FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term G protein-coupled receptor activity ID (Ontology) GO:0004930 (Gene Ontology)
Definition Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Also Known As "G protein coupled receptor activity" ; "G protein linked receptor activity" ; "G-protein coupled receptor activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 G protein-coupled receptor activity (all annotations which use CV term, excluding "NOT" statements)
     enables | G protein-coupled receptor activity       --
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  signaling receptor activity
   |__transmembrane signaling receptor activity
       |__G protein-coupled receptor activity  137 rec.
           |__bioactive lipid receptor activity
           |   |__lysophosphatidic acid receptor activity
           |   |__sphingosine-1-phosphate receptor activity
           |__cannabinoid receptor activity
           |__choriogonadotropin hormone receptor activity
           |__corticotrophin-releasing factor receptor activity
           |__ecdysis-triggering hormone receptor activity 1 rec.
           |__G protein-coupled adenosine receptor activity 2 rec.
           |__G protein-coupled amine receptor activity 28 rec.
           |   |__2-phenylethylamine receptor activity
           |   |__adrenergic receptor activity(+) 2 rec.
           |   |__G protein-coupled acetylcholine receptor activity 4 rec.
           |   |__G protein-coupled serotonin receptor activity(+) 7 rec.
           |   |__histamine receptor activity
           |   |__octopamine receptor activity 8 rec.
           |   |__trace-amine receptor activity(+)
           |   |__tyramine receptor activity 4 rec.
           |__G protein-coupled bile acid receptor activity
           |__G protein-coupled chemoattractant receptor activity
           |   |__chemokine receptor activity(+)
           |__G protein-coupled chemorepellent receptor activity
           |__G protein-coupled cytokinin receptor activity
           |__G protein-coupled estrogen receptor activity
           |__G protein-coupled folate receptor activity
           |__G protein-coupled GABA receptor activity 4 rec.
           |__G protein-coupled glucose receptor activity
           |__G protein-coupled glutamate receptor activity 2 rec.
           |   |__adenylate cyclase inhibiting G protein-coupled glutamate receptor activity(+) 2 rec.
           |   |__PLC activating G protein-coupled glutamate receptor activity
           |__G protein-coupled neurotransmitter receptor activity 4 rec.
           |   |__G protein-coupled acetylcholine receptor activity 4 rec.
           |   |__G protein-coupled glycine receptor activity
           |__G protein-coupled nucleotide receptor activity
           |__G protein-coupled olfactory receptor activity
           |__G protein-coupled opioid receptor activity
           |   |__beta-endorphin receptor activity
           |   |__dynorphin receptor activity
           |   |__G protein-coupled enkephalin receptor activity
           |   |__morphine receptor activity
           |   |__nociceptin receptor activity
           |__G protein-coupled peptide receptor activity 60 rec.
           |   |__allatostatin receptor activity 5 rec.
           |   |__angiotensin receptor activity(+)
           |   |__apelin receptor activity
           |   |__bradykinin receptor activity
           |   |__calcitonin family receptor activity(+) 4 rec.
           |   |__cholecystokinin receptor activity
           |   |__dynorphin receptor activity
           |   |__endothelin receptor activity
           |   |__G protein-coupled enkephalin receptor activity
           |   |__gastrin receptor activity 2 rec.
           |   |__glucagon receptor activity
           |   |__glucagon-like peptide 1 receptor activity
           |   |__mating-type factor pheromone receptor activity(+)
           |   |__melanocortin receptor activity(+)
           |   |__myosuppressin receptor activity 2 rec.
           |   |__N-formyl peptide receptor activity
           |   |__neuropeptide receptor activity(+) 45 rec.
           |   |__nociceptin receptor activity
           |   |__orexin receptor activity
           |   |__oxytocin receptor activity
           |   |__peptide pheromone receptor activity(+)
           |   |__proteinase-activated receptor activity(+)
           |   |__urotensin II receptor activity
           |   |__vasopressin receptor activity 1 rec.
           |__G protein-coupled photoreceptor activity 8 rec.
           |__G protein-coupled purinergic nucleotide receptor activity
           |   |__cAMP receptor activity
           |   |__G protein-coupled ADP receptor activity
           |   |__G protein-coupled ATP receptor activity
           |__G protein-coupled pyrimidinergic nucleotide receptor activity
           |   |__G protein-coupled UDP receptor activity
           |   |__G protein-coupled UTP receptor activity
           |__G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
           |__gastric inhibitory peptide receptor activity
           |__gonadotropin-releasing hormone receptor activity
           |__GPCR taste receptor activity
           |   |__GPCR bitter taste receptor activity
           |   |__GPCR sweet taste receptor activity
           |   |__umami taste receptor activity
           |__growth hormone secretagogue receptor activity
           |__growth hormone-releasing hormone receptor activity
           |__icosanoid receptor activity 1 rec.
           |   |__leukotriene receptor activity(+)
           |   |__prostanoid receptor activity(+) 1 rec.
           |__luteinizing hormone receptor activity
           |__mast cell secretagogue receptor activity
           |__melanin-concentrating hormone receptor activity
           |__melatonin receptor activity
           |__nicotinic acid receptor activity
           |__parathyroid hormone receptor activity
           |__pheromone receptor activity
           |   |__mating-type factor pheromone receptor activity(+)
           |   |__peptide pheromone receptor activity(+)
           |__pituitary adenylate cyclase-activating polypeptide receptor activity
           |__platelet activating factor receptor activity
           |__prosaposin receptor activity
           |__secretin receptor activity
           |__thyroid-stimulating hormone receptor activity
           |__thyrotropin-releasing hormone receptor activity 1 rec.
           |__vasoactive intestinal polypeptide receptor activity
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Is a transmembrane signaling receptor activity
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Synonyms
  • "EBV-induced receptor" NARROW
    "Epstein-Barr Virus-induced receptor activity" NARROW
    "G protein coupled receptor activity" EXACT
    "G protein linked receptor activity" EXACT
    "G-protein coupled receptor activity" EXACT
    "G-protein coupled receptor activity, unknown ligand" NARROW
    "G-protein linked receptor activity" EXACT
    "GPCR activity" EXACT
    "ligand-dependent GPCR activity" EXACT
    "Mas proto-oncogene receptor activity" NARROW
    "orphan G protein coupled receptor activity" NARROW
    "orphan G-protein coupled receptor activity" NARROW
    "orphan GPCR activity" NARROW
    "RDC1 receptor activity" NARROW
    "receptor activity, G-protein coupled" EXACT
    "SREB receptor" NARROW
    "super conserved receptor expressed in brain receptor activity" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13"
Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq"
Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein"
Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)"
Wikipedia:GPCR