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General Information
Symbol
Dmel\RhoGEF64CEP3035
Species
D. melanogaster
Name
FlyBase ID
FBal0136060
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Inserted 91bp downstream from the start of the Gef64C first exon.

Insertion components
P{EP}EP3035
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ventral nerve cord commissures in stage 17 Gef64CEP3035; Scer\GAL4sca-4512 embryos are fused.

Expression of Gef64CEP3035 under the control of Scer\GAL4elav.PLu results in many axons abnormally projecting across the midline. The commissures are thicker than normal and there is a reduction in the longitudinal axon tracts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

pnrMD237/+ adults expressing Gef64CEP3035 under the control of Scer\GAL4pnr-MD237 have deformed macrochaetae.

Gef64CEP3035 dramatically enhances the axon guidance defects caused by expression of fra::roboScer\UAS.RF.T:Hsap\MYC under the control of Scer\GAL4elav.PLu, leading to a significant increase in ectopic midline crossing. Co-expression of Rac1N17.Scer\UAS has little or no effect on the gain of function axon guidance defects caused by expression of Gef64CEP3035 under the control of Scer\GAL4elav.PLu. Co-expression of Cdc42N17.Scer\UAS has little or no effect on the Co-expression of Rho1N19.Scer\UAS strongly suppresses the gain of function axon guidance defects caused by expression of Gef64CEP3035 Many commissural axons cross the midline, with some segments appearing nearly wild type, in embryos coexpressing roboY-F.Scer\UAS and Gef64CEP3035 under the control of Scer\GAL4elav.PLu.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Gef64CEP3035
RhoGEF64CEP3035
Name Synonyms
Secondary FlyBase IDs
    References (4)