FlyBase Gene Report: Dmel\Lgr4

General Information

Symbol

Dmel\Lgr4

Species

D. melanogaster

Name

Leucine-rich repeat-containing G protein-coupled receptor 4

Annotation Symbol

CG34411

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085440

Gene Model Status

Current

Stock Availability

27 publicly available

Gene Summary

Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) encodes a protein that shows highest similarity with vertebrate receptors for relaxin-like peptides. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DLGR4

Key Links

Genomic Location

Cytogenetic map

11E1-11E3

Sequence location

X:13,161,714..13,189,164 [-]

Recombination map

1-42

RefSeq locus

NC_004354 REGION:13161714..13189164

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000689980

(GO Reference Genome Project, 2011-)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR008112

(InterPro Project Members, 2004-)

enables neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

enables protein-hormone receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000689980

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

involved_in hormone-mediated signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000689980

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR008112

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR008112, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from sequence model

(Hewes and Taghert, 2001)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000689980

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Lgr4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry X2JJX6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Lgr4-RB

FBtr0300364

NM_001103496

2975

806

Lgr4-RC

FBtr0340300

NM_001298263

2870

809

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Lgr4-PB

FBpp0289593

90.4

806

6.53

FBpp0309261

90.8

809

6.53

X2JJX6

NP_001285192

AHN59662

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lgr4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34411_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.91

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage | male

larval central nervous system

(Van Hiel et al., 2015)

embryonic/larval salivary gland

(Van Hiel et al., 2015)

embryonic/larval tracheal section

(Van Hiel et al., 2015)

embryonic/larval Malpighian tubule

(Van Hiel et al., 2015)

embryonic/larval midgut

(Van Hiel et al., 2015)

embryonic/larval hindgut

(Van Hiel et al., 2015)

embryonic/larval fat body

(Van Hiel et al., 2015)

gonad

(Van Hiel et al., 2015)

wandering third instar larval stage | female

larval central nervous system

Comment: low level

(Van Hiel et al., 2015)

embryonic/larval salivary gland

Comment: low level

(Van Hiel et al., 2015)

embryonic/larval Malpighian tubule

Comment: low level

(Van Hiel et al., 2015)

embryonic/larval midgut

(Van Hiel et al., 2015)

embryonic/larval hindgut

(Van Hiel et al., 2015)

embryonic/larval fat body

Comment: low level

(Van Hiel et al., 2015)

adult stage | female

crop

Comment: low level

(Van Hiel et al., 2015)

adult brain

Comment: low level

(Van Hiel et al., 2015)

adult salivary gland

Comment: low level

(Van Hiel et al., 2015)

adult ventral nerve cord

Comment: low level

(Van Hiel et al., 2015)

adult Malpighian tubule

Comment: low level

(Van Hiel et al., 2015)

adult midgut

(Van Hiel et al., 2015)

adult hindgut

Comment: low level

(Van Hiel et al., 2015)

adult fat body

Comment: low level

(Van Hiel et al., 2015)

adult stage | male

crop

(Van Hiel et al., 2015)

rectum

(Van Hiel et al., 2015)

adult brain

(Van Hiel et al., 2015)

adult muscle system

(Van Hiel et al., 2015)

adult salivary gland

Comment: low level

(Van Hiel et al., 2015)

adult ventral nerve cord

(Van Hiel et al., 2015)

adult Malpighian tubule

Comment: low level

(Van Hiel et al., 2015)

adult midgut

(Van Hiel et al., 2015)

adult hindgut

Comment: low level

(Van Hiel et al., 2015)

adult fat body

Comment: low level

(Van Hiel et al., 2015)

Additional Descriptive Data

Lgr4 transcripts are expressed throughout development with a peak in first instar larvae and in broad range of tissues. Transcripts are more abundant in males than females and the difference increases with age. In wandering third instar larvae, significantly higher expression is observed in almost all male tissues relative to female tissues. Expression is high in adult male brain, thoracic-abdominal ganglion, crop and larval and adult male midgut.

