FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdc42N17.UAS
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General Information
Symbol
Dmel\Cdc42N17.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0038150
Feature type
allele
Associated gene
Dmel\Cdc42
Associated Insertion(s)
Carried in Construct
P{UAS-Cdc42.N17}
Also Known As
UAS-Cdc42N17, Cdc42N17, UAS-Dcdc42N17, UAS-Dcdc42N17, UAS-Cdc42DN, cdc42-DN, UAS-cdc42N17, UAS-Cdc42DN, Cdc42N17
Key Links
Transgenic product class
dominant_negative_variant
(Luo et al., 1994)
missense_variant
(Luo et al., 1994)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Luo et al., 1994)
missense_variant
(Luo et al., 1994)
Mutagen
in vitro construct
(Schneeberger and Raabe, 2003, Eaton et al., 1995, Luo et al., 1994)
Progenitor genotype
Carried in construct
P{UAS-Cdc42.N17}
Cytology
Description

UASt regulatory sequences drive expression of a dominant-negative form of Cdc42 (contains a T17N amino acid replacement).

(Luo et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cdc42
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal cell migration | embryonic stage, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PG

      (Balaghi et al., 2023)

      abnormal cell polarity, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA

      (Stramer et al., 2005)

      abnormal cell polarity, with Scer\GAL4wor.PA

      (Atwood et al., 2007)

      abnormal memory | adult stage, with Scer\GAL4elav.PU

      (Shuai et al., 2010)

      abnormal memory | adult stage, with Scer\GAL4ey-OK107

      (Shuai et al., 2010)

      abnormal neuroanatomy, with Scer\GAL4elav-C155

      (Kim et al., 2002)

      abnormal neuroanatomy, with Scer\GAL4Mhc.Switch.PO

      (Nahm et al., 2010)

      abnormal neuroanatomy, with Scer\GAL4Ntan1-Mz317

      (Jhaveri and Rodrigues, 2002)

      abnormal neuroanatomy | larval stage, with Scer\GAL41003.3

      (Tsubouchi et al., 2012)

      abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4elav-C155

      (Dominicci-Cotto et al., 2024)

      abnormal touch response | larval stage, with Scer\GAL41003.3

      (Tsubouchi et al., 2012)

      abnormal wound healing, with Scer\GAL4en-e16E

      (Wood et al., 2002)

      increased cell number | somatic clone, with Scer\GAL4wor.PA

      (de Torres-Jurado et al., 2022)

      lethal, with Scer\GAL4198Y

      (Murphy and Montell, 1996)

      lethal, with Scer\GAL4238Y

      (Schneeberger and Raabe, 2003)

      lethal - all die before end of pupal stage, with Scer\GAL4how-24B

      (Luo et al., 1994)

      lethal - all die during embryonic stage, with Scer\GAL469B

      (Riesgo-Escovar et al., 1996)

      partially lethal, with Scer\GAL4elav.PLu

      (Fritz and VanBerkum, 2002)

      some die during embryonic stage, with Scer\GAL469B

      (Riesgo-Escovar et al., 1996)

      some die during pupal stage, with Scer\GAL4how-24B

      (Luo et al., 1994)

      viable, with Scer\GAL4212

      (Murphy and Montell, 1996)

      viable, with Scer\GAL4306

      (Murphy and Montell, 1996)

      viable, with Scer\GAL4458

      (Murphy and Montell, 1996)

      viable, with Scer\GAL4hs.PB

      (Murphy and Montell, 1996)

      visible, with Scer\GAL4en-e16E

      (Fricke et al., 2009)
      Phenotype Manifest In

      adult heart, with Scer\GAL4how-24B

      (Qian et al., 2011)

      adult heart, with Scer\GAL4tin.CΔ4

      (Qian et al., 2011)

      antenna & glial cell, with Scer\GAL4Ntan1-Mz317

      (Jhaveri and Rodrigues, 2002)

