RhoA, Rho, Rho GTPase, Rho kinase, DrhoA
rho-subfamily GTPase - a molecular switch and functions as key regulator of the actin cytoskeleton in concert with DRhoGEF2, Rho1 mediates specific cell shape changes during gastrulation in response to the extracellular ligand, Folded gastrulation - plays a central role in actin cytoskeleton organization, microtubule dynamics, mophogenesis, border cell migration, cytokinesis, and wound repair
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rho1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rho1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes no cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin.
Rho1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for thr response of growth cones to midline repulsive signals.
Rho1 is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure.
Rho1 is necessary for actin cable formation, but not cellular extenion formation during wound healing in the embryo.
Rho1 is required for neuroblast proliferation but not for neuronal survival in the mushroom body.