FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rib2
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General Information
Symbol
Dmel\rib2
Species
D. melanogaster
Name
FlyBase ID
FBal0014573
Feature type
allele
Associated gene
Dmel\rib
Associated Insertion(s)
Carried in Construct
Also Known As
ribIIB44
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Shim et al., 2001)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: R58H.

(Bradley and Andrew, 2001)

Nucleotide substitution: G?A. Amino acid replacement: R58H.

(Shim et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,278,301..19,278,301 [+]
Nucleotide change:

G19278301A

Reported nucleotide change:

G?A

Amino acid change:

R58H | rib-PA; R58H | rib-PB; R58H | rib-PC

Reported amino acid change:

R58H

(Bradley and Andrew, 2001, Shim et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In rib2/rib2 or rib2/rib1 larvae, of those with scorable cuticles, small anterior dorsal holes and puckering of the dorsal epidermis occur in 36% of mutants and large dorsal holes occur in 64% of mutants. Denticle belt phenotypes are also seen. The lateral extent of rib2/rib2 denticle belts is narrowed to 27% that of wild-type, rib2/rib1 belts reduced to 46%. A loss of denticle diversity is also seen in the embryos.

      (Bradley and Andrew, 2001)

      Homozygous and rib2/Df(2R)rib-ex12 embryos show defects in tracheal branch outgrowth. A small number of ribP16/rib2 (2.7% expected) escapers survive to adulthood.

      (Shim et al., 2001)

      weak allele

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series: rib2/rib2 < rib2/rib1 = rib2/Df < rib1/rib1 = rib1/Df.

      (Bradley and Andrew, 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      rib2
      (Kerman et al., 2008)
      ribIIB44
      (Jack and Myette, 1999, Jack and Myette, 1997)
      ribIIB
      (Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)