FlyBase Allele Report: Dmel\rib[55.25]

General Information

Symbol

Dmel\rib^55.25

Species

D. melanogaster

Name

FlyBase ID

FBal0260753

Feature type

allele

Associated gene

Dmel\rib

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Weyers et al., 2011)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | embryonic stage (with rib^35.14)

(Silva et al., 2016)

Phenotype Manifest In

germline cell | embryonic stage (with rib¹)

(Silva et al., 2016)

germline cell | embryonic stage (with rib^35.14)

(Silva et al., 2016)

gonad | embryonic stage (with rib¹)

(Silva et al., 2016)

gonad | embryonic stage (with rib^6.24)

(Weyers et al., 2011)

gonad | embryonic stage (with rib^35.14)

(Silva et al., 2016)

gonadal sheath proper primordium (with rib¹)

(Silva et al., 2016)

gonadal sheath proper primordium (with rib^35.14)

(Silva et al., 2016)

gonadal sheath proper primordium | embryonic stage (with rib^6.24)

(Weyers et al., 2011)

Detailed Description

Statement

Reference

rib^55.25/rib^35.14 and rib^55.25/rib¹ transheterozygous embryos, but not rib^55.25 heterozygotes, display a significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.

rib^55.25/rib^35.14 transheterozygous embryos also display a significant increase in the number of extragonadal primordial germ cells, but no obvious defects in the development of the visceral mesoderm, as compared to controls.

(Silva et al., 2016)

rib^6.24/rib^55.25 embryos have gonads with at least one somatic gonadal precursor (SGP) cluster that does not fuse with other SGPs. Somatic gonadal precursor specification appears normal. Visceral mesoderm appears normal. Male-specific SGPs are not specified.

(Weyers et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

rib^35.14/rib^55.25 has gonad | embryonic stage phenotype, enhanceable by lola[+]/lola^22.05

(Silva et al., 2016)

rib^35.14/rib^55.25 has gonadal sheath proper primordium phenotype, enhanceable by lola[+]/lola^22.05

(Silva et al., 2016)

rib^35.14/rib^55.25 has germline cell | embryonic stage phenotype, enhanceable by lola[+]/lola^22.05

(Silva et al., 2016)

Enhancer of

Statement

Reference

rib^55.25/rib[+] is an enhancer of gonad | embryonic stage phenotype of lola^46.38/lola^22.05

(Silva et al., 2016)

rib^55.25/rib[+] is an enhancer of gonadal sheath proper primordium phenotype of lola^46.38/lola^22.05

(Silva et al., 2016)

rib^55.25/rib[+] is an enhancer of germline cell | embryonic stage phenotype of lola^46.38/lola^22.05

(Silva et al., 2016)

Other

Statement

Reference

lola^46.38, rib^55.25/rib[+] has gonadal sheath proper primordium phenotype

(Silva et al., 2016)

lola^46.38, rib^55.25/rib[+] has gonad | embryonic stage phenotype

(Silva et al., 2016)

lola^46.38, rib^55.25/rib[+] has germline cell | embryonic stage phenotype

(Silva et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

rib^55.25/+, lola^46.38/+ double heterozygous embryos display a significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.

Heterozygosity for rib^55.25 significantly enhances the defects exhibited by lola^46.38/lola^22.05 transheterozygous embryos to fuse together and compact primordial germ cells and somatic gonadal precursor cells.

(Silva et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

rib^55.25/rib¹ is partially rescued by Scer\GAL4^how-24B/rib^UAS.cBa

(Silva et al., 2016)

Comments

The defects exhibited by rib^55.25/rib¹ transheterozygous embryos to fuse together and compact primordial germ cells and somatic gonadal precursor cells are partially rescued by the expression of rib^Scer\UAS.cBa under the control of Scer\GAL4^how-24B.

(Silva et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rib^55.25

(Silva et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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