FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\rib
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General Information
Symbol
Dmel\rib
Species
D. melanogaster
Name
ribbon
Annotation Symbol
CG7230
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003254
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
56C6-56C6
Sequence location
Recombination map
2-88
RefSeq locus
NT_033778 REGION:19270078..19281396
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR007889
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity
traceable author statement
(Sudarsan, 2003)
Biological Process (20 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
involved_in central nervous system development
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in dorsal closure
inferred from mutant phenotype
(Blake et al., 1998)
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Bradley and Andrew, 2001, Shim et al., 2001)
involved_in establishment or maintenance of epithelial cell apical/basal polarity
inferred from mutant phenotype
(Kerman et al., 2008)
involved_in gonad development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in head involution
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in hindgut morphogenesis
inferred from mutant phenotype
(Blake et al., 1998, Jack and Myette, 1997)
involved_in intracellular protein localization
inferred from mutant phenotype
(Blake et al., 1998)
involved_in Malpighian tubule morphogenesis
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in open tracheal system development
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in regulation of cell shape
inferred from mutant phenotype
(Blake et al., 1998, Jack and Myette, 1997)
involved_in regulation of Malpighian tubule diameter
inferred from mutant phenotype
(Jack and Myette, 1997)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Kerman et al., 2008, Blake et al., 1998, Jack and Myette, 1997)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Kerman et al., 2008)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
involved_in cell migration
traceable author statement
(Abrams et al., 2003, Bradley et al., 2001)
involved_in cytoskeleton organization
traceable author statement
(Harden, 2002)
involved_in dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
non-traceable author statement
(Abrams et al., 2003)
involved_in membrane organization
traceable author statement
(Sudarsan, 2003)
involved_in open tracheal system development
traceable author statement
(Sudarsan, 2003)
non-traceable author statement
(Abrams et al., 2003)
involved_in regulation of cell shape
traceable author statement
(Bradley et al., 2001)
involved_in regulation of DNA-templated transcription
traceable author statement
(Sudarsan, 2003)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(GO Reference Genome Project, 2011-)
involved_in salivary gland development
traceable author statement
(Abrams et al., 2003, Sudarsan, 2003)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Shim et al., 2001)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(GO Reference Genome Project, 2011-)
located_in nucleus
traceable author statement
(Sudarsan, 2003)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PIPSQUEAK TRANSCRIPTION FACTORS -
Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
rib: ribbon
Homozygous embryonic lethal; lateral extents of belts narrow; fusion of adjacent dentical bands in ventral midline; dorsal closure defective.
Summary (Interactive Fly)

BTB/POZ domain transcription factor - a regulator of epithelial morphogenesis that promotes cell migration - regulates morphogenesis of the embryonic salivary gland through transcriptional activation and repression

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\rib for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KFC4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.50

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
rib-RA
FBtr0086512
NM_080534
3956
661
rib-RB
FBtr0330057
NM_001274155
4244
661
rib-RC
FBtr0330058
NM_001274156
3956
680
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
rib-PA
FBpp0085700
71.0
661
6.61
Q7KF43
NP_536795
AAF57588
rib-PB
FBpp0303090
71.0
661
6.61
Q7KF43
NP_001261084
AGB93616
rib-PC
FBpp0303091
73.1
680
6.46
A0A0B4KFC4
NP_001261085
AGB93617
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

661 aa isoforms: rib-PA, rib-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rib using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.25

