FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rho1
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General Information
Symbol
Dmel\Rho1
Species
D. melanogaster
Name
Rho1
Annotation Symbol
CG8416
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014020
Gene Model Status
Current
Stock Availability
49 publicly available
Gene Summary
Rho1 (Rho1) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, microtubule dynamics, mophogenesis, border cell migration, cytokinesis, and wound repair. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

RhoA, Rho, Rho GTPase, Rho kinase, DrhoA

Key Links
Genomic Location
Cytogenetic map
52E5-52E5
Sequence location
Recombination map
2-77
RefSeq locus
NT_033778 REGION:16102687..16107229
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (84 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables GTPase activity
inferred from direct assay
(Raymond et al., 2001)
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Denholm et al., 2005)
inferred from genetic interaction with FLYBASE:RhoGAPp190; FB:FBgn0026375
(Billuart et al., 2001)
inferred from genetic interaction with FLYBASE:RhoGEF64C; FB:FBgn0035574
(Simões et al., 2006)
enables kinase binding
inferred from physical interaction with FLYBASE:Rok; FB:FBgn0026181
(Winter et al., 2001)
enables protein binding
inferred from physical interaction with UniProtKB:A1Z7T0
(Betson and Settleman, 2007, Lu and Settleman, 1999)
inferred from physical interaction with FLYBASE:Rok; FB:FBgn0026181
(Mizuno et al., 1999)
inferred from physical interaction with FLYBASE:wash; FB:FBgn0033692
(Liu et al., 2009)
inferred from physical interaction with UniProtKB:P48554
(Lu and Settleman, 1999)
inferred from physical interaction with FLYBASE:pbl; FB:FBgn0003041
(Prokopenko et al., 1999)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
enables GTPase activity
traceable author statement
(Hanlon and Andrew, 2015)
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN008393484
(GO Reference Genome Project, 2011-)
Biological Process (70 terms)
Terms Based on Experimental Evidence (65 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from direct assay
(Abreu-Blanco et al., 2014)
inferred from mutant phenotype
(Abreu-Blanco et al., 2014, Padash Barmchi et al., 2005)
involved_in actin filament bundle assembly
inferred from mutant phenotype
(Wood et al., 2002)
involved_in actin filament organization
inferred from mutant phenotype
(Yan et al., 2009)
involved_in actin-mediated cell contraction
inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719
(Manning et al., 2013)
involved_in adherens junction maintenance
inferred from mutant phenotype
(Yashiro et al., 2014)
involved_in apical constriction
inferred from mutant phenotype
(Vishwakarma et al., 2022)
involved_in axon guidance
inferred from mutant phenotype
(Fritz and VanBerkum, 2002)
involved_in border follicle cell migration
inferred from mutant phenotype
(Gabbert et al., 2023, Zhou et al., 2022, Bastock and Strutt, 2007)
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Widmann and Dahmann, 2009)
involved_in cell projection organization
inferred from mutant phenotype
(Zhou et al., 2022)
involved_in cellularization
inferred from mutant phenotype
(Padash Barmchi et al., 2005)
involved_in compound eye morphogenesis
inferred from genetic interaction with FLYBASE:p120ctn; FB:FBgn0260799
(Larson et al., 2008)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Zhou et al., 2022, Jean et al., 2012, Denholm et al., 2005)
involved_in dendrite self-avoidance
inferred from genetic interaction with FLYBASE:stan; FB:FBgn0024836
(Matsubara et al., 2011)
involved_in determination of left/right symmetry
inferred from mutant phenotype
(Taniguchi et al., 2007)
involved_in dorsal closure, leading edge cell differentiation
inferred from mutant phenotype
(Jacinto et al., 2002)
involved_in dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(Jacinto et al., 2002)
involved_in dorsal closure
inferred from mutant phenotype
(Bloor and Kiehart, 2002)
inferred from mutant phenotype
(Lu and Settleman, 1999)
involved_in endocytic recycling
inferred from mutant phenotype
(Yashiro et al., 2014)
involved_in endocytosis
inferred from mutant phenotype
(Magie and Parkhurst, 2005)
involved_in establishment of planar polarity of embryonic epithelium
inferred from mutant phenotype
(Simões et al., 2014)
involved_in establishment of protein localization
inferred from mutant phenotype
(Dean et al., 2005)
involved_in establishment or maintenance of actin cytoskeleton polarity
inferred from mutant phenotype
(Simões et al., 2014)
involved_in gastrulation involving germ band extension
inferred from mutant phenotype
(Barrett et al., 1997)
involved_in germ-band extension
inferred from mutant phenotype
(Barrett et al., 1997)
involved_in glial cell migration
inferred from mutant phenotype
(Sepp and Auld, 2003)
involved_in hemocyte migration
inferred from mutant phenotype
(Stramer et al., 2005)
involved_in imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Manning et al., 2013)
involved_in imaginal disc-derived wing hair organization
inferred from mutant phenotype
(Yan et al., 2009)
inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085
(Winter et al., 2001)
involved_in lumen formation, open tracheal system
inferred from mutant phenotype
(Lee and Kolodziej, 2002)
involved_in maintenance of epithelial cell apical/basal polarity
inferred from mutant phenotype
(Xu et al., 2008)
involved_in melanization defense response
inferred from mutant phenotype
(Bidla et al., 2007)
involved_in mitotic actomyosin contractile ring assembly
inferred from mutant phenotype
(Prokopenko et al., 1999)
involved_in mitotic cytokinesis, division site positioning
inferred from expression pattern
(di Pietro et al., 2023)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Dean et al., 2005, Somma et al., 2002)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Dorsten et al., 2007)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Greer et al., 2013)
involved_in neuroblast proliferation
inferred from mutant phenotype
(Lee et al., 2000)
involved_in neuron projection morphogenesis
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in open tracheal system development
inferred from mutant phenotype
(Lovegrove et al., 2006, Matusek et al., 2006)
involved_in peripheral nervous system development
inferred from mutant phenotype
(Sepp and Auld, 2003, Sepp and Auld, 2003)
involved_in positive regulation of protein serine/threonine kinase activity
inferred from direct assay
(Lu and Settleman, 1999)
involved_in positive regulation of wound healing
inferred from direct assay
(Abreu-Blanco et al., 2014)
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
involved_in posterior midgut invagination
inferred from mutant phenotype
(Barrett et al., 1997)
involved_in protein localization involved in establishment of planar polarity
inferred from mutant phenotype
(Simões et al., 2014)
involved_in protein localization to adherens junction
inferred from mutant phenotype
(Simões et al., 2014)
involved_in pseudocleavage involved in syncytial blastoderm formation
inferred from mutant phenotype
(Webb et al., 2009)
involved_in regulation of actomyosin structure organization
inferred from genetic interaction with FLYBASE:dia; FB:FBgn0011202
(Homem and Peifer, 2008)
involved_in regulation of axonogenesis
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
(Ng and Luo, 2004)
involved_in regulation of cell migration
inferred from mutant phenotype
(Verboon et al., 2015)
involved_in regulation of cytoskeleton organization
inferred from direct assay
(Liu et al., 2009)
involved_in regulation of embryonic cell shape
inferred from mutant phenotype
(Xu et al., 2008)
involved_in regulation of filopodium assembly
inferred from mutant phenotype
(Bausek and Zeidler, 2014)
involved_in regulation of locomotor rhythm
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in regulation of Malpighian tubule size
inferred from mutant phenotype
(Denholm et al., 2005)
involved_in regulation of myoblast fusion
inferred from genetic interaction with FLYBASE:Rok; FB:FBgn0026181
(Kim et al., 2015)
inferred from genetic interaction with FLYBASE:kirre; FB:FBgn0028369
(Kim et al., 2015)
inferred from genetic interaction with FLYBASE:Ced-12; FB:FBgn0032409
(Kim et al., 2015)
involved_in regulation of tube length, open tracheal system
inferred from mutant phenotype
(Chung et al., 2009)
involved_in response to wounding
inferred from mutant phenotype
(Nakamura et al., 2017)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Xu et al., 2008)
involved_in spiracle morphogenesis, open tracheal system
inferred from mutant phenotype
(Simões et al., 2006)
involved_in tracheal pit formation in open tracheal system
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Brodu and Casanova, 2006)
involved_in ventral furrow formation
inferred from mutant phenotype
(Barrett et al., 1997)
involved_in wound healing
inferred from mutant phenotype
(Wood et al., 2002)
inferred from high throughput mutant phenotype
(Campos et al., 2010)
NOT involved_in dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
NOT involved_in myofibril assembly
inferred from mutant phenotype
(Bloor and Kiehart, 2001)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN001178055
(GO Reference Genome Project, 2011-)
involved_in dendrite morphogenesis
traceable author statement
(Gao and Bogert, 2003)
involved_in regulation of actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN008393484
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
involved_in small GTPase-mediated signal transduction
inferred from electronic annotation with InterPro:IPR003578
(InterPro Project Members, 2004-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Simões et al., 2006)
colocalizes_with apical plasma membrane
inferred from direct assay
(Rousso et al., 2013)
located_in cell cortex
inferred from direct assay
(Rosales-Nieves et al., 2006)
located_in cell hair
inferred from direct assay
(Yan et al., 2009)
located_in cell-cell contact zone
inferred from direct assay
(Kim et al., 2015)
is_active_in cleavage furrow rim
inferred from direct assay
(di Pietro et al., 2023)
located_in cytoplasm
inferred from direct assay
(Yan et al., 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN008393484
(GO Reference Genome Project, 2011-)
traceable author statement
(Hanlon and Andrew, 2015)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. (P48148)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rho1 (Rho1) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, microtubule dynamics, mophogenesis, border cell migration, cytokinesis, and wound repair. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Protein Function (UniProtKB)
Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867, PubMed:10556060). During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340). Involved in targeted recruitment of dia/diaphanous to apical membranes of polarized epithelial cells (PubMed:23853710).
(UniProt, P48148)
Summary (Interactive Fly)

rho-subfamily GTPase - a molecular switch and functions as key regulator of the actin cytoskeleton in concert with DRhoGEF2, Rho1 mediates specific cell shape changes during gastrulation in response to the extracellular ligand, Folded gastrulation - plays a central role in actin cytoskeleton organization, microtubule dynamics, mophogenesis, border cell migration, cytokinesis, and wound repair