      antenna & sensory neuron, with Scer\GAL4Ntan1-Mz317

      (Jhaveri and Rodrigues, 2002)

      bouton, with Scer\GAL4Mhc.Switch.PO

      (Nahm et al., 2010)

      cardiac myofibril, with Scer\GAL4how-24B

      (Qian et al., 2011)

      cardiac myofibril, with Scer\GAL4tin.CΔ4

      (Qian et al., 2011)

      cardial cell, with Scer\GAL4how-24B

      (Qian et al., 2011)

      cardial cell, with Scer\GAL4tin.CΔ4

      (Qian et al., 2011)

      crossvein | cell non-autonomous | ectopic, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      crossvein | increased number, with Scer\GAL4en-e16E

      (Blanke and Jackle, 2006)

      dorsal appendage, with Scer\GAL4CY2

      (Suzanne et al., 2001)

      embryo, with Scer\GAL4twi.PU

      (Clark et al., 2011)

      embryo | dorsal closure stage, with Scer\GAL4en-e16E

      (Jacinto et al., 2000)

      embryo | dorsal closure stage | heat sensitive, with Scer\GAL4hs.PB

      (Sem et al., 2002)

      embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1

      (Harden et al., 1999)

      embryonic/first instar larval cuticle, with Scer\GAL4twi.PG

      (Hacker and Perrimon, 1998)

      embryonic/first instar larval cuticle | dorsal, with Scer\GAL469B

      (Riesgo-Escovar et al., 1996)

      embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB

      (Harden et al., 1999)

      embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1

      (Raymond et al., 2001)

      embryonic/first instar larval cuticle | heat sensitive, with Scer\GAL4hs.PB

      (Sem et al., 2002)

      embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4da.G32

      (Silver et al., 2019)

      embryonic/larval hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA

      (Stramer et al., 2005)

      embryonic/larval midgut | embryonic stage, with Scer\GAL448Y

      (Martin-Bermudo et al., 1999)

      embryonic/larval neuromuscular junction | larval stage | conditional, with Scer\GAL4elav-C155

      (Dominicci-Cotto et al., 2024)

      embryonic/larval plasmatocyte, with Scer\GAL4da.G32

      (Paladi and Tepass, 2004)

      embryonic/larval tracheal dorsal trunk, with Scer\GAL4hs.2sev

      (Wolf et al., 2002)

      embryonic/larval tracheal lateral trunk, with Scer\GAL4btl.PS

      (Iordanou et al., 2014)

      embryonic cardioblast, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PG

      (Balaghi et al., 2023)

      embryonic epidermis, with Scer\GAL4hs.PB

      (Ricos et al., 1999)

      embryonic epidermis | dorsal, with Scer\GAL4en-e16E

      (Jacinto et al., 2000)

      embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA

      (Stramer et al., 2005)

      embryonic proventriculus, with Scer\GAL4retn-GAL4

      (Fuss et al., 2004)

      follicle cell, with Scer\GAL4Act5C.PP

      (Dobens et al., 2001)

      larval abdominal segmental nerve, with Scer\GAL4elav-C155

      (Kim et al., 2002)

      larval dorsal multidendritic neuron ddaA | larval stage, with Scer\GAL41003.3

      (Tsubouchi et al., 2012)

      medial row of triple row of wing sensilla, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      neuroblast | embryonic stage, with Scer\GAL4wor.PA

      (Atwood et al., 2007)

      neuroblast | increased number | somatic clone, with Scer\GAL4wor.PA

      (de Torres-Jurado et al., 2022)

      neuromuscular junction, with Scer\GAL4Mhc.Switch.PO

      (Nahm et al., 2010)

      presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS

      (Lee and Kolodziej, 2002)

      proventriculus inner layer primordium, with Scer\GAL4retn-GAL4

      (Fuss et al., 2004)

      proventriculus intermediate layer primordium, with Scer\GAL4retn-GAL4

      (Fuss et al., 2004)

      sensory dendrite | larval stage, with Scer\GAL41003.3

      (Tsubouchi et al., 2012)

      wing, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      wing hair | ectopic, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      wing hair | increased number, with Scer\GAL4en-e16E