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
epithelial cell
(Lecuyer et al., 2007)
epithelium
(Lecuyer et al., 2007)
embryonic stage 4 -- 6
foregut anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
foregut anlage
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
cardiogenic mesoderm
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
labral sensory complex primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal head epidermis
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval labral sensory complex
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Shim et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\rib in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of rib
Transgenic constructs containing regulatory region of rib
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with rib1)
lethal (with rib2)
lethal (with ribP16)
lethal (with ribP34)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration | embryonic stage (with rib35.14)
abnormal cell migration | embryonic stage (with rib55.25)
abnormal cell polarity (with rib1)
abnormal cell polarity (with ribP7)
abnormal neuroanatomy | larval stage | recessive
decreased cell growth rate | embryonic stage, with Scer\GAL4fkh.PH
decreased cell growth rate | embryonic stage (with rib1)
decreased cell growth rate | embryonic stage (with ribP7)
decreased cell size | embryonic stage (with rib1)
decreased cell size | embryonic stage (with ribP7)
decreased size | embryonic stage (with rib1)
decreased size | embryonic stage (with ribP7)
increased cell growth rate | embryonic stage, with Scer\GAL4fkh.PH
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 7 lateral pentascolopidial chordotonal organ lch5
denticle
denticle (with rib1)
denticle (with rib2)
embryo | dorsal
embryo | dorsal closure stage
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle (with rib1)
embryonic/first instar larval cuticle (with rib2)
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | dorsal (with rib1)
embryonic/first instar larval cuticle | dorsal (with rib2)
embryonic/larval dorsal tracheal branch
embryonic/larval ganglionic tracheal branch
embryonic/larval hindgut | embryonic stage
embryonic/larval midgut | embryonic stage
embryonic/larval salivary gland
embryonic/larval salivary gland | embryonic stage
embryonic/larval salivary gland | embryonic stage, with Scer\GAL4fkh.PH
embryonic/larval salivary gland | embryonic stage (with rib1)
embryonic/larval salivary gland | embryonic stage (with ribP7)
embryonic/larval salivary gland common duct | embryonic stage
embryonic/larval salivary gland duct
embryonic/larval salivary gland duct | embryonic stage
embryonic/larval tracheal dorsal trunk
embryonic/larval tracheal lateral trunk
embryonic epidermis
embryonic epidermis | dorsal
embryonic head
embryonic midgut constriction
germline cell | embryonic stage (with rib1)
germline cell | embryonic stage (with rib35.14)