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rho1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P48148)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rho1-RA
FBtr0087211
NM_057750
1288
192
Rho1-RB
FBtr0087212
NM_134308
2028
192
Rho1-RC
FBtr0087213
NM_134309
1899
192
Rho1-RD
FBtr0087214
NM_166139
1170
192
Rho1-RF
FBtr0087216
NM_206128
1971
192
Rho1-RG
FBtr0087217
NM_206127
1977
192
Additional Transcript Data and Comments
Reported size (kB)

3.7, 3.1, 2.1 (northern blot); 1.3 (unknown)

(Magie et al., 1999)

1.467 (longest cDNA)

(Hariharan et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rho1-PA
FBpp0086353
21.7
192
7.06
P48148
NP_477098
AAM70944
Rho1-PB
FBpp0086354
21.7
192
7.06
P48148
NP_599135
AAF58066
Rho1-PC
FBpp0086355
21.7
192
7.06
P48148
NP_599136
AAM70945
Rho1-PD
FBpp0086356
21.7
192
7.06
P48148
NP_725524
AAM70946
Rho1-PF
FBpp0089129
21.7
192
7.06
P48148
NP_995850
AAS64843
Rho1-PG
FBpp0089130
21.7
192
7.06
P48148
NP_995849
AAS64844
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

192 aa isoforms: Rho1-PA, Rho1-PB, Rho1-PC, Rho1-PD, Rho1-PF, Rho1-PG
Additional Polypeptide Data and Comments
Reported size (kDa)

192 (aa)

(Hariharan et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with capu (PubMed:10556060). Interacts (via REM repeats) with Pkn (via N-terminus) (PubMed:10323867, PubMed:17507675). Interacts (via N-terminus) with wash (via N-terminus) (PubMed:25739458). May interact with dia/diaphanous (via CBD/FH3 domain) (PubMed:23853710).

(UniProt, P48148)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rho1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.96

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Hariharan et al., 1995)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sasamura et al., 1997)
embryonic stage -- adult stage
(Magie et al., 1999, Sasamura et al., 1997)
P-stage
organism

Comment: female

(Magie et al., 1999)
pupal stage
organism

Comment: female

(Magie et al., 1999)
adult stage | female
organism
(Magie et al., 1999)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15 -- 17
embryonic/larval tracheal section
(Massarwa et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Rho1 protein shows apical localization in tracheal tubes.

