FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Moe
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General Information
Symbol
Dmel\Moe
Species
D. melanogaster
Name
Moesin
Annotation Symbol
CG10701
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011661
Gene Model Status
Current
Stock Availability
88 publicly available
Gene Summary
Moesin (Moe) encodes an Ezrin, Radixin, Moesin (ERM) protein involved in cortical cytoskeleton stability. It regulates the products of crb and Rho1. The product of Moe contributes to apical-basal polarity, mitotic spindle organisation and epithelial integrity. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dmoesin, Dmoe, l(1)G0067, l(1)G0415, l(1)G0404

Key Links
Genomic Location
Cytogenetic map
8B4-8B6
Sequence location
Recombination map
1-25
RefSeq locus
NC_004354 REGION:8873012..8898332
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (60 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables actin binding
inferred from direct assay
(McCartney and Fehon, 1996)
enables microtubule binding
inferred from mutant phenotype
(Solinet et al., 2013)
enables phosphatidylinositol-4,5-bisphosphate binding
inferred from direct assay
(Roch et al., 2010)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VTL1
(Kristó et al., 2017)
inferred from physical interaction with FLYBASE:conu; FB:FBgn0039994
(Neisch et al., 2013)
inferred from physical interaction with FLYBASE:Mer; FB:FBgn0086384
(McCartney and Fehon, 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables actin binding
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
non-traceable author statement
(Gibson and Perrimon, 2003)
inferred from electronic annotation with InterPro:IPR008954, InterPro:IPR011174
(InterPro Project Members, 2004-)
enables cell adhesion molecule binding
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
enables cytoskeletal protein binding
inferred from electronic annotation with InterPro:IPR000798
(InterPro Project Members, 2004-)
Biological Process (34 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Polesello et al., 2002)
involved_in branching involved in open tracheal system development
inferred from mutant phenotype
(Ukken et al., 2014)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Jayanandanan et al., 2014, Carreno et al., 2008)
involved_in cortical microtubule organization
inferred from mutant phenotype
(Solinet et al., 2013)
involved_in determination of left/right symmetry
inferred from mutant phenotype
(Taniguchi et al., 2007)
involved_in epithelial structure maintenance
inferred from mutant phenotype
(Yang et al., 2012)
involved_in establishment or maintenance of epithelial cell apical/basal polarity
inferred from mutant phenotype
(Speck et al., 2003)
inferred from direct assay
(McCartney and Fehon, 1996)
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium
inferred from mutant phenotype
(Speck et al., 2003)
involved_in lumen formation, open tracheal system
inferred from mutant phenotype
(Jayanandanan et al., 2014)
involved_in microtubule anchoring
inferred from mutant phenotype
(Solinet et al., 2013)
involved_in oocyte anterior/posterior axis specification
inferred from mutant phenotype
(Polesello et al., 2002)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Ruan et al., 2013)
involved_in positive regulation of cell population proliferation
inferred from genetic interaction with FLYBASE:conu; FB:FBgn0039994
(Neisch et al., 2013)
involved_in positive regulation of endocytosis
inferred from mutant phenotype
(Schottenfeld-Roames et al., 2014)
involved_in positive regulation of mitotic spindle elongation
inferred from mutant phenotype
(Solinet et al., 2013)
involved_in protein localization to rhabdomere
inferred from mutant phenotype
(Ogi et al., 2019)
involved_in regulation of actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2008)
involved_in regulation of cell shape
inferred from mutant phenotype
(Solinet et al., 2013)
involved_in regulation of membrane potential in photoreceptor cell
inferred from direct assay
(Chorna-Ornan et al., 2005)
involved_in rhabdomere development
inferred from mutant phenotype
(Ogi et al., 2019, Karagiosis and Ready, 2004)
involved_in rhabdomere membrane biogenesis
inferred from mutant phenotype
(Ogi et al., 2019, Karagiosis and Ready, 2004)
involved_in RNA export from nucleus
inferred from mutant phenotype
(Kristó et al., 2017)
Terms Based on Predictions or Assertions (13 terms)
CV Term
Evidence
References
involved_in actin filament-based process
non-traceable author statement
(Baum, 2002)
involved_in anterior/posterior pattern specification
traceable author statement
(Polesello and Payre, 2004)
involved_in cytoskeleton organization
traceable author statement
(Polesello and Payre, 2004)
involved_in establishment or maintenance of apical/basal cell polarity
traceable author statement
(Polesello and Payre, 2004)
involved_in eye photoreceptor cell development
traceable author statement
(Polesello and Payre, 2004)
involved_in intracellular protein localization
traceable author statement
(Polesello and Payre, 2004)
involved_in morphogenesis of an epithelium
traceable author statement
(Polesello and Payre, 2004)
involved_in pole plasm assembly
traceable author statement
(Polesello and Payre, 2004)
involved_in pole plasm protein localization
traceable author statement
(Polesello and Payre, 2004)
involved_in positive regulation of early endosome to late endosome transport
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in positive regulation of protein localization to early endosome
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
involved_in regulation of organelle assembly
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
Cellular Component (20 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
colocalizes_with actin cytoskeleton
inferred from direct assay
(Roch et al., 2010)
colocalizes_with actin filament
inferred from direct assay
(Vilmos et al., 2009)
located_in adherens junction
inferred from direct assay
(McCartney and Fehon, 1996)
located_in apical plasma membrane
inferred from direct assay
(Jayanandanan et al., 2014)
located_in cell cortex
inferred from direct assay
(Roch et al., 2010, Vilmos et al., 2009, Carreno et al., 2008)
located_in cleavage furrow
inferred from direct assay
(Carreno et al., 2008)
colocalizes_with cytoplasm
inferred from direct assay
(Roch et al., 2010)
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Ghimire et al., 2019, Yang et al., 2012)
located_in cytoplasm
inferred from direct assay
(Jayanandanan et al., 2014, Vilmos et al., 2009)
inferred from direct assay
(Kristó et al., 2017)
located_in cytosol
inferred from direct assay
(Solinet et al., 2013)
located_in euchromatin
inferred from direct assay
(Kristó et al., 2017)
is_active_in extrinsic component of cytoplasmic side of plasma membrane
inferred from direct assay
(Shiomi et al., 2021)
located_in mitotic spindle midzone
inferred from direct assay
(Carreno et al., 2008)
colocalizes_with nucleus
inferred from direct assay
(Roch et al., 2010)
located_in nucleus
inferred from direct assay
(Kristó et al., 2017)
inferred from direct assay
(Vilmos et al., 2009)
located_in plasma membrane
inferred from direct assay
(Verdier et al., 2006, de Cuevas et al., 1996, McCartney and Fehon, 1996)
inferred from direct assay
(Solinet et al., 2013)
located_in rhabdomere
inferred from direct assay
(Ogi et al., 2019)
colocalizes_with spindle
inferred from direct assay
(Vilmos et al., 2009)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
is_active_in adherens junction
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
is_active_in apical part of cell
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
located_in cytoplasm
non-traceable author statement
(Polesello and Payre, 2004)
is_active_in filopodium
inferred from biological aspect of ancestor with PANTHER:PTN001150648
(GO Reference Genome Project, 2011-)
is_active_in microvillus
inferred from biological aspect of ancestor with PANTHER:PTN000589934
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000589933
(GO Reference Genome Project, 2011-)
located_in plasma membrane
non-traceable author statement
(Polesello and Payre, 2004)
part_of subapical complex
traceable author statement
(Medina et al., 2002)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Moesin (Moe) encodes an Ezrin, Radixin, Moesin (ERM) protein involved in cortical cytoskeleton stability. It regulates the products of crb and Rho1. The product of Moe contributes to apical-basal polarity, mitotic spindle organisation and epithelial integrity. [Date last reviewed: 2019-03-14]
Protein Function (UniProtKB)
Involved in connections of major cytoskeletal structures to the plasma membrane (PubMed:8666669). Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124). In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles (PubMed:28554770).
(UniProt, P46150)
Summary (Interactive Fly)

