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Citation
Nolan, K.M., Barrett, K., Lu, Y., Hu, K.Q., Vincent, S., Settleman, J. (1998). Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a rac signaling pathway utilized for multiple developmental processes.  Genes Dev. 12(21): 3337--3342.
FlyBase ID
FBrf0105287
Publication Type
Research paper
Abstract

The Rac and Cdc42 GTPases share several regulators and effectors, yet perform distinct biological functions. The factors determining such specificity in vivo have not been identified. In a mutational screen in Drosophila to identify Rac-specific signaling components, we isolated 11 alleles of myoblast city (mbc). mbc mutant embryos exhibit defects in dorsal closure, myogenesis, and neural development. DOCK180, the mammalian homolog of Mbc, associates with Rac, but not Cdc42, in a nucleotide-independent manner. These results suggest that Mbc is a specific upstream regulator of Rac activity that mediates several morphogenetic processes in Drosophila embryogenesis.

PubMed ID
PubMed Central ID
PMC317223 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (1)
    Alleles (9)
    Genes (11)
    Experimental Tools (1)
    Transgenic Constructs (4)