(Massarwa et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Simões et al., 2006)
colocalizes_with apical plasma membrane
inferred from direct assay
(Rousso et al., 2013)
located_in cell cortex
inferred from direct assay
(Rosales-Nieves et al., 2006)
located_in cell hair
inferred from direct assay
(Yan et al., 2009)
located_in cell-cell contact zone
inferred from direct assay
(Kim et al., 2015)
is_active_in cleavage furrow rim
inferred from direct assay
(di Pietro et al., 2023)
located_in cytoplasm
inferred from direct assay
(Yan et al., 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rho1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 38 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 50 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rho1
Transgenic constructs containing regulatory region of Rho1
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4ey-OK107
lethal, with Scer\GAL4tin.CΔ4
lethal (with Df(2R)ED2457)
lethal (with Df(2R)Jp8)
lethal (with Rho112-6)
lethal (with Rho1E3.10)
lethal (with Rho1J3.8)
lethal | embryonic stage | maternal effect | recessive
lethal | embryonic stage | recessive
lethal | recessive
lethal - all die before end of P-stage
lethal - all die before end of P-stage, with Scer\GAL4ppl.PP
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Scer\GAL4en-e16E
lethal - all die during embryonic stage, with Scer\GAL4prd.RG1
lethal - all die during embryonic stage, with Scer\GAL4repo
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4repo.PU
Sterility
Allele
semi-fertile, with Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal body size | P-stage
abnormal cell migration
abnormal cell migration, with Rho11B
abnormal cell migration, with Rho1KDQ.AAA
abnormal cell migration, with Scer\GAL4ptc-559.1
abnormal cell migration, with Scer\GAL4Pxn.PS
abnormal cell migration | embryonic stage 10, with Scer\GAL4VP16.nanos.UTR
abnormal cell shape
abnormal cell shape | adult stage, with Scer\GAL4GMR.PU
abnormal cell shape | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B
abnormal cell shape | embryonic stage, with Scer\GAL4en-e16E
abnormal cell shape | P-stage, with Scer\GAL4hh-Gal4
abnormal cell shape | P-stage, with Scer\GAL4pros.PSG
abnormal cell shape | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
abnormal circadian behavior, with Scer\GAL4P0.5.Pdf
abnormal cytokinesis
abnormal cytokinesis, with Scer\GAL4neur-P72
abnormal cytokinesis, with Scer\GAL4twi.PB
abnormal cytokinesis | embryonic stage | recessive
abnormal cytokinesis | recessive
abnormal locomotor behavior | adult stage, with Scer\GAL4elav.PLu
abnormal locomotor rhythm, with Scer\GAL4tim.PE
abnormal mitotic cell cycle, with Scer\GAL4prd.RG1
abnormal mitotic cell cycle | recessive
abnormal neuroanatomy, with Scer\GAL4Appl.G1a
abnormal neuroanatomy, with Scer\GAL4ey-OK107
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy, with Scer\GAL4P0.5.Pdf
abnormal neuroanatomy | adult stage, with Scer\GAL4path-c135
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4ftz.ng
abnormal neuroanatomy | embryonic stage, with Scer\GAL4repo
abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4elav-C155
abnormal neuroanatomy | recessive | somatic clone
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4path-c135
abnormal neurophysiology | adult stage, with Scer\GAL4tim.PE
abnormal phototaxis, with Scer\GAL4Appl.G1a
abnormal planar polarity
abnormal planar polarity, with Scer\GAL4dpp.blk1
abnormal planar polarity, with Scer\GAL4hs.2sev
abnormal planar polarity | recessive | somatic clone
abnormal planar polarity | somatic clone
abnormal sleep, with Scer\GAL4tim.PE
abnormal wound healing (with Rho172O)
abnormal wound healing (with Rho172R)
chemical resistant, with Scer\GAL4NP1514
decreased efficacy of memory | adult stage, with Scer\GAL4ey-OK107
decreased occurrence of cell division | larval stage | somatic clone
decreased size | P-stage, with Scer\GAL4sv.PJ
increased cell death, with Scer\GAL4dpp.blk1
increased cell death, with Scer\GAL4ptc-559.1
non-enhancer of variegation, with In(1)wm4h
non-suppressor of variegation, with In(1)wm4h
some die during embryonic stage
some die during embryonic stage, with Scer\GAL4en-e16E
some die during embryonic stage, with Scer\GAL4prd.RG1
some die during embryonic stage, with Scer\GAL4repo
some die during embryonic stage | recessive
some die during pharate adult stage, with Scer\GAL4ppl.PP
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4ppl.PP
visible | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B
visible | recessive
Phenotype manifest in
Allele
abdominal ventral denticle belt
actin cytoskeleton | blastoderm stage | germline clone
actin cytoskeleton | P-stage, with Scer\GAL4hh-Gal4
actin filament & embryonic/larval tracheal system, with Scer\GAL4btl.PS
adherens junction | P-stage, with Scer\GAL4sv.PJ
adherens junction | pupal stage, with Scer\GAL4GMR.PF
adherens junction | somatic clone
adherens junction | somatic clone, with Scer\GAL4Act5C.PI
adult abdomen | dorsal, with Scer\GAL4ppl.PP
adult cuticle | dorsal, with Scer\GAL4ppl.PP
adult mushroom body, with Scer\GAL4ey-OK107
adult mushroom body | somatic clone
amnioproctodeal invagination, with Scer\GAL4nanos.PG
anterior midgut primordium, with Scer\GAL4twi.PG
Bolwig nerve, with Scer\GAL4GMR.PF
border follicle cell, with Scer\GAL4slbo.2.6
cell projection, with Scer\GAL4Pxn.PS
cephalic furrow | absent | embryonic stage 6, with Scer\GAL4VP16.mat.αTub67C
circular trunk visceral muscle primordium
commissure | embryonic stage 16, with Scer\GAL4ftz.ng
cone cell | P-stage, with Scer\GAL4pros.PSG
cone cell | P-stage, with Scer\GAL4sv.PJ
cortical actin cytoskeleton & embryonic posterior spiracle, with Scer\GAL4ems.HRE
cortical actin cytoskeleton & spiracular chamber (with Rho11B)
cortical actin cytoskeleton & spiracular chamber (with Rho172R)
cortical actin cytoskeleton | P-stage, with Scer\GAL4hh-Gal4
dendrite, with Scer\GAL4P0.5.Pdf
dendrite | larval stage | somatic clone
disc epithelium proper & dorsal mesothoracic disc, with Scer\GAL4ptc-559.1
embryo
embryo | blastoderm stage | germline clone
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL4en-e16E
embryo | dorsal closure stage, with Scer\GAL4LE
embryo | dorsal closure stage, with Scer\GAL4pnr-MD237
embryo | dorsal closure stage, with Scer\GAL4prd.RG1
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4en-e16E
embryonic/first instar larval cuticle, with Scer\GAL4prd.RG1
embryonic/first instar larval cuticle, with Scer\GAL4twi.PG
embryonic/first instar larval cuticle, with Scer\GAL4VP16.mat.αTub67C
embryonic/first instar larval cuticle & embryonic head
embryonic/first instar larval cuticle | anterior
embryonic/first instar larval cuticle | anterior | dorsal
embryonic/first instar larval cuticle | anterior | dorsal (with Df(2R)Jp8)
embryonic/first instar larval cuticle | anterior | dorsal (with Rho172O)
embryonic/first instar larval cuticle | anterior | dorsal (with Rho1E3.10)
embryonic/first instar larval cuticle | anterior | dorsal (with Rho1J3.8)
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/larval anterior midgut, with Scer\GAL4NP3392
embryonic/larval carpet glial cell | third instar larval stage, with Scer\GAL4path-c135
embryonic/larval cuticle
embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval cuticle | ventral
embryonic/larval dorsal tracheal anastomosis, with Scer\GAL4btl.PS
embryonic/larval hemocyte
embryonic/larval hemocyte, with Rho11B
embryonic/larval hemocyte, with Rho1KDQ.AAA
embryonic/larval hemocyte, with Scer\GAL4Pxn.PS
embryonic/larval hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4srp.Hemo
embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4He.PZ
embryonic/larval hindgut, with Scer\GAL4NP2432
embryonic/larval midgut primordium, with Scer\GAL4NP2432
embryonic/larval neuromuscular junction | larval stage | conditional, with Scer\GAL4elav-C155
embryonic/larval optic stalk surface glial cell | third instar larval stage, with Scer\GAL4path-c135
embryonic/larval posterior spiracle
embryonic/larval posterior spiracle (with Rho172O)
embryonic/larval posterior spiracle (with Rho1E3.10)
embryonic/larval spiracle primordium, with Scer\GAL4ems.HRE
embryonic/larval tracheal dorsal trunk (with Rho172F)
embryonic/larval tracheal dorsal trunk (with Rho172O)
embryonic/larval tracheal section
embryonic/larval tracheal section, with Scer\GAL4btl.PS
embryonic dorsal epidermis
embryonic dorsal epidermis | anterior
embryonic epidermis, with Scer\GAL4en-e16E
embryonic epidermis, with Scer\GAL4prd.RG1
embryonic epidermis | dorsal
embryonic epidermis | dorsal, with Scer\GAL4LE
embryonic epidermis | dorsal | maternal effect
embryonic epidermis | maternal effect
embryonic epidermis | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic head
embryonic head (with Rho172O)
embryonic head (with Rho172R)
embryonic head | maternal effect
embryonic hindgut, with Scer\GAL4NP2432
embryonic leading edge cell
embryonic leading edge cell, with Scer\GAL4en-e16E
embryonic leading edge cell, with Scer\GAL4prd.RG1
embryonic leading edge cell (with Rho172O)
embryonic leading edge cell (with Rho172R)
embryonic Malpighian tubule tip cell, with Scer\GAL4ct.CtB
embryonic segment
epithelial cell | P-stage, with Scer\GAL4hh-Gal4
epithelial cell | pupal stage, with Scer\GAL4GMR.PF
external sensory organ precursor cell, with Scer\GAL4neur-P72
eye
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye | pupal stage, with Scer\GAL4GMR.PF
eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
eye disc & photoreceptor cell & axon, with Scer\GAL4GMR.PF
eye disc & subretinal glial cell, with Scer\GAL4GMR.PF
eye disc | third instar larval stage, with Scer\GAL4path-c135
eye disc morphogenetic furrow | somatic clone
eye photoreceptor cell, with Scer\GAL4hs.2sev
eye photoreceptor cell | somatic clone
eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PF
filamentous actin | adult stage, with Scer\GAL4GMR.PU
filopodium, with Scer\GAL4en-e16E
filopodium, with Scer\GAL4srp.Hemo
filopodium (with Rho172O)
filopodium (with Rho172R)
filzkorper
filzkorper, with Scer\GAL4ems.HRE
germline cell | ectopic | embryonic stage | maternal effect, with Scer\GAL4VP16.nanos.UTR
germline cell | embryonic stage, with Scer\GAL4VP16.nanos.UTR
head
hemocyte, with Scer\GAL4Cg.PU
hub cell | somatic clone, with Scer\GAL4Act5C.PI