(Van Hiel et al., 2015)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.1}Lgr4^{MI06794-TG4.1}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

neuron | subset of adult pars intercerebralis

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lgr4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Lgr4

View exonic expression by tissue for Dmel\Lgr4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740505/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085440

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085440

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085440

Flygut - An atlas of the Drosophila adult midgut

FBgn0085440

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Lgr4

Transgenic constructs containing regulatory region of Lgr4

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 19 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^Eaat1.PR

Lgr4^JF03070

partially lethal, with Scer\GAL4^GMR54C07

Lgr4^JF03070

partially lethal, with Scer\GAL4^GMR77A03

Lgr4^JF03070

partially lethal, with Scer\GAL4^GMR85G01

Lgr4^JF03070

partially lethal, with Scer\GAL4^GMR86E01

Lgr4^JF03070

partially lethal, with Scer\GAL4^Ntan1-Mz97

Lgr4^JF03070

partially lethal, with Scer\GAL4^repo

partially lethal - majority die, with Scer\GAL4^Lgr4-2A-GAL4

Lgr4^JF03070

partially lethal - majority die, with Scer\GAL4^{Lgr4-MI06794-TG4.1}

Lgr4^JF03070

partially lethal - majority live, with Lgr4^JF03070

partially lethal - majority live, with Lgr4^MB01485

Lgr4^JF03070

partially lethal - majority live, with Lgr4^MB03440

Lgr4^JF03070

partially lethal - majority live, with Scer\GAL4^GMR24A08

Lgr4^JF03070

partially lethal - majority live, with Scer\GAL4^GMR25C08

Lgr4^JF03070

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Lgr4^GD725

viable, with Scer\GAL4^17A

Lgr4^JF03070

viable, with Scer\GAL4^A58

Lgr4^JF03070

viable, with Scer\GAL4^alrm.PD

Lgr4^JF03070

viable, with Scer\GAL4^elav-C155

Lgr4^JF03070

viable, with Scer\GAL4^gcm-rA87.C

Lgr4^JF03070

viable, with Scer\GAL4^GMR56F03

Lgr4^JF03070

viable, with Scer\GAL4^GMR75H03

Lgr4^JF03070

viable, with Scer\GAL4^lama-A8

Lgr4^JF03070

viable, with Scer\GAL4^Mef2.PR

Lgr4^GD725

viable, with Scer\GAL4^Mz709

Lgr4^JF03070

viable, with Scer\GAL4^NP2222

Lgr4^JF03070

viable, with Scer\GAL4^pnr-MD237

Lgr4^GD725

Other Phenotypes

Allele

abnormal oxidative stress response

Lgr4^MB01485

decreased rate of adult locomotory behavior, with Scer\GAL4^repo

Lgr4^JF03070

decreased rate of mating behavior, with Scer\GAL4^repo

Lgr4^JF03070

increased mortality during development, with Scer\GAL4^repo

Lgr4^JF03070

short lived | male, with Scer\GAL4^repo

Lgr4^JF03070

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (114)

Hsap\RXFP1

8 of 14

Yes

7 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\APLNR

1 of 14

Hsap\AVPR1A

1 of 14

Yes

Hsap\BDKRB2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CPN2

1 of 14

Hsap\CXCR3

1 of 14

Yes

Hsap\DCN

1 of 14

Hsap\DRD1

1 of 14

Hsap\EDNRB

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR34

1 of 14

Yes

Hsap\GPR50

1 of 14

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC8D

1 of 14

Yes

Hsap\LRRC8E

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\MC5R

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\P2RY8

1 of 14

Yes

Hsap\PHLPP1

1 of 14

Hsap\PODN

1 of 14

Yes

Hsap\PODNL1

1 of 14

Hsap\PPP1R7

1 of 14

Hsap\RTN4R

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (60)

Rnor\Rxfp1

8 of 14

Yes

7 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr21

1 of 14

Rnor\Gpr26

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrrc8e

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (57)

Mmus\Rxfp1

7 of 14

Yes

Mmus\Rxfp2

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrrc8e

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (90)

Xtro\rxfp1

6 of 13

Yes

5 of 13

4 of 13

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\dcn

1 of 13

Xtro\drd1

1 of 13

Xtro\ednrb

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\flrt3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mfhas1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\prelp

1 of 13

Xtro\rho

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slitrk4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tril

1 of 13

Xtro\uts2rl2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (106)