germline cell | embryonic stage (with rib55.25)
gonad | embryonic stage (with rib1)
gonad | embryonic stage (with rib6.24)
gonad | embryonic stage (with rib35.14)
gonad | embryonic stage (with rib55.25)
gonadal sheath proper primordium (with rib1)
gonadal sheath proper primordium (with rib35.14)
gonadal sheath proper primordium (with rib55.25)
gonadal sheath proper primordium | embryonic stage (with rib6.24)
gonadal sheath proper primordium | embryonic stage (with rib55.25)
head
larval dorsal hair
larval tracheal system
Malpighian tubule
nucleolus | embryonic stage (with rib1)
nucleolus | embryonic stage (with ribP7)
P-body | embryonic stage (with rib1)
P-body | embryonic stage (with ribP7)
peripheral nervous system precursor cluster
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
presumptive embryonic/larval tracheal system
presumptive embryonic/larval tracheal system (with Df(2R)rib-ex12)
presumptive embryonic salivary gland
presumptive embryonic salivary gland (with rib1)
presumptive embryonic salivary gland (with ribP7)
tracheal dorsal trunk primordium
tracheal dorsal trunk primordium (with rib1)
tracheal dorsal trunk primordium (with ribP7)
tracheal precursor cell (with rib1)
tracheal precursor cell (with ribP7)
tracheal section
ventral denticle belt
ventral denticle belt (with rib1)
ventral denticle belt (with rib2)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (41)
Hsap\BTBD18
2 of 14
Yes
No
Hsap\ABTB1
1 of 14
No
Yes
Hsap\KBTBD2
1 of 14
No
No
Hsap\KBTBD3
1 of 14
No
No
Hsap\KBTBD4
1 of 14
No
No
Hsap\KLHL2
1 of 14
No
No
Hsap\KLHL3
1 of 14
No
No
Hsap\KLHL12
1 of 14
No
No
Hsap\KLHL15
1 of 14
No
No
Hsap\KLHL17
1 of 14
No
No
Hsap\KLHL20
1 of 14
No
No
Hsap\KLHL21
1 of 14
No
No
Hsap\KLHL23
1 of 14
No
No
Hsap\KLHL24
1 of 14
No
No
Hsap\KLHL26
1 of 14
No
No
Hsap\KLHL30
1 of 14
No
No
Hsap\KLHL31
1 of 14
No
No
Hsap\KLHL34
1 of 14
No
No
Hsap\KLHL36
1 of 14
No
No
Hsap\MYNN
1 of 14
No
No
Hsap\PHOSPHO2-KLHL23
1 of 14
No
No
Hsap\PRDM1
1 of 14
No
No
Hsap\ZBTB3
1 of 14
No
Yes
Hsap\ZBTB6
1 of 14
No
No
Hsap\ZBTB7A
1 of 14
No
No
1  
Hsap\ZBTB7C
1 of 14
No
Yes
Hsap\ZBTB9
1 of 14
No
No
Hsap\ZBTB14
1 of 14
No
No
Hsap\ZBTB17
1 of 14
No
Yes
Hsap\ZBTB18
1 of 14
No
Yes
Hsap\ZBTB20
1 of 14
No
No
Hsap\ZBTB21
1 of 14
No
No
Hsap\ZBTB24
1 of 14
No
No
1  
Hsap\ZBTB37
1 of 14
No
No
Hsap\ZBTB41
1 of 14
No
No
Hsap\ZBTB43
1 of 14
No
Yes
Hsap\ZBTB44
1 of 14
No
No
Hsap\ZBTB48
1 of 14
No
No
Hsap\ZNF131
1 of 14
No
No
Hsap\ZNF524
1 of 14
No
No
Hsap\ZNF563
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (33)
Rnor\Btbd18
2 of 14
Yes
No
Rnor\Abtb1
1 of 14
No
Yes
Rnor\Kbtbd3
1 of 14
No
No
Rnor\Kbtbd4
1 of 14
No
No
Rnor\Klhl2
1 of 14
No
No
Rnor\Klhl12
1 of 14
No
No
Rnor\Klhl15
1 of 14
No
No
Rnor\Klhl20
1 of 14
No
No
Rnor\Klhl21
1 of 14
No
No
Rnor\Klhl24
1 of 14
No
No
Rnor\Klhl26
1 of 14
No
No
Rnor\Klhl34
1 of 14
No
No
Rnor\Klhl40
1 of 14
No
No
Rnor\Nacc2
1 of 14
No
No
Rnor\Zbtb3
1 of 14