imaginal disc | third instar larval stage, with Scer\GAL4dpp.blk1
individualization stage spermatid, with Scer\GAL4VP16.bam
interommatidial bristle
lamina | third instar larval stage, with Scer\GAL4GMR.PF
larval ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng
larval VL3/4 motor neuron
leg
l-LNv neuron, with Scer\GAL4tim.PE
mesectoderm, with Scer\GAL4en-e16E
mesoderm, with Scer\GAL4twi.PG
mitotic domain 1 | extended germ band stage
mitotic domain 1 | extended germ band stage, with Scer\GAL4c381
mitotic domain 1 | extended germ band stage, with Scer\GAL4Kr.PM
mushroom body & dendrite, with Scer\GAL4Tab2-201Y
mushroom body & dendrite | somatic clone
mushroom body & dendrite | somatic clone, with Scer\GAL4Tab2-201Y
mushroom body & neuron | somatic clone
myoblast, with Rho172O, Scer\GAL4kirre-rP298-G4
myoblast, with Rho1N19.UAS, Scer\GAL4kirre-rP298-G4
myoblast, with Scer\GAL4kirre-rP298-G4
nucleus | increased number, with Scer\GAL4Cg.PU
nurse cell ring canal | maternal effect
ommatidial precursor cluster | somatic clone
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4hs.2sev
ommatidium | somatic clone
oocyte | maternal effect
perineurium | adult stage, with Scer\GAL4path-c135
perineurium | embryonic stage
perineurium | larval stage, with Scer\GAL4moody.PS
photoreceptor neuron
photoreceptor neuron, with Scer\GAL4GMR.PF
photoreceptor neuron, with Scer\GAL4hs.2sev
pigment cell
pigment cell | adult stage, with Scer\GAL4GMR.PU
plasma membrane | third instar larval stage, with Scer\GAL4path-c135
PNS glial cell
PNS glial cell, with Scer\GAL4repo
PNS glial cell | embryonic stage, with Scer\GAL4repo
posterior spiracle primordium, with Scer\GAL4ems.HRE
presumptive embryonic/larval muscle system, with Scer\GAL4how-24B
presumptive embryonic/larval tracheal system
presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS
presumptive embryonic salivary gland
presumptive embryonic salivary gland, with Scer\GAL4en-e16E
presumptive embryonic salivary gland, with Scer\GAL4fkh.PH
presumptive embryonic salivary gland, with Scer\GAL4twi.PB
presumptive embryonic salivary gland (with Df(2R)Jp1)
pupa
retina
retina, with Scer\GAL4GMR.PF
rhabdomere
secondary pigment cell
sensory neuron & axon, with Scer\GAL4repo
septate junction | larval stage, with Scer\GAL4moody.PS
s-LNv Pdf neuron, with Scer\GAL4P0.5.Pdf
sperm individualization complex, with Scer\GAL4VP16.bam
stomodeal invagination, with Scer\GAL4nanos.PG
tertiary pigment cell
tracheal dorsal trunk primordium, with Scer\GAL4btl.PS
tracheal lateral trunk primordium, with Scer\GAL4btl.PS
tracheal primordium
vacuole, with Scer\GAL4Appl.G1a
vacuole, with Scer\GAL4GMR.PF
vacuole | increased number, with Scer\GAL4Pxn.PS
ventral denticle belt | maternal effect
ventral furrow, with Scer\GAL4nanos.PG
ventral longitudinal muscle cell, with Scer\GAL4how-24B
vertical lobe of adult mushroom body, with Scer\GAL4ey-OK107
wing | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B
wing | somatic clone
wing | somatic clone, with Scer\GAL4Act.PU
wing blade, with Scer\GAL4dpp.blk1
wing disc, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4ptc-559.1
wing disc | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B
wing disc | third instar larval stage, with Scer\GAL4dpp.blk1
wing hair, with Scer\GAL4dpp.blk1
wing hair | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B
wing hair | increased number | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B
wing hair | somatic clone
wing hair | somatic clone | increased number
wing hair | somatic clone | increased number, with Scer\GAL4Act.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\RHOA
12 of 14
Yes
Yes
4  
Hsap\RHOC
11 of 14
No
Yes
1  
Hsap\RHOB
9 of 14
No
Yes
1  
Hsap\RHOD
4 of 14
No
Yes
Hsap\RHOF
3 of 14
No
Yes
Hsap\RAC1
2 of 14
No
No
8  
Hsap\RAC2
2 of 14
No
No
1  
Hsap\RAC3
2 of 14
No
No
Hsap\RHOBTB1
2 of 14
No
No
Hsap\RHOBTB2
2 of 14
No
No
1  
Hsap\RHOG
2 of 14
No
No
Hsap\RHOH
2 of 14
No
No
1  
Hsap\RHOJ
2 of 14
No
No
Hsap\RHOQ
2 of 14
No
No
1  
Hsap\RHOU
2 of 14
No
No
Hsap\RHOV
2 of 14
No
No
Hsap\RND1
2 of 14
No
Yes
Hsap\RND2
2 of 14
No
Yes
Hsap\RND3
2 of 14
No
Yes
Hsap\CDC42
1 of 14
No
No
0  
Hsap\RHOBTB3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Rhoa
12 of 14
Yes
Yes
Rnor\Rhoc
10 of 14
No
Yes
Rnor\Rhob
9 of 14
No
Yes
Rnor\RSA-14-44
9 of 14
No
Yes
Rnor\Rhod
4 of 14
No
Yes
Rnor\Rhof
3 of 14
No
Yes
Rnor\Cdc42
2 of 14
No
No
Rnor\Rac1
2 of 14
No
No
Rnor\Rac2
2 of 14
No
No
Rnor\Rhobtb1
2 of 14
No
No
Rnor\Rhobtb2
2 of 14
No
No
Rnor\Rhog
2 of 14
No
No
Rnor\Rhoh
2 of 14
No
No
Rnor\Rhoj
2 of 14
No
No
Rnor\Rhoq
2 of 14
No
No
Rnor\Rhov
2 of 14
No
No
Rnor\Rnd2
2 of 14
No
Yes
Rnor\Rnd3
2 of 14
No
Yes
Rnor\Rac3
1 of 14
No
No
Rnor\Rhobtb3
1 of 14
No
No
Rnor\Rnd1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (22)
Mmus\Rhoa
12 of 14
Yes
Yes
Mmus\Rhoc
12 of 14
Yes
Yes
Mmus\4930544G11Rik
9 of 14
No
Yes
Mmus\Rhob
9 of 14
No
Yes
Mmus\Rhod
4 of 14
No
Yes
Mmus\Rhof
3 of 14
No
Yes
Mmus\Cdc42
2 of 14
No
No
Mmus\Rac1
2 of 14
No
No
Mmus\Rac2
2 of 14
No
No
Mmus\Rac3
2 of 14
No
No
Mmus\Rhobtb1
2 of 14
No
No
Mmus\Rhobtb2
2 of 14
No
No
Mmus\Rhog
2 of 14
No
No
Mmus\Rhoh
2 of 14
No
No
Mmus\Rhoj
2 of 14
No
No
Mmus\Rhoq
2 of 14
No
No
Mmus\Rhou
2 of 14
No
No
Mmus\Rhov
2 of 14
No
No
Mmus\Rnd1
2 of 14
No
Yes
Mmus\Rnd2
2 of 14
No
Yes
Mmus\Rnd3
2 of 14
No
Yes
Mmus\Rhobtb3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\rhoc
10 of 13
Yes
Yes
Xtro\rhoa.2
9 of 13
No
Yes
Xtro\rhob
6 of 13
No
Yes
Xtro\cdc42
1 of 13
No
No
Xtro\celf1
1 of 13
No
No
Xtro\dynlt5
1 of 13
No
No
Xtro\htr2b
1 of 13
No
No
Xtro\LOC105945198
1 of 13
No
Yes
Xtro\pias1
1 of 13
No
No
Xtro\rac1
1 of 13
No
No
Xtro\rac2
1 of 13
No
No
Xtro\rac3
1 of 13
No
No
Xtro\rhoa
1 of 13
No
Yes
Xtro\rhobtb2
1 of 13
No
No
Xtro\rhog2
1 of 13
No
No
Xtro\rhoh
1 of 13
No
No
Xtro\rhoj
1 of 13
No
No
Xtro\rhoq
1 of 13
No
No
Xtro\rhov
1 of 13
No
No
Xtro\rnd1
1 of 13
No
Yes
Danio rerio (Zebrafish) (40)
Drer\rhoaa
13 of 14
Yes
Yes
Drer\rhoca
13 of 14
Yes
Yes
Drer\rhocb
13 of 14
Yes
Yes
Drer\rhoac
12 of 14
No
Yes
Drer\rhoab
11 of 14
No
Yes
Drer\rhof
3 of 14
No
Yes
Drer\cdc42
2 of 14
No
No
Drer\cdc42l2
2 of 14
No
No
Drer\cdc42l
2 of 14
No
No
Drer\rac1a
2 of 14
No
No
Drer\rac1b
2 of 14
No
No
Drer\rac1l
2 of 14
No
No
Drer\rac3a
2 of 14
No
No
Drer\rac3b
2 of 14
No
No
Drer\rhobtb1
2 of 14
No
No
Drer\rhobtb2b
2 of 14
No
No
Drer\rhobtb4
2 of 14
No
No
Drer\rhoga
2 of 14
No
No
Drer\rhogb
2 of 14
No
No
Drer\rhogc
2 of 14
No
No
Drer\rhogd
2 of 14
No
No
Drer\rhoh
2 of 14
No
No
Drer\rhoj
2 of 14
No
No
Drer\rhoq
2 of 14
No
No
Drer\rhoua
2 of 14
No
No
Drer\rhoub
2 of 14
No
No
Drer\rnd1a
2 of 14
No
Yes
Drer\rnd1b
2 of 14
No
Yes
Drer\rnd2
2 of 14
No
Yes
Drer\rnd3a
2 of 14
No
Yes
Drer\rnd3b
2 of 14
No
Yes
Drer\LOC793862
1 of 14
No
No
Drer\LOC100537765
1 of 14
No
No
Drer\rac2
1 of 14
No
No
Drer\rhobtb3
1 of 14
No
No
Drer\rhov
1 of 14
No
No
Drer\si:ch211-1f22.1
1 of 14
No
No
Drer\si:ch211-1f22.2
1 of 14
No
No
Drer\si:ch211-133l11.10
1 of 14
No
No
Drer\zgc:153713
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\rho-1
13 of 14
Yes
Yes
Cele\cdc-42
2 of 14
No
No
Cele\chw-1
2 of 14
No
No
Cele\crp-1
2 of 14
No
No
Cele\mig-2
2 of 14
No
No
Cele\rac-2
2 of 14
No
No
Cele\ced-10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP005160
11 of 12
Yes
Yes
Agam\AgaP_AGAP001573
2 of 12
No
No
Agam\AgaP_AGAP003092
2 of 12
No
No
Agam\AgaP_AGAP003931
2 of 12
No
No
Agam\AgaP_AGAP005445
2 of 12
No
No
Agam\AgaP_AGAP006279
2 of 12
No
No
Agam\AgaP_AGAP006474
2 of 12
No
No
Agam\CDC42_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\ARAC1
3 of 13
Yes
No
Atha\ARAC5
3 of 13
Yes
No
Atha\ARAC9
3 of 13
Yes
No
Atha\RAC2
3 of 13
Yes
No
Atha\RAC3
3 of 13
Yes
No
Atha\RAC6
3 of 13
Yes
No
Atha\RAC10
3 of 13
Yes
No
Atha\ROP1
3 of 13
Yes
No
Atha\ROP2
3 of 13
Yes
No
Atha\ROP9
3 of 13
Yes
No
Atha\ROP10
3 of 13
Yes
No
Atha\AT3G51290
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\RHO1
10 of 13
Yes
Yes
Scer\RHO2
3 of 13
No
Yes
Scer\RHO3
3 of 13
No
Yes
Scer\RHO4
3 of 13
No
Yes
Scer\CDC42
2 of 13
No
No
1  
Scer\RHO5
2 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\rho1
10 of 12
Yes
Yes
Spom\rho5
10 of 12
Yes
Yes
Spom\rho2
3 of 12
No
Yes
Spom\rho3
3 of 12
No
Yes
Spom\rho4
3 of 12
No
Yes
Spom\cdc42
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rho1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
Cdc42
4 of 13
Mtl
4 of 13
Rac1
4 of 13
Rac2
4 of 13
RhoBTB
4 of 13
RhoL
4 of 13
RhoU
3 of 13
Miro
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 10 )
    Allele
    Disease
    Interaction
    References
    Rho11B
    ameliorates  hematologic cancer
    modeled by hopT42
    (Bausek and Zeidler, 2014)
    Rho172F
    exacerbates  carcinoma
    modeled by scrib1
    (Kong et al., 2022)
    ameliorates  neurodegenerative disease
    modeled by SNF4Aγloe
    (Cook et al., 2012)
    exacerbates  hereditary systemic amyloidosis 1
    modeled by Hsap\TTRV30M.UAS.Tag:HA
    (Oliveira da Silva et al., 2020)
    Rho1N19.UAS
    ameliorates  neuropathy
    modeled by Hsap\TRPV4R269C.UAS
    (McCray et al., 2021)
    Rho1V14.E40L.UAS
    ameliorates  peroxisomal biogenesis disorder
    modeled by Pex5GD14972
    (Nath et al., 2022)
    modeled by Pex5HMC04009
    (Nath et al., 2022)
    Rho1V14.UAS
    exacerbates  neurodegenerative disease
    modeled by SNF4Aγloe
    (Cook et al., 2012)
    model of  neurodegenerative disease
    is ameliorated by SNF4AγloeI.UAS
    (Cook et al., 2012)
    Rho1RNAi.UAS.cBa
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.B
    (Minjarez et al., 2016)
    exacerbates  Alzheimer's disease
    modeled by Hsap\APP2xAPP.SP.UAS
    (Minjarez et al., 2016)
    ameliorates  high grade glioma
    modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
    (Chen et al., 2019)
    Rho1RNAi.1.UAS
    ameliorates  high grade glioma
    modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
    (Chen et al., 2019)
    Rho1RNAi.2.UAS
    ameliorates  high grade glioma
    modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
    (Chen et al., 2019)
    Rho1GD4726
    ameliorates  cancer
    modeled by RhoGEF2RE.UAS, RafUAS.F179
    (Khoo et al., 2013)
    Rho1JF02809
    ameliorates  high grade glioma
    modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
    (Chen et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RHOA; ras homolog family member A
    12 of 14
    165390
       