the sole Drosophila Ezrin, Radixin, Moesin (ERM) protein - involved in cortical cytoskeleton stability - actin-binding protein - functions to promote cortical actin assembly, apical-basal polarity and mitotic spindle organisation - Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC

Gene Model and Products
Number of Transcripts
13
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\Moe for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P46150)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Moe-RA
FBtr0071271
NM_167169
2353
640
Moe-RB
FBtr0071270
NM_167168
2462
649
Moe-RC
FBtr0071272
NM_167170
2027
512
Moe-RD
FBtr0071269
NM_080343
3003
575
Moe-RE
FBtr0071273
NM_206669
2283
575
Moe-RF
FBtr0071274
NM_206668
2919
575
Moe-RG
FBtr0071275
NM_206667
2295
575
Moe-RH
FBtr0071276
NM_206666
2236
575
Moe-RI
FBtr0071277
NM_206665
2282
575
Moe-RJ
FBtr0071278
NM_206664
2401
578
Moe-RK
FBtr0308193
NM_001258654
3064
646
Moe-RL
FBtr0308194
NM_001258655
2528
578
Moe-RM
FBtr0331601
NM_001272432
2995
584
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Moe-PA
FBpp0071214
75.3
640
5.48
NP_727291
AAF46417
Moe-PB
FBpp0071213
76.2
649
6.02
NP_727290
AAF46416
Moe-PC
FBpp0071215
60.6
512
5.53
NP_727292
AAF46418
Moe-PD
FBpp0071212
67.9
575
5.78
NP_525082
AAF46415
Moe-PE
FBpp0089231
67.9
575
5.78
NP_996392
AAS65294
Moe-PF
FBpp0089232
67.9
575
5.78
NP_996391
AAS65295
Moe-PG
FBpp0089233
67.9
575
5.78
NP_996390
AAS65296
Moe-PH
FBpp0089234
67.9
575
5.78
NP_996389
AAS65297
Moe-PI
FBpp0089235
67.9
575
5.78
NP_996388
AAS65298
Moe-PJ
FBpp0089236
68.1
578
5.78
P46150
NP_996387
AAS65299
Moe-PK
FBpp0300513
75.9
646
6.02
C7LAH9
NP_001245583
AFH07297
Moe-PL
FBpp0300514
68.1
578
5.78
P46150
NP_001245584
AFH07298
Moe-PM
FBpp0303991
68.9
584
5.78
M9PHG2
NP_001259361
AGB95204
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

575 aa isoforms: Moe-PD, Moe-PE, Moe-PF, Moe-PG, Moe-PH, Moe-PI
578 aa isoforms: Moe-PJ, Moe-PL
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with wgn (PubMed:23544124). Interacts with Mer and arm at the adherens junction (PubMed:8666669). Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (PubMed:8666669). Interacts with PCID2 (possibly via FERM domain) (PubMed:28554770).

(UniProt, P46150)
Post Translational Modification

Phosphorylated on Thr-559 (PubMed:18948416). In the oocyte this phosphorylation is induced by phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) generated by sktl (PubMed:18948416).

(UniProt, P46150)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Moe using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.61

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic anal pad
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic small intestine
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
mesothoracic bristle
(Guild et al., 2002)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval proventriculus
(Hegan et al., 2007)
embryonic/larval anterior midgut
(Hegan et al., 2007)
pharate adult stage
rhabdomere
(Karagiosis and Ready, 2004)
adult stage
rhabdomere
(Karagiosis and Ready, 2004)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Moe protein localizes to the base of the rhabdomere, and is seen in this location from about 50% through pupal development.

(Karagiosis and Ready, 2004)

Use of a Moe-GFPfusion construct was used as a marker of actin bundles in 32-56 hour developing pupal bristles in the thorax.