No
Yes
Rnor\Zbtb9
1 of 14
No
Yes
Rnor\Zbtb16
1 of 14
No
No
Rnor\Zbtb20
1 of 14
No
No
Rnor\Zbtb24
1 of 14
No
Yes
Rnor\Zbtb34
1 of 14
No
Yes
Rnor\Zbtb37
1 of 14
No
No
Rnor\Zbtb40
1 of 14
No
Yes
Rnor\Zbtb43
1 of 14
No
No
Rnor\Zbtb44
1 of 14
No
No
Rnor\Zbtb49
1 of 14
No
Yes
Rnor\Zfp62
1 of 14
No
No
Rnor\Zfp131
1 of 14
No
No
Rnor\Zfp161
1 of 14
No
No
Rnor\Zfp184
1 of 14
No
No
Rnor\Zfp251
1 of 14
No
Yes
Rnor\Zfp335
1 of 14
No
No
Rnor\Zfp354c
1 of 14
No
No
Rnor\Zfp494
1 of 14
No
Yes
Mus musculus (laboratory mouse) (29)
Mmus\Abtb1
1 of 14
Yes
Yes
Mmus\Btbd18
1 of 14
Yes
No
Mmus\Kbtbd3
1 of 14
Yes
No
Mmus\Kbtbd4
1 of 14
Yes
No
Mmus\Klhl2
1 of 14
Yes
No
Mmus\Klhl3
1 of 14
Yes
No
Mmus\Klhl12
1 of 14
Yes
No
Mmus\Klhl15
1 of 14
Yes
No
Mmus\Klhl20
1 of 14
Yes
No
Mmus\Klhl21
1 of 14
Yes
No
Mmus\Klhl24
1 of 14
Yes
No
Mmus\Klhl40
1 of 14
Yes
No
Mmus\Zbtb9
1 of 14
Yes
Yes
Mmus\Zbtb14
1 of 14
Yes
Yes
Mmus\Zbtb16
1 of 14
Yes
No
Mmus\Zbtb18
1 of 14
Yes
Yes
Mmus\Zbtb20
1 of 14
Yes
Yes
Mmus\Zbtb24
1 of 14
Yes
Yes
Mmus\Zbtb37
1 of 14
Yes
Yes
Mmus\Zbtb43
1 of 14
Yes
Yes
Mmus\Zbtb44
1 of 14
Yes
No
Mmus\Zbtb48
1 of 14
Yes
No
Mmus\Zfp60
1 of 14
Yes
No
Mmus\Zfp131
1 of 14
Yes
No
Mmus\Zfp335
1 of 14
Yes
No
Mmus\Zfp354b
1 of 14
Yes
Yes
Mmus\Zfp454
1 of 14
Yes
No
Mmus\Zfp879
1 of 14
Yes
No
Mmus\Zfp975
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\abtb1
2 of 13
Yes
Yes
Xtro\bcl6
1 of 13
No
Yes
Xtro\btbd18
1 of 13
No
No
Xtro\cdkl5
1 of 13
No
No
Xtro\kbtbd2
1 of 13
No
No
Xtro\klhl2
1 of 13
No
No
Xtro\klhl21
1 of 13
No
No
Xtro\klhl22
1 of 13
No
No
Xtro\klhl23
1 of 13
No
No
Xtro\klhl24
1 of 13
No
No
Xtro\klhl28
1 of 13
No
No
Xtro\klhl36
1 of 13
No
No
Xtro\klhl40
1 of 13
No
No
Xtro\LOC100496285
1 of 13
No
No
Xtro\zbtb6
1 of 13
No
Yes
Xtro\zbtb11
1 of 13
No
No
Xtro\zbtb14
1 of 13
No
Yes
Xtro\zbtb18
1 of 13
No
Yes
Xtro\zbtb20
1 of 13
No
Yes
Xtro\zbtb21
1 of 13
No
Yes
Xtro\zbtb37
1 of 13
No
No
Xtro\zbtb41
1 of 13
No
No
Xtro\zbtb43
1 of 13
No
No
Xtro\zbtb44
1 of 13
No
Yes
Xtro\zscan2
1 of 13
No
No
Danio rerio (Zebrafish) (37)
Drer\abtb1
1 of 14
Yes
Yes
Drer\bach1a
1 of 14
Yes
Yes
Drer\bcl6b
1 of 14
Yes
Yes
Drer\gan
1 of 14
Yes
No
Drer\hic2
1 of 14
Yes
Yes
Drer\kbtbd3
1 of 14
Yes
No
Drer\klhl7
1 of 14
Yes
No
Drer\klhl10a
1 of 14
Yes
No
Drer\klhl12
1 of 14
Yes
No
Drer\klhl15
1 of 14
Yes
No
Drer\klhl17
1 of 14
Yes
No
Drer\klhl20
1 of 14
Yes
No
Drer\klhl21
1 of 14
Yes
No
Drer\klhl22
1 of 14
Yes
No
Drer\klhl24b
1 of 14
Yes
No
Drer\klhl26
1 of 14
Yes
No
Drer\klhl35
1 of 14
Yes
No
Drer\klhl36
1 of 14
Yes
No
Drer\klhl40a
1 of 14
Yes
No
Drer\klhl40b
1 of 14
Yes
No
Drer\klhl41b
1 of 14
Yes
No
Drer\LOC100334838
1 of 14
Yes
Yes
Drer\LOC108178999
1 of 14
Yes
No
Drer\LOC108182318
1 of 14
Yes
No
Drer\LOC108183930
1 of 14
Yes
No
Drer\si:ch211-119o8.6
1 of 14
Yes
Yes
Drer\si:dkey-56e3.3
1 of 14
Yes
Yes
Drer\zbtb3
1 of 14
Yes
Yes
Drer\zbtb8b
1 of 14
Yes
Yes
Drer\zbtb14
1 of 14
Yes
Yes
Drer\zbtb20
1 of 14
Yes
No
Drer\zbtb24