      RHOC; ras homolog family member C
      11 of 14
      165380
           
          RHOB; ras homolog family member B
          9 of 14
          165370
               
              RHOD; ras homolog family member D
              4 of 14
              605781
                  RHOF; ras homolog family member F, filopodia associated
                  3 of 14
                  618867
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      Interaction Browsers
                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                      Please see the Physical Interaction reports below for full details
                      RNA-protein
                      Physical Interaction
                      Assay
                      References
                      Rho1 - bel
                      clip-seq
                      (Kotov et al., 2020)
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      Rho1 - Fhos
                      pull down, anti tag western blot
                      (Lammel et al., 2014)
                      Rho1 - Moe
                      pull down, western blot
                      (Bagci et al., 2020)
                      Rho1 - Pkn
                      bimolecular fluorescence complementation, luminiscence technology, pull down, western blot, anti tag western blot
                      (Bagci et al., 2020, Betson and Settleman, 2007, Lu and Settleman, 1999)
                      Rho1 - PlexB
                      pull down, autoradiography
                      (Hu et al., 2001)
                      Rho1 - RhoGAP100F
                      pull down, anti tag western blot
                      (Spinner et al., 2018)
                      Rho1 - RhoGAP18B
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Ojelade et al., 2015)
                      Rho1 - RhoGDI
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Rho1 - RhoGEF2
                      pull down, western blot, autoradiography
                      (Lin et al., 2022, Nakamura et al., 2017)
                      Rho1 - Rok
                      two hybrid, pull down, autoradiography, western blot
                      (Nahm et al., 2006, Winter et al., 2001, Mizuno et al., 1999)
                      Rho1 - Slik
                      pull down, western blot, anti bait coimmunoprecipitation, bimolecular fluorescence complementation, luminiscence technology, anti tag coimmunoprecipitation, anti tag western blot
                      (Bagci et al., 2020)
                      Rho1 - capu
                      pull down, autoradiography, anti bait coimmunoprecipitation, western blot
                      (Liu et al., 2009, Rosales-Nieves et al., 2006, Magie et al., 1999)
                      Rho1 - conu
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Neisch et al., 2013)
                      Rho1 - cta
                      pull down, autoradiography
                      (Magie et al., 1999)
                      Rho1 - cv-c
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Neisch et al., 2013)
                      Rho1 - mwh
                      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation
                      (Yan et al., 2009)
                      Rho1 - pbl
                      two hybrid, pull down, autoradiography, enzymatic study
                      (Nakamura et al., 2017, van Impel et al., 2009, Prokopenko et al., 1999)
                      Rho1 - scra
                      pull down, anti tag western blot, autoradiography
                      (Stjepić et al., 2024, Liu et al., 2012)
                      Rho1 - slpr
                      pull down, autoradiography, anti tag coimmunoprecipitation, western blot
                      (Neisch et al., 2010)
                      Rho1 - spir
                      anti bait coimmunoprecipitation, western blot, pull down, autoradiography
                      (Liu et al., 2009, Rosales-Nieves et al., 2006)
                      Rho1 - sti
                      pull down, autoradiography, two hybrid
                      (Bassi et al., 2011, Shandala et al., 2004)
                      Rho1 - wash
                      pull down, autoradiography, anti bait coimmunoprecipitation, western blot, anti tag western blot
                      (Verboon et al., 2015, Liu et al., 2009)
                      Rho1 - wnd
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Ma et al., 2016)
                      Summary of Genetic Interactions
                      Interaction Browsers
                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Rho1
                      enhanceable
                      Atf3
                      (Sekyrova et al., 2010)
                      Rho1
                      suppressible
                      bsk
                      (Neisch et al., 2010)
                      Rho1
                      enhanceable
                      capu
                      (Magie et al., 1999)
                      Rho1
                      suppressible
                      Cdc37
                      (Hariharan et al., 1995)
                      Rho1
                      suppressible
                      Cdc42
                      (Warner and Longmore, 2009)
                      Rho1
                      enhanceable
                      CE2-1
                      (Sullivan and Rubin, 2002)
                      Rho1
                      enhanceable
                      CE3-1
                      (Sullivan and Rubin, 2002)
                      Rho1
                      suppressible
                      conu
                      (Neisch et al., 2013)
                      Rho1
                      suppressible
                      crb
                      (Xu et al., 2008)
                      Rho1
                      enhanceable
                      cta
                      (Magie et al., 1999)
                      Rho1
                      suppressible
                      cv-c
                      (Brodu and Casanova, 2006)
                      Rho1
                      suppressible
                      cyst
                      (Silver et al., 2019)
                      Rho1
                      suppressible
                      dia
                      (Prokopenko et al., 1999)
                      Rho1
                      enhanceable
                      dia
                      (Homem and Peifer, 2008)
                      Rho1
                      suppressible
                      ena
                      (Rudrapatna et al., 2014)
                      Rho1
                      suppressible
                      Fim
                      (Kim et al., 2015)
                      Rho1
                      enhanceable
                      fra
                      (Dorsten et al., 2007)
                      Rho1
                      suppressible
                      fz
                      (Bastock and Strutt, 2007)
                      Rho1
                      suppressible
                      hep
                      (Neisch et al., 2010)
                      Rho1
                      suppressible
                      lilli
                      (Tang et al., 2001)
                      zip|Rho1
                      suppressible
                      Mbs
                      (Mizuno et al., 2002)
                      Rho1
                      enhanceable
                      Mbs
                      (Tan et al., 2003)
                      Rho1
                      suppressible
                      Mbs
                      (Petsakou et al., 2015)
                      Rho1
                      suppressible
                      p120ctn
                      (Fox et al., 2005)
                      Rho1
                      enhanceable
                      p120ctn
                      (Fox et al., 2005, Magie et al., 2002)
                      Rho1
                      suppressible
                      Parp1
                      (Uchida et al., 2002)
                      Rho1
                      suppressible
                      Pax
                      (Chen et al., 2005)
                      Rho1
                      suppressible
                      pbl
                      (Prokopenko et al., 1999)
                      Rho1
                      suppressible
                      PlexA
                      (Yu et al., 2010)
                      Rho1
                      enhanceable
                      puc
                      (Neisch et al., 2010)
                      Rho1
                      suppressible
                      puc
                      (Neisch et al., 2010)
                      Rho1
                      suppressible
                      Pura
                      (Petsakou et al., 2015)
                      Rho1
                      suppressible
                      Rab5
                      (Warner and Longmore, 2009)
                      Rho1
                      enhanceable
                      Rab11
                      (Warner and Longmore, 2009)
                      Rho1
                      suppressible
                      RhoGEF2
                      (Barrett et al., 1997)
                      Rho1
                      suppressible
                      RhoGEF64C
                      (Simões et al., 2006)
                      Rho1
                      enhanceable
                      rin
                      (Pazman et al., 2000)
                      Rho1
                      enhanceable
                      robo1
                      (Fritz and VanBerkum, 2002)
                      Rho1
                      suppressible
                      Rok
                      (Xu et al., 2008)
                      Rho1
                      suppressible
                      SNF4Aγ
                      (Cook et al., 2012)
                      Rho1
                      suppressible
                      sqh
                      (Dorsten et al., 2007)
                      Rho1|kirre
                      suppressible
                      sqh
                      (Kim et al., 2015)
                      fra|Rho1
                      suppressible
                      sqh
                      (Dorsten et al., 2007)
                      Rok|Rho1
                      suppressible
                      sqh
                      (Kim et al., 2015)
                      Rho1
                      suppressible
                      Tak1|slpr
                      (Neisch et al., 2010)
                      Rho1
                      suppressible
                      tsr
                      (Rudrapatna et al., 2014)
                      Rho1
                      enhanceable
                      α-Cat
                      (Magie et al., 2002)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Abl
                      enhanceable
                      Rho1
                      (Dorsten et al., 2007)
                      Arf6|Dcr-2
                      enhanceable
                      Rho1
                      (Johnson et al., 2011)
                      Atf3
                      suppressible
                      Rho1
                      (Sekyrova et al., 2010)
                      Atf3
                      enhanceable
                      Rho1
                      (Sekyrova et al., 2010)
                      baz
                      enhanceable
                      Rho1
                      (Shao et al., 2010)
                      br
                      enhanceable
                      Rho1
                      (Chen et al., 2004, Ward et al., 2003)
                      Ced-12
                      enhanceable
                      Rho1
                      (Kim et al., 2015)
                      CG10939
                      suppressible
                      Rho1
                      (Hughes et al., 2010)
                      cindr
                      enhanceable
                      Rho1
                      (Johnson et al., 2008)
                      crb
                      suppressible
                      Rho1
                      (Flores-Benitez and Knust, 2015)
                      Csk
                      suppressible
                      Rho1
                      (Vidal et al., 2006)
                      cv-c
                      suppressible
                      Rho1
                      (Sotillos et al., 2018, Sato et al., 2010, Denholm et al., 2005)
                      CycE
                      enhanceable
                      Rho1
                      (Brumby et al., 2004)
                      DAAM
                      enhanceable
                      Rho1
                      (Matusek et al., 2008, Matusek et al., 2006)
                      Dad
                      suppressible
                      Rho1
                      (Widmann and Dahmann, 2009)
                      Drak
                      enhanceable
                      Rho1
                      (Neubueser and Hipfner, 2010)
                      dsh
                      suppressible
                      Rho1
                      (Boutros et al., 1998, Strutt et al., 1997)
                      egr
                      enhanceable
                      Rho1
                      (Ruan et al., 2016)
                      exp
                      suppressible
                      Rho1
                      (Iordanou et al., 2014)
                      exp
                      enhanceable
                      Rho1
                      (Iordanou et al., 2014)
                      flw
                      suppressible
                      Rho1
                      (Sun et al., 2011, Vereshchagina et al., 2004)
                      fz
                      suppressible
                      Rho1
                      (Winter et al., 2001, Strutt et al., 1997)
                      H
                      enhanceable
                      Rho1
                      (Müller et al., 2005)
                      hop
                      suppressible
                      Rho1
                      (Bausek and Zeidler, 2014)
                      kay
                      suppressible
                      Rho1
                      (Belyaeva et al., 2022)
                      kirre
                      enhanceable
                      Rho1
                      (Kim et al., 2015)
                      LIMK1
                      suppressible
                      Rho1
                      (Chen et al., 2004, Ng and Luo, 2004)
                      LIMK1
                      enhanceable
                      Rho1
                      (Ng and Luo, 2004)
                      Moe
                      suppressible
                      Rho1
                      (Neisch et al., 2010, Molnar and de Celis, 2006, Speck et al., 2003)
                      mtm
                      suppressible
                      Rho1
                      (Hu et al., 2022)
                      mwh
                      enhanceable
                      Rho1
                      (Yan et al., 2009)
                      mwh
                      suppressible
                      Rho1
                      (Yan et al., 2009)
                      p120ctn
                      enhanceable
                      Rho1
                      (Larson et al., 2008)
                      Pak
                      enhanceable
                      Rho1
                      (Ng and Luo, 2004)
                      pbl
                      suppressible
                      Rho1
                      (Murray et al., 2012, van Impel et al., 2009, Prokopenko et al., 1999)
                      pbl
                      enhanceable
                      Rho1
                      (Gregory et al., 2007, Shandala et al., 2004, Echard and O'Farrell, 2003, Prokopenko et al., 1999)
                      peb
                      suppressible
                      Rho1
                      (Wilk et al., 2004)
                      Pi3K92E|btl::Egfr
                      suppressible
                      Rho1
                      (Chen et al., 2019)
                      pk
                      suppressible
                      Rho1
                      (Jenny et al., 2003)
                      Pka-C1
                      suppressible
                      Rho1
                      (Li et al., 2021)
                      Pkn
                      enhanceable
                      Rho1
                      (Lu and Settleman, 1999)
                      PlexB
                      suppressible
                      Rho1
                      (Hu et al., 2001)
                      prom|eys
                      enhanceable
                      Rho1
                      (Nie et al., 2014)
                      puc|Moe
                      suppressible
                      Rho1
                      (Neisch et al., 2010)
                      Rac1
                      suppressible
                      Rho1
                      (Tan et al., 2003, Fanto et al., 2000)
                      Rac1
                      enhanceable
                      Rho1
                      (Fanto et al., 2000)
                      Raf|RhoGEF2
                      suppressible
                      Rho1
                      (Khoo et al., 2013)
                      Ras85D
                      suppressible
                      Rho1
                      (Zeng et al., 2010)
                      RhoGAP18B
                      suppressible
                      Rho1
                      (Rothenfluh et al., 2006)
                      RhoGAPp190
                      enhanceable
                      Rho1
                      (Billuart et al., 2001)
                      RhoGEF2
                      suppressible
                      Rho1
                      (Khoo et al., 2013)
                      RhoGEF64C
                      suppressible
                      Rho1
                      (Bashaw et al., 2001)
                      robo1
                      enhanceable
                      Rho1
                      (Fritz and VanBerkum, 2002)
                      Rok
                      suppressible
                      Rho1
                      (Verdier et al., 2006)
                      Sb
                      enhanceable
                      Rho1
                      (Chen et al., 2004)
                      Sb
                      suppressible
                      Rho1
                      (Bayer et al., 2003)
                      Sema1a
                      enhanceable
                      Rho1
                      (Yu et al., 2010)
                      sgg
                      suppressible
                      Rho1
                      (Petsakou et al., 2015)
                      shg
                      enhanceable
                      Rho1
                      (Mirkovic and Mlodzik, 2006, Fox et al., 2005)
                      shg
                      suppressible
                      Rho1
                      (Fox et al., 2005)
                      shot
                      suppressible
                      Rho1
                      (Sun et al., 2019)
                      SNF4Aγ
                      suppressible
                      Rho1
                      (Cook et al., 2012)
                      SNF4Aγ
                      enhanceable
                      Rho1
                      (Cook et al., 2012)
                      Sos
                      enhanceable
                      Rho1
                      (Fritz and VanBerkum, 2002)
                      Sos
                      suppressible
                      Rho1
                      (Fritz and VanBerkum, 2002)
                      Src64B
                      suppressible
                      Rho1
                      (Fernández et al., 2014)
                      ssh
                      suppressible
                      Rho1
                      (Ng and Luo, 2004)
                      sstn
                      suppressible
                      Rho1
                      (Liu et al., 2015)
                      step
                      suppressible
                      Rho1
                      (Lee and Harris, 2013)
                      sti
                      enhanceable
                      Rho1
                      (D'Avino et al., 2004)
                      stumps|btl
                      enhanceable
                      Rho1
                      (Zhu et al., 2005)
                      tkv
                      enhanceable
                      Rho1
                      (Cordero et al., 2007)
                      tow
                      suppressible
                      Rho1
                      (Chung et al., 2007)
                      tow
                      enhanceable
                      Rho1
                      (Chung et al., 2007)
                      trc
                      enhanceable
                      Rho1
                      (He et al., 2005)
                      upd1
                      suppressible
                      Rho1
                      (Bertet et al., 2009)
                      wun2|wun
                      suppressible
                      Rho1
                      (Renault et al., 2010)
                      External Data
                      Subunit Structure (UniProtKB)
                      Interacts with capu (PubMed:10556060). Interacts (via REM repeats) with Pkn (via N-terminus) (PubMed:10323867, PubMed:17507675). Interacts (via N-terminus) with wash (via N-terminus) (PubMed:25739458). May interact with dia/diaphanous (via CBD/FH3 domain) (PubMed:23853710).
                      (UniProt, P48148 )
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Class of Gene
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2R
                      Recombination map
                      2-77
                      Cytogenetic map
                      52E5-52E5
                      Sequence location
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      52E5-52E5
                      Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      Cytological location reported in FBrf0080078 was in error.
                      (Settleman and Hariharan, 1997.8.8)
                      52E-52E
                      (Magie, 1999.8.17)
                      52E-52E
                      (determined by in situ hybridisation)
                      (Magie et al., 1999)
                      52E5-52E6
                      (determined by in situ hybridisation)
                      (Spradling et al., 1999)
                      52E3-52E6
                      (determined by in situ hybridisation)
                      (Settleman and Hariharan, 1997.8.8, Strutt et al., 1997)
                      52E2-52E9
                      (determined by in situ hybridisation)
                      (Sasamura et al., 1997)
                      52D-52D
                      (determined by in situ hybridisation)
                      (Sasamura, 1995)
                      3C-3C
                      (determined by in situ hybridisation)
                      (Hariharan et al., 1995)
                      52E5-52E6
                      (BDGP Project Members, 1994-1999)
                      Hybridization of Rho1 cDNA to Df(2R)KL32 and Df(2R)Jp6 confirmed that Rho1 maps to 52E.
                      (Sasamura et al., 1997)
                      Experimentally Determined Recombination Data
                      Location

