FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Cdc42
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General Information
Symbol
Dmel\Cdc42
Species
D. melanogaster
Name
Cell division cycle 42
Annotation Symbol
CG12530
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010341
Gene Model Status
Current
Stock Availability
41 publicly available
Gene Summary
Cell division cycle 42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, morphogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dcdc42, DmCDC42

Key Links
Genomic Location
Cytogenetic map
18E1-18E1
Sequence location
Recombination map
1-64
RefSeq locus
NC_004354 REGION:19697091..19699938
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (69 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables GTPase activating protein binding
inferred from physical interaction with FLYBASE:RacGAP84C; FB:FBgn0045843
(Raymond et al., 2001)
enables GTPase activity
inferred from direct assay
(Raymond et al., 2001)
enables protein binding
inferred from physical interaction with FLYBASE:Whamy; FB:FBgn0037750
(Liu et al., 2009)
inferred from physical interaction with UniProtKB:Q9VUC6
(Dollar et al., 2016)
inferred from physical interaction with UniProtKB:Q9VXE5
(Schneeberger and Raabe, 2003)
inferred from physical interaction with UniProtKB:Q9W1B0
(Luo et al., 1997)
enables protein kinase binding
inferred from physical interaction with FLYBASE:mbt; FB:FBgn0025743
(Schneeberger and Raabe, 2003)
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
(Harden et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR037874
(InterPro Project Members, 2004-)
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN008604840
(GO Reference Genome Project, 2011-)
Biological Process (55 terms)
Terms Based on Experimental Evidence (48 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
involved_in actin filament organization
inferred from mutant phenotype
(Zhou et al., 2022)
involved_in actin filament polymerization
inferred from mutant phenotype
(Eaton et al., 1996)
involved_in axon extension
inferred from genetic interaction with FLYBASE:Frl; FB:FBgn0267795
(Dollar et al., 2016)
involved_in axon guidance
inferred from mutant phenotype
(Fritz and VanBerkum, 2002, Kim et al., 2002)
involved_in border follicle cell migration
inferred from mutant phenotype
(Zhou et al., 2022)
involved_in branch fusion, open tracheal system
inferred from mutant phenotype
(Wolf et al., 2002)
involved_in branching involved in open tracheal system development
inferred from mutant phenotype
(Jones and Metzstein, 2011)
involved_in cell projection assembly
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in cell projection organization
inferred from mutant phenotype
(Zhou et al., 2022)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Kamiyama and Chiba, 2009, Sanchez-Soriano et al., 2005, Scott et al., 2003, Gao et al., 1999)
involved_in dorsal appendage formation
inferred from mutant phenotype
(Suzanne et al., 2001)
involved_in dorsal closure
inferred from mutant phenotype
(Sem et al., 2002)
inferred from mutant phenotype
(Riesgo-Escovar et al., 1996)
involved_in encapsulation of foreign target
inferred from mutant phenotype
(Sampson et al., 2012)
involved_in establishment of neuroblast polarity
inferred from mutant phenotype
(Atwood et al., 2007)
involved_in exocyst localization
inferred from mutant phenotype
(Jones et al., 2014)
involved_in hemocyte migration
inferred from mutant phenotype
(Stramer et al., 2005)
involved_in imaginal disc-derived wing hair outgrowth
inferred from mutant phenotype
(Eaton et al., 1996)
involved_in maintenance of cell polarity
inferred from mutant phenotype
(Stramer et al., 2005)
involved_in maintenance of protein location
inferred from mutant phenotype
(Schneeberger and Raabe, 2003)
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Dorsten et al., 2007)
involved_in nephrocyte filtration
inferred from mutant phenotype
(Zhang et al., 2013)
involved_in neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
(Pilgram et al., 2011)
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Pilgram et al., 2011)
involved_in neuron projection development
inferred from mutant phenotype
(Allen et al., 2000)
involved_in neuron projection morphogenesis
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in ommatidial rotation
inferred from genetic interaction with UniProtKB:Q9VUC6
(Dollar et al., 2016)
involved_in phagocytosis
inferred from mutant phenotype
(Sampson et al., 2012)
involved_in positive regulation of filopodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010, Wolf et al., 2002)
involved_in positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333,FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in positive regulation of lamellipodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010)
involved_in positive regulation of protein kinase activity
inferred from mutant phenotype
(Schneeberger and Raabe, 2003)
involved_in positive regulation of wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Jones et al., 2014)
involved_in regulation of actin filament polymerization
inferred from mutant phenotype
(Rotkopf et al., 2011)
inferred from direct assay
(Rodal et al., 2008)
involved_in regulation of axonogenesis
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
(Ng and Luo, 2004)
involved_in regulation of cell shape
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in regulation of neurotransmitter secretion
inferred from mutant phenotype
(Jantrapirom et al., 2019)
involved_in regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Rodal et al., 2008)
inferred from direct assay
(Nahm et al., 2010)
involved_in response to wounding
inferred from mutant phenotype
(Nakamura et al., 2017)
involved_in Rho protein signal transduction
inferred from genetic interaction with FLYBASE:Zir; FB:FBgn0031216
(Sampson et al., 2012)
involved_in sensory perception of touch
inferred from mutant phenotype
(Tsubouchi et al., 2012)
involved_in spermatid development
inferred from mutant phenotype
(Rotkopf et al., 2011)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333,FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in vesicle-mediated transport
inferred from mutant phenotype
(Jones et al., 2014)
involved_in wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2012, Wood et al., 2002)
NOT involved_in dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
traceable author statement
(Johnstone and Lasko, 2001)
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
involved_in axonogenesis
traceable author statement
(Gao et al., 1999)
involved_in cellularization
traceable author statement
(Mazumdar and Mazumdar, 2002)
involved_in dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN008604842
(GO Reference Genome Project, 2011-)
involved_in establishment of cell polarity
inferred from biological aspect of ancestor with PANTHER:PTN008604842
(GO Reference Genome Project, 2011-)
involved_in oogenesis
traceable author statement
(Harden, 2002)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
involved_in small GTPase-mediated signal transduction
inferred from electronic annotation with InterPro:IPR003578
(InterPro Project Members, 2004-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
located_in axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in cell cortex
inferred from direct assay
(Leibfried et al., 2013)
located_in cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
located_in growth cone
inferred from direct assay
(Kim et al., 2002)
located_in lamellipodium
inferred from direct assay
(Shim et al., 2010)
located_in nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (P40793)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Cell division cycle 42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, morphogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).
(UniProt, P40793)
Summary (Interactive Fly)

a Ras type GTPase - involved in epithelial cell elongation - facilitates nucleation of actin filaments - Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis - disruption Cdc42/Par6/aPKC polarity complex promotes epithelial proliferation

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cdc42 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P40793)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cdc42-RA
FBtr0074751
NM_078690
1392
191
Cdc42-RC
FBtr0309214
NM_001258833
2078
191
Cdc42-RD
FBtr0309215
NM_001258834
2005
191
Additional Transcript Data and Comments
Reported size (kB)

2.3 (northern blot)

(Luo et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cdc42-PA
FBpp0074520
21.4
191
7.21
P40793
NP_523414
AAF49007
Cdc42-PC
FBpp0301153
21.4
191
7.21
P40793
NP_001245762
AFH07474
Cdc42-PD
FBpp0301154
21.4
191
7.21
P40793
NP_001245763
AFH07475
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

191 aa isoforms: Cdc42-PA, Cdc42-PC, Cdc42-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

191 (aa)

(Luo et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:12490550, PubMed:9371783). When GTP-bound, interacts with Pak (PubMed:8628256).