1 of 14
Yes
Yes
Drer\zbtb44
1 of 14
Yes
Yes
Drer\zgc:112998
1 of 14
Yes
Yes
Drer\zgc:113343
1 of 14
Yes
No
Drer\zgc:173726
1 of 14
Yes
Yes
Drer\znf983
1 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\eor-1
1 of 14
Yes
No
Cele\kel-3
1 of 14
Yes
No
Cele\kel-20
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (40)
Agam\AgaP_AGAP011902
12 of 12
Yes
Yes
Agam\AgaP_AGAP000080
2 of 12
No
No
Agam\AgaP_AGAP001073
2 of 12
No
No
Agam\AgaP_AGAP001646
2 of 12
No
No
Agam\AgaP_AGAP002165
2 of 12
No
No
Agam\AgaP_AGAP002297
2 of 12
No
No
Agam\AgaP_AGAP002303
2 of 12
No
No
Agam\AgaP_AGAP003189
2 of 12
No
No
Agam\AgaP_AGAP003439
2 of 12
No
No
Agam\AgaP_AGAP003537
2 of 12
No
No
Agam\AgaP_AGAP003685
2 of 12
No
No
Agam\AgaP_AGAP006454
2 of 12
No
No
Agam\AgaP_AGAP008959
2 of 12
No
No
Agam\AgaP_AGAP010063
2 of 12
No
No
Agam\AgaP_AGAP010355
2 of 12
No
No
Agam\AgaP_AGAP011247
2 of 12
No
No
Agam\AgaP_AGAP011583
2 of 12
No
No
Agam\AgaP_AGAP000585
1 of 12
No
No
Agam\AgaP_AGAP001258
1 of 12
No
Yes
Agam\AgaP_AGAP002304
1 of 12
No
Yes
Agam\AgaP_AGAP003286
1 of 12
No
No
Agam\AgaP_AGAP003428
1 of 12
No
No
Agam\AgaP_AGAP003645
1 of 12
No
No
Agam\AgaP_AGAP005244
1 of 12
No
No
Agam\AgaP_AGAP005245
1 of 12
No
No
Agam\AgaP_AGAP005745
1 of 12
No
No
Agam\AgaP_AGAP005747
1 of 12
No
No
Agam\AgaP_AGAP005748
1 of 12
No
No
Agam\AgaP_AGAP006018
1 of 12
No
No
Agam\AgaP_AGAP006457
1 of 12
No
No
Agam\AgaP_AGAP006458
1 of 12
No
No
Agam\AgaP_AGAP008031
1 of 12
No
No
Agam\AgaP_AGAP008362
1 of 12
No
No
Agam\AgaP_AGAP008506
1 of 12
No
No
Agam\AgaP_AGAP008827
1 of 12
No
No
Agam\AgaP_AGAP009641
1 of 12
No
No
Agam\AgaP_AGAP010684
1 of 12
No
No
Agam\AgaP_AGAP011142
1 of 12
No
No
Agam\AgaP_AGAP012550
1 of 12
No
No
Agam\AgaP_AGAP012669
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:rib. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (30)
ab
5 of 13
br
5 of 13
BtbVII
5 of 13
CG6118
5 of 13
CG8924
5 of 13
chinmo
5 of 13
lov
5 of 13
ttk
5 of 13
bab1
4 of 13
bab2
4 of 13
CG3726
4 of 13
CG12236
4 of 13
fru
4 of 13
lolal
4 of 13
lola
4 of 13
mod(mdg4)
4 of 13
psq
4 of 13
tono
4 of 13
Trl
4 of 13
CG15812
3 of 13
CG34376
3 of 13
mamo
3 of 13
CG6765
2 of 13
CG4496
1 of 13
CG4820
1 of 13
CG9426
1 of 13
CG15097
1 of 13
CG30431
1 of 13
ken
1 of 13
rdx
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    rib
    suppressible
    crb
    (Kerman et al., 2008)
    rib
    enhanceable
    lola
    (Silva et al., 2016)
    rib
    suppressible
    Moe
    (Kerman et al., 2008)
    rib
    suppressible
    zip
    (Blake et al., 1999)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    lola
    enhanceable
    rib
    (Silva et al., 2016)
    lolal
    enhanceable
    rib
    (Kerman et al., 2008)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-88
    Cytogenetic map
    56C6-56C6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    56C6-56C6
    Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-88

