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General Information
Symbol
Dmel\zipIIX62
Species
D. melanogaster
Name
FlyBase ID
FBal0036091
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Deficiency breakpoint within the zip locus.

    Caused by aberration
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    zip2/zipIIX62 embryos show a dorsal closure phenotype with a low penetrance. Time-lapse imaging shows that in affected embryos there is a decrease in the rate of closure at end stages and the distribution of F-actin in leading-edge cells is disorganized as closure progresses. Additionally, there is a failure in the structural integrity of the amnioserosa, leading-edge cells, and the junction between them.

    zip1/zipIIX62 embryos exhibit dramatic defects in head involution. 58% of zip1/zipIIX62 embryos have a clear dorsal hole (i.e.- dorsal closure is incomplete). The remaining embryos complete dorsal closure, although they frequently show puckering or segment misalignments along the closed midline seam. During dorsal closure the leading edge in zip1/zipIIX62 embryos is very disporganized and extends a broader extent of lamellipodial and filopodial protrusions per unit length of leading edge than wild-type.

    Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference

    zipIIX62 is a suppressor of lethal | male phenotype of flw6

    zipIIX62 is a suppressor of lethal | male phenotype of flwG0172/flwG0172

    Other
    Statement
    Reference
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The multiple wing hair phenotype caused by expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of zipIIX62.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (9)