(Guild et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with actin cytoskeleton
inferred from direct assay
(Roch et al., 2010)
colocalizes_with actin filament
inferred from direct assay
(Vilmos et al., 2009)
located_in adherens junction
inferred from direct assay
(McCartney and Fehon, 1996)
located_in apical plasma membrane
inferred from direct assay
(Jayanandanan et al., 2014)
located_in cell cortex
inferred from direct assay
(Roch et al., 2010, Vilmos et al., 2009, Carreno et al., 2008)
located_in cleavage furrow
inferred from direct assay
(Carreno et al., 2008)
colocalizes_with cytoplasm
inferred from direct assay
(Roch et al., 2010)
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Ghimire et al., 2019, Yang et al., 2012)
located_in cytoplasm
inferred from direct assay
(Jayanandanan et al., 2014, Vilmos et al., 2009)
inferred from direct assay
(Kristó et al., 2017)
located_in cytosol
inferred from direct assay
(Solinet et al., 2013)
located_in euchromatin
inferred from direct assay
(Kristó et al., 2017)
is_active_in extrinsic component of cytoplasmic side of plasma membrane
inferred from direct assay
(Shiomi et al., 2021)
located_in mitotic spindle midzone
inferred from direct assay
(Carreno et al., 2008)
colocalizes_with nucleus
inferred from direct assay
(Roch et al., 2010)
located_in nucleus
inferred from direct assay
(Kristó et al., 2017)
inferred from direct assay
(Vilmos et al., 2009)
located_in plasma membrane
inferred from direct assay
(Verdier et al., 2006, de Cuevas et al., 1996, McCartney and Fehon, 1996)
inferred from direct assay
(Solinet et al., 2013)
located_in rhabdomere
inferred from direct assay
(Ogi et al., 2019)
colocalizes_with spindle
inferred from direct assay
(Vilmos et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Moe in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 68 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 98 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Moe
Transgenic constructs containing regulatory region of Moe
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with MoePL106, Scer\GAL4αTub84B.PL
lethal, with MoeTD.UAS.EGFP, Scer\GAL4αTub84B.PL
lethal, with Scer\GAL4αTub84B.PL
lethal | embryonic stage
lethal | larval stage
lethal | pharate adult stage
lethal | pupal stage
lethal | recessive
lethal - all die before end of first instar larval stage, with Scer\GAL4αTub84B.PL
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage
lethal - all die before end of pupal stage | recessive
partially lethal - majority die
partially lethal - majority die, with MoeKN.UASp.GFP, Scer\GAL4αTub84B.PL
partially lethal - majority die, with MoeKNTA.UASp.GFP, Scer\GAL4αTub84B.PL
partially lethal - majority die, with MoeKNTD.UASp.GFP, Scer\GAL4αTub84B.PL
partially lethal - majority die, with MoePL106, Scer\GAL4αTub84B.PL
partially lethal - majority die, with MoeTA.UAS.EGFP, Scer\GAL4αTub84B.PL
partially lethal - majority die | female
partially lethal - majority die | male
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4dpp.blk1
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | female (with MoeG0415)
viable | female (with MoeNES)
viable | male
Sterility
Allele
fertile
fertile | paternal effect
grandchildless | female (with MoeG0415)
grandchildless | female (with MoeNES)
sterile | dominant | maternal effect
sterile | maternal effect (with MoeG0415)
sterile | maternal effect (with MoeNES)
Other Phenotypes
Allele
abnormal developmental rate | female (with MoeG0415)
abnormal developmental rate | female (with MoeNES)
abnormal developmental rate | male
abnormal developmental rate | recessive
abnormal locomotor behavior | male
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4GMR.PF
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4sca-109-68
abnormal size
abnormal size | recessive
abnormal smell perception
abnormal song
decreased size | maternal effect | oogenesis (with MoeG0415)
decreased size | maternal effect | oogenesis (with MoeNES)
decreased size | maternal effect | spermatogenesis (with MoeG0415)
decreased size | maternal effect | spermatogenesis (with MoeNES)
increased cell death, with Scer\GAL4dpp.blk1
increased cell death | recessive
increased cell death | somatic clone | third instar larval stage
increased cell death | somatic clone | third instar larval stage, with MoeKNTD.UASp.GFP, Scer\GAL4αTub84B.PL
increased cell death | somatic clone | third instar larval stage, with MoePL106, Scer\GAL4αTub84B.PL
increased cell death | third instar larval stage
majority die during embryonic stage | maternal effect (with MoeG0415)
majority die during embryonic stage | maternal effect (with MoeNES)
short lived | female | heat sensitive (with MoeG0415)
short lived | female | heat sensitive (with MoeNES)
short lived | male
some die during embryonic stage | maternal effect
some die during first instar larval stage, with Scer\GAL4αTub84B.PL
some die during larval stage
some die during larval stage | maternal effect (with MoeG0415)
some die during larval stage | maternal effect (with MoeNES)
some die during larval stage | recessive
some die during pharate adult stage
some die during P-stage | maternal effect (with MoeG0415)
some die during P-stage | maternal effect (with MoeNES)
some die during pupal stage | recessive
visible
visible, with MoeKN.UASp.GFP, Scer\GAL4αTub84B.PL
visible, with MoeKNTA.UASp.GFP, Scer\GAL4αTub84B.PL
visible, with MoePL106, Scer\GAL4αTub84B.PL
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4MD-638
visible | adult stage | male
visible | adult stage | maternal effect (with MoeG0415)
visible | adult stage | maternal effect (with MoeNES)