                      2-77

                      (FlyBase, 2016)

                      2-80.4

                      (Comeron et al., 2012)

                      2-

                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (49)
                      Genomic Clones (21)
                      cDNA Clones (138)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          sti is necessary for correct Rho1 localisation at the cleavage site in late telophase.

                          (Bassi et al., 2011)

                          Rho1 is an upstream regulator of DAAM.

                          (Matusek et al., 2006)

                          The active Rho1 product promotes microtubule/microfilament crosslinking by sequestering the spir-PD isoform, preventing this protein from binding to spir-PC and capu.

                          (Rosales-Nieves et al., 2006)

                          Rho1 regulates shg but not arm localisation and the effect of loss of Rho1 is not enhanced or suppressed by removing p120ctn.

                          (Fox et al., 2005)

                          trc

                          (He et al., 2005)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes no cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                          (Boutros et al., 2004)

                          dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

                          (Echard et al., 2004)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.

                          (Eggert et al., 2004)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin.

                          (Kiger et al., 2003)

                          Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia.

                          (Sepp and Auld, 2003)

                          Rho1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for thr response of growth cones to midline repulsive signals.

                          (Fritz and VanBerkum, 2002)

                          Rho1 is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure.

                          (Jacinto et al., 2002)

                          Rho1 is necessary for actin cable formation, but not cellular extenion formation during wound healing in the embryo.

                          (Wood et al., 2002)

                          Rho1 is required for neuroblast proliferation but not for neuronal survival in the mushroom body.

                          (Lee et al., 2000)

                          Together with Pkn, Rho1 mediates a pathway for cell shape changes in dorsal closure that is independent of the Rac GTPase-mediated Jun amino (N)-terminal kinase (JNK) cascade.

                          (Lu and Settleman, 1999)

                          Rho1 is required for many early events, both maternally and zygotically. Rho1 does not interact with members of the JNK signalling pathway.

                          (Magie et al., 1999)

                          pbl is linked through Rho1 activity to the reorganisation of the actin cytoskeleton.

                          (Prokopenko et al., 1999)

                          Rho1 is required for invagination of mesodermal and endodermal primordia during gastrulation and its activation is likely to be regulated by RhoGEF2.

                          (Hacker and Perrimon, 1998)

                          Complements S.cerevisiae RHO1 mutation.

                          (Sasamura et al., 1997)

                          Rho1 has been cloned and sequenced. Rho1 is required for the generation of tissue polarity. Genetic interactions indicate that Rho1 has a role in signalling mediated by fz and dsh.

                          (Strutt et al., 1997)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Rho1 l(2)k02107b

                          (Magie et al., 1999)

