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FB2026_01
,
released March 12, 2026
eyeful, rumpf, BTB-V, psk, rum
BTB domain & Psq motif transcription factor that targets a Polycomb group protein complex to Polycomb response elements - epigenetic silencers Lola and Pipsqueak collaborate with Notch to promote malignant tumours by Rb silencing
Please see the JBrowse view of Dmel\psq for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 6.02
Double stop-codon suppression (UGA, UGA) postulated; FBrf0243886.
Gene model reviewed during 6.32
6.0, 5.1, 4.4 (northern blot)
5.7, 5.0, >7.0 (northern blot)
1065 (aa); 150 (kD observed)
1085, 666, 660, 535 (aa)
Downstream from the BTB (or POZ) domain, the psq+P1065 protein contains 34 alternating histidine residues, (HX)n,which may act as an additional protein-protein interaction domain. The psq protein also contains a 52-55 amino acid motif tandemly repated four times at the C terminus, which the authors call "the psq motif". The function of the evolutionarily conserved psq motif is unknown. The putative product of the psq+R4.4 transcript lacks both the BTB and (HX)n motifs, but still posesses the psq motifs.
The BTB-domain is predicted for the products of
the class A transcripts (psq+R7.0A1 and psq+R7.0A2) only,
psqA
one of several products generated by alternative splicing
psqB
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\psq using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reference states 0-2 hr AEL
psq transcripts are first distributed uniformly in the embryo. At stage 5 transcript accumulation is observed dorsally between 20 and 70% egg length. In addition to a low level uniform expression, high levels of psq transcripts are found through stage 7/8 in the dorso-anterior domain and in the amnioserosa (detected with an intronic probe). In later stages, expression is detected in the mandibular, maxillary, and labial lobes.
psq protein localizes to the nucleus.
The psq protein localizes to the nuclei of somatic and germ cells during oogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\psq in JBrowseMaps to 2R.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Genetic interaction data suggest that psq may have a role in control of homeotic gene activity.
Identification: as a suppressor of the small eye phenotype caused by overexpression of fng in the eye.
Source for merge of: psq zep
Source for merge of: psq BtbV
Source for merge of: psq rum
Source for merge of psq BtbV was sequence comparison ( date:000202 ).
Source for identity of: psq CG2368