Phenotype manifest in
Allele
abdominal tergite | adult stage | maternal effect (with MoeG0415)
abdominal tergite | adult stage | maternal effect (with MoeNES)
apical plasma membrane, with Scer\GAL4bs.PM
basement membrane
crossvein | maternal effect (with MoeG0415)
crossvein | maternal effect (with MoeNES)
cyst progenitor cell, with Scer\GAL4C587
cyst progenitor cell | somatic clone, with Scer\GAL4Act5C.PI
embryonic/first instar larval cuticle | non-rescuable maternal effect
embryonic/larval midgut primordium, with Scer\GAL4byn-Gal4
embryonic abdominal segment | non-rescuable maternal effect
embryonic hindgut, with Scer\GAL4byn-Gal4
eye, with MoeKN.UASp.GFP, Scer\GAL4αTub84B.PL
eye, with MoeKNTA.UASp.GFP, Scer\GAL4αTub84B.PL
eye, with MoeKNTD.UASp.GFP, Scer\GAL4αTub84B.PL
eye, with MoePL106, Scer\GAL4αTub84B.PL
eye, with MoeTA.UAS.EGFP, Scer\GAL4αTub84B.PL
eye, with Scer\GAL4αTub84B.PL
eye | maternal effect (with MoeG0415)
eye | maternal effect (with MoeNES)
eye photoreceptor cell stalk | adult stage
first posterior wing cell
first posterior wing cell, with Scer\GAL4dpp.blk1
germline cell | embryonic stage
germline cell | embryonic stage (with Df(1)KA14)
germline cell | embryonic stage (with MoeEP1652)
germline cell | embryonic stage (with MoeG0323)
germline cell | embryonic stage (with MoeG0415)
germline cell | embryonic stage (with MoeGT193)
imaginal disc
imaginal disc | third instar larval stage
lamina plexus | third instar larval stage
lamina plexus | third instar larval stage, with Scer\GAL4GMR.PF
lamina plexus | third instar larval stage, with Scer\GAL4sca-109-68
male genitalia
male genitalia | absent | maternal effect (with MoeG0415)
male genitalia | absent | maternal effect (with MoeNES)
male germline stem cell | somatic clone, with Scer\GAL4VP16.nanos.-FRT
medulla | third instar larval stage
medulla | third instar larval stage, with Scer\GAL4GMR.PF
medulla | third instar larval stage, with Scer\GAL4sca-109-68
nurse cell & actin filament
nurse cell & actin filament, with Scer\GAL4Moe-PG26
nurse cell & actin filament, with Scer\GAL4VP16.nanos.UTR
ommatidium
ommatidium | somatic clone
oocyte & actin filament
oocyte & actin filament | ectopic, with Scer\GAL4VP16.nanos.UTR
oocyte & cytoskeleton (with MoeEP1652)
oocyte & cytoskeleton (with MoeG0415)
outer photoreceptor cell | pupal stage | somatic clone
ovary | maternal effect (with MoeG0415)
ovary | maternal effect (with MoeNES)
photoreceptor cell R2 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R2 | third instar larval stage
photoreceptor cell R3 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R3 | third instar larval stage
photoreceptor cell R4 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R4 | third instar larval stage
photoreceptor cell R5 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R5 | third instar larval stage
photoreceptor cell R8 | cell autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R8 | somatic clone | third instar larval stage
photoreceptor cell R8 | third instar larval stage
photoreceptor neuron, with MoeRNAi.327-775.UAS, Scer\GAL4GMR.PF
photoreceptor neuron, with MoeRNAi.818-1326.UAS, Scer\GAL4GMR.PF
photoreceptor neuron | somatic clone
presumptive embryonic salivary gland
presumptive embryonic salivary gland, with Scer\GAL4fkh.PH
primordial germ cell | non-rescuable maternal effect
retina, with Scer\GAL4ninaE.PD
rhabdomere & actin filament, with MoeRNAi.327-775.UAS, Scer\GAL4GMR.PF
rhabdomere & actin filament, with MoeRNAi.327-775.UAS, Scer\GAL4hs.PB
rhabdomere & actin filament, with MoeRNAi.818-1326.UAS, Scer\GAL4GMR.PF
rhabdomere & actin filament, with MoeRNAi.818-1326.UAS, Scer\GAL4hs.PB
rhabdomere & actin filament | somatic clone
rhabdomere & cytoskeleton | apical, with Scer\GAL4hs.PB
rhabdomere & microvillus, with Scer\GAL4hs.PB
rhabdomere & plasma membrane | apical, with Scer\GAL4hs.PB
rhabdomere & plasma membrane | apical | somatic clone
rhabdomere microvillus | adult stage
rhabdomere of eye photoreceptor cell | adult stage
rhabdomere of eye photoreceptor cell | pupal stage | somatic clone
spindle, with Scer\GAL4C587
terminal tracheal cell, with Scer\GAL4bs.PM
testis | maternal effect (with MoeG0415)
testis | maternal effect (with MoeNES)
tracheal dorsal trunk primordium
tracheal lumen, with Scer\GAL4bs.PM
wing
wing, with MoeRNAi.327-775.UAS, Scer\GAL4MD-638
wing, with MoeRNAi.818-1326.UAS, Scer\GAL4MD-638
wing, with Scer\GAL4MD-638
wing blade
wing blade, with MoeKN.UASp.GFP, Scer\GAL4αTub84B.PL
wing blade, with MoeKNTA.UASp.GFP, Scer\GAL4αTub84B.PL
wing blade, with MoePL106, Scer\GAL4αTub84B.PL
wing blade, with Scer\GAL4Bx-MS1096
wing blade, with Scer\GAL4dpp.blk1
wing disc
wing disc, with MoeRNAi.327-775.UAS, Scer\GAL4MD-638
wing disc, with MoeRNAi.818-1326.UAS, Scer\GAL4MD-638
wing disc, with Scer\GAL4ap-md544
wing disc | somatic clone | third instar larval stage
wing disc | somatic clone | third instar larval stage, with MoeKNTD.UASp.GFP, Scer\GAL4αTub84B.PL
wing disc | somatic clone | third instar larval stage, with MoePL106, Scer\GAL4αTub84B.PL
wing disc | third instar larval stage
wing disc | third instar larval stage, with Scer\GAL4dpp.blk1
wing hinge
wing hinge, with MoeRNAi.327-775.UAS, Scer\GAL4MD-638
wing hinge, with MoeRNAi.818-1326.UAS, Scer\GAL4MD-638
wing margin | maternal effect (with MoeG0415)
wing margin | maternal effect (with MoeNES)
wing vein, with MoeRNAi.327-775.UAS, Scer\GAL4MD-638
wing vein, with MoeRNAi.818-1326.UAS, Scer\GAL4MD-638
wing vein, with Scer\GAL4dpp.3KK
wing vein L3
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (35)
Hsap\MSN
14 of 14
Yes
Yes
Hsap\EZR
13 of 14
No
Yes
1  
Hsap\RDX