(UniProt, P40793)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.12

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sasamura et al., 1997)
presumptive embryonic/larval central nervous system
(Luo et al., 1994)
larval digestive system
(Luo et al., 1994)
embryonic stage -- adult stage
(Sasamura et al., 1997, Luo et al., 1994)
blastoderm stage
organism | ubiquitous
(Luo et al., 1994)
embryonic stage 10 -- 12
somatic trunk mesoderm
(Luo et al., 1994)
Additional Descriptive Data

Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.

(Sasamura et al., 1997)

Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.

(Luo et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female & oogenesis
female germline cell
(Leibfried et al., 2013)
oogenesis & adult stage | female
nurse cell
(Leibfried et al., 2013)
oocyte | anterior
(Leibfried et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
located_in axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in cell cortex
inferred from direct assay
(Leibfried et al., 2013)
located_in cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
located_in growth cone
inferred from direct assay
(Kim et al., 2002)
located_in lamellipodium
inferred from direct assay
(Shim et al., 2010)
located_in nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc42 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 57 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc42
Transgenic constructs containing regulatory region of Cdc42
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4198Y
lethal, with Scer\GAL4238Y
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4hs.PB
lethal | female, with Scer\GAL4306
lethal | recessive
lethal | somatic clone
lethal - all die before end of larval stage, with Scer\GAL4109-30
lethal - all die before end of larval stage, with Scer\GAL4109-39
lethal - all die before end of larval stage, with Scer\GAL4109-53
lethal - all die before end of larval stage, with Scer\GAL4109-69
lethal - all die before end of larval stage, with Scer\GAL4109-79
lethal - all die before end of larval stage, with Scer\GAL4sca-109-68
lethal - all die before end of pupal stage, with Scer\GAL4how-24B
lethal - all die during embryonic stage, with Scer\GAL469B
lethal - all die during embryonic stage, with Scer\GAL4en-e16E
lethal - all die during embryonic stage, with Scer\GAL4how-24B, Scer\GAL4insc-Mz1407
lethal - all die during embryonic stage | maternal effect | partially (with Cdc423)
lethal - all die during embryonic stage | maternal effect | partially (with Cdc424)
lethal - all die during embryonic stage | maternal effect | partially (with Cdc426)
lethal - all die during embryonic stage | non-rescuable maternal effect
partially lethal, with Scer\GAL4elav.PLu
partially lethal - majority die, with Scer\GAL4212
viable
viable, with Scer\GAL4212
viable, with Scer\GAL4306
viable, with Scer\GAL4458
viable, with Scer\GAL4hs.PB
viable | heat sensitive
Sterility
Allele
male sterile, with Scer\GAL4A3.eya
Other Phenotypes
Allele
abnormal cell migration | embryonic stage, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PG
abnormal cell migration | embryonic stage, with Scer\GAL4Pxn.PS
abnormal cell polarity
abnormal cell polarity, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
abnormal cell polarity, with Scer\GAL4wor.PA
abnormal cell polarity | maternal effect (with Cdc423)
abnormal cell polarity | maternal effect (with Cdc426)
abnormal cell polarity | oogenesis | somatic clone
abnormal cell shape, with Scer\GAL4Cg.PU
abnormal cell shape | oogenesis | somatic clone
abnormal immune response | larval stage
abnormal memory | adult stage, with Scer\GAL4elav.PU
abnormal memory | adult stage, with Scer\GAL4ey-OK107
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4eve.RN2
abnormal neuroanatomy, with Scer\GAL4Mhc.Switch.PO
abnormal neuroanatomy, with Scer\GAL4Ntan1-Mz317
abnormal neuroanatomy, with Scer\GAL4P0.5.Pdf
abnormal neuroanatomy, with Scer\GAL4shot-OK307
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4ftz.ng
abnormal neuroanatomy | larval stage, with Scer\GAL41003.3
abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4elav-C155
abnormal neuroanatomy | P-stage
abnormal neuroanatomy | P-stage, with Scer\GAL4lz.PU
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage
abnormal neurophysiology, with Scer\GAL4shot-OK307
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Mhc.PU
abnormal planar polarity
abnormal planar polarity | somatic clone
abnormal size | third instar larval stage
abnormal touch response | larval stage, with Scer\GAL41003.3
abnormal wound healing, with Scer\GAL4en-e16E
abnormal wound healing | embryonic stage (with Cdc424)
abnormal wound healing | embryonic stage (with Cdc426)
chemical resistant, with Scer\GAL4NP1514
chemical sensitive, with Scer\GAL4NP1514
decreased cell number | adult stage, with Scer\GAL4sev.EP
decreased cell size | somatic clone
increased cell number | somatic clone, with Scer\GAL4wor.PA
some die during embryonic stage, with Scer\GAL469B
some die during embryonic stage, with Scer\GAL4en-e16E
some die during embryonic stage, with Scer\GAL4how-24B, Scer\GAL4insc-Mz1407
some die during embryonic stage | non-rescuable maternal effect
some die during embryonic stage | partially (with Cdc423)
