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General Information
Symbol
Dmel\Cdc42GMR.PN
Species
D. melanogaster
Name
glass multimer reporter construct of Nolan
FlyBase ID
FBal0094048
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-Cdc42
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Full length coding region is expressed under the control of GMR regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Cdc42GMR.PN have slight eye defects associated with occasional fusion of ommatidial units and misoriented bristles.

Cdc42GMR.PN flies have rough eyes.

Flies carrying Cdc42GMR.PN have moderately reduced rough eyes with an almost normal array of well-defined ommatidia.

Expression of Cdc42GMR.PN in a wild-type background does not disrupt photoreceptor axon projections.

Flies bearing one copy of P{GMR-Cdc42.N} show a rough eye phenotype distinct from that caused by P{GMR-Rac1.N} or P{GMR-Rac2.N}. Ommatidial morphology is disrupted and photoreceptor cells are occasionally lost. Rhabdomere morphology is abnormal. Postmitotic elongation that establishes the depth of the retina is aberrant.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Other
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

Cdc42GMR.PN has eye phenotype, non-enhanceable by Mbs[+]/Mbs03802

Suppressed by
NOT suppressed by
Statement
Reference

Cdc42GMR.PN has eye phenotype, non-suppressible by Mbs[+]/Mbs03802

Cdc42GMR.PN has eye phenotype, non-suppressible by mbc1.63

Cdc42GMR.PN has eye phenotype, non-suppressible by mbc2.35

Cdc42GMR.PN has eye phenotype, non-suppressible by mbc3.5

Cdc42GMR.PN has eye phenotype, non-suppressible by mbc4.25

NOT Enhancer of
Statement
Reference

Cdc42GMR.PN is a non-enhancer of phenotype of trioGEF1.GMR.Tag:MYC

NOT Suppressor of
Statement
Reference

Cdc42GMR.PN is a non-suppressor of phenotype of trioGEF1.GMR.Tag:MYC

Other
Additional Comments
Genetic Interactions
Statement
Reference

The rough eye phenotype of Cdc42GMR.PN flies in unaffected by heterozygosity for Mbs03802.

Flies carrying Cdc42GMR.PN in a Df(3R)rn20/+ background have larger and less rough eyes than flies carrying Cdc42GMR.PN in a wild-type background, but ommatidial packing is affected more in Cdc42GMR.PN Df(3R)rn20/+ flies; the ommatidia are less closely associated with each other, resulting in gaps or channels between them. Interommatidial bristle are sometimes duplicated.

Does not significantly alter the photoreceptor axon projection defects caused by expression of trioGEF1.GMR.T:Hsap\MYC.

Xenogenetic Interactions
Statement
Reference

Co-expression of Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF restores the eye morphology to wild type in Cdc42GMR.PN flies.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Cdc42GMR.PN
Name Synonyms
glass multimer reporter construct of Nolan
Secondary FlyBase IDs
    References (6)