      (Fricke et al., 2009)

      wing margin, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      wing margin bristle, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)

      wing vein | ectopic, with Scer\GAL4Bx-MS1096

      (Baron et al., 2000)
      Detailed Description
      Statement
      Reference

      The expression of Cdc42N17.UAS under the control of Scer\GAL4da.G32 leads to severe cuticle defects in the embryo.

      (Silver et al., 2019)

      Scer\GAL4btl.PS-mediated expression of Cdc42N17.Scer\UAS causes tracheal lateral trunk fusion defects.

      (Iordanou et al., 2014)

      Class III ddaA neurons expressing Cdc42N17.Scer\UAS under the control of Scer\GAL41003.3 show a significant decrease in the number of dendritic sensory filopodia compared to wild type. The average length of the filopodia is significantly increased compared to wild type, while the total length of primary dendritic branches is not altered.

      Larvae expressing Cdc42N17.Scer\UAS under the control of Scer\GAL41003.3 show a reduced response to gentle touch compared to controls.

      (Tsubouchi et al., 2012)

      Flies expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4tin.CΔ4 (in combination with GAL80 to restrict the expression to the first week of adult life) exhibit a significantly increased pacing-induced heart failure rate, increased incidence of arrhythmias, overall lower heart rates due to longer diastolic intervals, severely misaligned myofibrils, and irregularities in the Z-line pattern of the cardiomyocytes, as compared with controls. Systolic intervals are not significantly changed in these flies.

      Flies expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4how-24B (in combination with GAL80 to restrict the expression to the first week of adult life) exhibit a significantly increased pacing-induced heart failure rate, increased incidence of arrhythmias, severely misaligned myofibrils, and irregularities in the Z-line pattern of the cardiomyocytes, as compared with controls. Systolic intervals are not significantly changed in these flies.

      (Qian et al., 2011)

      Expression of Cdc42N17.Scer\UAS in the muscles driven by Scer\GAL4Mhc.Switch.PO in the absence of RU486 is sufficient to decrease all parameters of synaptic growth.

      (Nahm et al., 2010)

      Expression of Cdc42N17.Scer\UAS under the control of either Scer\GAL4elav.PU or Scer\GAL4ey-OK107 (using tub-Gal80[ts] to limit the expression to the adult stage) significantly improves 3 hr memory of adult flies in an aversive olfactory assay compared to controls.

      (Shuai et al., 2010)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4en-e16E results in a strong multiple wing hair phenotype.

      (Fricke et al., 2009)

      Mitotic neuroblasts expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4pros.PMG display normal cell polarity. Expression of Cdc42N17.Scer\UAS in neuroblasts from their formation, under the control of Scer\GAL4wor.PA, results in a dramatic increase in the number of neuroblasts with cell polarity defects.

      (Atwood et al., 2007)

      Scer\GAL4en-e16E-mediated expression of Cdc42N17.Scer\UAS causes duplications of crossveins.

      (Blanke and Jackle, 2006)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4ato.3.6 does not affect dorsal cluster neuron axon extension across the optic chiasm in adult flies.

      (Srahna et al., 2006)

      Expression of Cdc42N17.Scer\UAS in border cells, driven by Scer\GAL4slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

      (Medioni and Noselli, 2005)

      Hemocytes in embryos expressing Cdc42N17.Scer\UAS under the simultaneous control of both Scer\GAL4Pxn.PS and Scer\GAL4crq.PA show normal developmental dispersal and normal recruitment to sites of laser-induced tissue damage. However, during the migratory phase and after arrival at the wound site, the mutant hemocytes often possess several leading edges suggesting that they cannot maintain a persistent polarity.