Drer\rxfp1

7 of 14

Yes

Drer\rxfp2b

7 of 14

Yes

Drer\rxfp2l

7 of 14

Yes

6 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\c5ar1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cmklrl2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lrrc8ab

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\mc5ra

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\qrfprb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch73-160i9.2

1 of 14

Yes

Drer\si:ch211-237i5.4

1 of 14

Drer\si:dkey-1j5.4

1 of 14

Drer\si:dkey-182i3.11

1 of 14

Drer\si:dkey-192l18.9

1 of 14

Drer\si:dkey-247m21.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\taar14g

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (34)

Cele\aex-2

1 of 14

Yes

Cele\aexr-1

1 of 14

Yes

Cele\aexr-2

1 of 14

Yes

Cele\aexr-3

1 of 14

Yes

Cele\ckr-1

1 of 14

Yes

Cele\dop-4

1 of 14

Yes

Cele\EEED8.10

1 of 14

Yes

Cele\egg-6

1 of 14

Yes

Cele\fbxl-1

1 of 14

Yes

Cele\fshr-1

1 of 14

Yes

Cele\iglr-3

1 of 14

Yes

Cele\let-4

1 of 14

Yes

Cele\lron-1

1 of 14

Yes

Cele\lron-2

1 of 14

Yes

Cele\lron-3

1 of 14

Yes

Cele\lron-8

1 of 14

Yes

Cele\lron-11

1 of 14

Yes

Cele\lron-14

1 of 14

Yes

Cele\lron-15

1 of 14

Yes

Cele\nish-1

1 of 14

Yes

Cele\npr-22

1 of 14

Yes

Cele\npr-33

1 of 14

Yes

Cele\ntr-2

1 of 14

Yes

Cele\pan-1

1 of 14

Yes

Cele\sds-22

1 of 14

Yes

Cele\sma-10

1 of 14

Yes

Cele\soc-2

1 of 14

Yes

Cele\T28B4.1

1 of 14

Yes

Cele\tkr-1

1 of 14

Yes

Cele\tkr-3

1 of 14

Yes

Cele\tol-1

1 of 14

Yes

Cele\trhr-1

1 of 14

Yes

Cele\tyra-3

1 of 14

Yes

Cele\ZK546.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (112)

Agam\GPRGPH

11 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004016

1 of 12

Yes

Agam\AgaP_AGAP004485

1 of 12

Agam\AgaP_AGAP004832

1 of 12

Agam\AgaP_AGAP004913

1 of 12

Yes

Agam\AgaP_AGAP005273

1 of 12

Agam\AgaP_AGAP005496

1 of 12

Yes

Agam\AgaP_AGAP005667

1 of 12

Yes

Agam\AgaP_AGAP005668

1 of 12

Yes

Agam\AgaP_AGAP005693

1 of 12

Agam\AgaP_AGAP005744

1 of 12

Yes

Agam\AgaP_AGAP006183

1 of 12

Agam\AgaP_AGAP006327

1 of 12

Yes

Agam\AgaP_AGAP007030

1 of 12

Yes

Agam\AgaP_AGAP007034

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007443

1 of 12

Yes

Agam\AgaP_AGAP007445

1 of 12

Agam\AgaP_AGAP007446

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007456

1 of 12

Agam\AgaP_AGAP007457

1 of 12

Yes

Agam\AgaP_AGAP007461

1 of 12

Agam\AgaP_AGAP007462

1 of 12

Yes

Agam\AgaP_AGAP007463

1 of 12

Agam\AgaP_AGAP007464

1 of 12

Yes

Agam\AgaP_AGAP007465

1 of 12

Agam\AgaP_AGAP007466

1 of 12

Agam\AgaP_AGAP007467

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008173

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010804

1 of 12

Agam\AgaP_AGAP010809

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012385

1 of 12

Agam\AgaP_AGAP012442

1 of 12

Agam\AgaP_AGAP012584

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT1G50980

1 of 13

Yes

Atha\AT4G05460

1 of 13

Yes

Atha\AT4G05470

1 of 13

Yes

Atha\AT4G05475

1 of 13

Yes

Atha\AT4G05500

1 of 13

Yes

Atha\AT5G19680

1 of 13

Yes

Atha\AT5G23340

1 of 13

Yes

Atha\AT5G27920

1 of 13

Yes

Atha\RLP24

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Lgr4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (53)