12 of 14
No
Yes
1  
Hsap\NF2
3 of 14
No
No
10  
Hsap\FRMD4A
2 of 14
No
Yes
Hsap\FRMD4B
2 of 14
No
Yes
Hsap\CCDC120
1 of 14
No
Yes
Hsap\EPB41
1 of 14
No
No
Hsap\EPB41L1
1 of 14
No
No
Hsap\EPB41L2
1 of 14
No
No
1  
Hsap\EPB41L3
1 of 14
No
No
Hsap\EPB41L4A
1 of 14
No
No
Hsap\EPB41L4B
1 of 14
No
No
Hsap\EPB41L5
1 of 14
No
No
Hsap\FARP1
1 of 14
No
No
Hsap\FARP2
1 of 14
No
No
Hsap\FRMD1
1 of 14
No
No
Hsap\FRMD3
1 of 14
No
No
Hsap\FRMD5
1 of 14
No
No
7  
Hsap\FRMD6
1 of 14
No
No
Hsap\FRMD7
1 of 14
No
No
Hsap\FRMD8
1 of 14
No
No
Hsap\FRMD8P1
1 of 14
No
No
Hsap\FRMPD2
1 of 14
No
No
Hsap\INAVA
1 of 14
No
Yes
Hsap\KRIT1
1 of 14
No
No
Hsap\LAMB2
1 of 14
No
No
Hsap\MYLIP
1 of 14
No
No
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN13
1 of 14
No
No
Hsap\PTPN14
1 of 14
No
No
Hsap\PTPN21
1 of 14
No
No
Hsap\TLN1
1 of 14
No
No
Hsap\TLN2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (26)
Rnor\Msn
14 of 14
Yes
Yes
Rnor\Ezr
13 of 14
No
Yes
Rnor\Rdx
13 of 14
No
Yes
Rnor\Nf2
3 of 14
No
No
Rnor\Frmd4b
2 of 14
No
Yes
Rnor\Ccdc120
1 of 14
No
Yes
Rnor\Epb41l1
1 of 14
No
No
Rnor\Epb41l2
1 of 14
No
No
Rnor\Epb41l3
1 of 14
No
No
Rnor\Epb41l4b
1 of 14
No
No
Rnor\Epb41l5
1 of 14
No
No
Rnor\Epb41
1 of 14
No
No
Rnor\Farp1
1 of 14
No
No
Rnor\Farp2
1 of 14
No
No
Rnor\Frmd5
1 of 14
No
No
Rnor\Frmd6
1 of 14
No
No
Rnor\Frmd7
1 of 14
No
No
Rnor\Frmd8
1 of 14
No
No
Rnor\Frmpd2
1 of 14
No
Yes
Rnor\Inava
1 of 14
No
Yes
Rnor\Krit1
1 of 14
No
No
Rnor\Ptpn3
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Ptpn13
1 of 14
No
No
Rnor\Ptpn14
1 of 14
No
No
Rnor\Ptpn21
1 of 14
No
No
Mus musculus (laboratory mouse) (29)
Mmus\Msn
14 of 14
Yes
Yes
Mmus\Ezr
13 of 14
No
Yes
Mmus\Rdx
12 of 14
No
Yes
Mmus\Nf2
3 of 14
No
No
Mmus\Frmd4a
2 of 14
No
Yes
Mmus\Frmd4b
2 of 14
No
Yes
Mmus\Frmd7
2 of 14
No
No
Mmus\Ccdc120
1 of 14
No
Yes
Mmus\Epb41l1
1 of 14
No
No
Mmus\Epb41l2
1 of 14
No
No
Mmus\Epb41l3
1 of 14
No
No
Mmus\Epb41l4a
1 of 14
No
No
Mmus\Epb41l4b
1 of 14
No
No
Mmus\Epb41l5
1 of 14
No
No
Mmus\Epb41
1 of 14
No
No
Mmus\Farp1
1 of 14
No
No
Mmus\Farp2
1 of 14
No
No
Mmus\Frmd3
1 of 14
No
No
Mmus\Frmd5
1 of 14
No
No
Mmus\Frmd6
1 of 14
No
No
Mmus\Frmd8
1 of 14
No
No
Mmus\Frmpd2
1 of 14
No
Yes
Mmus\Inava
1 of 14
No
Yes
Mmus\Krit1
1 of 14
No
No
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Ptpn13
1 of 14
No
No
Mmus\Ptpn14
1 of 14
No
No
Mmus\Ptpn21
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\msn
8 of 13
Yes
Yes
Xtro\rdx
7 of 13
No
Yes
Xtro\ezr
6 of 13
No
Yes
Xtro\pdha1
5 of 13
No
No
Xtro\cldn2
1 of 13
No
Yes
Xtro\clk3
1 of 13
No
No
Xtro\epb41l3
1 of 13
No
No
Xtro\farp1
1 of 13
No
No
Xtro\frmd3
1 of 13
No
No
Xtro\frmd4a
1 of 13
No
Yes
Xtro\frmd4b
1 of 13
No
Yes
Xtro\frmd6
1 of 13
No
No
Xtro\frmd7
1 of 13
No
No
Xtro\frmd8
1 of 13
No
No
Xtro\krit1
1 of 13
No
Yes
Xtro\LOC100485014
1 of 13
No
No
Xtro\LOC101731001
1 of 13
No
No
Xtro\mylip
1 of 13
No
No
Xtro\nf2
1 of 13
No
No
Xtro\ptpn14
1 of 13
No
No
Xtro\ptpn21
1 of 13
No
No
Danio rerio (Zebrafish) (39)
Drer\ezra
13 of 14
Yes
Yes
Drer\ezrb
13 of 14
Yes
Yes
Drer\msna
13 of 14
Yes
Yes
Drer\msnb
12 of 14
No
Yes
Drer\nf2a
3 of 14
No
No
Drer\frmd4ba
2 of 14
No
Yes
Drer\nf2b
2 of 14
No
No
Drer\ccdc120a
1 of 14
No
Yes
Drer\ccdc120b
1 of 14
No
Yes
Drer\epb41a
1 of 14
No
No
Drer\epb41b
1 of 14
No
No
Drer\epb41l3a
1 of 14
No
No
Drer\epb41l3b
1 of 14
No
No
Drer\epb41l4a
1 of 14
No
No
Drer\epb41l4b
1 of 14
No
No
Drer\epb41l5
1 of 14
No
No
Drer\farp1
1 of 14
No
No
Drer\farp2
1 of 14
No
No
Drer\frmd3
1 of 14
No
No
Drer\frmd4a
1 of 14
No
No
Drer\frmd4bb
1 of 14
No
No
Drer\frmd5b
1 of 14
No
No
Drer\frmd6
1 of 14
No
No
Drer\frmd7
1 of 14
No
No
Drer\frmd8
1 of 14
No
No
Drer\frmpd2
1 of 14
No
No
Drer\inavaa
1 of 14
No
Yes
Drer\inavab
1 of 14
No
Yes
Drer\krit1
1 of 14
No
Yes
Drer\LOC557811
1 of 14
No
No
Drer\LOC570903
1 of 14
No
No
Drer\mylipa
1 of 14
No
No
Drer\ptpn3
1 of 14
No
No
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\ptpn13
1 of 14
No
Yes
Drer\ptpn21
1 of 14
No
No
Drer\si:dkey-178k16.1
1 of 14
No
No
Drer\zgc:172136
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\erm-1
12 of 14
Yes
Yes
Cele\nfm-1
2 of 14
No
No
Cele\epi-1
1 of 14
No
No
Cele\F07C6.4
1 of 14
No
Yes
Cele\frm-1
1 of 14
No
No
Cele\frm-2
1 of 14
No
No
Cele\frm-3
1 of 14
No
No
Cele\frm-4
1 of 14
No
No
Cele\frm-5.1
1 of 14
No
Yes
Cele\frm-5.2
1 of 14
No
No
Cele\frm-7
1 of 14
No
No
Cele\frm-10
1 of 14
No
No
Cele\ptp-1
1 of 14
No
No
Cele\tln-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (15)
Agam\MOEH_ANOGA
11 of 12
Yes
Yes
Agam\AgaP_AGAP010346
3 of 12
No
No
Agam\AgaP_AGAP001287
1 of 12
No
No
Agam\AgaP_AGAP001609
1 of 12
No
No
Agam\AgaP_AGAP001632
1 of 12
No
No
Agam\AgaP_AGAP002678
1 of 12
No
No
Agam\AgaP_AGAP004136
1 of 12
No
No
Agam\AgaP_AGAP007130
1 of 12
No
No
Agam\AgaP_AGAP007474
1 of 12
No
No
Agam\AgaP_AGAP008413
1 of 12
No
No
Agam\AgaP_AGAP008811
1 of 12
No
No
Agam\AgaP_AGAP009126
1 of 12
No
No
Agam\AgaP_AGAP009975
1 of 12
No
No
Agam\AgaP_AGAP012185
1 of 12
No
No
Agam\AgaP_AGAP013042
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Moe. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
Mer
5 of 13
Bili
1 of 13
Cdep
1 of 13
CG34347
1 of 13
cora
1 of 13
dnr1
1 of 13
ex
1 of 13
Frmd5
1 of 13
Pez
1 of 13
Ptpmeg
1 of 13
rhea
1 of 13
sstn
1 of 13
yrt
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Human Ortholog
    Disease
    Evidence
    References
    MSN; moesin
    model of  immunodeficiency 50
    IEA
    (FlyBase, 2019-)
    RDX; radixin
    model of  autosomal recessive nonsyndromic deafness 24
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MSN; moesin
    14 of 14
    309845
    EZR; ezrin
    13 of 14
    123900
         
