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General Information
Symbol
Dmel\exp135
Species
D. melanogaster
Name
FlyBase ID
FBal0298064
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}PI31G7971 removing exons 3-11 of exp and potentially generates a severely truncated protein (39 aa) that lacks the entire MH2 and C-terminal domains.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous, hemizygous and trans-heterozygous (with exp11) mutant embryos exhibit bubble-like cysts with an enlarged diameter in unicellular (lateral trunk, ganglionic branch) and intracellular (lateral ganglionic branch) tracheal branches, but not in multicellular branches (dorsal trunk) or intracellular fusion branches. Bubbles are also seen in the dorsal branch and visceral branch, but to a lesser extent. Despite this, the tracheal network exhibits normal branching patterns. Tracheal cell number is also unaffected in exp135 mutants.

Tracheal cysts in exp135 embryos are modified apical extracellular lumen in unicellular branches, and intracellular vacuole-like compartments in intracellular branches.

Defective accumulation of a subset of luminal components is observed in unicellular and intracellular (but not multicellular) tracheal branches where cysts form in exp135 mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4btl.PS-mediated expression of EgfrElp.Scer\UAS or btlScer\UAS.T:λ\cI-DD enhances, whereas expression of EgfrDN.Scer\UAS.cBa or btlDN.Scer\UAS suppresses the tracheal cyst phenotype of exp135 embryos.

Scer\GAL4btl.PS-mediated expression of Rho1V14.Scer\UAS enhances, whereas expression of Cdc42V12.Scer\UAS or Rac1N17.Scer\UAS or Rho1N19.Scer\UAS partially suppresses the tracheal cyst phenotype of exp135 embryos. Scer\GAL4btl.PS-mediated expression of Cdc42N17.Scer\UAS has no obvious effect on this phenotype.

Neither a put135 background nor Scer\GAL4btl.PS-mediated expression of tkvQD.Scer\UAS.cUa has any effect on the tracheal cyst phenotype of exp135 embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Scer\GAL4btl.PS-mediated expression of expB.Scer\UAS.T:Ivir\HA1 completely rescues the tracheal phenotype of exp135 and exp11 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)