                          Source for merge of: Rho1 l(2)52Fa

                          (Halsell et al., 2000)
                          Additional comments
                          Nomenclature History
                          Source for database identify of
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (36)
                          Reported As
                          Symbol Synonym
                          19549712
                          (Rojas et al., 2012)
                          8416
                          (Ravi et al., 2009)
                          AAF01186
                          (Jekely, 2003)
                          CG8416
                          (National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Hosono et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Christis and Munro, 2012, Howell et al., 2012, Jaspers et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Quinones-Coello, 2007, Colicelli, 2004, Rogers et al., 2003)
                          D-Rho1
                          (Ryabinina et al., 2006)
                          DRho
                          (Noselli, 2002)
                          DRho1
                          (Blanke and Jackle, 2006, Lawrence and Morel, 2003, Chen et al., 2002, Mizuno et al., 2002, Stronach and Perrimon, 1999)
                          DRhoA
                          (Bateman and Van Vactor, 2001, Hacker and Perrimon, 1998, Hacker et al., 1998)
                          Dm Rho1
                          (Jekely, 2003)
                          DmRHO-A
                          (Mentzel and Raabe, 2005)
                          Drho1
                          (Raymond et al., 2001, Mizuno et al., 1999)
                          DrhoA
                          (Greco et al., 2001, Agnes and Noselli, 1999, Noselli and Agnes, 1999, Noselli, 1998, Sasamura et al., 1997, Sasamura et al., 1995)
                          E3.10/J3.8
                          (Halsell and Kiehart, 1998)
                          P48148
                          (Rojas et al., 2012)
                          RHO
                          (Muller and Littlewood-Evans, 2001)
                          RHO1
                          (Mirey et al., 2003)
                          RHOA
                          (Losada-Perez, 2018, Kumar et al., 2015)
                          Rho
                          (Fernandez-Gonzalez and Harris, 2023, Lv et al., 2022, Blackie et al., 2020, Paré and Zallen, 2020, Wolterhoff et al., 2020, Thuma et al., 2018, Gilmour et al., 2017, Ly et al., 2017, Qin et al., 2017, Battistini and Tamagnone, 2016, Clavería and Torres, 2016, Matsubayashi and Millard, 2016, Munjal et al., 2015, Takeda et al., 2013, Weavers and Skaer, 2013, Murray et al., 2012, Kirilly et al., 2011, Muyskens and Guillemin, 2011, Szafer-Glusman et al., 2011, Ball et al., 2010, Blanchard et al., 2010, Goldbach et al., 2010, He et al., 2010, Uehara et al., 2010, Gupta et al., 2009, Homem and Peifer, 2009, Schotman et al., 2009, Larson et al., 2008, Ng, 2008, Warren-Paquin et al., 2008, Artabazon et al., 2007, Avet-Rochex et al., 2007, Dorsten et al., 2007, Gregory et al., 2007, Xu et al., 2007, Fehon, 2006, Homem et al., 2006, Hozumi et al., 2006, Kolesnikov, 2006, Stewart et al., 2006, Talbot and VanBerkum, 2006, Xu et al., 2006, Yang and Bashaw, 2006, Bejsovec, 2005, Emery et al., 2005, Grzeschik and Knust, 2005, McClatchey and Giovannini, 2005, Rosales-Nieves et al., 2005, Stewart and Ward, 2005, Stramer et al., 2005, Talbot and VanBerkum, 2005, Avet-Rochex et al., 2004, D'Avino et al., 2004, Finn and Fehon, 2004, Fox et al., 2004, Jefferson et al., 2004, Keung et al., 2004, Stramer et al., 2004, Fan et al., 2003, Jekely, 2003, Matani et al., 2003, Shilo, 2003, Speck et al., 2003, Baum, 2002, Bokel and Brown, 2002, Etienne-Manneville and Hall, 2002, Manning et al., 2002, Park et al., 2002, Strutt et al., 2002, Bashaw et al., 2001, Bashaw et al., 2001, Bee et al., 2001, Chen et al., 2001, Fritz and VanBerkum, 2001, Fritz and Vanberkum, 2001, Guichard et al., 2001, Jacinto and Martin, 2001, Jacinto et al., 2001, Johnson et al., 2001, Bloor and Kiehart, 2000, Chang and Ready, 2000, Chen et al., 2000, Luo, 2000, Seidensticker and Behrens, 2000, Frasch, 1999, Magie et al., 1999, Martin-Bermudo et al., 1999, Montell, 1999, Sutherland and Witke, 1999, Bloor and Kiehart, 1998, Crawford et al., 1998, Kerber et al., 1998, O'Leary et al., 1998, Meyer and Parkhurst, 1997, Meyer and Parkhurst, 1997)
                          Rho A
                          (Dawes-Hoang and Wieschaus, 2001)
                          Rho GTPase
                          (Miller, 2003, Vincent and Magee, 2002)
                          Rho1
                          (Dey et al., 2025, Gujar and Wang, 2025, Jin et al., 2025, Kong et al., 2025, McDonald et al., 2025, Montemurro et al., 2025, Cui et al., 2024, Kamalesh et al., 2024, Kumar et al., 2024, Li et al., 2024, Miao et al., 2024, Mira-Osuna and Borgne, 2024, Rosa-Birriel et al., 2024, Stjepić et al., 2024, Tokamov et al., 2024, Trujillo et al., 2024, Xu et al., 2024, di Pietro et al., 2023, Faria et al., 2023, Gabbert et al., 2023, González et al., 2023, Guo et al., 2023, Han et al., 2023, Koehler and Huber, 2023, Nandy and Roy, 2023, Belyaeva et al., 2022, Chen and He, 2022, Guo et al., 2022, Jia et al., 2022, Koehler et al., 2022, Li et al., 2022, Lin et al., 2022, Messina et al., 2022, Mitchell et al., 2022, Molina et al., 2022, Rout et al., 2022, Yin et al., 2022, Zhou et al., 2022, Bilder et al., 2021, Bischoff et al., 2021, Bonello et al., 2021, Camelo and Luschnig, 2021, Font-Noguera et al., 2021, Heredia et al., 2021, Hu et al., 2021, Johnson, 2021, Kapoor et al., 2021, Luhur et al., 2021, McCray et al., 2021, Park et al., 2021, Popkova et al., 2021, Song et al., 2021, Tavares et al., 2021, Zhang et al., 2021, Carim et al., 2020, Chougule et al., 2020, Dehapiot et al., 2020, Eritano et al., 2020, Gheisari et al., 2020, King and Sehgal, 2020, Kong and Großhans, 2020, La Marca and Richardson, 2020, Lin et al., 2020, Nakamura et al., 2020, Nematbakhsh et al., 2020, Perez-Vale and Peifer, 2020, Popkova et al., 2020, Qin et al., 2020, Rich et al., 2020, Smits and Shvartsman, 2020, Verboon et al., 2020, Wang et al., 2020, Zheng et al., 2020, Bailles et al., 2019, Banerjee et al., 2019, Chen et al., 2019, Dent et al., 2019, Franco and Carmena, 2019, Gao et al., 2019, Garcia De Las Bayonas et al., 2019, Herrera-Perez and Kasza, 2019, Ho et al., 2019, Jiang et al., 2019, Li et al., 2019, Rodriguez-Fernandez et al., 2019, Sarpal et al., 2019, Silver et al., 2019, Singh et al., 2019, Steinhauer et al., 2019, Wang et al., 2019, Das et al., 2018, Hao et al., 2018, Lee et al., 2018, Mortensen et al., 2018, Qin et al., 2018, Richardson and Portela, 2018, Schmidt and Grosshans, 2018, Segal et al., 2018, Sotillos et al., 2018, Toret et al., 2018, Banisch et al., 2017, Couturier et al., 2017, Hernandez-Fleming et al., 2017, Nakamura et al., 2017, Park et al., 2017, Tran and Ten Hagen, 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Chang et al., 2016, Das et al., 2016, Gene Disruption Project members, 2016-, Green et al., 2016, Kockel et al., 2016, Kuleesha et al., 2016, Levinson and Cagan, 2016, Ma et al., 2016, Minjarez et al., 2016, Ng et al., 2016, Rousso et al., 2016, Ruan et al., 2016, Sarov et al., 2016, Schimizzi et al., 2016, Takashima et al., 2016, Hanlon and Andrew, 2015, Morán et al., 2015, Myat et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlachos et al., 2015, Yasunaga et al., 2015, Abreu-Blanco et al., 2014, Bausek and Zeidler, 2014, Eliazer et al., 2014, Fernández et al., 2014, Gersten et al., 2014, Hain et al., 2014, Hsieh et al., 2014, Iordanou et al., 2014, Kitazawa et al., 2014, Nie et al., 2014, Rudrapatna et al., 2014, Sechi et al., 2014, Simões et al., 2014, Swope et al., 2014, Toret et al., 2014, Yashiro et al., 2014, Bonke et al., 2013, Carter, 2013, Das and Cagan, 2013, Das et al., 2013, Das et al., 2013, Fernandez-Gonzalez and Zallen, 2013, Greer et al., 2013, Guillot and Lecuit, 2013, Khoo et al., 2013, Melzer et al., 2013, Morais-de-Sá and Sunkel, 2013, Neisch et al., 2013, Parkhurst, 2013.10.2, Peters and Rogers, 2013, Pirraglia et al., 2013, Rousso et al., 2013, Saravanan et al., 2013, Schertel et al., 2013, Sen et al., 2013, Sen et al., 2013, Sotillos et al., 2013, Takeda et al., 2013, Terriente-Felix et al., 2013, Vaque et al., 2013, Vaqué et al., 2013, Webber et al., 2013, Yin et al., 2013, Baek et al., 2012, Chountala et al., 2012, Crest et al., 2012, Felix et al., 2012, Giansanti and Fuller, 2012, Howell et al., 2012, Iyer et al., 2012, Jeon et al., 2012, Jeong et al., 2012, Morris et al., 2012, Axelsson et al., 2011, Brumby et al., 2011, Degennaro et al., 2011, Fauvarque and Williams, 2011, Johnson et al., 2011, Lee et al., 2011, Makhijani et al., 2011, Song and Giniger, 2011, Sun et al., 2011, Szafer-Glusman et al., 2011, Takemura and Adachi-Yamada, 2011, Tanaka et al., 2011, Taniguchi et al., 2011, Xu et al., 2011, Asensio et al., 2010, Baek et al., 2010, Ball et al., 2010, Blanchard et al., 2010, Campos et al., 2010, Elsaesser et al., 2010, Hughes et al., 2010, Kadandale et al., 2010, Neisch et al., 2010, Pataki et al., 2010, Renault et al., 2010, Sato et al., 2010, Sekyrova et al., 