        RDX; radixin
        12 of 14
        179410
         
        NF2; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
        3 of 14
        NF2, MOESIN-EZRIN-RADIXIN-LIKE (MERLIN) TUMOR SUPPRESSOR; NF2
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Moe - Acaa
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Act5C
        bimolecular fluorescence complementation, fluorescence microscopy
        (Kristó et al., 2024)
        Moe - Akap200
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - AnxB10
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Ar1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Ar2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Ar5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Bacc
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - CG10939
        anti tag coimmunoprecipitation, western blot, two hybrid, anti tag western blot
        (Hughes et al., 2010)
        Moe - CG11267
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - CG14715
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - CG2852
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - CG4598
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Calr
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Chd64
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Cndp2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Df31
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Eb1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - EndoGI
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Eno
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Fim
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Fkbp12
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Fkbp14
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Gdi
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - GstE6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - GstO3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Gtpx
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - HINT1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Hsf
        bimolecular fluorescence complementation, fluorescence microscopy, pull down, anti tag western blot
        (Kristó et al., 2024)
        Moe - Hsp110
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Inos
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Lamp1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - MED15
        comigration in non denaturing gel electrophoresis, western blot, anti tag western blot, pull down, autoradiography, bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Kristó et al., 2024)
        Moe - MED17
        pull down, anti tag western blot
        (Kristó et al., 2024)
        Moe - MED6
        anti tag coimmunoprecipitation, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy, Identification by mass spectrometry
        (Kristó et al., 2024)
        Moe - Mdh2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Men
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Nacα
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Nlp
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Nrd1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Yoon et al., 2017)
        Moe - Ntf-2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - PCID2
        anti tag coimmunoprecipitation, western blot
        (Kristó et al., 2017)
        Moe - PCNA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - PHDP
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Moe - Patj
        anti bait coimmunoprecipitation, western blot
        (Medina et al., 2002)
        Moe - Pdi
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Pgam1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Pgd
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Pgk
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Pp1-87B
        anti tag coimmunoprecipitation, western blot
        (Rodrigues et al., 2015)
        Moe - Prosα1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Prosβ5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Prx6c
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Rab11
        pull down, western blot, peptide massfingerprinting, anti tag western blot
        (Ramel et al., 2013)
        Moe - Rho1
        pull down, western blot
        (Bagci et al., 2020)
        Moe - RhoGDI
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Sema1a
        anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
        (Hsieh et al., 2014)
        Moe - Sh3β
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Slik
        pull down, autoradiography, enzymatic study
        (De Jamblinne et al., 2020, Panneton et al., 2015, Hughes and Fehon, 2006)
        Moe - Stip1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Sumo
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - TER94
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Taldo
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Tkt
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Trxr1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Tudor-SN
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - Uch
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - awd
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - btsz
        pull down, anti tag western blot, western blot, two hybrid
        (Pilot et al., 2006)
        Moe - cPges
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - capt
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - chic
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - cib
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - conu
        anti tag coimmunoprecipitation, anti tag western blot, western blot, two hybrid
        (Neisch et al., 2013)
        Moe - crb
        anti bait coimmunoprecipitation, western blot
        (Medina et al., 2002)
        Moe - eEF1δ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - eEF2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - eEF5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - fabp
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - fax
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - flr
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - flw
        pull down, autoradiography
        (Yang et al., 2012)
        Moe - msn
        enzymatic study, autoradiography
        (Plutoni et al., 2019)
        Moe - regucalcin
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - scf
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - scu
        experimental knowledge based
        (Guruharsha et al., 2011)
        Moe - wgn
        pull down, anti tag western blot
        (Ruan et al., 2013)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Moe
        enhanceable
        conu
        (Neisch et al., 2013)
        Moe
        suppressible
        conu
        (Neisch et al., 2013)
        puc|Moe
        suppressible
        hep
        (Neisch et al., 2010)
        puc|Moe
        suppressible
        POSH
        (Neisch et al., 2010)
        Moe
        enhanceable
        puc
        (Neisch et al., 2010)
        Moe
        suppressible
        Rho1
        (Neisch et al., 2010, Molnar and de Celis, 2006, Speck et al., 2003)
        puc|Moe
        suppressible
        Rho1
        (Neisch et al., 2010)
        Moe
        suppressible
        Rok
        (Speck et al., 2003)
        puc|Moe
        suppressible
        slpr
        (Neisch et al., 2010)
        Moe
        enhanceable
        smo
        (Molnar and de Celis, 2006)
        puc|Moe
        suppressible
        Tak1
        (Neisch et al., 2010)
        Moe
        suppressible
        zip
        (Speck et al., 2003)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        CG10939
        enhanceable
        Moe
        (Hughes et al., 2010)
        crb
        suppressible
        Moe
        (Flores-Benitez and Knust, 2015)
        dsh
        suppressible
        Moe
        (Speck et al., 2003)
        Nsf2
        suppressible
        Moe
        (Laviolette et al., 2005)
        pbl
        enhanceable
        Moe
        (Gregory et al., 2007)
        rib
        suppressible
        Moe
        (Kerman et al., 2008)
        Slik
        suppressible
        Moe
        (Hipfner et al., 2004)
        Smn
        suppressible
        Moe
        (Chang et al., 2008)
        Syx7
        suppressible
        Moe
        (Schottenfeld-Roames et al., 2014)
        wgn
        enhanceable
        Moe
        (Ruan et al., 2013)
        External Data
        Subunit Structure (UniProtKB)
        Interacts with wgn (PubMed:23544124). Interacts with Mer and arm at the adherens junction (PubMed:8666669). Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (PubMed:8666669). Interacts with PCID2 (possibly via FERM domain) (PubMed:28554770).
        (UniProt, P46150 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-25
        Cytogenetic map
        8B4-8B6
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        8B4-8B6
        (determined by in situ hybridisation); Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        8B4-8B4
        (determined by in situ hybridisation)
        (Molnar et al., 2006)
        8B1-8B4
        (determined by in situ hybridisation) 8B3--7 (determined by in situ hybridisation)
        (Peter et al., 2002, Schäfer et al., 1999.8.12)
        8B-8B
        (Edwards, 1994.3.30)
        8B1-8B4
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.6.15)
        8E3-8E4
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.3.29)
        8B-8C
        (Akaboshi and Inoue, 1997)
        Experimentally Determined Recombination Data
        Location

        1-25

        (FlyBase, 2016)

        1-26.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (88)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (401)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Bajusz et al., 2021)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
        Other Stable Cell Lines
         
          Other Comments

          The effect of slik on Mer is not mediated through its effects on Moe activation.

          (Hughes and Fehon, 2006)

          Mutations that impair phosphorylation of Moe abolish the movement of Moe upon illumination and result in light-activated degeneration of the photoreceptor cells.

          (Chorna-Ornan et al., 2005)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

          (Rogers et al., 2003)

          Moe is required to maintain apical-basal polarity, epithelial integrity and correct actin distribution in imaginal disc cells.

          (Speck et al., 2003)

          Mutant phenotypes include lethality, female sterility and imperfect eye and wing development, in addition to a maternal effect loss of germ cells in embryos.

          (Jankovics et al., 2002)

          Alteration of the actin cytoskeleton in oocytes resulting from Moe mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. Moe mutations also lead to defects in the actin cytoskeleton of nurse cells and consequently produce severe defects in nurse-cell shape.

          (Polesello et al., 2002)

          Moe is required during oogenesis for anchoring microfilaments to the oocyte cortex.

          (Polesello et al., 2002)

          Transcript induced by MMS treatment of S1CII cells.

          (Akaboshi and Inoue, 1997)

          Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm.

          (McCartney and Fehon, 1996)

          The Moe gene product is not a component of fusome.

          (de Cuevas et al., 1996)

          A yeast phenotypic screen efficiently identifies conserved genes from more complex organisms and sheds light on their potential in vivo functions. Induced expression of Moe proteins causes aberrant cell shapes reflecting defects in cytokinesis and/or cell shape maintenance.