some die during embryonic stage | partially (with Cdc424)
some die during embryonic stage | partially (with Cdc426)
some die during larval stage, with Scer\GAL4109-30
some die during larval stage, with Scer\GAL4109-39
some die during larval stage, with Scer\GAL4109-53
some die during larval stage, with Scer\GAL4109-69
some die during larval stage, with Scer\GAL4109-79
some die during larval stage, with Scer\GAL4sca-109-68
some die during pupal stage, with Scer\GAL4how-24B
visible
visible, with Scer\GAL4en-e16E
visible (with Cdc421)
visible (with Cdc425)
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | somatic clone
wild-type
Phenotype manifest in
Allele
A1-7 ventral longitudinal muscle cell | third instar larval stage, with Scer\GAL4Mhc.PU
abdominal posterior fascicle neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
aCC neuron & dendrite, with Scer\GAL4eve.RN2
actin filament, with Scer\GAL4T155
actin filament & rhabdomere | somatic clone
actin filament | germline clone | maternal effect (with Cdc424)
actin filament | germline clone | maternal effect (with Cdc426)
adult antennal lobe commissure, with Scer\GAL4SG18.1
adult heart, with Scer\GAL4how-24B
adult heart, with Scer\GAL4tin.CΔ4
adult mushroom body alpha-lobe | adult stage
adult mushroom body beta-lobe | adult stage
antenna & glial cell, with Scer\GAL4Ntan1-Mz317
antenna & sensory neuron, with Scer\GAL4Ntan1-Mz317
antennal lobe glomerulus, with Scer\GAL4SG18.1
anterior crossvein | ectopic
anterior crossvein | ectopic (with Cdc421)
anterior crossvein | ectopic (with Cdc425)
anterior-posterior compartment boundary of the wing disc, with Scer\GAL4ptc-559.1
axon
axon | adult stage
bouton
bouton, with Scer\GAL4C57
bouton, with Scer\GAL4Mhc.Switch.PO
cardiac myofibril, with Scer\GAL4how-24B
cardiac myofibril, with Scer\GAL4tin.CΔ4
cardial cell, with Scer\GAL4how-24B
cardial cell, with Scer\GAL4tin.CΔ4
commissure | embryonic stage 16, with Scer\GAL4ftz.ng
crossvein | cell non-autonomous | ectopic, with Scer\GAL4Bx-MS1096
crossvein | ectopic
crossvein | increased number, with Scer\GAL4en-e16E
dendrite, with Scer\GAL4insc-Mz1407
dendrite, with Scer\GAL4shot-OK307
dendrite | dorsal | embryonic stage, with Scer\GAL460
dendrite | ectopic
dendritic spine
dMP2 neuron, with Scer\GAL4ftz.ng
dorsal appendage, with Scer\GAL4CY2
dorsal multidendritic neuron & dendrite & embryo, with Scer\GAL460
embryo, with Scer\GAL4twi.PU
embryo | anterior | maternal effect (with Cdc423)
embryo | anterior | maternal effect (with Cdc426)
embryo | dorsal closure stage, with Scer\GAL4en-e16E
embryo | dorsal closure stage | heat sensitive, with Scer\GAL4hs.PB
embryo | dorsal closure stage | maternal effect (with Cdc423)
embryo | dorsal closure stage | maternal effect (with Cdc426)
embryo | maternal effect (with Cdc423)
embryo | maternal effect (with Cdc424)
embryo | maternal effect (with Cdc426)
embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle, with Scer\GAL4twi.PG
embryonic/first instar larval cuticle | dorsal, with Scer\GAL469B
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle | heat sensitive, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc423)
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc426)
embryonic/larval anterior midgut, with Scer\GAL4NP3392
embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4da.G32
embryonic/larval hemocyte, with Scer\GAL4Pxn.PS
embryonic/larval hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic/larval hemocyte (with Cdc423)
embryonic/larval hemocyte (with Cdc426)
embryonic/larval midgut | embryonic stage, with Scer\GAL448Y
embryonic/larval neuromuscular junction | larval stage | conditional, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval plasmatocyte
embryonic/larval plasmatocyte, with Scer\GAL4Col4a1-A109.1F2.P
embryonic/larval plasmatocyte, with Scer\GAL4da.G32
embryonic/larval plasmatocyte, with Scer\GAL4gcm-rA87.P
embryonic/larval tracheal dorsal trunk, with Scer\GAL4hs.2sev
embryonic/larval tracheal lateral trunk, with Scer\GAL4btl.PS
embryonic/larval tracheal section, with Scer\GAL4btl.PS
embryonic abdominal dorsal sensory organ precursor cluster, with Scer\GAL4insc-Mz1407
embryonic cardioblast, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PG
embryonic epidermis, with Scer\GAL4hs.PB
embryonic epidermis | dorsal, with Scer\GAL4en-e16E
embryonic epidermis | maternal effect | ventral (with Cdc423)
embryonic epidermis | maternal effect | ventral (with Cdc426)
embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic proventriculus
embryonic proventriculus, with Scer\GAL4retn-GAL4
epithelium, with Scer\GAL4NP1624
eye
eye, with Scer\GAL4eya.enh1+E+2
eye (with Cdc421)
eye (with Cdc425)
eye disc, with Scer\GAL4ey.PH
eye photoreceptor cell, with Scer\GAL4sev.EP
eye photoreceptor cell | somatic clone
female germline cyst, with Scer\GAL4NP1624
filopodium | increased number, with Scer\GAL4Hml.PU
follicle cell, with Scer\GAL4Act5C.PP
follicle cell | somatic clone
ganglionic tracheal branch primordium
giant axon, with Scer\GAL4shot-OK307
giant fiber neuron, with Scer\GAL4shakB.lethal.4.1
glomerulus | ectopic, with Scer\GAL4SG18.1
growth cone, with Scer\GAL4elav.PLu
growth cone, with Scer\GAL4elav-C155
head cyst cell, with Scer\GAL4T155