    (FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

    2-94.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    (Shim et al., 2001)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (19)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (256)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Loganathan et al., 2022)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       

      • New stable cell line derived from S2-unspecified : 75 stable S2 cell lines containing a library of intrinsically disordered regions (IDRs) fluorescently tagged with mNeonGreen were constructed. In addition, stable S2 cell lines expressing the following full-length transcription factors were generated: da, rib, CG10321, CG13287, tgo, Spps, CG31510, brk, and disco.

        (Hannon and Eisen, 2024)
      Other Comments

      rib is required for specific tracheal branch migration.

      (Bradley and Andrew, 2001)

      Mutations in rib disrupt the coupling of movement of the cell bodies and apical and basal surfaces of the tracheal epithelium that is normally seen during tracheal system development; in rib mutants the basal surface continues to extend towards its normal targets, but movement and morphogenesis of the tracheal cell boies and apical surface is severely impaired.

      (Shim et al., 2001)

      rib is required for the proper shape of tubular epithelial tissues in Drosophila.

      (Jack and Myette, 1997)
      Relationship to Other Genes
      Source for database merge of

      Source for merge of: CG7230 rib

      (Bradley and Andrew, 2001)
      Additional comments
      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (9)
      Reported As
      Symbol Synonym
      CG7230
      (National Institute of Genetics Fly Stocks, 2022-, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Haussmann et al., 2008, Brody et al., 2002, Siegmund and Lehmann, 2002, Shim et al., 2001)
      RIB
      (Cheng et al., 2013, Bajpe et al., 2008)
      Rib
      (Loganathan et al., 2021, Chaharbakhshi and Jemc, 2016)
      fus1
      (Weyers et al., 2011)
      gene 5
      (Bradley and Andrew, 2001)
      rib
      (Balakireva et al., 2024, Zane et al., 2023, Deshpande et al., 2022, Loganathan et al., 2022, Zhao et al., 2022, Dorogova et al., 2020, Overton et al., 2020, FlyBase Genome Annotators, 2019-, Hall et al., 2019, Shokri et al., 2019, Mortensen et al., 2018, Karaiskos et al., 2017, Loganathan et al., 2016, Sarov et al., 2016, Silva et al., 2016, Aleksic et al., 2013, Humphreys et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Brumby et al., 2011, Jungreis et al., 2011, Kazemian et al., 2011, Weake et al., 2011, Weyers et al., 2011, Xu et al., 2011, Cunha et al., 2010, Kong et al., 2010, Fang et al., 2009, Bates et al., 2008, Cheshire et al., 2008, Kerman et al., 2008, Christensen and Cook, 2007.10.29, Kerman et al., 2007, Lecuyer et al., 2007, Riedl et al., 2007, Sandmann et al., 2007, Tomancak et al., 2007, Luschnig et al., 2006, Stark et al., 2005)
      Name Synonyms
      Ribbon
      (Bonchuk et al., 2024)
      SGP cluster fusion defects 1
      (Weyers et al., 2011)
      ribbon
      (McKowen and Hart, 2022, Cohen et al., 2020, Wieschaus and Nüsslein-Volhard, 2016, Humphreys et al., 2013, Weyers et al., 2011, Biehs et al., 2010, Bates et al., 2008, Cheshire et al., 2008, Kerman et al., 2008, Kerman et al., 2007)
      Secondary FlyBase IDs
      • FBgn0034424
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 47 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      References (123)