          (Edwards et al., 1994)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Moe l(1)G0323

          (Speck et al., 2003)

          Source for merge of: Moe l(1)G0415

          (Jankovics et al., 2002)

          Source for merge of: Moe anon-WO03040301.155 anon-WO03040301.157 anon-WO03040301.159 anon-WO03040301.161

          (FlyBase, 1996-)
          Additional comments

          "l(1)G0187" may affect "Moe".

          (Peter et al., 2002)

          Source for merge of Moe anon-WO03040301.155 anon-WO03040301.157 anon-WO03040301.159 anon-WO03040301.161 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (32)
          Reported As
          Symbol Synonym
          CG10701
          (Trivedi et al., 2020, Schwartz et al., 2016, Balakrishnan et al., 2015, Hosono et al., 2015, Ramel et al., 2013, Christis and Munro, 2012, Yano et al., 2012, Kim et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Perkins et al., 2009, Chang et al., 2008, Ni et al., 2008, Stuart et al., 2007, Molnar et al., 2006, Laviolette et al., 2005, Rogers et al., 2003, Bourbon et al., 2002, Goldstein and Gunawardena, 2000)
          D17
          (Edwards et al., 1994)
          DMoe
          (Flores-Benitez and Knust, 2015)
          Dmoe
          (Bajur et al., 2019, McNeil et al., 2009, Seabrooke and Stewart, 2008, Polesello and Payre, 2004, Jankovics et al., 2002, Medina et al., 2002, Polesello et al., 2002)
          EMR1
          (Winge, 1995.3.30)
          ERM
          (Nikiforova and Fehon, 2002)
          Emr1
          GMA
          (Franz et al., 2018)
          Moe
          (Davis et al., 2025, Klimkowski Arango and Morgante, 2025, Kong et al., 2025, Merle et al., 2025, Ghosh and Treisman, 2024, Tang et al., 2024, Barbaste et al., 2023, Burghardt et al., 2023, Cabrera et al., 2023, Nagao and Umeda, 2023, Zhao et al., 2023, Jia et al., 2022, van de Leemput et al., 2022, Bajusz et al., 2021, Biehler et al., 2021, Garland et al., 2021, Järvelä-Stölting et al., 2021, Pang et al., 2021, Raun et al., 2021, Shiomi et al., 2021, Canales Coutiño et al., 2020, De Jamblinne et al., 2020, Lecheta et al., 2020, Raghuraman et al., 2020, Fouchécourt et al., 2019, Ghimire et al., 2019, Jiang and Harris, 2019, Lattner et al., 2019, Ogi et al., 2019, Xu et al., 2019, Yee et al., 2019, Gene Disruption Project members, 2018-, Lee et al., 2018, Molinar-Inglis et al., 2018, Zhang et al., 2018, Chanet et al., 2017, Kristó et al., 2017, Salis et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, David-Morrison et al., 2016, Duque and Gorfinkiel, 2016, Flores-Benitez and Knust, 2016, Silva et al., 2016, Wang et al., 2016, Yadav et al., 2016, Miao and Hayashi, 2015, Panneton et al., 2015, Sabino et al., 2015, Sherrard and Fehon, 2015, Ashwal-Fluss et al., 2014, Butí et al., 2014, Hsieh et al., 2014, Luck et al., 2014, Pézeron et al., 2014, Schottenfeld-Roames et al., 2014, Ukken et al., 2014, Fuse et al., 2013, Klose et al., 2013, Kwon et al., 2013, Nakajima et al., 2013, Neisch et al., 2013, Salzmann et al., 2013, Sen et al., 2013, Sengupta et al., 2013, Song et al., 2013, Terriente-Felix et al., 2013, Förster and Luschnig, 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Letizia et al., 2011, Mukherjee et al., 2011, Xu et al., 2011, Blanchard et al., 2010, David et al., 2010, Forster et al., 2010, Foussard et al., 2010, Georgiou and Baum, 2010, Gervais and Casanova, 2010, Hughes et al., 2010, Ling et al., 2010, Monier et al., 2010, Neisch et al., 2010, Neubueser and Hipfner, 2010, Popodi et al., 2010-, Robinson et al., 2010, Roch et al., 2010, Simone and DiNardo, 2010, Tajiri et al., 2010, Dworkin et al., 2009, Genevet et al., 2009, Grusche et al., 2009, Moran and Kyriacou, 2009, Solon et al., 2009, Vilmos et al., 2009, Wolfstetter et al., 2009, Zanet et al., 2009, Carreno et al., 2008, Cavey et al., 2008, Chang et al., 2008, Cheshire et al., 2008, Gervais et al., 2008, Homem and Peifer, 2008, Kunda et al., 2008, Rauzi et al., 2008, Toyama et al., 2008, Bakal et al., 2007, Fox and Peifer, 2007, Garcia et al., 2007, Kerman et al., 2007, Li et al., 2007, Macdonald and Long, 2007, Nishimura et al., 2007, Polesello and Tapon, 2007, Robida et al., 2007, Stuart et al., 2007, Taniguchi et al., 2007, Blankenship et al., 2006, Hughes and Fehon, 2006, Jankovics and Brunner, 2006, Molnar et al., 2006, Ramos et al., 2006, Cabernard and Affolter, 2005)
          Moes
          (Sen et al., 2013)
          Moesin
          (Colombani and Andersen, 2023, Vedelek et al., 2021, Colombié et al., 2017, Yoon et al., 2017, Bielmeier et al., 2016)
          anon-WO03040301.155
          anon-WO03040301.157
          anon-WO03040301.159
          anon-WO03040301.161
          dMoe
          (Foussard et al., 2007)
          gma
          (Schönbauer et al., 2011)
          l(1)G0067
          (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
          l(1)G0323
          (Schäfer et al., 1999.6.15)
          l(1)G0404
          (Schäfer et al., 1999.8.12)
          l(1)G0415
          (Schäfer et al., 1999.8.12)
          moe
          (Balachandra and Amodeo, 2025, Sutton et al., 2024, Li et al., 2022, Ricolo et al., 2021, Wolterhoff et al., 2020, Pinheiro et al., 2017, Vilmos et al., 2016, Siegenthaler et al., 2015, Boukhatmi et al., 2014, Chen and Krasnow, 2014, Claret et al., 2014, Claret et al., 2014, Ruan et al., 2013, Boukhatmi et al., 2012, Abruzzi et al., 2011, Araújo and Casanova, 2011, Cobreros-Reguera et al., 2010, Khuong et al., 2010, Khuong et al., 2010, Renault et al., 2010, Wang et al., 2010, Weil et al., 2010, Layton et al., 2009, McNeil et al., 2009, Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009, Sawyer et al., 2009, Vlisidou et al., 2009, Wang et al., 2009, Caussinus et al., 2008, Kerman et al., 2008, Rodriguez-Diaz et al., 2008, Royou et al., 2008, Chanut-Delalande et al., 2007, Inoue and Hayashi, 2007, Tsarouhas et al., 2007, Molnar and de Celis, 2006, Keleman et al., 2005, Laviolette et al., 2005, Sano et al., 2005, Ribeiro et al., 2004, Bourbon et al., 2002, Edwards et al., 1997)