hemocyte, with Scer\GAL4Cg.PU
hemocyte, with Scer\GAL4Hml.PU
interommatidial bristle
interommatidial bristle (with Cdc421)
interommatidial bristle (with Cdc425)
larval abdominal intersegmental nerve, with Scer\GAL4elav.PLu
larval abdominal intersegmental nerve, with Scer\GAL4insc-Mz1407
larval abdominal segmental nerve, with Scer\GAL4elav.PLu
larval abdominal segmental nerve, with Scer\GAL4elav-C155
larval DA1 motor neuron, with Scer\GAL4eve.RN2
larval dorsal multidendritic neuron | embryonic stage, with Scer\GAL460
larval dorsal multidendritic neuron ddaA | larval stage, with Scer\GAL41003.3
larval longitudinal connective | maternal effect (with Cdc423)
larval longitudinal connective | maternal effect (with Cdc426)
larval pericardial cell, with Scer\GAL4Ugt36A1.PK
larval RP2 motor neuron | ectopic, with Scer\GAL4eve.RN2
larval somatic muscle cell, with Scer\GAL4twi.PG
larval tracheocyte | larval stage, with Scer\GAL4btl.PS
larval ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng
macrochaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
medial row of triple row of wing sensilla, with Scer\GAL4Bx-MS1096
mesothoracic leg disc, with Scer\GAL4dpp.blk1
mesothoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
metathoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
microchaeta, with Scer\GAL4ptc-559.1
microchaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
microchaeta & wing, with Scer\GAL4ptc-559.1
motor neuron, with Scer\GAL4elav.PLu
motor neuron, with Scer\GAL4elav-C155
muscle attachment site, with Scer\GAL4twi.PG
myotube, with Scer\GAL4twi.PG
neurite, with Scer\GAL4shot-OK307
neuroblast | embryonic stage, with Scer\GAL4wor.PA
neuroblast | increased number | somatic clone, with Scer\GAL4wor.PA
neuroblast | third instar larval stage
neuromuscular junction
neuromuscular junction, with Scer\GAL4C57
neuromuscular junction, with Scer\GAL4Mhc.Switch.PO
neuron, with Scer\GAL4elav.PLu
neuron, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage
nurse cell
nurse cell, with Scer\GAL4VP16.osk
nurse cell & actin filament | germ-line clone | maternal effect
nurse cell ring canal | germline clone | maternal effect (with Cdc424)
nurse cell ring canal | germline clone | maternal effect (with Cdc426)
ommatidium
ommatidium, with Scer\GAL4sev.EP
ommatidium (with Cdc421)
ommatidium (with Cdc425)
ommatidium | P-stage
ommatidium | P-stage, with Scer\GAL4lz.PU
ommatidium | somatic clone
oocyte | germline clone
oocyte | germline clone | maternal effect
pCC neuron, with Scer\GAL4ftz.ng
photoreceptor
pigment cell
plasma membrane bounded cell projection | embryonic stage, with Scer\GAL4Pxn.PS
presumptive embryonic/larval central nervous system | maternal effect (with Cdc423)
presumptive embryonic/larval central nervous system | maternal effect (with Cdc426)
presumptive embryonic/larval peripheral nervous system | dorsal, with Scer\GAL460
presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS
proventriculus inner layer primordium
proventriculus inner layer primordium, with Scer\GAL4retn-GAL4
proventriculus intermediate layer primordium
proventriculus intermediate layer primordium, with Scer\GAL4retn-GAL4
retina | somatic clone
rhabdomere
RP2 neuron & cell body, with Scer\GAL4eve.RN2
RP2 neuron & dendrite, with Scer\GAL4eve.RN2
RP2 neuron & neurite, with Scer\GAL4eve.RN2
seminal vesicle, with Scer\GAL4A3.eya
sensory dendrite | larval stage, with Scer\GAL41003.3
s-LNv Pdf neuron, with Scer\GAL4P0.5.Pdf
somatic muscle cell, with Scer\GAL4how-24B
spermatid cyst, with Scer\GAL4A3.eya
spermatid cyst, with Scer\GAL4T155
tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
terminal tracheal cell | somatic clone
tracheocyte | P-stage, with Scer\GAL4btl.PS
vertical system neuron
vMP2 neuron, with Scer\GAL4ftz.ng
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4ptc-559.1
wing (with Cdc421)
wing (with Cdc425)
wing hair, with Scer\GAL4Bx-MS1096
wing hair | ectopic, with Scer\GAL4Bx-MS1096
wing hair | increased number, with Scer\GAL4en-e16E
wing hair | somatic clone | increased number
wing margin, with Scer\GAL4Bx-MS1096
wing margin bristle, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (38)
Hsap\CDC42
11 of 14
Yes
Yes
0  
Hsap\RAC1
5 of 14
No
No
8  
Hsap\RAC2
5 of 14
No
No
1  
Hsap\RAC3
5 of 14
No
No
Hsap\RHOG
5 of 14
No
Yes
Hsap\RHOQ
5 of 14
No
Yes
1  
Hsap\RHOJ
4 of 14
No
Yes
Hsap\RHOU
4 of 14
No
Yes
Hsap\RHOV
4 of 14
No
Yes
Hsap\RHOF
3 of 14
No
Yes
Hsap\RHOH
3 of 14
No
No
1  
Hsap\RHOA
2 of 14
No
No
4  
Hsap\RHOB
2 of 14
No
No
1  
Hsap\RHOBTB1
2 of 14
No
No
Hsap\RHOBTB2
2 of 14
No
No
1  
Hsap\RHOD
2 of 14
No
No
Hsap\RND1
2 of 14
No
Yes
Hsap\RND2
2 of 14
No
Yes
Hsap\RND3
2 of 14
No
Yes
Hsap\GEM
1 of 14
No
No
Hsap\MRAS
1 of 14
No
No
Hsap\RALA
1 of 14
No
No
1  
Hsap\RAP1A
1 of 14
No
No
3  
Hsap\RAP1B
1 of 14
No
No
3  
Hsap\RAP2B
1 of 14
No
No
Hsap\RAP2C
1 of 14
No
No
Hsap\RASL11A
1 of 14
No
No
1  
Hsap\RASL11B
1 of 14
No
No
1  
Hsap\RASL12
1 of 14
No
No
Hsap\RERG
1 of 14
No
No
Hsap\RERGL
1 of 14
No
No
Hsap\RHEB
1 of 14
No
No
1  
Hsap\RHEBL1
1 of 14
No
No
Hsap\RHOBTB3
1 of 14
No
No
Hsap\RHOC
1 of 14
No
No
1  
Hsap\RIT1
1 of 14
No
No
1  
Hsap\RIT2
1 of 14
No
No
Hsap\RRAS2
1 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Cdc42
11 of 14
Yes
Yes
Rnor\Rac1
5 of 14