      The failure of hemocytes to maintain polarity in embryos expressing Cdc42N17.Scer\UAS under the simultaneous control of both Scer\GAL4Pxn.PS and Scer\GAL4crq.PA leads them to adopt a haphazard migratory route. This defect is countered by the mutant hemocytes migrating at approximately twice the normal speed so that they reach the wound as rapidly as in wild type embryos.

      (Stramer et al., 2005)

      Expression of Cdc42N17.Scer\UAS in the muscle, under the regulation of Scer\GAL4Mhc.PW has no effect on synapse development.

      (Albin and Davis, 2004)

      In Cdc42N17.Scer\UAS; Scer\GAL4retn-GAL4 embryos, invagination of the ectodermal keyhole cells during development of the proventriculus is defective.

      (Fuss et al., 2004)

      Expression of Cdc42N17.Scer\UAS under the control of either Scer\GAL4Cg25C-A109.1F2.P or Scer\GAL4gcm-rA87.P does not interfere with the migration or distribution of macrophages in the embryo.

      Macrophages have wild-type cytoplasmic protrusions and normal F-actin content in embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4gcm-rA87.P. Macrophages have wild-type morphology in embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4Cg25C-A109.1F2.P.

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4da.G32 causes defects in macrophage migration in the embryo.

      (Paladi and Tepass, 2004)

      When Cdc42N17.Scer\UAS is overexpressed, mutants do not exhibit longitudinal axon ectopic midline crossing defects.

      (Fan et al., 2003)

      Cdc42N17.Scer\UAS when driven by Scer\GAL4nos.UTR.T:Hsim\VP16 has no effect on transepithelial migration of germ cells in the embryo.

      (Kunwar et al., 2003)

      Cdc42N17.Scer\UAS driven by Scer\GAL4repo has no effect on the glia of the peripheral nervous system.

      (Sepp and Auld, 2003)

      When Cdc42N17.Scer\UAS is driven by Scer\GAL4ftz.ng, no midline crossovers are seen in the pCC/MP2 pathway axons. When Cdc42N17.Scer\UAS is driven by Scer\GAL4elav.PLu only half of the expected number of adults eclose.

      (Fritz and VanBerkum, 2002)

      Expression of Cdc42N17.Scer\UAS driven by Scer\GAL4332.3 does not affect either the dorsal cuticle or amnioserosa morphology.

      (Harden et al., 2002)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4Mz317 results in a reduction in the number of glial cells in the antenna, and the residual glial cells are aggregated with no apparent processes. Sensory neurons in the antenna show a number of defects in fasciculation. The antennal glomeruli in the olfactory lobe develop normally in these animals and there are no defects in the lobe-associated glia or their extensions into the lobe.

      (Jhaveri and Rodrigues, 2002)

      Expression of dominant-negative Cdc42N17.Scer\UAS in SNb neurons under the control of Scer\GAL4elav-C155 results in abnormal pathfinding patterns in 15% of cases.

      (Kim et al., 2002)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4btl.PS does not affect lumen formation in the tracheal system although these embryos do show some defects in tracheal branch migration.

      (Lee and Kolodziej, 2002)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB using heat shock results in a failure of dorsal closure in the embryo, producing dorsal holes in the cuticle.

      (Sem et al., 2002)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.2sev using heat shock results in breaks in the tracheal dorsal trunk in embryos in 32% of cases.

      (Wolf et al., 2002)

      Cdc42N17.Scer\UAS; Scer\GAL4en-e16E embryos complete dorsal closure but fail to survive to larval stages. In these embryos, small laser wounds (approximately 2 cell diameters in width) assemble an actin cable in leading-edge cells at the same rate as in wild-type. However, no filopodial or lamellipodial protrusions extend from any of the leading-edge cells throughout wound closure. At 30 min after wounding, the hole is almost closed but, unlike wild-type epithelium, which undergoes this final closure phase in less than 15 min, the hole remains unsealed even 2 hours after wounding.