          moesin
          (Salis et al., 2017, Rodrigues et al., 2015)
          moesin/ezrin/radixin homolog mRNA
          (Edwards, 1994.3.30)
          p-Moesin
          (Roberto and Emery, 2022)
          Name Synonyms
          DMoesin
          (Verdier et al., 2006, Williams et al., 2004, Medina et al., 2003, Müller and Bossinger, 2003, Knust and Bossinger, 2002, Medina et al., 2002, Medina et al., 2002)
          Dmoesin
          (Chen and Zhang, 2013, McNeil et al., 2009, Parnas et al., 2009, Hegan et al., 2007, Suzuki and Ohno, 2006, Chorna-Ornan et al., 2005, Batchelor et al., 2004, Polesello and Payre, 2004, Cereijido et al., 2003, Gibson and Perrimon, 2003, Karagiosis and Ready, 2003, Miller, 2003, Anonymous, 2002, Baum, 2002, Karagiosis and Ready, 2002, Muller, 2000, de Cuevas et al., 1996, McCartney and Fehon, 1996, Fehon, 1995.1.12, McCartney and Fehon, 1995, McCartney and Fehon, 1994)
          Ezrin-Radixin-Moesin
          (Pilot et al., 2006)
          Ezrin-moesin-radixin-1
          Moesin
          (Koehler and Huber, 2023, Pradhan et al., 2023, Buckley and St Johnston, 2022, Barrera-Velázquez and Ríos-Barrera, 2021, Aguilar-Aragon et al., 2020, Finegan and Bergstralh, 2020, Wang et al., 2020, Lim et al., 2019, Saito et al., 2018, Schmidt and Grosshans, 2018, Freymuth and Fitzsimons, 2017, Battistini and Tamagnone, 2016, Duque and Gorfinkiel, 2016, Schimizzi et al., 2016, Wang et al., 2016, Chakrabarti et al., 2015, Holly et al., 2015, Sabino et al., 2015, Sherrard and Fehon, 2015, Bausek and Zeidler, 2014, Carvalho et al., 2014, Hsieh et al., 2014, Jayanandanan et al., 2014, Schottenfeld-Roames et al., 2014, Tan et al., 2014, Ukken et al., 2014, Antunes et al., 2013, Guillot and Lecuit, 2013, Manhire-Heath et al., 2013, Solinet et al., 2013, Förster and Luschnig, 2012, Kunda et al., 2012, Tepass, 2012, Yano et al., 2012, Zanet et al., 2012, Zoller and Schulz, 2012, Cohen et al., 2011, Galy et al., 2011, Letizia et al., 2011, Mukherjee et al., 2011, Olguín et al., 2011, Rotkopf et al., 2011, Tucker et al., 2011, Blanchard et al., 2010, David et al., 2010, Foussard et al., 2010, Hughes et al., 2010, Khuong et al., 2010, Ling et al., 2010, Neisch et al., 2010, Neubueser and Hipfner, 2010, Robinson et al., 2010, Roch et al., 2010, Siekhaus et al., 2010, Tajiri et al., 2010, Bradu et al., 2009, Genevet et al., 2009, Grusche et al., 2009, Hijazi et al., 2009, Lebo et al., 2009, Liu et al., 2009, Martin et al., 2009, Massarwa et al., 2009, Solon et al., 2009, Webb et al., 2009, Cao et al., 2008, Carreno et al., 2008, Chang et al., 2008, Cheshire et al., 2008, Gervais et al., 2008, Homem and Peifer, 2008, Hoopfer et al., 2008, Kerman et al., 2008, Kunda et al., 2008, Millard and Martin, 2008, Bakal et al., 2007, Besse et al., 2007, Gregory et al., 2007, Kerman et al., 2007, Mitonaka et al., 2007, Neisch et al., 2007, Polesello and Tapon, 2007, Prasad and Montell, 2007, Riggs et al., 2007, Baum, 2006, Blankenship et al., 2006, Fehon, 2006, Hughes and Fehon, 2006, Medina et al., 2006, Pilot et al., 2006, Price et al., 2006, Sambandan et al., 2006, Schneider et al., 2006, Silva et al., 2006, Walters et al., 2006, Weis and Nelson, 2006, Fox et al., 2005, Schwabe et al., 2005, de Heredia and Jansen, 2004, Rogers et al., 2003)
          Moesin-like
          (Moran and Kyriacou, 2009)
          dMoesin
          (Carreno et al., 2007, Foussard et al., 2007, Roubinet et al., 2007)
          moesin
          (Campanale et al., 2022, Davidson and Wood, 2020, Popkova et al., 2020, Wolterhoff et al., 2020, Chang et al., 2019, Deneke et al., 2019, Franz et al., 2018, Hayes and Solon, 2017, Hunter et al., 2015, Rodrigues et al., 2015, Siegenthaler et al., 2015, Fernandez-Gonzalez and Zallen, 2013, Manning et al., 2013, Peters et al., 2013, Song et al., 2013, Sano et al., 2012, Wheeler et al., 2012, Abreu-Blanco et al., 2011, Boggiano et al., 2011, Cheng et al., 2011, Fernandez-Gonzalez and Zallen, 2011, Geiger et al., 2011, Hatan et al., 2011, Kanesaki et al., 2011, Parkhurst, 2011.4.14, Cohen et al., 2010, Fabian et al., 2010, Fishilevich et al., 2010, Gervais and Casanova, 2010, He et al., 2010, Khuong et al., 2010, Okumura et al., 2010, Roch et al., 2010, Sekyrova et al., 2010, Kaido et al., 2009, Leiss et al., 2009, Ma et al., 2009, Sawyer et al., 2009, Sheng et al., 2009, Vilmos et al., 2009, Vlisidou et al., 2009, Wang et al., 2009, Widmann and Dahmann, 2009, Carreno et al., 2008, Cavey et al., 2008, Kakihara et al., 2008, Royou et al., 2008, Seabrooke and Stewart, 2008, Shindo et al., 2008, Stramer et al., 2008, Weil et al., 2008, Fox and Peifer, 2007, Inoue and Hayashi, 2007, Kondo et al., 2007, Maddox et al., 2007, Seabrooke and Stewart, 2007, Tsarouhas et al., 2007, Wada et al., 2007, Franke et al., 2006, Hozumi et al., 2006, Laplante and Nilson, 2006, Oshima, 2006, Oshima et al., 2006, Peyre et al., 2006, Pilot et al., 2006, Golovnina et al., 2005, Sano et al., 2005, Stramer et al., 2005, Harris and Peifer, 2004, Somogyi and Rorth, 2004, Fei et al., 2002, Dorman et al., 2000, Dove, 2000, Turunen et al., 1998)
          pMoesin
          (Madsen et al., 2015)
          Secondary FlyBase IDs
          • FBgn0013950
          • FBgn0014345
          • FBgn0026689
          • FBgn0027218
          • FBgn0028282
          • FBgn0028289
          • FBgn0066841
          • FBgn0066842
          • FBgn0066843
          • FBgn0066844
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
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          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 110 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (595)