No
No
Rnor\Rac2
5 of 14
No
No
Rnor\Rhog
5 of 14
No
Yes
Rnor\Rhoq
5 of 14
No
Yes
Rnor\Rac3
4 of 14
No
No
Rnor\Rhoj
4 of 14
No
Yes
Rnor\Rhov
4 of 14
No
Yes
Rnor\Rhof
3 of 14
No
Yes
Rnor\Rhoh
3 of 14
No
No
Rnor\Rhoa
2 of 14
No
No
Rnor\Rhob
2 of 14
No
No
Rnor\Rhobtb1
2 of 14
No
No
Rnor\Rhobtb2
2 of 14
No
No
Rnor\Rhoc
2 of 14
No
No
Rnor\Rhod
2 of 14
No
No
Rnor\RSA-14-44
2 of 14
No
No
Rnor\Rhobtb3
1 of 14
No
No
Rnor\Rhou
1 of 14
No
Yes
Rnor\Rnd2
1 of 14
No
No
Rnor\Rnd3
1 of 14
No
No
Mus musculus (laboratory mouse) (22)
Mmus\Cdc42
11 of 14
Yes
Yes
Mmus\Rac1
5 of 14
No
No
Mmus\Rac2
5 of 14
No
No
Mmus\Rac3
5 of 14
No
No
Mmus\Rhog
5 of 14
No
Yes
Mmus\Rhoq
5 of 14
No
Yes
Mmus\Rhoj
4 of 14
No
Yes
Mmus\Rhou
4 of 14
No
Yes
Mmus\Rhof
3 of 14
No
Yes
Mmus\Rhoh
3 of 14
No
No
Mmus\Rhov
3 of 14
No
Yes
Mmus\4930544G11Rik
2 of 14
No
No
Mmus\Rhoa
2 of 14
No
No
Mmus\Rhob
2 of 14
No
No
Mmus\Rhobtb1
2 of 14
No
No
Mmus\Rhobtb2
2 of 14
No
No
Mmus\Rhoc
2 of 14
No
No
Mmus\Rhod
2 of 14
No
No
Mmus\Rhobtb3
1 of 14
No
No
Mmus\Rnd1
1 of 14
No
No
Mmus\Rnd2
1 of 14
No
No
Mmus\Rnd3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\cdc42
9 of 13
Yes
Yes
Xtro\rac1
4 of 13
No
No
Xtro\rac2
4 of 13
No
No
Xtro\rac3
4 of 13
No
No
Xtro\rhog2
4 of 13
No
Yes
Xtro\rhoq
4 of 13
No
Yes
Xtro\dynlt5
3 of 13
No
Yes
Xtro\rhog
3 of 13
No
Yes
Xtro\rhoj
3 of 13
No
Yes
Xtro\rhov
3 of 13
No
Yes
Xtro\rhoh
2 of 13
No
No
Xtro\rhou
2 of 13
No
Yes
Xtro\celf1
1 of 13
No
No
Xtro\gem
1 of 13
No
No
Xtro\LOC100488596
1 of 13
No
No
Xtro\LOC105945198
1 of 13
No
Yes
Xtro\pias1
1 of 13
No
No
Xtro\rap1b
1 of 13
No
No
Xtro\rap2a
1 of 13
No
No
Xtro\rap2c
1 of 13
No
No
Xtro\rasl11b
1 of 13
No
No
Xtro\rergl
1 of 13
No
No
Xtro\rerg
1 of 13
No
No
Xtro\rhebl1
1 of 13
No
No
Xtro\rhoa.2
1 of 13
No
No
Xtro\rhobtb2
1 of 13
No
No
Xtro\rhob
1 of 13
No
No
Xtro\rhoc
1 of 13
No
No
Xtro\rhof
1 of 13
No
Yes
Xtro\rnd1
1 of 13
No
Yes
Danio rerio (Zebrafish) (40)
Drer\cdc42l
13 of 14
Yes
Yes
Drer\cdc42
11 of 14
No
Yes
Drer\cdc42l2
5 of 14
No
Yes
Drer\rac1a
5 of 14
No
No
Drer\rac1b
5 of 14
No
No
Drer\rac3a
5 of 14
No
No
Drer\rac3b
5 of 14
No
No
Drer\rhoga
5 of 14
No
Yes
Drer\rhogb
5 of 14
No
Yes
Drer\rhogc
5 of 14
No
Yes
Drer\rhogd
5 of 14
No
Yes
Drer\rhoq
5 of 14
No
Yes
Drer\LOC100537765
4 of 14
No
No
Drer\rac2
4 of 14
No
No
Drer\rhoj
4 of 14
No
Yes
Drer\rhoua
4 of 14
No
Yes
Drer\rhoub
4 of 14
No
Yes
Drer\rhov
4 of 14
No
Yes
Drer\rac1l
3 of 14
No
No
Drer\rhof
3 of 14
No
Yes
Drer\rhoh
3 of 14
No
No
Drer\si:ch211-1f22.1
3 of 14
No
No
Drer\si:ch211-133l11.10
3 of 14
No
Yes
Drer\rhoaa
2 of 14
No
No
Drer\rhobtb1
2 of 14
No
No
Drer\rhobtb2b
2 of 14
No
No
Drer\rhobtb4
2 of 14
No
No
Drer\rhoca
2 of 14
No
No
Drer\rhocb
2 of 14
No
No
Drer\rnd1b
2 of 14
No
Yes
Drer\LOC793862
1 of 14
No
No
Drer\rhoab
1 of 14
No
No
Drer\rhoac
1 of 14
No
No
Drer\rhobtb2a
1 of 14
No
No
Drer\rhobtb3
1 of 14
No
No
Drer\rnd1a
1 of 14
No
No
Drer\rnd2
1 of 14
No
No
Drer\rnd3a
1 of 14
No
No
Drer\rnd3b
1 of 14
No
No
Drer\si:ch211-1f22.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\cdc-42
13 of 14
Yes
Yes
Cele\mig-2
5 of 14
No
No
Cele\rac-2
5 of 14
No
No
Cele\ced-10
4 of 14
No
No
Cele\chw-1
4 of 14
No
Yes
Cele\crp-1
4 of 14
No
Yes
Cele\rho-1
2 of 14
No
No
Cele\rap-1
1 of 14
No
No
Cele\rap-2
1 of 14
No
No
Cele\rap-3
1 of 14
No
No
Cele\ras-1
1 of 14
No
No
Cele\ras-2
1 of 14
No
No
Cele\Y71F9AR.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (19)
Agam\CDC42_ANOGA
10 of 12
Yes
Yes
Agam\AgaP_AGAP001573
5 of 12
No
No
Agam\AgaP_AGAP005445
5 of 12
No
No
Agam\AgaP_AGAP003931
3 of 12
No
No
Agam\AgaP_AGAP006279
3 of 12
No
Yes
Agam\AgaP_AGAP003092
2 of 12
No
No
Agam\AgaP_AGAP006474
2 of 12
No
No
Agam\AgaP_AGAP001874
1 of 12
No
No
Agam\AgaP_AGAP001902
1 of 12
No
No
Agam\AgaP_AGAP002812
1 of 12
No
No
Agam\AgaP_AGAP003577
1 of 12
No
No
Agam\AgaP_AGAP004769
1 of 12
No
No
Agam\AgaP_AGAP005159
1 of 12
No
No
Agam\AgaP_AGAP005160
1 of 12
No
No
Agam\AgaP_AGAP005243
1 of 12
No
No
Agam\AgaP_AGAP006025
1 of 12
No
No
Agam\AgaP_AGAP008224
1 of 12
No
No
Agam\AgaP_AGAP008989
1 of 12
No
No
Agam\AgaP_AGAP011306
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\ARAC1
9 of 13
Yes
No
Atha\ARAC5
9 of 13
Yes
No
Atha\ARAC9
9 of 13
Yes
No
Atha\RAC2
9 of 13
Yes
No
Atha\RAC3
9 of 13
Yes
No
Atha\RAC6
9 of 13
Yes
No
Atha\RAC10
9 of 13
Yes
No
Atha\ROP1
9 of 13
Yes
No
Atha\ROP2
9 of 13
Yes
No
Atha\ROP9
9 of 13
Yes
No
Atha\ROP10
9 of 13
Yes
No
Atha\AT3G51290
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (8)
Scer\CDC42
12 of 13
Yes
Yes
1  
Scer\RHO1
2 of 13
No
No
Scer\RHO2
2 of 13
No
No
Scer\RHO3
2 of 13
No
No
Scer\RHO4
2 of 13
No
No
Scer\RHO5
2 of 13
No
Yes
Scer\RAS1
1 of 13
No
No
Scer\RAS2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\cdc42
11 of 12
Yes
Yes
Spom\rho1
2 of 12
No
No
Spom\rho2
2 of 12
No
No
Spom\rho3
2 of 12
No
No
Spom\rho4
2 of 12
No
No
Spom\rho5
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cdc42. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
Mtl
10 of 13
Rac1
10 of 13
Rac2
10 of 13
Rho1
4 of 13
RhoBTB
4 of 13
RhoL
4 of 13
RhoU
4 of 13
Miro
2 of 13
CG5160
1 of 13
CG8519
1 of 13
CG30158
1 of 13
CG42541
1 of 13
Rab21
1 of 13
Rap1
1 of 13
Rheb
1 of 13
Ric
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CDC42; cell division cycle 42
11 of 14
CELL DIVISION CYCLE 42; CDC42
     