      (Wood et al., 2002)

      Co-expression of Cdc42N17.Scer\UAS has little or no effect on the gain of function axon guidance defects caused by expression of Gef64CEP3035 under the control of Scer\GAL4elav.PLu.

      (Bashaw et al., 2001)

      Cells expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4Act5C.PP in large clones in the posterior follicle cells delaminate and leave the continuous follicle epithelium.

      (Dobens et al., 2001)

      Embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4ptc-559.1 have a dorsal hole.

      (Raymond et al., 2001)

      Eggs derived from females expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4CY2 have thinner dorsal appendages than normal which are irregular in shape.

      (Suzanne et al., 2001)

      Cdc42N17.Scer\UAS when driven by Scer\GAL4Bx-MS1096, results in a strong multiple wing hair phenotype, a reduction in wing size, ectopic vein tissue and wing margin phenotypes. In the wing margin, expression causes a reduction of bristle density with the stout mechanosensors being most affected; in many wings these are completely absent. However the remaining margin occupies a broader area than normal. When driven by Scer\GAL4ptc-559.1, a non-autonomous ectopic crossvein phenotype is seen.

      (Baron et al., 2000)

      When Cdc42N17.Scer\UAS is driven by Scer\GAL4en-e16E in embryos at the zippering stage, just before dorsal closure, the normal extension of actin based filopodia and lamellae is not seen at the dorsal holes edge. A severe failure to seam and a misalignment of the seamed edges is also seen in these embryos.

      (Jacinto et al., 2000)

      Embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4ptc-559.1 show a high frequency of dorsal cuticle defects, with most embryos having a large hole towards the posterior of the embryo. Embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB (using heat shock) can survive to the first larval instar stage depending on the Scer\GAL4hs.PB line used. Phenotypes include a mild puckering of the cuticle with very few dorsal holes, dorsal holes in the cuticle and embryos having at least one or usually several instances of the dorsal ends of segments being pulled together at the leading edge into bunches.

      (Harden et al., 1999)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL448Y in the developing midgut causes a delay in migration of the endodermal midgut cells.

      (Martin-Bermudo et al., 1999)

      Embryos expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB show bunching of epidermal segments at the end of dorsal closure.

      (Ricos et al., 1999)

      Scer\GAL4twi.PG-mediated expression causes severe cuticle defects.

      (Hacker and Perrimon, 1998)

      Scer\GAL4-mediated expression fails to cause any defects.

      (Murphy and Montell, 1996)

      When expression is driven by Scer\GAL469B the embryos show a dorsal open phenotype.

      (Riesgo-Escovar et al., 1996)

      Semi-embryonic lethal with Scer\GAL41407, some individuals survive to adulthood.

      (Luo et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by kisEP474, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by kisEP474, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4elav-C155/Cdc42N17.UAS is a non-enhancer of abnormal neuroanatomy | heat sensitive phenotype of Nl1N-ts1

      (Song and Giniger, 2011)
      Suppressor of
      Statement
      Reference

      Cdc42N17.UAS/Scer\GAL4ey.PH is a suppressor of visible | somatic clone | adult stage phenotype of btlLG19

      (Mukherjee et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4NP2225/Cdc42N17.UAS is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of cv-c1260

      (Sato et al., 2010)
      Other
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by kisEP474, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Cdc42N17.UAS, Scer\GAL4da.G32 has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by cystUASp.R, Scer\GAL4da.G32

      (Silver et al., 2019)

      Cdc42N17.UAS, Scer\GAL4da.G32 has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by cystN.UASp.R, Scer\GAL4da.G32

      (Silver et al., 2019)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by kisEP474, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Cdc42N17.UAS, Scer\GAL4hs.PB has embryonic epidermis phenotype, non-suppressible by tkvTAJ3

      (Ricos et al., 1999)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4ey.PH rescues the glossy eye phenotype seen in btlLG19 mutant clones.

