activity 2 rec.
                                            |   |__neuropeptide hormone activity(+) 30 rec.
                                            |   |__pituitary adenylate cyclase activating polypeptide activity
                                            |   |__thyrotropin-releasing hormone activity
                                            |__morphogen activity 5 rec.
                                            |__neuropeptide activity 33 rec.
                                            |   |__neuropeptide hormone activity(+) 30 rec.
                                            |__opioid peptide activity
                                            |__pathogen-derived receptor ligand activity
                                            |__pheromone activity
                                                |__competence pheromone activity
                                                |__mating pheromone activity
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Is a signaling receptor activator activity
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Synonyms
  • "agonist" BROAD
    "receptor agonist activity" RELATED
    "signaling molecule" BROAD
    "signaling receptor ligand activity" EXACT
Secondary IDs
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Reactome:R-HSA-381612 "GLP1R binds GLP1"
Reactome:R-HSA-8848663 "ADIPOQ trimer binds ADIPOR dimers"