    RAC1; Rac family small GTPase 1
    5 of 14
    RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; RAC1
     
    RAC2; Rac family small GTPase 2
    5 of 14
    RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2; RAC2
     
    RAC3; Rac family small GTPase 3
    5 of 14
    602050
      RHOG; ras homolog family member G
      5 of 14
      179505
          RHOQ; ras homolog family member Q
          5 of 14
          605857
               
              RHOJ; ras homolog family member J
              4 of 14
              607653
                  RHOU; ras homolog family member U
                  4 of 14
                  606366
                      RHOV; ras homolog family member V
                      4 of 14
                      620101
                          RHOF; ras homolog family member F, filopodia associated
                          3 of 14
                          618867
                              RHOH; ras homolog family member H
                              3 of 14
                              602037
                               
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              Interaction Browsers
                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                              Please see the Physical Interaction reports below for full details
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              Cdc42 - Abi
                              pull down, western blot
                              (Fricke et al., 2009)
                              Cdc42 - CG12299
                              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                              (Rhee et al., 2014)
                              Cdc42 - Cip4
                              pull down, anti tag western blot, western blot, two hybrid, autoradiography
                              (Brinkmann et al., 2016, Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
                              Cdc42 - Frl
                              pull down, autoradiography
                              (Dollar et al., 2016)
                              Cdc42 - GEFmeso
                              pull down, autoradiography, enzymatic study
                              (Sundaram, 2015, Blanke and Jackle, 2006)
                              Cdc42 - Pak
                              pull down, autoradiography, western blot
                              (Nahm et al., 2006, Harden et al., 1996)
                              Cdc42 - Pak3
                              anti tag coimmunoprecipitation, western blot
                              (Mentzel and Raabe, 2005)
                              Cdc42 - RhoGAP100F
                              pull down, anti tag western blot, enzymatic study, fluorescence technology
                              (Spinner et al., 2018)
                              Cdc42 - RhoGAP18B
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Ojelade et al., 2015)
                              Cdc42 - RhoGAP92B
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Neisch et al., 2013)
                              Cdc42 - RhoGEF2
                              pull down, autoradiography
                              (Nakamura et al., 2017)
                              Cdc42 - SCAR
                              pull down, western blot
                              (Fricke et al., 2009)
                              Cdc42 - Sumo
                              pull down, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                              (Handu et al., 2015)
                              Cdc42 - WASp
                              pull down, western blot, autoradiography, anti tag western blot, enzymatic study, fluorescent resonance energy transfer, fluorescence microscopy
                              (Sharifai et al., 2014, Nahm et al., 2010, Fricke et al., 2009, Liu et al., 2009, Rodal et al., 2008)
                              Cdc42 - Whamy
                              pull down, anti tag western blot, autoradiography
                              (Brinkmann et al., 2016, Liu et al., 2009)
                              Cdc42 - aPKC
                              anti bait coimmunoprecipitation, western blot
                              (Leibfried et al., 2013)
                              Cdc42 - dsx
                              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                              (Rhee et al., 2014)
                              Cdc42 - gek
                              two hybrid, pull down, autoradiography
                              (Luo et al., 1997)
                              Cdc42 - mbt
                              pull down, anti tag western blot, western blot, anti tag coimmunoprecipitation
                              (Rötte et al., 2024, Melzer et al., 2013, Schneeberger and Raabe, 2003)
                              Cdc42 - nwk
                              enzymatic study
                              (Rodal et al., 2008)
                              Cdc42 - par-6
                              pull down, molecular weight estimation by coomasie staining, western blot, autoradiography, nuclear magnetic resonance
                              (Nunes de Almeida et al., 2019, Atwood et al., 2007, Hutterer et al., 2004, Peterson et al., 2004)
                              Cdc42 - pbl
                              pull down, anti tag western blot, autoradiography
                              (Nakamura et al., 2017, Rosa et al., 2015)
                              Cdc42 - scra
                              pull down, autoradiography
                              (Stjepić et al., 2024)
                              Cdc42 - slpr
                              pull down, autoradiography, anti tag coimmunoprecipitation, western blot
                              (Garlena et al., 2010, Neisch et al., 2010)
                              RNA-protein
                              Physical Interaction
                              Assay
                              References
                              Cdc42 - fne
                              anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                              (Alizzi et al., 2020)
                              Summary of Genetic Interactions
                              Interaction Browsers
                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                              Please look at the allele data for full details of the genetic interactions
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Cdc42
                              suppressible
                              Ack
                              (Sem et al., 2002)
                              Cdc42
                              enhanceable
                              bchs
                              (Raymond et al., 2004)
                              Cdc42
                              enhanceable
                              bol
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              C3G
                              (Raymond et al., 2004)
                              Cdc42
                              enhanceable
                              CG7231
                              (Zhu et al., 2005)
                              Cdc42
                              suppressible
                              chic
                              (Fritz and VanBerkum, 2002)
                              Cdc42
                              enhanceable
                              Cip4
                              (Nahm et al., 2010)
                              Cdc42
                              enhanceable
                              dco
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              Dlat
                              (Raymond et al., 2004)
                              Cdc42
                              suppressible
                              Dora
                              (Molina-Pelayo et al., 2022)
                              Cdc42
                              enhanceable
                              Eip78C
                              (Zhu et al., 2005)
                              Cdc42
                              suppressible
                              fra
                              (Dorsten et al., 2007)
                              Cdc42
                              suppressible
                              Frl
                              (Dollar et al., 2016)
                              Cdc42
                              enhanceable
                              Frl
                              (Gazsó-Gerhát et al., 2023, Dollar et al., 2016)
                              Cdc42
                              enhanceable
                              grp
                              (Raymond et al., 2004)
                              Cdc42
                              suppressible
                              Ip6k
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              lilli
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              N
                              (Baron et al., 2000)
                              Cdc42
                              enhanceable
                              NFAT
                              (Zhu et al., 2005)
                              Cdc42
                              suppressible
                              numb
                              (Raymond et al., 2004)
                              Cdc42
                              enhanceable
                              nwk
                              (Rodal et al., 2008)
                              Cdc42
                              enhanceable
                              pbl
                              (Raymond et al., 2004)
                              Cdc42
                              suppressible
                              poe
                              (Raymond et al., 2004)
                              Cdc42
                              enhanceable
                              Tao
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              Tlk
                              (Zhu et al., 2005)
                              Cdc42
                              enhanceable
                              WASp|Cip4
                              (Nahm et al., 2010)
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Arpc4
                              suppressible
                              Cdc42
                              (Molina et al., 2022)
                              bnl
                              suppressible
                              Cdc42
                              (Wolf et al., 2002)
                              btl
                              suppressible
                              Cdc42
                              (Mukherjee et al., 2012)
                              Cip4
                              enhanceable
                              Cdc42
                              (Nahm et al., 2010)
                              Cip4
                              enhanceable
                              Cdc42|WASp
                              (Nahm et al., 2010)
                              CycB
                              suppressible
                              Cdc42
                              (Ji et al., 2002)
                              DAAM
                              enhanceable
                              Cdc42
                              (Gazsó-Gerhát et al., 2023)
                              Dyb
                              suppressible
                              Cdc42
                              (Jantrapirom et al., 2019)
                              exp
                              suppressible
                              Cdc42
                              (Iordanou et al., 2014)
                              Frl
                              suppressible
                              Cdc42
                              (Dollar et al., 2016)
                              Frl
                              enhanceable
                              Cdc42
                              (Dollar et al., 2016)
                              kermit
                              enhanceable
                              Cdc42
                              (Djiane and Mlodzik, 2010)
                              LIMK1
                              suppressible
                              Cdc42
                              (Ng and Luo, 2004)
                              msn
                              enhanceable
                              Cdc42
                              (Ruan et al., 2002)
                              Mtl
                              enhanceable
                              Cdc42
                              (Muñoz-Descalzo et al., 2007)
                              Mtl
                              suppressible
                              Cdc42
                              (Muñoz-Descalzo et al., 2007)
                              Mtl|Rac2|Rac1
                              enhanceable
                              Cdc42
                              (Muñoz-Descalzo et al., 2007)
                              ninaE
                              suppressible
                              Cdc42
                              (Chang and Ready, 2000)
                              nwk
                              enhanceable
                              Cdc42
                              (Rodal et al., 2008)
                              nwk
                              suppressible
                              Cdc42
                              (Rodal et al., 2008)
                              Pak
                              suppressible
                              Cdc42
                              (Ng and Luo, 2004)
                              pbl
                              suppressible
                              Cdc42
                              (Murray et al., 2012)
                              Pi3K92E|btl::Egfr
                              suppressible
                              Cdc42
                              (Chen et al., 2019)
                              Pvr
                              enhanceable
                              Cdc42
                              (Ishimaru et al., 2004)
                              Ras85D
                              enhanceable
                              Cdc42
                              (Pagliarini and Xu, 2003)
                              Rho1
                              suppressible
                              Cdc42
                              (Warner and Longmore, 2009)
                              robo1
                              suppressible
                              Cdc42
                              (Fritz and VanBerkum, 2002)
                              Sos
                              enhanceable
                              Cdc42
                              (Fritz and VanBerkum, 2002)
                              ssh
                              suppressible
                              Cdc42
                              (Ng and Luo, 2004)
                              Tcs5
                              suppressible
                              Cdc42
                              (Molina et al., 2022)
                              Ten-m
                              enhanceable
                              Cdc42
                              (Xu et al., 2024)
                              tkv
                              suppressible
                              Cdc42
                              (Ricos et al., 1999)
                              trc
                              enhanceable
                              Cdc42
                              (He et al., 2005)
                              tum
                              suppressible
                              Cdc42
                              (Sotillos and Campuzano, 2000)
                              WASp
                              enhanceable
                              Cdc42|Cip4
                              (Nahm et al., 2010)
                              Zir
                              suppressible
                              Cdc42
                              (Sampson et al., 2012)
                              External Data
                              Subunit Structure (UniProtKB)
                              Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:12490550, PubMed:9371783). When GTP-bound, interacts with Pak (PubMed:8628256).
                              (UniProt, P40793 )
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Class of Gene
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              X
                              Recombination map
                              1-64
                              Cytogenetic map
                              18E1-18E1
                              Sequence location
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              18E1-18E1
                              Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              18E-18E
                              (determined by in situ hybridisation)
                              (Sasamura et al., 1997)
                              18D-18D
                              (determined by in situ hybridisation)
                              (Sasamura, 1995)
                              Experimentally Determined Recombination Data
                              Location