Lgr3

7 of 13

Lgr1

3 of 13

18w

1 of 13

AdoR

1 of 13

AstA-R1

1 of 13

AstA-R2

1 of 13

atk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

chp

1 of 13

Con

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

lbk

1 of 13

Lkr

1 of 13

Lrt

1 of 13

mAChR-C

1 of 13

PK2-R1

1 of 13

Ppa

1 of 13

Pxn

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sli

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

trn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RXFP1; relaxin family peptide receptor 1

8 of 14

606654

RXFP2; relaxin family peptide receptor 2

7 of 14

606655

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Lgr4 - Ilp7

anti tag coimmunoprecipitation, anti tag western blot

(Imambocus et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

625136

DroID - A comprehensive database of gene and protein interactions.

FBgn0085440

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-42

Cytogenetic map

11E1-11E3

Sequence location

X:13,161,714..13,189,164 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11E1-11E3

Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640^EP1626;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-42

(FlyBase, 2016)

1-41.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

84478

w^* TI{TI}Lgr4^attP

49058

w¹¹¹⁸; P{GMR24A08-GAL4}attP2

49120

w¹¹¹⁸; P{GMR25C08-GAL4}attP2

601254

w¹¹¹⁸; P{R24A08-p65.AD}JK22C

53515

w¹¹¹⁸; P{GMR24A08-lexA}attP40

54698

w¹¹¹⁸; P{GMR25C08-lexA}attP40

69372

w¹¹¹⁸; P{R24A08-GAL4.DBD}attP2

69882

w¹¹¹⁸; P{R25C08-GAL4.DBD}attP2

4187R-1

4187R-4

v102681

v108915

More stocks available...

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP11226

Other clones

RT10158

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085440

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085440

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG32637) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG32637 CG4187

(FlyBase Genome Annotators, 2007)

Source for merge of: CG4187 anon-WO0170980.19 anon-WO0170980.20

(FlyBase, 1996-)

Additional comments

Annotations CG32637 and CG4187 merged as CG34411 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Source for merge of CG4187 anon-WO0170980.19 anon-WO0170980.20 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Lgr4 CG34411

(Van Hiel et al., 2015)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG32637

CG34411

(Mao et al., 2024, Chen et al., 2023, Kondo et al., 2020, Veenstra, 2020, Vallejo et al., 2015, Van Hiel et al., 2015, Ashwal-Fluss et al., 2014, Ozkan et al., 2013, Sen et al., 2013, Caers et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jordan et al., 2012, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

CG4187

(Houot et al., 2012, Hauser et al., 2006, Hauser et al., 2006, Metpally and Sowdhamini, 2005)

DLGR4

(Hauser et al., 2006, Hauser et al., 2006)

LGR4

(Taghert, 2022, Liu et al., 2021, Veenstra, 2020)

Lgr4

(Zhang et al., 2025, Schlichting et al., 2022, Prince et al., 2021, Kondo et al., 2020, Rao and Deng, 2019.10.23, Lee et al., 2018, Li-Kroeger et al., 2018, Gene Disruption Project members, 2016-, Jaszczak et al., 2016)

anon-WO0170980.19

anon-WO0170980.20

dLGR4

(Van Hiel et al., 2015)

lgr4

(Colombani et al., 2015, Vallejo et al., 2015)

Name Synonyms

CG32637

CG4187

Leucine-rich repeat-containing G protein-coupled receptor 4

Lgr4

(Caers et al., 2012)

Secondary FlyBase IDs

FBgn0046558
FBgn0046550
FBgn0052637
FBgn0030458

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740505

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

X2JJX6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

X2JJX6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740505/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085440

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085440

FlyMine - An integrated database for Drosophila genomics

FBgn0085440

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34411

MARRVEL_MODEL - MARRVEL (model organism gene)

5740505

Linkouts

BioGRID - A database of protein and genetic interactions.

625136

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085440

DroID - A comprehensive database of gene and protein interactions.

FBgn0085440

DRSC - Results frm RNAi screens

FBgn0085440

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34411_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085440

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085440

Flygut - An atlas of the Drosophila adult midgut

FBgn0085440

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085440

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (63)

The following external sites may use different assemblies or annotations than FlyBase.

-0.91

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