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FB2025_04
,
released October 2, 2025
l(3)02937
leucine-rich repeat transmembrane protein involved in selective synapse formation; contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing - consolidates R cell growth cone segregation
Please see the JBrowse view of Dmel\caps for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.44
Double stop-codon suppression (UAG, UGA) postulated (FBrf0212160, FlyBase analysis); supported by conservation of the extended ORF across Drosophila species (FBrf0202906).
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 6.02
2.951 (sequence analysis)
532 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\caps using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
caps mRNA expression is identical to the enhancer trap expression pattern.Expression is observed in four dorsal and 6 ventral muscles. In ventral longitudinal muscle 1, the expression is observed in a single nucleus of the syncytial muscle, near the contact site of the motorneuronal growth cone. Expression is also observed in the CNS in motoneurons aCC, RP2, RP5, and U.
Comment: muscle 12
Comment: 24hrs APF
Comment: 75hrs APF
In brains taken from 48hr APF pupae, caps is variably expressed in antennal lobe glomeruli, with some expressing high levels and others low.
Comment: 24-55h APF
Comment: 40hrs APF
JBrowse - Visual display of RNA-Seq signals
View Dmel\caps in JBrowse3-40
3-34.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
caps is not involved in synapse formation in R8 photoreceptors.
caps expressed in the target layer does not mediate M3 layer recognition.
The RHR motif of the caps protein is essential for its role in tracheal development.
caps protein confers affinity for dorsal cells during wing development.
Panneural ectopic expression of caps results in pathfinding defects of motorneurons that innervate muscle 12.
Phenotypic and expression pattern analysis suggest a role for caps in selective synapse formation.
caps functions in a homophilic manner, to mediate specific target selection.
caps is an essential gene. Mutants show defects in neuromuscular target recognition.
Discovered in an enhancer trap screen.
Mutants die during late embryogenesis or soon after hatching. Morphology of muscle 12 synaptic terminal is abnormal.
Source for merge of: caps BcDNA:LD07388
Source for merge of: caps l(3)02937