                              1-64

                              (FlyBase, 2016)

                              1-62.4

                              (Comeron et al., 2012)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (41)
                              Genomic Clones (9)
                               

                              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                              cDNA Clones (185)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Cell Line Information
                                Publicly Available Cell Lines
                                 
                                  Other Stable Cell Lines
                                   
                                    Other Comments

                                    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                                    (Stroschein-Stevenson et al., 2006)

                                    Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

                                    (Agaisse et al., 2005)

                                    Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

                                    (Philips et al., 2005)

                                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                    (Kiger et al., 2003)

                                    RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.

                                    (Kiger et al., 2003)

                                    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                                    (Rogers et al., 2003)

                                    Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.

                                    (Fritz and VanBerkum, 2002)

                                    Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.

                                    (Wood et al., 2002)

                                    Cdc42 may be a negative regulator of N signalling.

                                    (Baron et al., 2000)

                                    Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.

                                    (Genova et al., 2000)

                                    Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.

                                    (Agnes et al., 1999)

                                    Cdc42 has a function in dendritic development.

                                    (Gao et al., 1999)

                                    ISNb growth cones require Cdc42 for extension to appropriate targets.

                                    (Kaufmann et al., 1998)

                                    Cdc42 is not allelic to btdl.

                                    (Fehon et al., 1997)

                                    Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.

                                    (Glise and Noselli, 1997)

                                    Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.

                                    (Murphy and Montell, 1996)

                                    Comparison of expression of constitutively active or dominantly negative Cdc42 and Rac1 mutants demonstrates that similar GTPases in the same subfamily have unique roles in morphogenesis in vivo.

                                    (Luo et al., 1994)
                                    Relationship to Other Genes
                                    Source for database merge of
                                    Additional comments

                                    The Rac2 gene may have been derived from the Cdc42 gene by retroposition.