2010, Simões et al., 2010, von Hilchen et al., 2010, Warner, 2010.9.15, Yu et al., 2010, Zimmerman et al., 2010, Aleksic et al., 2009, Dworkin et al., 2009, Frank et al., 2009, Liu et al., 2009, Massarwa et al., 2009, Mirouse et al., 2009, Patch et al., 2009, Snee and Macdonald, 2009, Tan et al., 2009, van Impel et al., 2009, Warner and Longmore, 2009, Warner and Longmore, 2009, Webb et al., 2009, Widmann and Dahmann, 2009, Yan et al., 2009, Alves-Silva et al., 2008, Artabazon et al., 2008, Benjamin et al., 2008, Hickson and O'Farrell, 2008, Homem and Peifer, 2008, Johnson et al., 2008, Koelsch and Leptin, 2008, Larson et al., 2008, Matusek et al., 2008, Morgan and Kalm, 2008, Patch et al., 2008, Qin et al., 2008, Sweeney et al., 2008, Xu et al., 2008, Xu et al., 2008, Zhou et al., 2008, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Betson and Settleman, 2007, Cordero et al., 2007, Fox and Peifer, 2007, Luo, 2007.3.23, Minidorff et al., 2007, Minidorff et al., 2007, Mulinari et al., 2007, Neisch et al., 2007, Quinones-Coello, 2007, Taniguchi et al., 2007, Wang and Riechmann, 2007, Wenzl and Großhans, 2007, Williams et al., 2007, Zeitlinger et al., 2007, Zhang et al., 2007, Brodu and Casanova, 2006, Dean and Spudich, 2006, Lovegrove et al., 2006, Polaski et al., 2006, Rothenfluh et al., 2006, Simões et al., 2006, Vidal et al., 2006, Vig et al., 2006, Avet-Rochex et al., 2005, Chen et al., 2005, Fox et al., 2005, He et al., 2005, Padash Barmchi et al., 2005, Sommer et al., 2005, Stramer et al., 2005, Paladi and Tepass, 2004, Rogers et al., 2003, Magie et al., 1999)
                          RhoA
                          (Diaz et al., 2025, Sekine et al., 2024, Kakanj et al., 2022, Mieszczanek et al., 2022, Qu et al., 2022, Roberto and Emery, 2022, Bischoff and Bogdan, 2021, Brantley and Di Talia, 2021, Camelo and Luschnig, 2021, Founounou et al., 2021, Garland et al., 2021, Mickael et al., 2021, Puñal et al., 2021, Strutt and Strutt, 2021, Greig and Bulgakova, 2020, Jeon et al., 2020, Ko and Martin, 2020, Martin, 2020, Miwa et al., 2020, Thuveson et al., 2019, Verma and Maresca, 2019, Verma and Maresca, 2019, Dunn et al., 2018, Katanaev et al., 2018, Spinner et al., 2018, Carvajal-Gonzalez et al., 2016, Gombos et al., 2015, Hosono et al., 2015, Rodal et al., 2015, Sterne et al., 2015, Sundaram, 2015, Lammel et al., 2014, Pichaud, 2014, Puram and Bonni, 2013, Saravanan et al., 2013, Vaqué et al., 2013, Warrington et al., 2013, Zuo et al., 2013, Cook et al., 2012, Bassi et al., 2011, Ben El Kadhi et al., 2011, Hermle et al., 2011, Matsubara et al., 2011, Mirkovic et al., 2011, Nahm and Lee, 2011, Szafer-Glusman et al., 2011, Blanchard et al., 2010, Cao et al., 2010, Colinet et al., 2010, Nahm et al., 2010, Pataki et al., 2010, Zeng et al., 2010, Schotman et al., 2009, Albertson et al., 2008, Cao et al., 2008, Carreno et al., 2008, Gregory et al., 2008, Llense and Martín-Blanco, 2008, Matusek et al., 2008, Morgan and Kalm, 2008, Rodriguez-Diaz et al., 2008, Bastock and Strutt, 2007, Bidla et al., 2007, Chung et al., 2007, Colinet et al., 2007, Corrigall et al., 2007, Franke et al., 2007, Gregory et al., 2007, Impel et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Roubinet et al., 2007, Taniguchi et al., 2007, Tolwinski, 2007, Tyler et al., 2007, Fox and Kalm, 2006, Kerkhoff, 2006, Matusek et al., 2006, McBride et al., 2006, Minin et al., 2006, Mirkovic and Mlodzik, 2006, Nahm et al., 2006, Ruggiero et al., 2006, Sanny et al., 2006, Srahna et al., 2006, D'Avino et al., 2005, Govek et al., 2005, Hu et al., 2005, Matusek et al., 2005, Ng and Luo, 2005, Piekny et al., 2005, Wilson et al., 2005, Zhu et al., 2005, Balasubramanian et al., 2004, Halsell et al., 2004, Ishimaru et al., 2004, Polesello and Payre, 2004, Shandala et al., 2004, Starz-Gaiano and Montell, 2004, Wilk et al., 2004, Bayer et al., 2003, Echard and O'Farrell, 2003, Gao and Bogert, 2003, Ghabrial et al., 2003, Goda and Davis, 2003, Jacinto and Baum, 2003, Lee et al., 2003, Pasterkamp and Kolodkin, 2003, Schumacher et al., 2003, Solnica-Krezel and Eaton, 2003, Strutt, 2003, Strutt and Strutt, 2003, Strutt and Strutt, 2003, Tan et al., 2003, Adler, 2002, Aigaki et al., 2002, Bloor and Kiehart, 2002, Castellani and Rougon, 2002, Harden et al., 2002, Kolodziej and Lee, 2002, Lee and Kolodziej, 2002, Mlodzik, 2002, Patel and Van Vactor, 2002, Strutt et al., 2002, Tree et al., 2002, von Kalm et al., 2002, Wedlich, 2002, Wood et al., 2002, Adler and Lee, 2001, Billuart et al., 2001, Billuart et al., 2001, Bloor and Kiehart, 2001, Bloor and Kiehart, 2001, Cooper and Strutt, 2001, Das and Mlodzik, 2001, Hu et al., 2001, Johnstone and Lasko, 2001, Pilch et al., 2001, Somers et al., 2001, Strutt, 2001, Uchida et al., 2001, Whitford and Ghosh, 2001, Wiemann et al., 2001, Winter et al., 2001, Winter et al., 2001, Acebes and Ferrus, 2000, Fanto, 2000, Fanto et al., 2000, Halsell and Kiehart, 2000, Halsell et al., 2000, Lee et al., 2000, Mlodzik, 2000, Newsome et al., 2000, O'Keefe et al., 2000, Pazman et al., 2000, Peifer and Tepass, 2000, Sotillos and Campuzano, 2000, Asha et al., 1999, Halsell and Kiehart, 1999, Harden et al., 1999, Harden et al., 1999, Kollmar, 1999, Lee et al., 1999, Mlodzik, 1999, Paricio et al., 1999, Rangarajan et al., 1999, Reifegerste and Moses, 1999, Sawamoto et al., 1999, Sawamoto et al., 1999, Sutherland and Witke, 1999, Thomas and Wassarman, 1999, Axelrod et al., 1998, Boutros et al., 1998, Dale, 1998, Goberdhan and Wilson, 1998, Shulman et al., 1998, Tree and Gubb, 1998, Eaton, 1997, Martin-Blanco, 1997, Strutt et al., 1997, Strutt et al., 1997, Van Aelst and D'Souza-Schorey, 1997)
                          RhoN19
                          (West and Harris, 2020, Blanchard et al., 2010)
                          dRho1
                          (Magie and Parkhurst, 2001)
                          dRhoA
                          (Bertolio et al., 2019, Das et al., 2002)
                          dnRho
                          (Fritz and VanBerkum, 2002)
                          l(2)52Fa
                          l(2)k02107b
                          (BDGP Project Members, 1994-1999)
                          n(2)k07236
                          (Spradling, 1999.12.9)
                          rho
                          (González-Ramírez et al., 2022, Pinheiro et al., 2017, Jean et al., 2012, Gafuik and Steller, 2011, Brown et al., 2007, O'Keefe et al., 2007, Huelsmann et al., 2006, Pandur et al., 2002, Pazman and Haynes, 2000, Beitel and Krasnow, 1998)
                          rho1
                          (Rothenberg et al., 2023, Hu et al., 2022, Ding et al., 2021, Hu et al., 2021, Yin et al., 2021, Kotov et al., 2020, Oliveira da Silva et al., 2020, Pulido Companys et al., 2020, Dent et al., 2019, Lee and Chen, 2019, Hernandez-Fleming et al., 2017, Álvarez-Fernández et al., 2015, Kim et al., 2015, Liu et al., 2015, Lee and Harris, 2013, Manning et al., 2013, Pirraglia et al., 2013, Lesch and Page, 2012, Pilgram et al., 2011, Vlachos and Harden, 2011, Carrillo et al., 2010, Neubueser and Hipfner, 2010, Shao et al., 2010, Bertet et al., 2009, Higuchi et al., 2009, van Impel et al., 2009, Artabazon et al., 2007, Sarkar et al., 2007, Wang and Riechmann, 2007, Dworkin and Gibson, 2006, Verdier et al., 2006, Cafferty et al., 2005, Dean et al., 2005, Echard et al., 2004, Jacinto et al., 2002, Schock and Perrimon, 2002, Somma et al., 2002, Settleman, 2001, Somma et al., 2001, Nolan et al., 1998)
                          rhoA
                          (Kitazawa et al., 2014, Reid et al., 2012, Asensio et al., 2010, Djiane and Mlodzik, 2010, Chung et al., 2009, Molnar and de Celis, 2006, Yang and Bashaw, 2006, Jenny et al., 2005, Brumby et al., 2004, Grueber and Jan, 2004, Jacinto et al., 2002, Pandur et al., 2002, Zhu et al., 2002, Kadam and Reuter, 2001, Kockel et al., 2001, Hemavathy et al., 2000, Schock and Perrimon, 2000, Boutros and Mlodzik, 1999, Stronach and Perrimon, 1999, Cox and Peifer, 1998, Cadigan and Nusse, 1997)
                          Name Synonyms
                          Rho GTPase
                          (Gou et al., 2020, Paré and Zallen, 2020, Rousso et al., 2016, Sailem et al., 2014, Simões et al., 2014, Xu et al., 2007, Sepp and Auld, 2003)
                          Rho kinase
                          (Czerniak et al., 2016, Nance and Zallen, 2011, Mok et al., 2005, Nikolaidou and Barrett, 2005, Barros et al., 2003, Kiehart, 2003)
                          Rho1
                          (Jaspers et al., 2012, Cammarato et al., 2011, Zimmerman et al., 2010, Prokopenko and Chia, 2008, Zhou et al., 2008)
                          RhoA
                          (Fanto and McNeill, 2004)
                          RhoA kinase
                          (Morris et al., 2012)
                          rho kinase
                          (Dworkin and Gibson, 2006)
                          rho1
                          (Verdier et al., 2006)
                          rho1 kinase
                          (Dworkin and Gibson., 2006)
                          Secondary FlyBase IDs
                          • FBgn0014021
                          • FBgn0024874
                          • FBgn0024880
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 113 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (911)