      (Mukherjee et al., 2012)

      The ISNb bypass phenotype of Nl1N-ts1 mutant embryos is not significantly modulated by expression of Cdc42N17.Scer\UAS (under the control of Scer\GAL4elav-C155).

      (Song and Giniger, 2011)

      Expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4NP2225 does not suppress the reduction in length of secondary dendritic branches which is seen in the ddaE neurons of cv-c1260 embryos at 20-22 hours after egg laying.

      (Sato et al., 2010)

      When Cdc42N17.Scer\UAS is added to RhoGAP93BScer\UAS.cHa, Scer\GAL4elav.PLu embryos, no enhancement of the ectopic midline crossing phenotype is seen in the ventral nerve cord.

      (Hu et al., 2005)

      Co-expression of Cdc42N17.Scer\UAS and Rac1N17.Scer\UAS in the muscle, under the regulation of Scer\GAL4Mhc.PW has no effect on gross synapse development.

      (Albin and Davis, 2004)

      The combination of heterozygous sli2 and pan-neural overexpression of Cdc42N17.Scer\UAS (expressed under the control of Scer\GAL4elav.PLu) does not cause longitudinal axon ectopic midline crossing defects.

      (Fan et al., 2003)

      The addition of Cdc42N17.Scer\UAS (driven by Scer\GAL4ftz.ng) to robo1/+ embryos partially suppresses the midline crossover phenotype seen in the pCC/MP2 pathway axons. 18% of embryos exhibit the phenotype. An average of 1.2 crossovers are seen per embryo. The addition of Cdc42N17.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49/+ embryos has no effect on the midline crossover phenotype seen in the pCC/MP2 pathway axons. The addition of chicsand-1 to Cdc42N17.Scer\UAS has no effect on their midline crossover phenotypes in the pCC/MP2 pathway axons.

      (Fritz and VanBerkum, 2002)

      Co-expression of AckScer\UAS.cSa partially suppresses the dorsal closure defects caused by expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB using heat shock.

      (Sem et al., 2002)

      The loss of one copy of N by the addition of Df(1)N-54l9 to Cdc42N17.Scer\UAS, Scer\GAL4Bx-MS1096 flies restores the stout mechanosensor bristle phenotype. The addition of NAx-E2 enhances the wing margin phenotype.

      (Baron et al., 2000)

      The dorsal closure defects of embryos co-expressing Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB and Rac1N17.hs (using heat shock) 4 to 8 hours after egg laying are more severe than the defects produced by expression of either Rac1N17.hs or Cdc42N17.Scer\UAS alone. In contrast, the defects produced by co-expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB and Rac1N17.hs (using heat shock) 8 to 12 hours after egg laying are weaker than Rac1N17.hs expressed alone, but stronger than Cdc42N17.Scer\UAS expressed alone.

      (Harden et al., 1999)

      tkvTAJ3 has no effect on the phenotype caused by expression of Cdc42N17.Scer\UAS under the control of Scer\GAL4hs.PB.

      (Ricos et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference

      The addition of Cdc42N17.Scer\UAS to Ggal\MLCKct.Scer\UAS, Scer\GAL4ftz.ng embryos partially suppresses the midline crossover phenotype seen in the pCC/MP2 pathway axons. 4.4% of embryos exhibit the phenotype. An average of 1.3 crossovers are seen per embryo.

      (Fritz and VanBerkum, 2002)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Cdc42N17.Scer\UAS
      Cdc42N17.UAS
      Cdc42N17
      (Flores-Benitez and Knust, 2015, Stramer et al., 2005, Hutterer et al., 2004)
      D-Cdc42DN
      (Kockel et al., 2001)
      DCdc42N17
      (Medioni and Noselli, 2005)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0038149
      References (74)