                                    (Dai et al., 2006)
                                    Nomenclature History
                                    Source for database identify of
                                    Nomenclature comments
                                    Etymology
                                    Synonyms and Secondary IDs (20)
                                    Reported As
                                    Symbol Synonym
                                    CDC-42
                                    (Jouette et al., 2017)
                                    CDC42
                                    (Buckley and St Johnston, 2022, Mickael et al., 2021, Majumdar and Liu, 2020, Qin et al., 2020, Sundaram, 2015, Wang et al., 2014, Margolis and Borg, 2005, Mirey et al., 2003, Pastor-Pareja et al., 2001, Schejter et al., 2001, Mushegian et al., 1998, O'Leary et al., 1998, Barrett et al., 1997, Eaton, 1997, Eaton, 1997, Tanaka and Sabry, 1995, Harden et al., 1993)
                                    CG12530
                                    (Meadows, 2017.1.11, Schertel et al., 2013, Christis and Munro, 2012, Howell et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Li et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Derré et al., 2007, Dai et al., 2006, Colicelli, 2004, Rogers et al., 2003)
                                    Cdc 42
                                    (Pradhan et al., 2023)
                                    Cdc-42
                                    (Lang and Munro, 2017)
                                    Cdc42
                                    (Bischoff et al., 2025, Bischoff et al., 2025, Diaz et al., 2025, Li et al., 2025, McDonald et al., 2025, Parkhurst, 2025.5.25, Berry et al., 2024, Hizawa et al., 2024, Miao et al., 2024, Mira-Osuna and Borgne, 2024, Rötte et al., 2024, Stjepić et al., 2024, Xu et al., 2024, Burghardt et al., 2023, Fernandez-Gonzalez and Harris, 2023, Garcia-Vaquero et al., 2023, Jones et al., 2023, Koehler and Huber, 2023, Pradhan et al., 2023, Sanal et al., 2023, Bourouliti and Skoulakis, 2022, Campanale et al., 2022, Kong et al., 2022, Molina et al., 2022, Molina-Pelayo et al., 2022, Osswald et al., 2022, Roberto and Emery, 2022, Thangadurai et al., 2022, Thompson, 2022, Zhou et al., 2022, Bischoff and Bogdan, 2021, Bischoff et al., 2021, Kapoor et al., 2021, Loganathan et al., 2021, Noyes et al., 2021, Popkova et al., 2021, Wang et al., 2021, Yeates and Frank, 2021, Zhang et al., 2021, Dong et al., 2020, Jossin, 2020, Luo et al., 2020, Mlodzik, 2020, Nakamura et al., 2020, Oliveira da Silva et al., 2020, Sidor et al., 2020, Sun et al., 2020, Verboon et al., 2020, Volovetz et al., 2020, Wang et al., 2020, Boucher et al., 2019, Chen et al., 2019, Franco and Carmena, 2019, Gao et al., 2019, Guan et al., 2019, Jantrapirom et al., 2019, Kono et al., 2019, Nunes de Almeida et al., 2019, Silver et al., 2019, Akishina et al., 2018, Carmena, 2018, Garrido-Jimenez et al., 2018, Medina, 2018, Saito et al., 2018, Schmidt and Grosshans, 2018, Spinner et al., 2018, Tsai et al., 2018, Akishina et al., 2017, Banisch et al., 2017, Colombié et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Koch et al., 2017, Lou et al., 2017, Nakamura et al., 2017, Ozasa et al., 2017, Park et al., 2017, Rui et al., 2017, Siddall and Hime, 2017, Tang et al., 2017, Ajduk and Zernicka-Goetz, 2016, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Dollar et al., 2016, Fear et al., 2016, Matsubayashi and Millard, 2016, Meehan et al., 2016, Roman-Fernandez and Bryant, 2016, Sarov et al., 2016, Schimizzi et al., 2016, Whitney et al., 2016, Flores-Benitez and Knust, 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Meserve and Duronio, 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlisidou and Wood, 2015, Abreu-Blanco et al., 2014, Iordanou et al., 2014, Jones et al., 2014, Lammel et al., 2014, Pichaud, 2014, Sailem et al., 2014, Sharifai et al., 2014, Swope et al., 2014, Yashiro et al., 2014, Beckett et al., 2013, Bergstralh et al., 2013, Chen et al., 2013, Leibfried et al., 2013, Melzer et al., 2013, Muha and Müller, 2013, Neisch et al., 2013, Puram and Bonni, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Zhang et al., 2013, Zhu, 2013, Abreu-Blanco et al., 2012, Baek et al., 2012, Fabian and Brill, 2012, Gates, 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Murray et al., 2012, Peltan et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Tepass, 2012, Tsubouchi et al., 2012, Zoller and Schulz, 2012, Clark et al., 2011, Fauvarque and Williams, 2011, Gontang et al., 2011, Jones and Metzstein, 2011, Laprise and Tepass, 2011, Meiklejohn et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Pilgram et al., 2011, Qian et al., 2011, Razzell et al., 2011, Rotkopf et al., 2011, Song and Giniger, 2011, Tanaka et al., 2011, Zhang et al., 2011, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, Colosimo et al., 2010, D'Ambrosio and Vale, 2010, Dorsten et al., 2010, Elsaesser et al., 2010, Garlena et al., 2010, Georgiou and Baum, 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Robinson et al., 2010, Sato et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Venken et al., 2010, Walther and Pichaud, 2010, Warner, 2010.9.15, Warner et al., 2010, Asano et al., 2009, Frank et al., 2009, Fricke et al., 2009, Gupta et al., 2009, Hirano et al., 2009, Kamiyama and Chiba, 2009, Liu et al., 2009, Patch et al., 2009, van Impel et al., 2009, Warner and Cook, 2009.11.19, Warner and Longmore, 2009, Warner and Longmore, 2009, Bakal et al., 2008, Harris and Tepass, 2008, Harris and Tepass, 2008, Kim et al., 2008, Larson et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Rodal et al., 2008, Vogler et al., 2008, Warren-Paquin et al., 2008, Zhou et al., 2008, Atwood et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Derré et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Jovceva et al., 2007, Leibfried et al., 2007, Muñoz-Descalzo et al., 2007, Taniguchi et al., 2007, Tepass and Harris, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Hozumi et al., 2006, Humbert et al., 2006, Kerkhoff, 2006, Nahm et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Talbot and VanBerkum, 2006, Avet-Rochex et al., 2005, Cho et al., 2005, Go, 2005, Sen et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hofmann et al., 2004, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Gao and Bogert, 2003, Rogers et al., 2003, Kim et al., 2002, Wolf et al., 2002)
                                    Cdc42Dm
                                    (Zhang et al., 1999)
                                    D-CDC42
                                    (Ip and Davis, 1998)
                                    D-Cdc42
                                    (Knust, 1997)
                                    D-cdc42
                                    (Ryabinina et al., 2006)
                                    DCDC42
                                    (Hummel et al., 2000, Sasamura et al., 1995)
                                    DCdc42
                                    (Blanke and Jackle, 2006, Van Aelst and Symons, 2002, Dobens et al., 2001, Dobens et al., 2000, Paladi and Tepass, 2000, Sotillos and Campuzano, 2000, Szuts and Bienz, 2000, Hacker and Perrimon, 1998, Martin-Blanco, 1997, Van Aelst and D'Souza-Schorey, 1997)
                                    Dcdc42
                                    (Shuai et al., 2010, Dorsten et al., 2007, He et al., 2005, Xia and Karin, 2004, He and Adler, 2003, Vasenkova et al., 2003, Adler, 2002, Harden et al., 2002, He and Adler, 2002, Kim et al., 2002, Noselli, 2002, Sem et al., 2002, Zahedi et al., 2002, Dawber et al., 2001, Harden et al., 2001, Luginbuhl et al., 2001, Raymond et al., 2001, Raymond et al., 2001, Suzanne et al., 2001, Zarske et al., 2001, Allen et al., 2000, Baron et al., 2000, Benlali et al., 2000, Dobens and Raftery, 2000, Jacobs et al., 2000, Kim and Chiba, 2000, Muller, 2000, Raymond et al., 2000, Agnes and Noselli, 1999, Agnes and Noselli, 1999, Agnes et al., 1999, Gao et al., 1999, Harden et al., 1999, Harden et al., 1999, Noselli and Agnes, 1999, Paululat et al., 1999, Ricos et al., 1999, Ricos et al., 1999, Stronach and Perrimon, 1999, Goberdhan and Wilson, 1998, Noselli, 1998, Zohn et al., 1998, Luo et al., 1997, Sasamura et al., 1997, Sone et al., 1997, Eaton et al., 1995, Luo et al., 1995, Luo, 1994.7.5, Luo et al., 1994)
                                    Dm Cdc42
                                    (Jekely, 2003)
                                    DmCDC42
                                    (Mentzel and Raabe, 2005, Piekny et al., 2005)
                                    Dmcdc42
                                    (Riesgo-Escovar et al., 1996)
                                    P40793
                                    (Rojas et al., 2012)
                                    cdc42
                                    (Wang et al., 2023, Chen et al., 2022, González-Ramírez et al., 2022, Milas and Telley, 2022, DeAngelis et al., 2021, Fic et al., 2021, Morin-Poulard et al., 2021, Khoury and Bilder, 2020, Popkova et al., 2020, Barr et al., 2019, Hao and Jin, 2017, Khanal et al., 2016, Liu et al., 2016, Ruan et al., 2016, Hosono et al., 2015, Kamiyama et al., 2015, Ugrankar et al., 2015, de Vreede et al., 2014, Jalvingh et al., 2014, Pereira et al., 2014, Bergstralh et al., 2013, Cook et al., 2012, Fletcher et al., 2012, Mukherjee et al., 2012, Miles et al., 2011, Ohsawa et al., 2011, Chang et al., 2010, Djiane and Mlodzik, 2010, Nahm et al., 2010, Higuchi et al., 2009, Kamiyama and Chiba, 2009, Qian and Bodmer, 2009, van Impel et al., 2009, Georgiou et al., 2008, Leibfried et al., 2008, Llense and Martín-Blanco, 2008, McGraw et al., 2008, Rodal et al., 2008, Atwood et al., 2007, Avet-Rochex et al., 2007, Schafer et al., 2007, Huelsmann et al., 2006, Houalla et al., 2005, Leptin, 2005, Zhu et al., 2005, Ng and Luo, 2004, Polesello and Payre, 2004, Pagliarini and Xu, 2003, Rogers et al., 2003, Mlodzik, 2002, Pandur et al., 2002, Ruan et al., 2002, Jhaveri and Rodrigues, 2001, Kadam and Reuter, 2001, Sepp and Auld, 2001, Schock and Perrimon, 2000, Asha et al., 1999, Nairz and Hafen, 1999, Prokopenko et al., 1999, Sawamoto et al., 1999, Sawamoto et al., 1999, Boutros et al., 1998, Matova et al., 1998, Nolan et al., 1998, Matova et al., 1997, Murphy and Montell, 1995)
                                    Name Synonyms
                                    Cdc42
                                    (Frank, 2014, Melzer et al., 2013, Cammarato et al., 2011, Robinson et al., 2010, Patch et al., 2009, Zhou et al., 2008, Wolf et al., 2002)
                                    Cdc42-like
                                    Cell division cycle 42
                                    Secondary FlyBase IDs
                                    • FBgn0012059
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    External Crossreferences and Linkouts ( 90 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    FlyMine - An integrated database for Drosophila genomics
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                    References (622)